Melting point	260-265 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
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Synthetic Route

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Name	CAS

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Peer-Reviewed Papers

Formulated squalene for food related applications.Eleni Naziri et al.Recent patents on food, nutrition & agriculture, 5(2), 83-104 (2012-12-29) Fungal sterol C22-desaturase is not an antimycotic target as shown by selective inhibitors and testing on clinical isolates.Christoph Müller et al.Steroids, 101, 1-6 (2015-05-30) The combined molecular adjuvant CASAC enhances the CD8+ T cell response to a tumor-associated self-antigen in aged, immunosenescent mice.Gee Jun Tye et al.Immunity & ageing : I & A, 12, 6-6 (2015-07-15) Assessment of antigen-specific and cross-reactive antibody responses to an MF59-adjuvanted A/H5N1 prepandemic influenza vaccine in adult and elderly subjects.Iván Bihari et al.Clinical and vaccine immunology : CVI, 19(12), 1943-1948 (2012-10-20) Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection.Jamie F S Mann et al.Journal of controlled release : official journal of the Controlled Release Society, 170(3), 452-459 (2013-06-19) Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase.Yuan-Ting Liu et al.Organic letters, 14(20), 5222-5225 (2012-10-10) Inactivated and adjuvanted influenza vaccines.Giuseppe Del Giudice et al.Current topics in microbiology and immunology, 386, 151-180 (2014-07-21) Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria.Melinda L Micallef et al.BMC genomics, 16, 669-669 (2015-09-04) The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination.Maria Vono et al.Proceedings of the National Academy of Sciences of the United States of America, 110(52), 21095-21100 (2013-12-11) Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.Sarah Nicolai et al.Science immunology, 5(43) (2020-01-05) Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses.Alicja M Chmielewska et al.Journal of virology, 88(10), 5502-5510 (2014-03-07) An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.Kevin A Robertson et al.PLoS biology, 14(3), e1002364-e1002364 (2016-03-05) The mannoprotein TIR3 (CAGL0C03872g) is required for sterol uptake in Candida glabrata.Tatsuya Inukai et al.Biochimica et biophysica acta, 1851(2), 141-151 (2014-12-03) Generation and preclinical immunogenicity study of dengue type 2 virus-like particles derived from stably transfected mosquito cells.Amporn Suphatrakul et al.Vaccine, 33(42), 5613-5622 (2015-09-19) Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model.Hideaki Kabuto et al.Journal of oleo science, 62(1), 21-28 (2013-01-30) Safety review: squalene and thimerosal in vaccines.Marc Montana et al.Therapie, 65(6), 533-541 (2010-12-24) Atmospheric pressure chemical ionization mass spectrometry at low flow rates: Importance of ion source housing.Timotej Strmeň et al.Rapid communications in mass spectrometry : RCM, 34(10), e8722-e8722 (2020-01-09) Multi-centre observational study of transplacental transmission of influenza antibodies following vaccination with AS03(A)-adjuvanted H1N1 2009 vaccine.Richard Puleston et al.PloS one, 8(1), e47448-e47448 (2013-02-02) Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene.Richard E Ostlund et al.Nutrition reviews, 60(11), 349-359 (2002-12-05) Biological importance and applications of squalene and squalane.Se-Kwon Kim et al.Advances in food and nutrition research, 65, 223-233 (2012-03-01) Niosomes based on synthetic cationic lipids for gene delivery: the influence of polar head-groups on the transfection efficiency in HEK-293, ARPE-19 and MSC-D1 cells.E Ojeda et al.Organic & biomolecular chemistry, 13(4), 1068-1081 (2014-11-22) Triterpene hydrocarbon production engineered into a metabolically versatile host--Rhodobacter capsulatus.Nymul E Khan et al.Biotechnology and bioengineering, 112(8), 1523-1532 (2015-03-03) CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.Annemieke de Jong et al.Nature immunology, 15(2), 177-185 (2013-12-24) Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis.Jeffrey C Noro et al.Journal of natural products, 71(9), 1623-1624 (2008-08-20) Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases.Ryousuke Ito et al.The FEBS journal, 280(5), 1267-1280 (2013-01-09) The importance and perspective of plant-based squalene in cosmetology.Katarzyna Wołosik et al.Journal of cosmetic science, 64(1), 59-66 (2013-03-02) Cytotoxic flavonoids from the leaves of Cryptocarya chinensis.Tsung-Hsien Chou et