Melting point	124-125 ºC**
Density	1.02±0.1 g/cm3 (20 ºC

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Influence of chemical and structural features of low molecular weight heparins (LMWHs) on skin penetration.S Franzè et al.International journal of pharmaceutics, 481(1-2), 79-83 (2015-02-07) Sodium-hydrogen exchangers (NHE) in human cardiovascular diseases: interfering strategies and their therapeutic applications.Rosalinda Madonna et al.Vascular pharmacology, 59(5-6), 127-130 (2013-10-22) Hypertonic saline in the traumatic hypovolemic shock: meta-analysis.Jia-Wei Wang et al.The Journal of surgical research, 191(2), 448-454 (2014-05-20) Effect of cation trapping on thermal stability of magnetite nanoparticles.S S Pati et al.Journal of nanoscience and nanotechnology, 14(6), 4114-4123 (2014-04-18) Prolongation of action potential duration and QT interval during epilepsy linked to increased contribution of neuronal sodium channels to cardiac late Na+ current: potential mechanism for sudden death in epilepsy.Michael Biet et al.Circulation. Arrhythmia and electrophysiology, 8(4), 912-920 (2015-06-13) Effect of Protein-Lipid-Salt Interactions on Sodium Availability in the Mouth and Consequent Perception of Saltiness: As Affected by Hydration in Powders.Umut Yucel et al.Journal of agricultural and food chemistry, 63(34), 7494-7498 (2015-08-11) Physiological and performance responses to a training camp in the heat in professional Australian football players.Sebastien Racinais et al.International journal of sports physiology and performance, 9(4), 598-603 (2013-10-04) Ion transport function of SLC4A11 in corneal endothelium.Supriya S Jalimarada et al.Investigative ophthalmology & visual science, 54(6), 4330-4340 (2013-06-08) Sodium and copeptin levels in children with community acquired pneumonia.August Wrotek et al.Advances in experimental medicine and biology, 835, 31-36 (2014-09-26) Glucose stimulates calcium-activated chloride secretion in small intestinal cells.Liangjie Yin et al.American journal of physiology. Cell physiology, 306(7), C687-C696 (2014-01-31) Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices.Young Jo Kim et al.Proceedings of the National Academy of Sciences of the United States of America, 110(52), 20912-20917 (2013-12-11) Total synthesis of hematoporphyrin and protoporphyrin; a conceptually new approach.Pierre Martin et al.Chimia, 67(4), 204-206 (2013-08-24) An amino acid mixture mitigates radiation-induced gastrointestinal toxicity.Liangjie Yin et al.Health physics, 106(6), 734-744 (2014-04-30) Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis.Srinivas Rengarajan et al.American journal of physiology. Renal physiology, 306(9), F1059-F1068 (2014-03-07) Outcome of individualized dialysate sodium concentration for hemodialysis patients.Yasser Elshahawy et al.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(3), 507-513 (2013-05-04) Epinephrine stimulation of anion secretion in the Calu-3 serous cell model.Amiraj Banga et al.American journal of physiology. Lung cellular and molecular physiology, 306(10), L937-L946 (2014-04-08) Bacterial sodium channels: models for eukaryotic sodium and calcium channels.Todd Scheuer Handbook of experimental pharmacology, 221, 269-291 (2014-04-17) Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies.Patrícia Severino et al.Colloids and surfaces. B, Biointerfaces, 129, 191-197 (2015-04-13) Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?Carey A Hobbs et al.The Journal of physiology, 591(18), 4377-4387 (2013-07-24) An in vitro study of peptide-loaded alginate nanospheres for antagonizing the inhibitory effect of Nogo-A protein on axonal growth.Peng Zhai et al.Biomedical materials (Bristol, England), 10(4), 045016-045016 (2015-08-05) Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.Wei-Zhong Ying et al.American journal of physiology. Renal physiology, 307(1), F58-F63 (2014-05-03) Impact of seawater on distribution of fluoride and other ions in groundwater of Diplo area, Thar Desert Pakistan.Tahir Rafique et al.Water environment research : a research publication of the Water Environment Federation, 85(7), 579-586 (2013-08-16) Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function.Paul A Welling Current opinion in nephrology and hypertension, 23(1), 1-8 (2013-11-21) Folding and unfolding pathways of the human telomeric G-quadruplex.Robert D Gray et al.Journal of molecular biology, 426(8), 1629-1650 (2014-02-04) Excretion of NaCl and KCl loads in mosquitoes. 