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2-Fluoro-3-nitrobenzoic acid methyl ester | CAS:946126-94-9
2-Fluoro-3-nitrobenzoic acid methyl ester
  • Name:2-Fluoro-3-nitrobenzoic acid methyl ester
  • CAS:946126-94-9
  • Synonyms:Methyl 2-fluoro-3-nitrobenzoate
  • Molecular Formula:C8H6FNO4
  • Molecular Weight:199.14
  • EINESC:

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Density 1.388±0.06 g/cm3 (20 º

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Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.Anja Krick et al.Journal of natural products, 70(3), 353-360 (2007-02-13) Induction of expression of aryl hydrocarbon receptor-dependent genes in human HepaRG cell line modified by shRNA and treated with β-naphthoflavone.Damian Brauze et al.Molecular and cellular biochemistry, 425(1-2), 59-75 (2016-11-01) Rapid and sensitive assessment of human hepatocyte functions.Roberto Gramignoli et al.Cell transplantation, 23(12), 1545-1556 (2014-04-08) Preparation of pellets with controlled release of glucose as prevention of hypoglycaemia in paediatric patients.Aleš Franc et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 75, 72-80 (2015-03-26) Evaluation of the cost-effectiveness of rifaximin-α for the management of patients with hepatic encephalopathy in the United Kingdom.Ellen Berni et al.Current medical research and opinion, 34(11), 2001-2008 (2018-07-12) Bird's nest fern epiphytes facilitate herpetofaunal arboreality and climate refuge in two paleotropic canopies.Christa M Seidl et al.Oecologia, 192(2), 297-309 (2019-12-12) Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens.Petr Hodek et al.Neuro endocrinology letters, 32 Suppl 1, 25-34 (2011-12-15) Diazotrophic bacteria from maize exhibit multifaceted plant growth promotion traits in multiple hosts.Shawn M Higdon et al.PloS one, 15(9), e0239081-e0239081 (2020-09-15) Improved assays for xenosensor activation based on reverse transfection.Jenni Küblbeck et al.Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1759-1765 (2015-07-19) Aryl hydrocarbon receptor agonists trigger avoidance of novel food in rats.Selma Mahiout et al.Physiology & behavior, 167, 49-59 (2016-10-25) Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation.David Fernandez-Antoran et al.Cell stem cell, 25(3), 329-341 (2019-07-23) Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.Bartomeu Colom et al.Nature genetics, 52(6), 604-614 (2020-05-20) Effect of β-naphthoflavone on hepatic cytochrome P4501A activity in the scribbled rabbitfish (Siganus spinus) from tropical Indo-Pacific coral reefs.Carmen Emborski et al.Ecotoxicology (London, England), 21(8), 2153-2162 (2012-07-05) The effects of the treatment conditions on the dissolution profile of ethylcellulose coated pellets.Sylvie Pavloková et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 132, 86-95 (2019-03-03) Evaluation of biomarker potential of cytochrome P450 1A (CYP1A) gene in the marine medaka, Oryzias melastigma exposed to water-accommodated fractions (WAFs) of Iranian crude oil.Ryeo-Ok Kim et al.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 157(2), 172-182 (2012-11-28) Arbuscular Mycorrhiza Stimulates Biological Nitrogen Fixation in TwoDavid Püschel et al.Frontiers in plant science, 8, 390-390 (2017-04-12) Direct surface visualization of biofilms with high spin coordination clusters using Magnetic Resonance Imaging.Florian Ranzinger et al.Acta biomaterialia, 31, 167-177 (2015-12-18) Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza.Sudarat Homhual et al.Journal of natural products, 69(3), 421-424 (2006-03-28) beta-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B4 secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammationHolen E and Olsvik P Fish & Shellfish Immunology, 54(1), 128-134 (2016) Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease.Chelsea A O'Driscoll et al.Particle and fibre toxicology, 15(1), 35-35 (2018-08-26) Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions.Sayaka Mizukami et al.Toxicology and applied pharmacology, 334, 207-216 (2017-09-14) Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis.Xiyu Gao et al.Immunobiology, 