al.Journal of natural products, 73(9), 1470-1475 (2010-08-14) Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation.Qiyan Xiong et al.Vaccine, 32(27), 3445-3451 (2014-04-16) Characteristics of rose hip (Rosa canina L.) cold-pressed oil and its oxidative stability studied by the differential scanning calorimetry method.Magdalena Grajzer et al.Food chemistry, 188, 459-466 (2015-06-05) Molecular cloning and characterization of three isoprenyl diphosphate synthase genes from alfalfa.Yan Sun et al.Molecular biology reports, 40(2), 2035-2044 (2012-12-15) Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study.F Rubinstein et al.BMJ (Clinical research ed.), 346, f393-f393 (2013-02-06) The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.Yun Xia et al.Cell, 175(4), 1059-1073 (2018-10-03) Rainbow trout leucocyte activity: influence on the ectoparasitic monogenean Gyrodactylus derjaviniBuchmann K and Bresciani J Diseases of Aquatic Organisms, 35(1), 13-22 (1999) A phase II, randomised clinical trial to demonstrate the non-inferiority of low-dose MF59-adjuvanted pre-pandemic A/H5N1 influenza vaccine in adult and elderly subjects.H Czajka et al.Journal of preventive medicine and hygiene, 53(3), 136-142 (2013-02-01) Simultaneous production of DHA and squalene from Aurantiochytrium sp. grown on forest biomass hydrolysates.Alok Patel et al.Biotechnology for biofuels, 12, 255-255 (2019-11-07) Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats.Akihiro Michihara et al.Biological & pharmaceutical bulletin, 38(12), 1879-1890 (2015-12-04) A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.Tomonori Takami et al.PloS one, 7(11), e49004-e49004 (2012-11-13) Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.Shirya Rashid et al.Circulation, 130(5), 431-441 (2014-07-30) A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine.Joanne M Langley et al.BMC infectious diseases, 12, 279-279 (2012-11-01) Atmospheric Oxidation of Squalene: Molecular Study Using COBRA Modeling and High-Resolution Mass Spectrometry.David R Fooshee et al.Environmental science & technology, 49(22), 13304-13313 (2015-10-23) The development of self-emulsifying oil-in-water emulsion adjuvant and an evaluation of the impact of droplet size on performance.Ruchi R Shah et al.Journal of pharmaceutical sciences, 104(4), 1352-1361 (2015-01-21) Molecular cloning and differential expression analysis of a squalene synthase gene from Dioscorea zingiberensis, an important pharmaceutical plant.Yun Ye et al.Molecular biology reports, 41(9), 6097-6104 (2014-07-06) Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy".Danuta M Skowronski et al.American journal of epidemiology, 177(6), 593-594 (2013-02-26) Chains, sheets, and droplets: assemblies of hydrophobic gold nanocrystals with saturated phosphatidylcholine lipid and squalene.Michael R Rasch et al.Langmuir : the ACS journal of surfaces and colloids, 28(43), 15160-15167 (2012-10-05) [Research progress on the squalene synthase].Mingwen Zhao et al.Wei sheng wu xue bao = Acta microbiologica Sinica, 43(5), 676-680 (2005-11-12) Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study.Jose A Plaza et al.The American Journal of dermatopathology, 37(11), 809-821 (2015-10-21) Structure and regulation of mammalian squalene synthase.T R Tansey et al.Biochimica et biophysica acta, 1529(1-3), 49-62 (2000-12-09) Lichen endophyte derived pyridoxatin inactivates Candida growth by interfering with ergosterol biosynthesis.Wenqiang Chang et al.Biochimica et biophysica acta, 1850(9), 1762-1771 (2015-05-12) Impact of formulation and particle size on stability and immunogenicity of oil-in-water emulsion adjuvants.Vidyashankara Iyer et al.Human vaccines & immunotherapeutics, 11(7), 1853-1864 (2015-06-20) Accumulation of squalene is associated with the clustering of lipid droplets.Minh T Ta et al.The FEBS journal, 279(22), 4231-4244 (2012-09-28) 2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice.Jin Zhang et al.Acta pharmacologica Sinica, 36(4), 483-496 (2015-04-04) Design and preclinical characterization of a novel vaccine adjuvant formulation consisting of a synthetic TLR4 agonist in a thermoreversible squalene emulsion.Jean Haensler et al.International journal of pharmaceutics, 486(1-2), 99-111 (2015-03-22) Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures.Catherine Naughton et al.Nature structural & molecular biology, 20(3), 387-395 (2013-02-19) Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.Christine Durier et al.AIDS (London, England), 27(1), 87-93 (2012-09-29) Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion.Zih-rou