2. Effects of the small molecule Kir channel modulator VU573 and its inactive analog VU342.Matthew F Rouhier et al.American journal of physiology. Regulatory, integrative and comparative physiology, 307(7), R850-R861 (2014-07-25) The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.Jeffrey D Calhoun et al.Handbook of experimental pharmacology, 221, 51-89 (2014-04-17) The characteristics of the stone and urine composition in Chinese stone formers: primary report of a single-center results.Wenqi Wu et al.Urology, 83(4), 732-737 (2014-02-04) [The cutting-edge of medicine; novel therapeutic agents for the treatment of diabetes sodium-glucose co-transporter (SGLT) 2 inhibitors].Toshiro Sugimoto et al.Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(6), 1474-1483 (2013-08-21) Development of a freeze-dried kit formulation for the preparation of 99mTc-NTP 15-5, a radiotracer for scintigraphic imaging of proteoglycans.Aurélien Vidal et al.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 101, 1-9 (2015-03-31) Pharmacological insights and quirks of bacterial sodium channels.Ben Corry et al.Handbook of experimental pharmacology, 221, 251-267 (2014-04-17) Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.M Shriver et al.Oncogene, 34(32), 4248-4259 (2014-11-11) Comparison of the therapeutic effect between sodium bicarbonate and insulin on acute propafenone toxicity.Hwa Yeon Yi et al.The American journal of emergency medicine, 32(10), 1200-1207 (2014-08-26) An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations.Mette U Anby et al.Molecular pharmaceutics, 11(11), 4069-4083 (2014-09-30) Functional and structural dynamics of NhaA, a prototype for Na(+) and H(+) antiporters, which are responsible for Na(+) and H(+) homeostasis in cells.Etana Padan Biochimica et biophysica acta, 1837(7), 1047-1062 (2013-12-24) Introduction to sodium channels.Colin H Peters et al.Handbook of experimental pharmacology, 221, 1-6 (2014-04-17) Do large pores in the glomerular capillary wall account for albuminuria in nephrotic states?Julijana Vuchkova et al.American journal of physiology. Renal physiology, 307(5), F525-F532 (2014-07-06) Molecular control of δ-opioid receptor signalling.Gustavo Fenalti et al.Nature, 506(7487), 191-196 (2014-01-15) A rapid, sensitive, simple plate assay for detection of microbial alginate lyase activity.Shailesh S Sawant et al.Enzyme and microbial technology, 77, 8-13 (2015-07-04) Sodium accumulation is associated with disability and a progressive course in multiple sclerosis.David Paling et al.Brain : a journal of neurology, 136(Pt 7), 2305-2317 (2013-06-27) Structural insights into alginate binding by bacterial cell-surface protein.Kanate Temtrirath et al.Carbohydrate research, 404, 39-45 (2015-02-11) Development of a rebamipide solid dispersion system with improved dissolution and oral bioavailability.Roshan Pradhan et al.Archives of pharmacal research, 38(4), 522-533 (2014-06-05) Urinary sodium and potassium excretion, mortality, and cardiovascular events.Martin O'Donnell et al.The New England journal of medicine, 371(7), 612-623 (2014-08-15) [The formation of the urine proteome in healthy human].I M Larina et al.Fiziologiia cheloveka, 39(2), 43-59 (2013-06-26) Structural and multi-scale rheophysical investigation of diphasic magneto-sensitive materials based on biopolymers.Stéphane Roger et al.The European physical journal. E, Soft matter, 38(8), 88-88 (2015-08-13) The sodium/iodide symporter: state of the art of its molecular characterization.Elisabeth Darrouzet et al.Biochimica et biophysica acta, 1838(1 Pt B), 244-253 (2013-08-31) The reply.Gregor Lindner et al.The American journal of medicine, 126(6), e15-e15 (2013-05-21) Sodium and potassium in health and disease.Hana R Pohl et al.Metal ions in life sciences, 13, 29-47 (2014-01-29) Treatment of severe hyponatremia in patients with kidney failure: role of continuous venovenous hemofiltration with low-sodium replacement fluid.Lenar Yessayan et al.American journal of kidney diseases : the official journal of the National Kidney Foundation, 64(2), 305-310 (2014-05-06) A large-scale cluster randomized trial to determine the effects of community-based dietary sodium reduction--the China Rural Health Initiative Sodium Reduction Study.Nicole Li et al.American heart journal, 166(5), 815-822 (2013-11-02) Control of vacuolar dynamics and regulation of stomatal aperture by