Boiling point	279-287 ºC
Flash point	216 ºC
Density	0.97
Refractive index	1.4825-1.4845

SDS/MSDS	S24/25

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Carbon monoxide (CO) is a novel inhibitor of connexin hemichannels.Carmen G León-Paravic et al.The Journal of biological chemistry, 289(52), 36150-36157 (2014-11-12) Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide.Wonki Kim et al.Antioxidants & redox signaling, 23(2), 163-177 (2015-03-31) CO Induces Nrf2-Dependent Heme Oxygenase-1 Transcription by Cooperating with Sp1 and c-Jun in Rat Brain Astrocytes.Pei-Ling Chi et al.Molecular neurobiology, 52(1), 277-292 (2014-08-26) Effects of purified human fibrinogen modified with carbon monoxide and iron on coagulation in rabbits injected with Crotalus atrox venom.Vance G Nielsen Journal of thrombosis and thrombolysis, 44(4), 481-488 (2017-09-11) One-step exchange-labelling of piperidines, piperazines and dialkylamines with deuterium oxide: catalysis by various ruthenium complexes.Alexakis E, et al. Tetrahedron Letters, 46(25), 4291-4293 (2005) Administration of CORM-2 inhibits diabetic neuropathy but does not reduce dyslipidemia in diabetic mice.Karen Alejandra Méndez-Lara et al.PloS one, 13(10), e0204841-e0204841 (2018-10-05) H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain.Yajun Chen et al.Inflammation, 38(5), 1835-1846 (2015-03-31) DNA damage and antioxidant properties of CORM-2 in normal and cancer cells.Michał Juszczak et al.Scientific reports, 10(1), 12200-12200 (2020-07-24) Protective effects of carbon monoxide releasing molecule‑2 on pancreatic function in septic mice.Yishu Liu et al.Molecular medicine reports, 19(5), 3449-3458 (2019-03-22) Cyclopenta [l] phenanthrenyl and Cyclopenta [a] acenaphthylenyl Half-Sandwich Complexes of Ruthenium as Racemization Catalysts for Secondary Alcohols.Mavrynsky D, et al. Organometallics, 28(2), 598-605 (2008) Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity.Hongzhuan Yin et al.BMC cancer, 14, 436-436 (2014-06-15) Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation.Sun-Uk Bak et al.BMB reports, 50(2), 103-108 (2017-01-17) Carbon monoxide attenuates lipopolysaccharide-induced lung injury by mitofusin proteins via p38 MAPK pathway.Shu-An Dong et al.The Journal of surgical research, 228, 201-210 (2018-06-17) Carbon monoxide inhibits hemotoxic activity of Elapidae venoms: potential role of heme.Vance G Nielsen et al.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 31(1), 51-59 (2017-11-25) The influence of ruthenium on vascular tone.Bart Pauwels et al.The Journal of pharmacy and pharmacology, 67(9), 1263-1271 (2015-04-14) Cellular mechanisms underlying carbon monoxide stimulated anion secretion in rat epididymal epithelium.Lei Peng et al.Nitric oxide : biology and chemistry, 100-101, 30-37 (2020-04-14) Heme Oxygenase-1 Influences Satellite Cells and Progression of Duchenne Muscular Dystrophy in Mice.Katarzyna Pietraszek-Gremplewicz et al.Antioxidants & redox signaling, 29(2), 128-148 (2018-04-20) CO-Releasing Molecule-2 Induces Nrf2/ARE-Dependent Heme Oxygenase-1 Expression Suppressing TNF-α-Induced Pulmonary Inflammation.Chih-Chung Lin et al.Journal of clinical medicine, 8(4) (2019-04-03) Carbon monoxide-releasing molecule-2 suppresses thrombomodulin and endothelial protein C receptor expression of human umbilical vein endothelial cells induced by lipopolysaccharide in vitro.Xianglin Meng et al.Medicine, 96(21), e6978-e6978 (2017-05-26) Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation.SiYuan Qin et al.Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(7), 537-548 (2015-06-08) Role of Hydroxytyrosol-dependent Regulation of HO-1 Expression in Promoting Wound Healing of Vascular Endothelial Cells via Nrf2 De Novo Synthesis and Stabilization.Houda Zrelli et al.Phytotherapy research : PTR, 29(7), 1011-1018 (2015-04-15) Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study.Michał Majewski et al.Antioxidants (Basel, Switzerland), 9(2) (2020-02-08) Carbon monoxide and biliverdin suppress bovine viral diarrhoea virus replication.Zhiqian Ma et al.The Journal of general virology, 98(12), 2982-2992 (2017-11-01) A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression.Joseph C Onyiah et al.Journal of innate immunity, 10(3), 228-238 (2018-05-24) The Heme Metabolite Carbon Monoxide Facilitates KSHV Infection by Inhibiting TLR4 Signaling in Endothelial Cells.Sara Botto et al.Frontiers in microbiology, 8, 568-568 (2017-04-20) Styrene-maleic acid copolymer-encapsulated carbon monoxide releasing molecule-2 (SMA/CORM-2) suppresses proliferation, migration and invasion of colorectal cancer cells in vitro and in vivo.Chi Lv et al.Biochemical and biophysical research communications, 520(2), 320-326 (2019-10-13) Ruthenium, Not Carbon Monoxide, Inhibits the Procoagulant Activity of Atheris, Echis, and Pseudonaja Venoms.Vance G Nielsen International journal of molecular sciences, 21(8) (2020-04-29) Direct Inhibitory Effects of Carbon Monoxide on Six Venoms Containing Fibrinogenolytic Metalloproteinases.Vance G Nielsen et al.Basic & clinical pharmacology & toxicology, 120(2), 207-212 (2016-08-23) The Effects of Heme Oxygenase By-Products on the Proliferation and Invasion of HUVECs, HTR-8/SVneo Cells, 3A(tPA 30-1) Cells, and HESCs Under Varying Oxygen Concentrations.Joong Gyu Ha et al.Reproductive sciences (Thousand Oaks, Calif.), 22(12), 1530-1538 (2015-06-05) Carbon monoxide inhibits the anticoagulant activity of Mojave rattlesnake venoms type A and B.Vance G Nielsen Journal of thrombosis and thrombolysis, 48(2), 256-262 (2019-05-28) Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers.Marcin Magierowski et al.British journal of pharmacology, 174(20), 3654-3668 (2017-08-03) IL-10/HMOX1 signaling modulates cochlear inflammation via negative regulation of MCP-1/CCL2 expression in cochlear fibrocytes.Jeong-Im Woo et al.Journal of immunology (Baltimore, Md. : 1950), 194(8), 3953-3961 (2015-03-18) Carbon Monoxide Potentiation of L-Type CaYoon Kyung Choi et al.Antioxidants & redox signaling, 27(1), 21-36 (2016-08-25) The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts.Pei-Ling Chi et al.British journal of pharmacology, 171(12), 2993-3009 (2014-03-19) Carbon monoxide releasing molecule enhances coagulation and decreases fibrinolysis in canine plasma exposed to Crotalus viridis venom in vitro and in vivo.Tyler E Johnson et al.Basic & clinical pharmacology & toxicology, 125(4), 328-336 (2019-05-07) Piceatannol attenuates homocysteine-induced endoplasmic reticulum stress and endothelial cell damage via heme oxygenase-1 expression.Jin-Sang Kil et al.Amino acids, 49(4), 735-745 (2016-12-21) A novel strategy for antimicrobial agent: role of exogenous carbon monoxide on suppressing Escherichia coli vitality and toxicity.Xuefeng Qiu et al.Pakistan journal of pharmaceutical sciences, 28(1 Suppl), 281-292 (2015-01-30) Examining the antimicrobial activity and toxicity to animal cells of different types of CO-releasing molecules.Lígia S Nobre et al.Dalton transactions (Cambridge, England : 2003), 45(4), 1455-1466 (2015-12-18) Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic Rats.Shulong Zhang et al.PloS one, 10(12), e0145988-e0145988 (2016-01-01) Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase/Akt mechanism.Po-Min Yang et al.Vascular pharmacology, 87, 209-218 (2016-10-11) Carbon monoxide augments electrical signaling in cultured neural networks of hippocampal neurons partly through activation of BKCa channels.Hucheng