225(4), 151965-151965 (2020-08-05) Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells.Shuai Zhao et al.Cancer letters, 317(2), 192-198 (2011-11-30) Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.Soon Young Shin et al.Bioorganic & medicinal chemistry letters, 21(20), 6036-6041 (2011-09-13) Expression and inducibility of CYP1A1, 1A2, 1B1 by β-naphthoflavone and CYP2B22, CYP3As by rifampicin in heart regions and coronary arteries of pig.Andrea Messina et al.Research in veterinary science, 94(1), 77-83 (2012-08-15) Assessment of energetic costs of AhR activation by β-naphthoflavone in rainbow trout (Oncorhynchus mykiss) hepatocytes using metabolic flux analysis.Rance Nault et al.Toxicology and applied pharmacology, 271(1), 86-94 (2013-05-04) Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene).Peter T Vedell et al.Molecular pharmacology, 83(3), 698-708 (2013-01-08) Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells.Ai Hayashi et al.Toxicology in vitro : an international journal published in association with BIBRA, 66, 104873-104873 (2020-04-26) Aryl-hydrocarbon receptor activity modulates prolactin expression in the pituitary.Tyler B Moran et al.Toxicology and applied pharmacology, 265(1), 139-145 (2012-09-15) Modeling the binding of diverse ligands within the Ah receptor ligand binding domain.Sara Giani Tagliabue et al.Scientific reports, 9(1), 10693-10693 (2019-07-25) Ferroelectric, Dielectric, Ferromagnetic, and Magnetoelectric Properties of BNF-NZF Bilayer Nanofilms Prepared via Sol-Gel Process.Kaixin Guo et al.Nanoscale research letters, 11(1), 387-387 (2016-09-08) Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone.Hitomi Hayashi et al.The Journal of toxicological sciences, 37(5), 969-985 (2012-10-06) Time trends and geographical variation in prescribing of antibiotics in England 1998-2017.Helen J Curtis et al.The Journal of antimicrobial chemotherapy, 74(1), 242-250 (2018-09-22) E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.Jean-Leon Chong et al.Nature, 462(7275), 930-934 (2009-12-18) In vitro recombinant yeast assay reveals the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and aryl hydrocarbon receptor (AhR) from scallop Chlamys farreri.Ya'nan Zhao et al.Toxicology in vitro : an international journal published in association with BIBRA, 59, 64-69 (2019-04-08) Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity.Shih-Yu Chang et al.Toxicology in vitro : an international journal published in association with BIBRA, 40, 170-183 (2017-01-17) Transcriptome regulation and chromatin occupancy by E2F3 and MYC in miceTang X, et al. Scientific data, 3(4), 160008-160008 (2016) Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies.Wenqi Lu et al.Drug metabolism and disposition: the biological fate of chemicals, 45(7), 748-754 (2017-05-05) Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis.Yuko Ito et al.Journal of applied toxicology : JAT, 40(11), 1467-1479 (2020-07-01) Ethylcellulose film coating of guaifenesin-loaded pellets: A comprehensive evaluation of the manufacturing process to prevent drug migration.Cecilia Melegari et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 100, 15-26 (2015-12-22) Different profiles of hepatic alkoxyresorufin O-dealkylase activities in small rodents.Waranya Chatuphonprasert et al.Journal of applied toxicology : JAT, 32(12), 1002-1007 (2012-05-23) Stage-dependent ethoxyresorufin-O-deethylase (EROD) in vivo activity in medaka (Oryzias latipes) embryos.Miguel González-Doncel et al.Chemosphere, 135, 108-115 (2015-05-02) Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes.Waranya Chatuphonprasert et al.Toxicology in vitro : an international journal published in association with BIBRA, 25(8), 1757-1763 (2011-10-04) The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polκ), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver.Damian Brauze et al.Environmental toxicology and pharmacology, 34(3), 819-825 (2012-10-03) Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.Nikè V J A Büller et al.Gastroenterology, 148(1), 170-180 (2014-10-14) Chemical Profile and Safety Assessment of a Food-Grade Acetogenin-Enriched