tonoplast potassium uptake.Zaida Andrés et al.Proceedings of the National Academy of Sciences of the United States of America, 111(17), E1806-E1814 (2014-04-16) CFTR genotype and clinical outcomes of adult patients carried as cystic fibrosis disease.Luciana Cardoso Bonadia et al.Gene, 540(2), 183-190 (2014-03-04) Comparison of Simple Eudragit Microparticles Loaded with Prednisolone and Eudragit-Coated Chitosan-Succinyl-Prednisolone Conjugate Microparticles: Part II. In Vivo Evaluation of Efficacy, Toxicity, and Biodisposition Characteristics.Hiraku Onishi et al.International journal of molecular sciences, 16(11), 26125-26136 (2015-11-06) Increased mortality in geriatric patients with hospital-acquired hypernatremia.Ditte Beck Jepsen et al.The American journal of medicine, 126(6), e13-e14 (2013-05-21) As(III) and As(V) removal from the aqueous phase via adsorption onto acid mine drainage sludge (AMDS) alginate beads and goethite alginate beads.Hongkyun Lee et al.Journal of hazardous materials, 292, 146-154 (2015-03-26) Age-dependent changes in diastolic Ca(2+) and Na(+) concentrations in dystrophic cardiomyopathy: Role of Ca(2+) entry and IP3.Alfredo Mijares et al.Biochemical and biophysical research communications, 452(4), 1054-1059 (2014-09-23) Variable dendritic integration in hippocampal CA3 pyramidal neurons.Judit K Makara et al.Neuron, 80(6), 1438-1450 (2013-12-24) [Congenital chloride diarrhea mimicking meconium ileus in newborn].Grażyna Krzemień et al.Medycyna wieku rozwojowego, 17(4), 320-323 (2014-02-13) Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance.Sumedha Malsure et al.Journal of the American Society of Nephrology : JASN, 25(7), 1453-1464 (2014-02-01) Pharmacokinetics and analgesic effect of ketorolac floating delivery system.Mahasen A Radwan et al.Drug delivery, 22(3), 320-327 (2014-02-12) Drying of organic solvents: quantitative evaluation of the efficiency of several desiccants.Williams D The Journal of Organic Chemistry, 75(24), 8351-8354 (2010) Association between urinary sodium, creatinine, albumin, and long-term survival in chronic kidney disease.Emily P McQuarrie et al.Hypertension (Dallas, Tex. : 1979), 64(1), 111-117 (2014-04-16) Exposure to waterborne Cu inhibits cutaneous Na⁺ uptake in post-hatch larval rainbow trout (Oncorhynchus mykiss).Alex M Zimmer et al.Aquatic toxicology (Amsterdam, Netherlands), 150, 151-158 (2014-04-01) Local pH domains regulate NHE3-mediated Na⁺ reabsorption in the renal proximal tubule.Jens Christian Brasen et al.American journal of physiology. Renal physiology, 307(11), F1249-F1262 (2014-10-10) Dopamine D₁-like receptors regulate the α₁A-adrenergic receptor in human renal proximal tubule cells and D₁-like dopamine receptor knockout mice.Riley Charles Ennis et al.American journal of physiology. Renal physiology, 307(11), F1238-F1248 (2014-10-24) Gating of the kir2.1 channel at the bundle crossing region by intracellular spermine and other cations.Chiung-Wei Huang et al.Journal of cellular physiology, 229(11), 1703-1721 (2014-03-19) [New guidelines for intravenous fluid therapy for children].Inger Marie Drage et al.Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(21), 2235-2236 (2013-11-15) Effect of nitric oxide signaling in bacterial-treated soybean plant under salt stress.Anukool Vaishnav et al.Archives of microbiology, 195(8), 571-577 (2013-05-28) Effect of sodium conductance variations on electrical behavior of a neocortical neuron model.T Shirahata Acta biologica Hungarica, 65(4), 379-384 (2014-12-06) Short-term adaptation of the ruminal epithelium involves abrupt changes in sodium and short-chain fatty acid transport.Brittney L Schurmann et al.American journal of physiology. Regulatory, integrative and comparative physiology, 307(7), R802-R816 (2014-08-01) Functional identification and characterization of sodium binding sites in Na symporters.Donald D F Loo et al.Proceedings of the National Academy of Sciences of the United States of America, 110(47), E4557-E4566 (2013-11-06) Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism.Benjamin D Rowlands et al.Journal of neuroscience research, 93(7), 1147-1156 (2015-02-14) Quantitative high throughput analytics to support polysaccharide production process development.Aaron Noyes et al.Vaccine, 32(24), 2819-2828 (2014-03-01) Disorders of plasma sodium--causes, consequences, and correction.Richard H Sterns The New England journal of medicine, 372(1), 55-65 (2015-01-01) Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG.Ganesan Vaidyanathan et al.Nuclear medicine and biology, 42(8), 673-684 (2015-05-10) Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas.P Tauber et al.Endocrinology, 155(4), 1353-1362 (2014-02-11) Functional consequences of NKCC2 splice isoforms: insights from a Xenopus oocyte model.Liangjian Lu et al.American journal of physiology. Renal physiology, 306(7), F710-F720 (2014-01-31) Calcium alginate gels as stem cell matrix-making paracrine stem cell activity available for enhanced healing after surgery.Andreas Schmitt et al.PloS one, 10(3), e0118937-e0118937 (2015-03-21) Effects of short-day treatment on long-term growth performance and maturation of farmed Arctic charr Salvelinus alpinus reared in brackish water.S Gunnarsson et al.Journal of fish biology, 85(4), 1211-1226 (2014-09-30) Role of sodium ions in the vitrification process: glass matrix modification, slag structure depolymerization, and influence of metal immobilization.Yi-Ming Kuo Journal of the Air & Waste Management Association (1995), 64(7), 774-784 (2014-08-16) [Ion-regulating renal function during oral and parenteral potassium loading].A S Marina et al.Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(3), 372-382 (2013-06-26) Urinary potassium excretion and risk of developing hypertension: the prevention of renal and vascular end-stage disease study.Lyanne M Kieneker et al.Hypertension (Dallas, Tex. : 1979), 64(4), 769-776 (2014-07-23) Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited.Bernard C Rossier et al.Physiological reviews, 95(1), 297-340 (2014-12-30) Claudins and the kidney.Alan S L Yu Journal of the American Society of Nephrology : JASN, 26(1), 11-19 (2014-06-21) Haematological and biochemical profile of growing Yankasa rams fed sorghum stover supplemented with graded levels of dried poultry droppings based diets.Abdul Waheed Adeyemi Bello et al.Pakistan journal of biological sciences : PJBS, 16(24), 1922-1928 (2014-02-13) Combined chemo- and photo-thermal therapy delivered by multifunctional theranostic gold nanorod-loaded microcapsules.Haiyan Chen et al.Nanoscale, 7(19), 8884-8897 (2015-04-29) The voltage sensor module in sodium channels.James R Groome Handbook of experimental pharmacology, 221, 7-31 (2014-04-17) Taking another "look" at sodium.Jens Titze et al.The Canadian journal of cardiology, 30(5), 473-475 (2014-03-19) Light-driven Na(+) pump from Gillisia limnaea: a high-affinity Na(+) binding site is formed transiently in the photocycle.Sergei P Balashov et al.Biochemistry, 53(48), 7549-7561 (2014-11-07) Invited commentary: Quantifying salt in urine--a complex solution.Ian H de Boer et al.American journal of epidemiology, 177(11), 1193-1195 (2013-05-16) [The ratio between the initial stages of assimilation of intact and hydrolyzed dipeptides in rat small intestine].S T Metel'skiĭ Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(4), 511-517 (2013-07-19) X-ray structure of the mammalian GIRK2-βγ G-protein complex.Matthew R Whorton et al.Nature, 498(7453), 190-197 (2013-06-07) Inherited sodium avid states.Jean-Michel Achard et al.Advances in chronic kidney disease, 13(2), 118-123 (2006-04-04) Defining the role of albumin infusion in cirrhosis-associated hyponatremia.Minhtri K Nguyen et al.American journal of physiology. Gastrointestinal and liver physiology, 307(2), G229-G232 (2014-05-17) Epidermal growth factors in the kidney and relationship to hypertension.Alexander Staruschenko et al.American journal of physiology. Renal physiology, 305(1), F12-F20 (2013-05-03) The role of cAMP-mediated intracellular signaling in regulating Na+ uptake in zebrafish larvae.Yusuke Kumai et al.American journal of physiology. Regulatory, integrative and comparative physiology, 306(1), R51-R60 (2013-11-22) Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury.Justin M Belcher et al.Hepatology (Baltimore, Md.), 60(2), 622-632 (2014-01-01) Developing an objective marker to optimize patient selection and predict survival benefit in early-phase cancer trials.Chara Stavraka et al.Cancer, 120(2), 262-270 (2014-01-09) Electrochemical synthesis of a novel compound, 5-acetyl-2, 9-decanedione, and theoretical analysis of its lithium ion complex.Cabasso I Royal Society of Chemistry Advances, 2(26), 9998-10006 (2012) Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample.C S Fox et al.Kidney international, 69(11), 2064-2069 (2006-03-31) Mutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes.Jasmin Hotzy et al.The Journal of biological chemistry, 288(51), 36492-36501 (2013-11-12) Effect of oral administration of aqueous leaves extract of Vitex doniana on serum electrolyte levels in rats.Isah Muhammad Ahmad et al.Pakistan journal of biological sciences : PJBS, 16(23), 1819-1822 (2014-02-11) Chronic haloperidol increases voltage-gated Na+ currents in mouse cortical neurons.Weiqiang Chen et al.Biochemical and biophysical research communications, 450(1), 55-60 (2014-05-31) Infrared spectroscopic studies on the V-ATPase.Hideki Kandori et al.Biochimica et biophysica acta, 1847(1), 134-141 (2014-08-12) T-type channels become highly permeable to sodium ions using an alternative extracellular turret region (S5-P) outside the selectivity filter.Adriano Senatore et al.The Journal of biological chemistry, 289(17), 11952-11969 (2014-03-07) Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K(+) cycling and to active Na(+) extrusion.C F Dick et al.Biochimica et biophysica acta, 1830(8), 4265-4273 (2013-05-07) Sodium homeostasis during liver transplantation and correlation with outcomes.Jana Hudcova et al.Anesthesia and analgesia, 119(6), 1420-1428 (2014-09-12) Structural basis of the alternating-access mechanism in a bile acid transporter.Xiaoming Zhou et al.Nature, 505(7484), 569-573 (2013-12-10) Cardiac sodium transport and excitation-contraction coupling.J M Aronsen et al.Journal of molecular and cellular cardiology, 61, 11-19 (2013-06-19) 'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug.Orlagh M Feeney et al.Journal of controlled release : official journal of the Controlled Release Society, 192, 219-227 (2014-07-25) Regulation/modulation of sensory neuron sodium channels.Mohamed Chahine et al.Handbook of experimental pharmacology, 221, 111-135 (2014-04-17) Probing gating mechanisms of sodium channels using pore blockers.Marcel P Goldschen-Ohm et al.Handbook of experimental pharmacology, 221, 183-201 (2014-04-17) Highly stable multi-anchored magnetic nanoparticles for optical imaging within biofilmsStone R C Journal of Colloid and Interface Science, 459, 175-182 (2015) Carolinas centralizes data analytics to reduce readmissions and redesign care.Joe Carlson Modern healthcare, 43(49), 28-28 (2014-01-15) Towards evidence based medicine for paediatricians. Question 1: Is measurement of sodium from capillary blood accurate enough for clinical decision making?Ilana Levene Archives of disease in childhood, 99(5), 481-482 (2014-04-11) Intrarenal ghrelin receptor antagonism prevents high-fat diet-induced hypertension in male rats.Brandon A Kemp et al.Endocrinology, 155(7), 2658-2666 (2014-05-07) Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase.Julia Steuber et al.Nature, 516(7529), 62-67 (2014-12-05) Urinary excretion of sodium, potassium, and chloride, but not iodine, varies by timing of collection in a 24-hour calibration study.Chia-Yih Wang et al.The Journal of nutrition, 143(8), 1276-1282 (2013-06-14) Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.Andrew G Edwards et al.Circulation. Arrhythmia and electrophysiology, 7(6), 1205-1213 (2014-09-23) Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control.Say Viengchareun et al.Journal of the American Society of Nephrology : JASN, 25(10), 2213-2221 (2014-04-05) Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.Gina M Clayton et al.Cell, 158(1), 132-142 (2014-07-06) Soluble urokinase plasminogen activator receptor: an indicator of pneumonia severity in children.A Wrotek et al.Advances in experimental medicine and biology, 835, 1-7 (2014-10-16) Mg²⁺-dependent modulation of BKCa channels by genistein in rat arteriolar smooth muscle cells.Xiaoran Wang et al.Journal of cellular physiology, 229(12), 1981-1989 (2014-04-15) Gastro-resistant characteristics of GRAS-grade enteric coatings for pharmaceutical and nutraceutical products.Justyna K Czarnocka et al.International journal of pharmaceutics, 486(1-2), 167-174 (2015-03-23) Interactions between phospholipids and titanium dioxide particles.Quoc-Chon Le et al.Colloids and surfaces. B, Biointerfaces, 123, 150-157 (2014-09-23) [Ratio of cations in hemolymph, blood serum of aquatic and terrestrial organisms].Iu V Natochin et al.Rossiiskii fiziologicheskii zhurnal imeni I.M. 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Control data.Rebecca M Hine et al.American journal of physiology. 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