Melting point	>300 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
Matrix	View & Download

Synthetic Route

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Name	CAS
5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone	870281-82-6	View

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Articles

Peer-Reviewed Papers

Ion-pair liquid chromatography-electrospray mass spectrometry for the analysis of cyclic nucleotides.E Witters et al.Journal of chromatography. B, Biomedical sciences and applications, 694(1), 55-63 (1997-06-20) Extracellular 2',3'-cAMP is a source of adenosine.Edwin K Jackson et al.The Journal of biological chemistry, 284(48), 33097-33106 (2009-10-06) The 2',3'-cAMP-adenosine pathway.Edwin K Jackson American journal of physiology. Renal physiology, 301(6), F1160-F1167 (2011-09-23) 2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors.Edwin K Jackson et al.The Journal of pharmacology and experimental therapeutics, 337(2), 444-450 (2011-01-29) The effects of endogenous diuretic and antidiuretic peptides and their second messengers in the Malpighian tubules of Tenebrio molitor: an electrophysiological study.Wiehart UIM, et al. Journal of Insect Physiology, 49(10), 955-965 (2003) Extracellular 2,3-cyclic adenosine monophosphate is a potent inhibitor of preglomerular vascular smooth muscle cell and mesangial cell growth [corrected].Edwin K Jackson et al.Hypertension (Dallas, Tex. : 1979), 56(1), 151-158 (2010-06-03) 3',5'-Cyclic nucleotide phosphodiesterase activity of the sulphatase A of ox liver.T Uchida et al.Biochimica et biophysica acta, 657(2), 356-363 (1981-02-13) The enhancement activities of histidyl-histidine in some prebiotic reactions.C Shen et al.Journal of molecular evolution, 31, 445-452 (1990-01-01) Preparation of cyclic 2',3'-monophosphates of oligoadenylates (A2'p)nA > p and A3'p(A2'p)n-1A > p.E I Budowsky et al.European journal of biochemistry, 220(1), 97-104 (1994-02-15) 2',3'-cAMP hydrolysis by metal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: Implications for PDE screening.Feng Rao et al.Biochemical and biophysical research communications, 398(3), 500-505 (2010-07-06) 2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors.Edwin K Jackson et al.American journal of physiology. Heart and circulatory physiology, 301(2), H391-H401 (2011-05-31) The possible cyclic AMP-dependence of an early prereplicative event that determines mitosis in regenerating rat liver.R H Rixon et al.Journal of cellular physiology, 124(3), 397-402 (1985-09-01) Concentration-dependent effect of trapidil on slow action potentials in cardiac muscle.J Azuma et al.Journal of molecular and cellular cardiology, 15(1), 43-52 (1983-01-01) Measuring dynamic changes in cAMP using fluorescence resonance energy transfer.Sandrine Evellin et al.Methods in molecular biology (Clifton, N.J.), 284, 259-270 (2004-06-03) Extracellular 2',3'-cAMP-adenosine pathway in proximal tubular, thick ascending limb, and collecting duct epithelial cells.Edwin K Jackson et al.American journal of physiology. Renal physiology, 304(1), F49-F55 (2012-10-19) The brain in vivo expresses the 2',3'-cAMP-adenosine pathway.Jonathan D Verrier et al.Journal of neurochemistry, 122(1), 115-125 (2012-03-01) Characterization of the 2',3' cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase.Niroshika Keppetipola et al.Nucleic acids research, 35(22), 7721-7732 (2007-11-08) N-cyanoimidazole and diimidazole imine: water-soluble condensing agents for the formation of the phosphodiester bond.J P Ferris et al.Nucleosides & nucleotides, 8(3), 407-414 (1989-01-01) Structural and functional analysis of the Lmo2642 cyclic nucleotide phosphodiesterase from Listeria monocytogenes.Yeon-Gil Kim et al.Proteins, 79(4), 1205-1214 (2011-01-20) gRICH68 and gRICH70 are 2',3'-cyclic-nucleotide 3'-phosphodiesterases induced during goldfish optic nerve regeneration.R P Ballestero et al.The Journal of biological chemistry, 272(17), 11479-11486 (1997-04-25) Extracellular cAMP-adenosine pathways in the mouse kidney.Edwin K Jackson et al.American journal of physiology. Renal physiology, 301(3), F565-F573 (2011-06-10) Interaction of 2′, 3′-cAMP with Rbp47b plays a role in stress granule formation.Kosmacz M, et al. Plant Physiology, pp-00285 (2018) Expression of the 2',3'-cAMP-adenosine pathway in astrocytes and microglia.Jonathan D Verrier et al.Journal of neurochemistry, 118(6), 979-987 (2011-07-23) Identification and quantification of 2',3'-cAMP release by the kidney.Jin Ren et al.The Journal of pharmacology and experimental therapeutics, 328(3), 855-865 (2008-11-27) Ca2+-dependent permeability transition regulation in rat brain mitochondria by 2',3'-cyclic nucleotides and 2',3'-cyclic nucleotide 3'-phosphodiesterase.Tamara Azarashvili et al.American journal of physiology. Cell physiology, 296(6), C1428-C1439 (2009-04-10) Modeling of prebiotic catalysis with adenylated polymeric templates: crystal structure studies and kinetic characterization of template-assisted phosphate ester hydrolysis.S G Srivatsan et al.Chemistry (Weinheim an der Bergstrasse, Germany), 8(22), 5184-5191 (2003-03-05) Repressible extracellular phosphodiesterases showing cyclic 2',3'- and cyclic 3',5'-nucleotide phosphodiesterase activities in Neurospora crassa.K Hasunuma Journal of bacteriology, 156(1), 291-300 (1983-10-01)

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