Melting point	158-163 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Determination of high-intensity sweeteners in river water and wastewater by solid-phase extraction and liquid chromatography-tandem mass spectrometry.Paula Arbeláez et al.Journal of chromatography. A, 1393, 106-114 (2015-04-05) Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death.Je-Min Choi et al.Biological & pharmaceutical bulletin, 30(2), 324-330 (2007-02-03) Improved water solubility of neohesperidin dihydrochalcone in sweetener blends.O Benavente-García et al.Journal of agricultural and food chemistry, 49(1), 189-191 (2001-02-15) Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores.Meirav Zubare-Samuelov et al.American journal of physiology. Cell physiology, 285(5), C1255-C1262 (2003-07-04) Crystal architecture and conformational properties of the inclusion complex, neohesperidin dihydrochalcone-cyclomaltoheptaose (beta-cyclodextrin), by X-ray diffraction.Luciana Malpezzi et al.Carbohydrate research, 339(12), 2117-2125 (2004-07-29) High-potency sweeteners and dental health.T H Grenby The Ohio dental journal, 64(2), 15-16 (1990-01-01) Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector.Elaheh Kashani-Amin et al.FEBS letters, 587(6), 652-658 (2013-02-05) Sweeteners--an overview. Part. 1.J H Shaw Dental abstracts; a selection of world dental literature, 26(3), 116-120 (1981-03-01) Degradation of neohesperidin dihydrochalcone by human intestinal bacteria.Annett Braune et al.Journal of agricultural and food chemistry, 53(5), 1782-1790 (2005-03-03) Validated high-performance liquid chromatographic method for quantitation of neohesperidine dihydrochalcone in foodstuffs.H Montijano et al.Journal of chromatography. A, 758(1), 163-166 (1997-01-10) PROP (6-n-Propylthiouracil) tasting and sensory responses to caffeine,sucrose, neohesperidin dihydrochalcone and chocolate.A Ly et al.Chemical senses, 26(1), 41-47 (2000-12-22) [Determination of neohesperidin dihydrochalcone in foods].M Nakazato et al.Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 42(1), 40-44 (2001-06-01) An estimation of the detection and quantitation limits of neohesperidine DC by high-performance liquid chromatography.H Montijano et al.World review of nutrition and dietetics, 85, 125-128 (2000-01-27) Subchronic (13-week) oral toxicity of neohesperidin dihydrochalcone in rats.B A Lina et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 28(7), 507-513 (1990-07-01) Taste responses to neohesperidin dihydrochalcone in rats and baboon monkeys.M Naim et al.Physiology & behavior, 28(6), 979-986 (1982-06-01) Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners.Andrew W Moran et al.The British journal of nutrition, 104(5), 637-646 (2010-03-27) Liquid chromatographic determination of naringin and neohesperidin as a detector of grapefruit juice in orange juice.R L Rouseff Journal - Association of Official Analytical Chemists, 71(4), 798-802 (1988-07-01) Double functionality of sweeteners: a case of study.F Borrego et al.World review of nutrition and dietetics, 85, 39-43 (2000-01-27) An exponential model for adaptation in taste.J F Gent Sensory processes, 3(4), 303-316 (1979-12-01) Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC.Ahuva Frydman et al.Journal of agricultural and food chemistry, 53(25), 9708-9712 (2005-12-08) Genetic toxicological of some plant flavonoids by the micronucleus test.R K Sahu et al.Mutation research, 89(1), 69-74 (1981-05-01) Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions.J H Kroeze Chemical senses, 25(5), 555-559 (2000-10-04) The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.Marcel Winnig et al.BMC structural biology, 7, 66-66 (2007-10-16) Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.Lihua Hu et al.Chemico-biological interactions, 213, 51-59 (2014-02-18) Transglycosylation of neohesperidin dihydrochalcone by Bacillus stearothermophilus maltogenic amylase.J S Cho et al.Journal of agricultural and food chemistry, 48(2), 152-154 (2000-02-26) Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection.Agata Zygler et al.Analytical and bioanalytical chemistry, 400(7), 2159-2172 (2011-04-06) Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats.D H Waalkens-Berendsen et al.Regulatory toxicology and pharmacology : RTP, 40(1), 74-79 (2004-07-22)

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