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2,5-Dimethylaniline | CAS:95-78-3
2,5-Dimethylaniline
  • Name:2,5-Dimethylaniline
  • CAS:95-78-3
  • Synonyms:1-Amino-2,5-dimethylbenzene; 2,5-Xylidine; 3-Amino-1,4-dimethylbenzene; p-Xylidine; 5-Methyl-o-toluidine; 6-Methyl-m-toluidine
  • Molecular Formula:C8H11N
  • Molecular Weight:121.18
  • EINESC:202-451-0

Description

Properties

Melting point 11.5 ºC
Boiling point 218 ºC
Flash point 93 ºC
Density 0.973
Refractive index 1.5582-1.5602

Safety

Symbol(GHS) T;N
Hazard Codes R23/24/25;R33;R51/53
SDS/MSDS S28A;S36/37;S45;S61

SDS

Source SDS/MSDS Samples
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Synthetic Route
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Articles
Peer-Reviewed Papers
[Determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi Indici by RP-HPLC].Haijin Shen et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(2), 191-193 (2010-04-17) Cytotoxic fraction from Artemisia sacrorum Ledeb. against three human cancer cell lines and separation and identification of its compounds.Guang-Chun Piao et al.Natural product research, 26(16), 1483-1491 (2011-10-20) Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice.Wei-Jan Huang et al.Journal of ethnopharmacology, 166, 18-22 (2015-03-15) Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages.Monika Warat et al.International journal of molecular sciences, 15(7), 11510-11522 (2014-07-01) Quantitative determination of flavonoids by column high-performance liquid chromatography with mass spectrometry and ultraviolet absorption detection in Artemisia afra and comparative studies with various species of Artemisia plants.Bharathi Avula et al.Journal of AOAC International, 92(2), 633-644 (2009-06-03) Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain.Hui-Jun Wu et al.Journal of molecular and cellular cardiology, 51(6), 966-973 (2011-09-13) [The influence of different processing on the content of flavones of Dendranthema morifolium].Chuan-shan Jin et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(5), 702-704 (2012-12-12) Antiviral flavonoids from Mosla scabra.Qiaofeng Wu et al.Fitoterapia, 81(5), 429-433 (2009-12-17) Simultaneous quantification of 25 active constituents in the total flavonoids extract from Herba Desmodii Styracifolii by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.Panpan Guo et al.Journal of separation science, 38(7), 1156-1163 (2015-01-27) [Studies on chemical constituents from flowers of Chrysanthemum indicum].Mei-Hua Gao et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(5), 682-684 (2008-10-02) The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo.Si-Yang Fan et al.Journal of ethnopharmacology, 141(2), 647-652 (2011-05-31) [Chemical constituents from flowers of Chrysanthemum indicum].Jinyue Wang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(6), 718-721 (2010-06-16) CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.Vasilis P Androutsopoulos et al.Toxicology, 264(3), 162-170 (2009-08-12) The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts.Alessandra Berto et al.Food & function, 6(9), 3081-3090 (2015-07-28) Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway.Ling-Zhi Liu et al.Biochemical and biophysical research communications, 413(2), 299-305 (2011-09-07) Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood.Daniela Ribeiro et al.Inflammation, 38(2), 858-870 (2014-08-21) Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients.Kazuma Kiyotani et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(8), 1287-1293 (2010-02-04) Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway.Kun-Hung Shen et al.Molecular and cellular biochemistry, 333(1-2), 279-291 (2009-08-21) Metabolic modifications of birch leaf phenolics by an herbivorous insect: detoxification of flavonoid aglycones via glycosylation.Juha-Pekka Salminen et al.Zeitschrift fur Naturforschung. C, Journal of biosciences, 59(5-6), 437-444 (2008-11-13) Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens King.Juriyati Jalil et al.Molecules (Basel, Switzerland), 17(9), 10893-10901 (2012-09-12) Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa.Hana Moon et al.PloS one, 10(5), e0127060-e0127060 (2015-05-16) Anti-aromatase activity of the constituents from damiana (Turnera diffusa).Jianping Zhao et al.Journal of ethnopharmacology, 120(3), 387-393 (2008-10-25) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.Vasilis P Androutsopoulos et al.Bioorganic & medicinal chemistry, 19(9), 2842-2849 (2011-04-13) Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo.Hyo Geun Kim et al.Biological & pharmaceutical bulletin, 35(8), 1287-1294 (2012-08-07) The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts.Alessandra Berto et al.Food & function, 6(9), 3081-3090 (2015-07-28) [Study on chemical constituents of Artemisia sphaerocephala].Jie Zhang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(2), 238-242 (2012-06-29) [Study on the flavanone constitutes of Buddleja davidii].Xue-Jing Peng et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(10), 1534-1537 (2012-03-01) Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.Xue Wang et al.Scientific reports, 5, 16127-16127 (2015-11-05) Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway.Ling-Zhi Liu et al.Biochemical and biophysical research communications, 413(2), 299-305 (2011-09-07) Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood.Daniela Ribeiro et al.Inflammation, 38(2), 858-870 (2014-08-21) Acacetin inhibits the invasion and migration of human non-small cell lung cancer A549 cells by suppressing the p38α MAPK signaling pathway.Shang-Tao Chien et al.Molecular and cellular biochemistry, 350(1-2), 135-148 (2011-01-07) Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade.Kiyotada Watanabe et al.Oncology reports, 27(1), 204-209 (2011-10-14) Acacetin blocks kv1.3 channels and inhibits human T cell activation.Ning Zhao et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(4), 1359-1372 (2014-10-11) Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1.Yaou Fong et al.Journal of food science, 75(1), H30-H38 (2010-05-25)
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