Zhao et al.Acta biochimica et biophysica Sinica, 47(5), 383-389 (2015-04-07) Effects of iron and carbon monoxide on Lachesis muta muta venom-mediated degradation of plasmatic coagulation.V G Nielsen et al.Human & experimental toxicology, 36(7), 727-733 (2016-08-05) Lycopene inhibits NF-κB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells.Po-Min Yang et al.International journal of molecular medicine, 39(6), 1533-1450 (2017-04-26) Characterization of the Rabbit as an In Vitro and In Vivo Model to Assess the Effects of Fibrinogenolytic Activity of Snake Venom on Coagulation.Vance G Nielsen et al.Basic & clinical pharmacology & toxicology, 122(1), 157-164 (2017-07-12) Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2.Hari Prasad Joshi et al.Molecular neurobiology, 56(8), 5539-5554 (2019-01-15) The impact of exogenous CO releasing molecule CORM-2 on inflammation and signaling of orthotopic lung cancer.Li Shao et al.Oncology letters, 16(3), 3223-3230 (2018-08-22) Exogenous carbon monoxide suppresses Escherichia coli vitality and improves survival in an Escherichia coli-induced murine sepsis model.Wei-chang Shen et al.Acta pharmacologica Sinica, 35(12), 1566-1576 (2014-11-18) Interactions Between the Circadian Clock and Heme Oxygenase in the Retina of Drosophila melanogaster.Milena Damulewicz et al.Molecular neurobiology, 54(7), 4953-4962 (2016-08-16) Heme oxygenase-1/carbon monoxide axis suppresses transforming growth factor-β1-induced growth inhibition by increasing ERK1/2-mediated phosphorylation of Smad3 at Thr-179 in human hepatocellular carcinoma cell lines.Seong Ji Park et al.Biochemical and biophysical research communications, 498(3), 609-615 (2018-03-11) Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway.Hyo Jeong Kim et al.Biochimica et biophysica acta, 1852(7), 1550-1559 (2015-04-29) Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells.Hyewon Moon et al.Biomolecules & therapeutics, 26(2), 175-181 (2018-02-13) Heme Oxygenase-1 Inhibits HLA Class I Antibody-Dependent Endothelial Cell Activation.Eva Zilian et al.PloS one, 10(12), e0145306-e0145306 (2015-12-23) Effects of frequently applied carbon monoxide releasing molecules (CORMs) in typical CO-sensitive model systems - A comparative in vitro study.David Stucki et al.Archives of biochemistry and biophysics, 687, 108383-108383 (2020-04-27) Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals.So Ra Kim et al.Biochemical pharmacology, 95(4), 279-289 (2015-04-22) Carbon monoxide inhibits the nuclear-cytoplasmic translocation of HMGB1 in an in vitro oxidative stress injury model of mouse renal tubular epithelial cells.Yu Jia et al.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 36(6), 791-795 (2016-12-08) Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated KMoza M Al-Owais et al.Cell death & disease, 8(11), e3163-e3163 (2017-11-03) Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities.Roberto Motterlini et al.Circulation research, 90(2), E17-E24 (2002-02-09) Thrombelastographic characterization of the thrombin-like activity of Crotalus simus and Bothrops asper venoms.Vance G Nielsen et al.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 28(3), 211-217 (2016-06-18) The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro.Angke Zhang et al.Frontiers in microbiology, 11, 412-412 (2020-04-02) Pharmacological Induction of Heme Oxygenase-1 Impairs Nuclear Accumulation of Herpes Simplex Virus Capsids upon Infection.Francisco J Ibáñez et al.Frontiers in microbiology, 8, 2108-2108 (2017-11-23) Nrf2/HO-1 partially regulates cytoprotective effects of carbon monoxide against urban particulate matter-induced inflammatory responses in oral keratinocytes.Ching-Yi Cheng et al.Cytokine, 133, 155185-155185 (2020-07-03) The