Flash point	4 ºC
Density	0.927

Symbol(GHS)	F;T
Hazard Codes	R11;R15;R23/24/25;R34
SDS/MSDS	S16;S26;S36/37/39;S45

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Peer-Reviewed Papers

Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine.S Rotzinger et al.Cellular and molecular neurobiology, 19(4), 427-442 (1999-06-24) Comparative study of neuroprotective effect of tricyclics vs. trazodone on animal model of depressive disorder.Ileana P Marinescu et al.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 53(2), 397-400 (2012-06-27) Managing acute coronary syndrome during medical air evacuation from a remote location at sea.Andrew H Westmoreland Aviation, space, and environmental medicine, 85(1), 71-74 (2014-02-01) FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression.Molly S Clark et al.American family physician, 84(9), 1-2 (2011-12-15) Trazodone increases extracellular serotonin levels in the frontal cortex of rats.M Pazzagli et al.European journal of pharmacology, 383(3), 249-257 (1999-12-14) Treatment of insomnia with hypnotics resulting in improved sexual functioning in post-menopausal women.Defne Eraslan et al.Psychiatria Danubina, 26(4), 353-357 (2014-11-08) Patient and facility characteristics associated with benzodiazepine prescribing for veterans with PTSD.Brian C Lund et al.Psychiatric services (Washington, D.C.), 64(2), 149-155 (2012-11-17) Sleep disturbances with suicidal ideation have resisted for many years: lessons from a PTSD case.Yuichiro Abe Asian journal of psychiatry, 5(2), 202-203 (2012-07-21) Mechanism of action of antidepressant medications.J P Feighner The Journal of clinical psychiatry, 60 Suppl 4, 4-11 (1999-03-23) Prescription compliance or illicit designer drug abuse?Matthew S Petrie et al.Clinical chemistry, 58(12), 1631-1634 (2012-11-30) Pharmacologic treatment of pediatric headaches: a meta-analysis.Khalil El-Chammas et al.JAMA pediatrics, 167(3), 250-258 (2013-01-30) [Trazodone in the treatment of addiction].Waldemar Kryszkowski et al.Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31(186), 384-387 (2012-01-14) Adjunctive sleep medications and depression outcome in the treatment of serotonin-selective reuptake inhibitor resistant depression in adolescents study.Wael Shamseddeen et al.Journal of child and adolescent psychopharmacology, 22(1), 29-36 (2012-01-19) Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.Andreia Teixeira-Castro et al.Brain : a journal of neurology, 138(Pt 11), 3221-3237 (2015-09-17) [Yimusake alone or combined with trazodone hydrochloride for primary premature ejaculation].Ji-Xiu Xu et al.Zhonghua nan ke xue = National journal of andrology, 18(4), 376-378 (2012-05-12) Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study.Kunihiro Kohmura et al.Psychopharmacology, 226(1), 75-81 (2012-10-12) Efficacy of trazodone in antipsychotic-induced akathisia resistant to conventional treatment.Roser Ribosa-Nogué et al.Parkinsonism & related disorders, 18(7), 902-903 (2012-05-03) Trazodone-induced severe headache.Huang-Chen Chen et al.Psychiatry and clinical neurosciences, 65(7), 681-682 (2011-12-20) Off-label uses of trazodone: a review.Letizia Bossini et al.Expert opinion on pharmacotherapy, 13(12), 1707-1717 (2012-06-21) Focal parietal necrosis of the sigmoid due to atypical neuroleptics: a case report.Arnaud Devresse et al.Acta gastro-enterologica Belgica, 75(2), 263-265 (2012-08-09) Trazodone is a potent agonist at 5-HT2C receptors mediating inhibition of the N-methyl-D-aspartate/nitric oxide/cyclic GMP pathway in rat cerebellum.M Marcoli et al.The Journal of pharmacology and experimental therapeutics, 285(3), 983-986 (1998-06-17) Spectroscopic and calorimetric studies on trazodone hydrochloride-phosphatidylcholine liposome interactions in the presence and absence of cholesterol.Dilek Yonar et al.Biochimica et biophysica acta, 1838(10), 2369-2379 (2014-06-21) Trazodone reduces the anticonvulsant action of certain classical antiepileptics in the mouse maximal electroshock model.Kinga K Borowicz et al.Pharmacological reports : PR, 64(5), 1136-1145 (2012-12-15) Rediscovering trazodone for the treatment of major depressive disorder.Andrea Fagiolini et al.CNS drugs, 26(12), 1033-1049 (2012-11-30) Animal behavior case of the month: thunderstorm phobia.Margaret E Gruen et al.Journal of the American Veterinary Medical Association, 241(10), 1293-1295 (2012-11-02) Antidepressants for patients with tinnitus.Paolo Baldo et al.The Cochrane database of systematic reviews, 9(9), CD003853-CD003853 (2012-09-14) Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain.Ramez Ghanbari et al.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 22(7), 518-526 (2011-12-14) [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression].Marek Jarema et al.Psychiatria polska, 45(4), 611-625 (2012-01-12) Managing acute coronary syndrome during medical air evacuation from a remote location at sea.Tolga Cakmak et al.Aviation, space, and environmental medicine, 85(4), 480-480 (2014-04-24) [Current treatment of depression and agitation in the elderly -- clinical use of trazodone].Péter Osváth Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 15(3), 147-155 (2013-10-11) Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis.Cynthia M Cooper et al.The New England journal of medicine, 372(5), 465-473 (2015-01-30) 5-HT receptor subtypes as key targets in mediating pigment dispersion within melanophores of teleost, Oreochromis mossambicus.Saima Salim et al.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 164(2), 117-123 (2012-12-01) Trazodone hydrochloride: a wide spectrum antidepressant with a unique pharmacological profile. A review of its neurochemical effects, pharmacology, clinical efficacy, and toxicology.A Georgotas et al.Pharmacotherapy, 2(5), 255-265 (1982-09-01) Commentary.Michael C Milone Clinical chemistry, 58(12), 1635-1635 (2012-11-30) Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro.Deena Ababneh et al.Birth defects research. Part B, Developmental and reproductive toxicology, 95(2), 184-193 (2012-04-25) Commentary.Michael Ganetsky Clinical chemistry, 58(12), 1634-1635 (2012-11-30) Drugs for insomnia. Treatment guidelines from the Medical Letter, 10(119), 57-60 (2012-07-11) An Innate Color Preference Displayed by Xenopus Tadpoles Is Persistent and Requires the Tegmentum.Jasper Elan Hunt et al.Frontiers in behavioral neuroscience, 14, 71-71 (2020-06-02)

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