Huang et al.Acta pharmacologica Sinica, 29(9), 1094-1102 (2008-08-23) Squalene: A natural triterpene for use in disease management and therapy.L Harivardhan Reddy et al.Advanced drug delivery reviews, 61(15), 1412-1426 (2009-10-07) Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream.Andreas Lauterbach et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 614-624 (2014-12-03) Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy.C Scialabba et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 695-705 (2014-10-05) Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor.Christine Barrault et al.The Journal of steroid biochemistry and molecular biology, 152, 34-44 (2015-04-14) Squalene: potential chemopreventive agent.T J Smith Expert opinion on investigational drugs, 9(8), 1841-1848 (2000-11-04) Queries about vaccines containing squalene.Frances Beck et al.Immunology and cell biology, 88(5), 497-499 (2010-02-17) The history of MF59(®) adjuvant: a phoenix that arose from the ashes.Derek T O'Hagan et al.Expert review of vaccines, 12(1), 13-30 (2012-12-22) seco-Abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima.Jih-Jung Chen et al.Journal of natural products, 72(2), 223-228 (2009-02-06) Squalene emulsions for parenteral vaccine and drug delivery.Christopher B Fox Molecules (Basel, Switzerland), 14(9), 3286-3312 (2009-09-29) The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.Sandra G Gonzalez Malagon et al.Biochemical pharmacology, 96(3), 267-277 (2015-06-07) Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosisLavrijsen APM, et al. The Journal of Investigative Dermatology, 105(4), 619-624 (1995) Gemcitabine-based therapy for pancreatic cancer using the squalenoyl nucleoside monophosphate nanoassemblies.Andrei Maksimenko et al.International journal of pharmaceutics, 482(1-2), 38-46 (2014-12-03) Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals.Roman Holič et al.Biochimica et biophysica acta, 1842(10), 1483-1490 (2014-07-30) Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene.Joachim Caron et al.Advanced healthcare materials, 2(1), 172-185 (2012-12-06) Nutritional evaluation and health promoting activities of nuts and seeds cultivated in Greece.Nick Kalogeropoulos et al.International journal of food sciences and nutrition, 64(6), 757-767 (2013-05-07) Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells.Pengfei Jiang et al.Oncotarget, 7(36), 57932-57942 (2016-07-28) Developmentally regulated sesquiterpene production confers resistance to Colletotrichum gloeosporioides in ripe pepper fruits.Sangkyu Park et al.PloS one, 9(10), e109453-e109453 (2014-10-07) Squalene-containing nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of diphencyprone for treating alopecia areata.Yin-Ku Lin et al.Pharmaceutical research, 30(2), 435-446 (2012-10-17) Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells.Urosh Vilimanovich et al.European journal of pharmacology, 765, 415-428 (2015-09-12) Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine.Joon Young Song et al.Journal of medical virology, 85(9), 1591-1597 (2013-07-16) Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination.Giuseppe Lofano et al.Journal of immunology (Baltimore, Md. : 1950), 195(4), 1617-1627 (2015-07-15) Immune response after one or two doses of pandemic influenza A (H1N1) monovalent, AS03-adjuvanted vaccine in HIV infected adults.Allan Bybeck Nielsen et al.Vaccine, 30(49), 7067-7071 (2012-10-06) Evaluation of asymmetric immunoliposomal nanoparticles for cellular uptake.Jeremiah Whittenton et al.Journal of microencapsulation, 30(1), 55-63 (2012-06-30) Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane.Katja Witschas et al.Biochimica et biophysica acta, 1848(5), 1147-1156 (2015-02-18) Acclimation mechanisms elicited by sprayed abscisic acid, solar UV-B and water deficit in leaf tissues of field-grown grapevines.Rodrigo Alonso et al.Plant physiology and biochemistry : PPB, 91, 56-60 (2015-04-18) Dietary squalene supplementation improves DSS-induced acute colitis by downregulating p38 MAPK and NFkB signaling pathways.Susana Sánchez-Fidalgo et al.Molecular nutrition & food research, 59(2), 284-292 (2014-11-13) The Palm Oil Miracle, 63-63 (2007) Biological importance and applications of squalene and squalane Advances in Food and Nutrition Research, 65, 223-233 (2012) Simple pencil-drawn paper-based devices for one-spot electrochemical detection of electroactive species in oil samples.Nicolò Dossi et al.Electrophoresis, 36(16), 1830-1836 (2015-04-22) Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes.Sholeem Griffin et al.Biology of reproduction, 99(4), 749-760 (2018-04-25) From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom.Cécile Vriet et al.Molecular plant, 6(6), 1738-1757 (2013-06-14) [Researches on influence of squalene synthase gene polymorphism on catalytic efficiency of its encode enzyme in Glycyrrhiza uralensis].Ying Liu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(24), 3777-3783 (2013-05-01) Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion.Nathalie Garçon et al.Expert review of vaccines, 11(3), 349-366 (2012-03-03) Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice.Thomas B Elliott et al.International journal of radiation biology, 91(9), 690-702 (2015-05-23) Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59 adjuvant: a randomized clinical trial.Robert B Belshe et al.JAMA, 312(14), 1420-1428 (2014-10-08) Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells.Urosh Vilimanovich et al.European journal of pharmacology, 765, 415-428 (2015-09-12) Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals.Roman Holič et al.Biochimica et biophysica acta, 1842(10), 1483-1490 (2014-07-30) Triterpenoid profiling and functional characterization of the initial genes involved in isoprenoid biosynthesis in neem (Azadirachta indica).Avinash Pandreka et al.BMC plant biology, 15, 214-214 (2015-09-04) CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets.Cyril Jean-Marie Martel et al.PloS one, 6(8), e22891-e22891 (2011-08-19) Building terpene production platforms in yeast.Xun Zhuang et al.Biotechnology and bioengineering, 112(9), 1854-1864 (2015-03-20) Squalene as novel food factor.Hari Narayan Bhilwade et al.Current pharmaceutical biotechnology, 11(8), 875-880 (2010-09-30) Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine.Joon Young Song et al.Journal of medical virology, 85(9), 1591-1597 (2013-07-16) Oil-in-Water Emulsion MF59 Increases Germinal Center B Cell Differentiation and Persistence in Response to Vaccination.Giuseppe Lofano et al.Journal of immunology (Baltimore, Md. : 1950), 195(4), 1617-1627 (2015-07-15) Squalene-containing nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of diphencyprone for treating alopecia areata.Yin-Ku Lin et al.Pharmaceutical research, 30(2), 435-446 (2012-10-17) Atorvastatin reduces long pentraxin 3 expression in vascular cells by inhibiting protein geranylgeranylation.Roberta Baetta et al.Vascular pharmacology, 67-69, 38-47 (2015-04-08) In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity. implications in cancer chemotherapy.B Das et al.European journal of cancer (Oxford, England : 1990), 39(17), 2556-2565 (2003-11-07) Benzophenone derivatives from the fruits of Garcinia multiflora and their anti-inflammatory activity.Jih-Jung Chen et al.Journal of natural products, 72(2), 253-258 (2009-02-11) Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice.Thomas B Elliott et al.International journal of radiation biology, 91(9), 690-702 (2015-05-23) Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.Magnus Bentinger et al.Biochimica et biophysica acta, 1841(7), 977-986 (2014-04-22) Phase coexistence in films composed of DLPC and DPPC: a comparison between different model membrane systems.Agustín Mangiarotti et al.Biochimica et biophysica acta, 1838(7), 1823-1831 (2014-03-04) How membrane permeation is affected by donor delivery solvent.Bernard P Binks et al.Physical chemistry chemical physics : PCCP, 14(44), 15525-15538 (2012-10-18) In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.P Jiang et al.British journal of cancer, 111(8), 1562-1571 (2014-08-06) Adjuvants in influenza vaccines.Kohhei Tetsutani et al.Vaccine, 30(52), 7658-7661 (2012-10-23) Structure-function mapping of key determinants for hydrocarbon biosynthesis by squalene and squalene synthase-like enzymes from the green alga Botryococcus braunii race B.Stephen A Bell et al.Biochemistry, 53(48), 7570-7581 (2014-11-14) Profound insights into squalene cyclization.Karl Poralla Chemistry & biology, 11(1), 12-14 (2004-04-29) Genome-scale transcriptome analysis in response to nitric oxide in birch cells: implications of the triterpene biosynthetic pathway.Fansuo Zeng et al.PloS one, 9(12), e116157-e116157 (2015-01-01) The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68.Tsz Yan Wong et al.The British journal of nutrition, 113(12), 1844-1852 (2015-05-16) Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly.Yuri Kashima et al.PloS one, 9(8), e105073-e105073 (2014-08-22) β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.Tsutomu Hoshino et al.Organic letters, 16(13), 3548-3551 (2014-06-25) Bioinspired Nanoemulsions Stabilized by Phosphoethanolamine and Phosphoglycerol Lipids.Carlo Caianiello et al.Nanomaterials (Basel, Switzerland), 10(6) (2020-06-24) Safety and immunogenicity of an MF59-adjuvanted A/H1N1 pandemic influenza vaccine in children from three to seventeen years of age.Markus Knuf et al.Vaccine, 33(1), 174-181 (2014-12-03) Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells.Jean-Rémi Bertrand et al.Nucleic acid therapeutics, 25(3), 121-129 (2015-04-22) Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.Hélène Autefage et al.Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4280-4285 (2015-04-02) Disorders of post-squalene cholesterol biosynthesis leading to human dysmorphogenesis.Hans C Andersson Cellular and molecular biology (Noisy-le-Grand, France), 48(2), 173-177 (2002-05-07) Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.Masanori Honsho et al.The Journal of biological chemistry, 290(48), 28822-28833 (2015-10-16) Obstructive component analysis of radioactive stents and common plastic stents in the bile duct.Yan Guo et al.European journal of gastroenterology & hepatology, 26(7), 795-802 (2014-06-06) Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.Masanori Honsho et al.The Journal of biological chemistry, 290(48), 28822-28833 (2015-10-16) β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.Tsutomu Hoshino et al.Organic letters, 16(13), 3548-3551 (2014-06-25) Profound insights into squalene cyclization.Karl Poralla Chemistry & biology, 11(1), 12-14 (2004-04-29) Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells.Jean-Rémi Bertrand et al.Nucleic acid therapeutics, 25(3), 121-129 (2015-04-22) Expanding the options for confronting pandemic influenza.John J Treanor JAMA, 312(14), 1401-1402 (2014-10-08) Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.Hélène Autefage et al.Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4280-4285 (2015-04-02) Effect of baking of sardine (Sardina pilchardus) and frying of anchovy (Engraulis encrasicholus) in olive and sunflower oil on their quality.Anastasios Zotos et al.Food science and technology international = Ciencia y tecnologia de los alimentos internacional, 19(1), 11-23 (2012-12-15) Differential roles of the mevalonate pathway in the development and survival of mouse Purkinje cells in culture.Andrew Barszczyk et al.Molecular neurobiology, 51(3), 1116-1129 (2014-06-30) Safety and immunogenicity of an MF59-adjuvanted A/H1N1 pandemic influenza vaccine in children from three to seventeen years of age.Markus Knuf et al.Vaccine, 33(1), 174-181 (2014-12-03) Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-Aβ antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution.Francesca Mantile et al.PloS one, 9(7), e101474-e101474 (2014-07-02) Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial.Mark J Mulligan et al.JAMA, 312(14), 1409-1419 (2014-10-08) Squalene-hopene cyclases.Gabriele Siedenburg et al.Applied and environmental microbiology, 77(12), 3905-3915 (2011-05-03) [Engineering of squalene cyclizing enzymes].Ikuro Abe Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 128(8), 1109-1118 (2008-08-02) Development of a non-blurring, dual-imaging tissue marker for gastrointestinal tumor localization.Hideki Hayashi et al.Surgical endoscopy, 29(6), 1445-1451 (2014-08-31) Influence of Interfacial Gas Enrichment on Controlled Coalescence of Oil Droplets in Water in Microfluidics.Jianlong Wang et al.Langmuir : the ACS journal of surfaces and colloids, 35(10), 3615-3623 (2019-02-13) Formulation and in vitro and in vivo evaluation of a cationic emulsion as a vehicle for improving adenoviral gene transfer.Soo-Yeon Kim et al.International journal of pharmaceutics, 475(1-2), 49-59 (2014-08-21) Modulation of human keratinocyte responses to solar UV by plant polyphenols as a basis for chemoprevention of non-melanoma skin cancers.V A Kostyuk et al.Current medicinal chemistry, 20(7), 869-879 (2012-12-06) FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.Stephen B Helliwell et al.Nature communications, 6, 8613-8613 (2015-10-13) Elevated serum squalene and cholesterol synthesis markers in pregnant obese women with gestational diabetes mellitus.Helena E Miettinen et al.Journal of lipid research, 55(12), 2644-2654 (2014-10-11) Broadened immunity and protective responses with emulsion-adjuvanted H5 COBRA-VLP vaccines.James D Allen et al.Vaccine, 35(38), 5209-5216 (2017-08-10)

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