anticoagulant effect of Apis mellifera phospholipase A2 is inhibited by CORM-2 via a carbon monoxide-independent mechanism.Vance G Nielsen Journal of thrombosis and thrombolysis, 49(1), 100-107 (2019-11-05) c-Src-dependent transactivation of EGFR mediates CORM-2-induced HO-1 expression in human tracheal smooth muscle cells.Chuen-Mao Yang et al.Journal of cellular physiology, 230(10), 2351-2361 (2015-04-30) Mechanisms Responsible for the Anticoagulant Properties of Neurotoxic Dendroaspis Venoms: A Viscoelastic Analysis.Vance G Nielsen et al.International journal of molecular sciences, 21(6) (2020-03-22) CORM-2 Pretreatment Attenuates Inflammation-mediated Islet Dysfunction.Xiang-Heng Cai et al.Cell transplantation, 29, 963689720903691-963689720903691 (2020-05-05) Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes.Peter Tzu-Yu Chien et al.Toxicology and applied pharmacology, 289(2), 349-359 (2015-09-20) Selective Susceptibility of Oligodendrocytes to Carbon Monoxide Poisoning: Implication for Delayed Neurologic Sequelae (DNS).Xiaofei Tian et al.Frontiers in psychiatry, 11, 815-815 (2020-09-10) Heme oxygenase-1 dampens the macrophage sterile inflammasome response and regulates its components in the hypoxic lung.Sally H Vitali et al.American journal of physiology. Lung cellular and molecular physiology, 318(1), L125-L134 (2019-10-31) CO-independent modification of KGuido Gessner et al.European journal of pharmacology, 815, 33-41 (2017-10-11) Harnessing carbon monoxide-releasing platforms for cancer therapy.Yang Zhou et al.Biomaterials, 255, 120193-120193 (2020-06-23) Carbon Monoxide Inhibits T Cell Proliferation by Suppressing Reactive Oxygen Species Signaling.Yutao Yan et al.Antioxidants & redox signaling, 32(7), 429-446 (2019-12-08) CORM-2-Solid Lipid Nanoparticles Maintain Integrity of Blood-Spinal Cord Barrier After Spinal Cord Injury in Rats.Hari Prasad Joshi et al.Molecular neurobiology, 57(6), 2671-2689 (2020-04-18) CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression.Ming-Horng Tsai et al.Redox biology, 12, 377-388 (2017-03-16) Carbon monoxide-releasing molecule attenuates allograft airway rejection.Takashi Ohtsuka et al.Transplant international : official journal of the European Society for Organ Transplantation, 27(7), 741-747 (2014-03-19) Carbon Monoxide Releasing Molecule-2-Upregulated ROS-Dependent Heme Oxygenase-1 Axis Suppresses Lipopolysaccharide-Induced Airway Inflammation.Chih-Chung Lin et al.International journal of molecular sciences, 20(13) (2019-07-03) Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation.Shakil Ahmad et al.Thrombosis and haemostasis, 113(2), 329-337 (2014-10-31) The Effects of Cobalt Protoporphyrin IX and Tricarbonyldichlororuthenium (II) Dimer Treatments and Its Interaction with Nitric Oxide in the Locus Coeruleus of Mice with Peripheral Inflammation.Patricia Moreno et al.International journal of molecular sciences, 20(9) (2019-05-08) Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug.Emanuela Mhillaj et al.Frontiers in cell and developmental biology, 8, 561179-561179 (2020-11-03) Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats.Peng Wang et al.International journal of molecular sciences, 16(9), 20595-20608 (2015-09-04) Role of heme modulation in inhibition of Atheris, Atractaspis, Causus, Cerastes, Echis, and Macrovipera hemotoxic venom activity.V G Nielsen et al.Human & experimental toxicology, 38(2), 216-226 (2018-08-09) Modulation of growth cone filopodial length by carbon monoxide.Stephen Estes et al.Developmental neurobiology, 77(6), 677-690 (2016-08-12) Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells.Niels A J Cremers et al.International journal of molecular sciences, 15(10), 17974-17999 (2014-10-10)

Remarks