Antimicrobial Extract from Avocado Seed.Dariana G Rodríguez-Sánchez et al.Molecules (Basel, Switzerland), 24(13) (2019-06-30) Physiological response of alligator gar juveniles (Atractosteus spatula) exposed to sub-lethal doses of pollutants.Carlos Aguilera González et al.Fish physiology and biochemistry, 41(4), 1015-1027 (2015-05-08) Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.Gulsum E Muku et al.Toxicological sciences : an official journal of the Society of Toxicology (2019-06-22) Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions.Zhongwen Li et al.Cell death & disease, 10(10), 763-763 (2019-10-12) Cyp1a reporter zebrafish reveals target tissues for dioxinKim KH, et al. Aquatic Toxicology (Amsterdam, Netherlands), 134, 57-65 (2013) Aryl hydrocarbon receptor is indispensable for β-naphthoflavone-induced novel food avoidance and may be involved in LiCl-triggered conditioned taste aversion in rats.Raimo Pohjanvirta et al.Physiology & behavior, 204, 58-64 (2019-02-16) Expression and inducibility of UDP-glucuronosyltransferase 1As in MCF-7 human breast carcinoma cells.Nobumitsu Hanioka et al.Basic & clinical pharmacology & toxicology, 110(3), 253-258 (2011-09-10) Precision-cut liver slices of Atlantic cod (Gadus morhua): an in vitro system for studying the effects of environmental contaminants.M Eide et al.Aquatic toxicology (Amsterdam, Netherlands), 153, 110-115 (2013-11-26) Peroxisome proliferator activated receptor gamma (PPAR-γ) ligand pioglitazone regulated gene networks in term human primary trophoblast cells.Rami El Dairi et al.Reproductive toxicology (Elmsford, N.Y.), 81, 99-107 (2018-07-23) A 3D-Structured Sustainable Solar-Driven Steam Generator Using Super-Black Nylon Flocking Materials.Ce Tu et al.Small (Weinheim an der Bergstrasse, Germany), 15(37), e1902070-e1902070 (2019-08-06) beta-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity.Yuji Fujita et al.Bioorganic & medicinal chemistry, 18(3), 1194-1203 (2010-01-12) Induction of a chloracne phenotype in an epidermal equivalent model by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock downForrester AR, et al. Journal of Dermatological Science, 73(1), 10-22 (2014) Mutagenicity, carcinogenicity and toxicity of beta-naphthoflavone, a potent inducer of P448.D McKillop et al.Biochemical pharmacology, 41(1), 1-7 (1991-01-01) Tissue specificity of aryl hydrocarbon receptor (AhR) mediated responses and relative sensitivity of white sturgeon (Acipenser transmontanus) to an AhR agonist.Jon A Doering et al.Aquatic toxicology (Amsterdam, Netherlands), 114-115, 125-133 (2012-03-27) Mass spectrometric analyses of microsomal cytochrome P450 isozymes isolated from β-naphthoflavone-treated Atlantic cod (Gadus morhua) liver reveal insights into the cod CYPome.Odd André Karlsen et al.Aquatic toxicology (Amsterdam, Netherlands), 108, 2-10 (2012-01-24) Biomarkers of organic contamination in the South American fish Poecilia vivipara and Jenynsia multidentata.Roger Stacke Ferreira et al.Journal of toxicology and environmental health. Part A, 75(16-17), 1023-1034 (2012-08-03) A Decade of Varicella Screening Within a Paediatric Inflammatory Bowel Disease Population.Rachel E Harris et al.Journal of Crohn's & colitis, 14(5), 608-616 (2020-01-01) NAP Family CG5017 Chaperone Pleiotropically Regulates Human AHR Target Genes Expression in Drosophila Testis.Angelina A Akishina et al.International journal of molecular sciences, 20(1) (2019-01-02) Identification of phase II in vivo metabolites of alkyl-anthracenes in rainbow trout (Oncorhynchus mykiss).Dominique Turcotte et al.Chemosphere, 85(10), 1585-1591 (2011-09-13) Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.Minoru Ishikawa et al.Journal of medicinal chemistry, 54(6), 1539-1554 (2011-02-25) Carbonyl reductase mRNA abundance and enzymatic activity as potential biomarkers of oxidative stress in marine fish.E Albertsson et al.Marine environmental research, 80, 56-61 (2012-07-24) Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin.Beikang Ge et al.Biopharmaceutics & drug disposition, 38(1), 33-49 (2016-12-08) beta-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity.Yuji Fujita et