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Synthetic Route

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Articles

Peer-Reviewed Papers

The sugar meal of the African malaria mosquito Anopheles gambiae and how deterrent compounds interfere with it: a behavioural and neurophysiological study.Sébastien Kessler et al.The Journal of experimental biology, 216(Pt 7), 1292-1306 (2012-12-25) The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions.Karel Talavera et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(5), 1343-1355 (2007-12-12) Molecular Logic and Evolution of Bitter Taste in Drosophila.Hany K M Dweck et al.Current biology : CB, 30(1), 17-30 (2019-12-17) Future bronchodilator therapy: a bitter pill to swallow?Rachel L Clifford et al.American journal of physiology. Lung cellular and molecular physiology, 303(11), L953-L955 (2012-10-02) "A spoonful of sugar helps the medicine go down": bitter masking by sucrose among children and adults.Julie A Mennella et al.Chemical senses, 40(1), 17-25 (2014-11-09) Ongoing ingestive behavior is rapidly suppressed by a preabsorptive, intestinal "bitter taste" cue.Lindsey A Schier et al.American journal of physiology. Regulatory, integrative and comparative physiology, 301(5), R1557-R1568 (2011-08-26) Riboflavin-binding protein is a novel bitter inhibitor.Kenji Maehashi et al.Chemical senses, 33(1), 57-63 (2007-09-12) Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways.Ki-Suk Kim et al.Diabetologia, 57(10), 2117-2125 (2014-07-14) Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.Anne Brockhoff et al.Journal of agricultural and food chemistry, 55(15), 6236-6243 (2007-06-28) Gustatory responsiveness to six bitter tastants in three species of nonhuman primates.Matthias Laska et al.Journal of chemical ecology, 35(5), 560-571 (2009-04-29) Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.Alexander Perniss et al.Immunity, 52(4), 683-699 (2020-04-16) Residual chemosensory capabilities in double P2X2/P2X3 purinergic receptor null mice: intraoral or postingestive detection?Robert M Hallock et al.Chemical senses, 34(9), 799-808 (2009-10-17) Denatonium benzoate: review of efficacy and safety.W Klein-Schwartz Veterinary and human toxicology, 33(6), 545-547 (1991-12-01) Characterization of ligands for fish taste receptors.Hideaki Oike et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(21), 5584-5592 (2007-05-25) Molecular Basis of Chemotactile Sensation in Octopus.Lena van Giesen et al.Cell, 183(3), 594-604 (2020-10-31) Trpm5 null mice respond to bitter, sweet, and umami compounds.Sami Damak et al.Chemical senses, 31(3), 253-264 (2006-01-27) Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking.Rémi Legastelois et al.PloS one, 10(5), e0127408-e0127408 (2015-05-21) Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals.Marco Tizzano et al.Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3210-3215 (2010-02-06) Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds.Hyekyung Yang et al.Cancer medicine, 4(2), 245-252 (2014-10-31) Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.Yunhua Zhu et al.The Journal of clinical investigation, 124(7), 3263-3273 (2014-06-10) Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation.Sai Prasad Pydi et al.Journal of neurochemistry, 122(3), 537-544 (2012-05-30) A new dopaminergic nigro-olfactory projection.Günter U Höglinger et al.Acta neuropathologica, 130(3), 333-348 (2015-06-15) Signalling mechanisms in mouse bitter responsive taste cells.Masataka Narukawa et al.Neuroreport, 20(10), 936-940 (2009-06-30) Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands.Shuzhen Hao et al.American journal of physiology. Regulatory, integrative and comparative physiology, 294(1), R33-R38 (2007-11-16) A post-ingestive amino acid sensor promotes food consumption in Drosophila.Zhe Yang et al.Cell research, 28(10), 1013-1025 (2018-09-14) Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate. International journal of toxicology, 27 Suppl 1, 1-43 (2008-07-17) The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.Ville Pulkkinen et al.American journal of physiology. Lung cellular and molecular physiology, 303(11), L956-L966 (2012-09-11) Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents.John I Glendinning et al.Physiology & behavior, 93(4-5), 757-765 (2008-01-05) Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.Yan Chen et al.Current biology : CB, 24(17), 1969-1977 (2014-08-19) Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro.Brian D Gulbransen et al.Journal of neurophysiology, 99(6), 2929-2937 (2008-04-18) The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.Stephan Born et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 201-213 (2013-01-04) Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction.Jasbir D Upadhyaya et al.PloS one, 9(10), e110373-e110373 (2014-10-24) Adverse reactions associated with respirator fit testing of healthcare workers in British Columbia, Canada: a review of compensation claim cases.Sami Youakim Archives of environmental & occupational health, 62(4), 197-200 (2008-05-07) Denatonium benzoate as a deterrent to ingestion of toxic substances: toxicity and efficacy.S R Hansen et al.Veterinary and human toxicology, 35(3), 234-236 (1993-06-01) The impact of bittering agents on suicidal ingestions of antifreeze.Nicole C White et al.Clinical toxicology (Philadelphia, Pa.), 46(6), 507-514 (2008-06-28) Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels.Monica C Chen et al.American journal of physiology. Cell physiology, 291(4), C726-C739 (2006-05-19) Denatonium inhibits growth and induces apoptosis of airway epithelial cells through mitochondrial signaling pathways.Xiaoxing Wen et al.Respiratory research, 16, 13-13 (2015-02-06) Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.Klaus Deckmann et al.Proceedings of the National Academy of Sciences of the United States of America, 111(22), 8287-8292 (2014-05-21) Combinatorial Pharyngeal Taste Coding for Feeding Avoidance in Adult Drosophila.Yu-Chieh David Chen et al.Cell reports, 29(4), 961-973 (2019-10-24) A non-invasive method for ending thumb- and fingersucking habits.Jeffrey T Kozlowski Journal of clinical orthodontics : JCO, 41(10), 636-636 (2008-01-08) Central Fos expression and conditioned flavor avoidance in rats following intragastric administration of bitter taste receptor ligands.Shuzhen Hao et al.American journal of physiology. Regulatory, integrative and comparative physiology, 296(3), R528-R536 (2008-12-17) Predators' toxin burdens influence their strategic decisions to eat toxic prey.John Skelhorn et al.Current biology : CB, 17(17), 1479-1483 (2007-08-25)

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