Melting point	105-106 ºC
Density	1.106

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Source	SDS/MSDS Samples
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Synthetic Route

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Peer-Reviewed Papers

Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.Lamia Ghezali et al.Experimental cell research, 319(7), 1043-1053 (2013-01-30) Development of an enzyme-linked immunosorbent assay for the veratrum plant teratogens: cyclopamine and jervine.Stephen T Lee et al.Journal of agricultural and food chemistry, 51(3), 582-586 (2003-01-23) [Determination of jervine and veratramine in Veratrum plants using high performance liquid chromatography coupled with evaporative light scattering detection].Sheng Zhang et al.Se pu = Chinese journal of chromatography, 26(1), 56-59 (2008-04-29) Genetic and teratogenic approaches to craniofacial development.D L Young et al.Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 11(3), 304-317 (2000-10-06) Cholesterol modification of proteins.R K Mann et al.Biochimica et biophysica acta, 1529(1-3), 188-202 (2000-12-09) Critical time window of hedgehog-dependent angiogenesis in murine yolk sac.Miki Nagase et al.Microvascular research, 71(2), 85-90 (2006-01-18) Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro.Jinbong Park et al.Evidence-based complementary and alternative medicine : eCAM, 2016, 8674397-8674397 (2016-05-05) ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.Jana Balbuena et al.Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(9), 672-683 (2011-07-21) Transformation of jervine by Cunninghamella elegans ATCC 9245.K A El Sayed et al.Phytochemistry, 55(1), 19-22 (2000-10-06) Teratogen-mediated inhibition of target tissue response to Shh signaling.M K Cooper et al.Science (New York, N.Y.), 280(5369), 1603-1607 (1998-06-11) Specific craniofacial defects induced by jervine in the cultured rat embryo.F R Sim et al.Teratogenesis, carcinogenesis, and mutagenesis, 3(2), 111-121 (1983-01-01) Embryonic tongue morphogenesis in an organ culture model of mouse mandibular arches: blocking Sonic hedgehog signaling leads to microglossia.Daisuke Torii et al.In vitro cellular & developmental biology. Animal, 52(1), 89-99 (2015-09-04) Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development.Carlos M Moran et al.Developmental dynamics : an official publication of the American Association of Anatomists, 240(6), 1354-1364 (2011-03-09) Effects of Veratrum nigrum alkaloids on central catecholaminergic neurons of renal hypertensive rats.H Li et al.Acta pharmacologica Sinica, 21(1), 23-28 (2001-03-27) Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development.Hong-Xiang Liu et al.Developmental biology, 276(2), 280-300 (2004-12-08) A preliminary assessment of the toxic and mutagenic potential of steroidal alkaloids in transgenic mice.L Crawford et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 33(3), 191-194 (1995-03-01) Ingestion of false hellebore plants can cross-react with a digoxin clinical chemistry assay.L K Bechtel et al.Clinical toxicology (Philadelphia, Pa.), 48(5), 435-442 (2010-07-01) Synthesis of all diastereomers of the piperidine--alkaloid substructure of cyclopamine.Philipp Heretsch et al.Organic letters, 11(23), 5410-5412 (2009-11-04) [Chemical studies on alkaloids from Veratrum nigrum].W J Zhao Zhong yao tong bao (Beijing, China : 1981), 12(1), 34-35 (1987-01-01) [The structure and absolute configuration of vertaline B isolated from Veratrum taliense Lose. f].Z D Min et al.Yao xue xue bao = Acta pharmaceutica Sinica, 23(8), 584-587 (1988-01-01) Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.Christopher W Wilson et al.PloS one, 4(4), e5182-e5182 (2009-04-15) Comparative effects of retinoic acid and jervine on chondrocyte differentiation.M Campbell et al.Teratology, 36(2), 235-243 (1987-10-01)

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