al.Bioorganic & medicinal chemistry, 18(3), 1194-1203 (2010-01-12) Mutagenicity, carcinogenicity and toxicity of beta-naphthoflavone, a potent inducer of P448.D McKillop et al.Biochemical pharmacology, 41(1), 1-7 (1991-01-01) Peroxisome proliferator activated receptor gamma (PPAR-γ) ligand pioglitazone regulated gene networks in term human primary trophoblast cells.Rami El Dairi et al.Reproductive toxicology (Elmsford, N.Y.), 81, 99-107 (2018-07-23) Artemisia annua L. and photoresponse: from artemisinin accumulation, volatile profile and anatomical modifications to gene expression.Ellen M Lopes et al.Plant cell reports, 39(1), 101-117 (2019-10-03) A 3D-Structured Sustainable Solar-Driven Steam Generator Using Super-Black Nylon Flocking Materials.Ce Tu et al.Small (Weinheim an der Bergstrasse, Germany), 15(37), e1902070-e1902070 (2019-08-06) Interactions between hypoxia and sewage-derived contaminants on gene expression in fish embryos.A McElroy et al.Aquatic toxicology (Amsterdam, Netherlands), 108, 60-69 (2011-11-23) mNP hyperthermia and hypofractionated radiation activate similar immunogenetic and cytotoxic pathways.Kayla E A Duval et al.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 37(1), 929-937 (2020-08-08) Activation of aryl hydrocarbon receptor suppresses invasion of esophageal squamous cell carcinoma cell lines.Jianhao Zhang et al.Tumori, 98(1), 152-157 (2012-04-13) Induction of a chloracne phenotype in an epidermal equivalent model by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock downForrester AR, et al. Journal of Dermatological Science, 73(1), 10-22 (2014) Tissue specificity of aryl hydrocarbon receptor (AhR) mediated responses and relative sensitivity of white sturgeon (Acipenser transmontanus) to an AhR agonist.Jon A Doering et al.Aquatic toxicology (Amsterdam, Netherlands), 114-115, 125-133 (2012-03-27) Mass spectrometric analyses of microsomal cytochrome P450 isozymes isolated from β-naphthoflavone-treated Atlantic cod (Gadus morhua) liver reveal insights into the cod CYPome.Odd André Karlsen et al.Aquatic toxicology (Amsterdam, Netherlands), 108, 2-10 (2012-01-24) Stereoselective metabolism of tetrahydropalmatine enantiomers in rat liver microsomes.Ming Zhao et al.Chirality, 24(5), 368-373 (2012-04-21) Inflammation and proliferation act together to mediate intestinal cell fusion.Paige S Davies et al.PloS one, 4(8), e6530-e6530 (2009-08-07) Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats.Hitomi Hayashi et al.The Journal of toxicological sciences, 37(3), 517-526 (2012-06-13) Biomarker Discovery for Cytochrome P450 1A2 Activity Assessment in Rats, Based on Metabolomics.Xiao Pu et al.Metabolites, 9(4) (2019-04-21) Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.Wei Zhang et al.Bioorganic & medicinal chemistry, 17(5), 2077-2090 (2009-02-10) Nanoparticle interactions with immune cells dominate tumor retention and induce T cell-mediated tumor suppression in models of breast cancer.Preethi Korangath et al.Science advances, 6(13), eaay1601-eaay1601 (2020-04-02) Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.Stephanie May et al.The Journal of pathology, 245(3), 270-282 (2018-04-01) Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs).Wade W Sugden et al.PloS one, 12(8), e0183433-e0183433 (2017-08-18) Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.Heidi J Einolf et al.Drug metabolism and disposition: the biological fate of chemicals, 45(12), 1304-1316 (2017-09-16) From the Cover: High Susceptibility of Lrig1 Sebaceous Stem Cells to TCDD in Mice.Fabienne Fontao et al.Toxicological sciences : an official journal of the Society of Toxicology, 160(2), 230-243 (2017-10-04) Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis.K Stolpmann et al.Cell death & disease, 3, e388-e388 (2012-09-07) Image-guided thermal therapy with a dual-contrast magnetic nanoparticle formulation: A feasibility study.Anilchandra Attaluri et al.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 32(5), 543-557 (2016-05-07) Associative nitrogen fixation in nodules of the conifer Lepidothamnus fonkii (Podocarpaceae) inhabiting 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