Melting point	103 ºC**
Density	1.260±0.06 g/cm3 (20 º

没有数据	没有数据

Source	SDS/MSDS Samples
没有数据	没有数据

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Neural computational prediction of oral drug absorption based on CODES 2D descriptors.A Guerra et al.European journal of medicinal chemistry, 45(3), 930-940 (2009-12-22) A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring.Keri L H Carpenter et al.Acta neurochirurgica. Supplement, 114, 271-276 (2012-04-06) Cerebellar fastigial nuclear GABAergic projections to the hypothalamus modulate immune function.Bei-Bei Cao et al.Brain, behavior, and immunity, 27(1), 80-90 (2012-10-11) Evidence-based guideline update: medical treatment of infantile spasms. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.C Y Go et al.Neurology, 78(24), 1974-1980 (2012-06-13) Vigabatrin pediatric dosing information for refractory complex partial seizures: results from a population dose-response analysis.Jace C Nielsen et al.Epilepsia, 55(12), e134-e138 (2014-10-15) Vigabatrin for infantile spasms.Kimberly A Pesaturo et al.Pharmacotherapy, 31(3), 298-311 (2011-03-03) Analysis of vigabatrin treatment causing visual field defects in infantile spasms.Catherine Chiron et al.Developmental medicine and child neurology, 57(1), 9-10 (2014-08-12) Taurine is a crucial factor to preserve retinal ganglion cell survival.Nicolas Froger et al.Advances in experimental medicine and biology, 775, 69-83 (2013-02-09) Vigabatrin versus carbamazepine monotherapy for epilepsy.Yousheng Xiao et al.The Cochrane database of systematic reviews, 1, CD008781-CD008781 (2012-01-20) Vigabatrin therapy for refractory complex partial seizures: review of clinical trial experience in the United States.E Faught Acta neurologica Scandinavica. Supplementum, (192)(192), 29-35 (2011-11-09) Long-term outcome in children with infantile spasms treated with vigabatrin: a cohort of 180 patients.Milena Djuric et al.Epilepsia, 55(12), 1918-1925 (2014-11-08) Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin.Jose I Juncosa et al.Bioorganic & medicinal chemistry, 21(4), 903-911 (2013-01-12) Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents.James W Wheless et al.BMC pediatrics, 12, 108-108 (2012-07-27) Changes in the ERG d-wave with vigabatrin treatment in a pediatric cohort.Rachel Dragas et al.Documenta ophthalmologica. Advances in ophthalmology, 129(2), 97-104 (2014-07-11) A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence.Eugene C Somoza et al.JAMA psychiatry, 70(6), 630-637 (2013-04-12) Clinical reasoning: a case of abnormal eye movements in an infant: more than meets the eye.Lance H Rodan et al.Neurology, 81(15), e112-e115 (2013-10-09) Justification of vigabatrin administration in West syndrome patients? Warranting a re-consideration for improvement in their quality of life.Harinder Jaseja Clinical neurology and neurosurgery, 111(2), 111-114 (2008-10-11) Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex.Jens V Andersen et al.Glia, 68(12), 2601-2612 (2020-06-26) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) Primer on visual field testing, electroretinography, and other visual assessments for patients treated with vigabatrin.R C Sergott et al.Acta neurologica Scandinavica. Supplementum, (192)(192), 48-56 (2011-11-09) Recommendations for visual evaluations of patients treated with vigabatrin.Robert C Sergott Current opinion in ophthalmology, 21(6), 442-446 (2010-09-03) Ohtahara syndrome or early-onset West syndrome? A case with overlapping features and favorable response to vigabatrin.Christian M Korff et al.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 16(6), 753-757 (2012-07-07) Vigabatrin-associated visual field loss.Chris Fecarotta et al.International ophthalmology clinics, 52(3), 87-94 (2012-06-07) FT-Raman, FT-IR and UV-visible spectral investigations and ab initio computations of anti-epileptic drug: vigabatrin.Bismi Edwin et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 114, 633-641 (2013-07-03) The effect of chronic treatment with the GABA transaminase inhibitors gamma-vinyl-GABA and ethanolamine-O-sulphate on the in vivo release of GABA from rat hippocampus.M Qume et al.Journal of neurochemistry, 64(5), 2256-2261 (1995-05-01) [Ocular toxicity of drugs].Isabelle Audo La Revue du praticien, 63(1), 63-67 (2013-03-06) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Visual field and ocular safety during short-term vigabatrin treatment in cocaine abusers.Tamara L Berezina et al.American journal of ophthalmology, 154(2), 326-332 (2012-06-19) Outcomes of epileptic spasms in patients aged less than 3 years: single-center United States experience.Martina Vendrame et al.Pediatric neurology, 46(5), 276-280 (2012-04-24) Vigabatrin therapy for refractory complex partial seizures: review of major European trials.E Ben-Menachem et al.Acta neurologica Scandinavica. Supplementum, (192)(192), 16-28 (2011-11-09) [The course and treatment of epilepsy in children with tuberose sclerosis].M Iu Dorofeeva et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(6 Pt 2), 27-31 (2012-09-18) An investigation into the relationship between vigabatrin, movement disorders, and brain magnetic resonance imaging abnormalities in children with infantile spasms.Choong Yi Fong et al.Developmental medicine and child neurology, 55(9), 862-867 (2013-06-25) Medical management of refractory epilepsy--practical treatment with novel antiepileptic drugs.Elinor Ben-Menachem Epilepsia, 55 Suppl 1, 3-8 (2014-01-10) Patterns of peripapillary retinal nerve fiber layer thinning in vigabatrin-exposed individuals.Lisa M Clayton et al.Ophthalmology, 119(10), 2152-2160 (2012-08-03) The potential value of a negative finding: an illustrative example.Kenneth Silverman et al.JAMA psychiatry, 70(6), 571-572 (2013-04-12) Vigabatrin-induced forced normalization and psychosis--prolongated termination of behavioral symptoms but persistent antiepileptic effect after withdrawal.Peter Weber et al.Epilepsy & behavior : E&B, 24(1), 138-140 (2012-04-17) Vigabatrin therapy for infantile spasms: review of major trials in Europe, Canada, and the United States; and recommendations for dosing.L Carmant Acta neurologica Scandinavica. Supplementum, (192)(192), 36-47 (2011-11-09) Vigabatrin monotherapy for infantile spasms.Eija Gaily Expert review of neurotherapeutics, 12(3), 275-286 (2012-03-01) Prevalence of visual field loss following exposure to vigabatrin therapy: a systematic review.Melissa J Maguire et al.Epilepsia, 51(12), 2423-2431 (2010-11-13) Does vigabatrin treatment for infantile spasms cause visual field defects? An international multicentre study.Raili Riikonen et al.Developmental medicine and child neurology, 57(1), 60-67 (2014-08-26) [Therapeutic drug monitoring of vigabatrin].Danièle Bentué-Ferrer et al.Therapie, 65(1), 23-27 (2010-03-09) Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex.Bo Zhang et al.PloS one, 8(2), e57445-e57445 (2013-02-26) Vigabatrin for refractory partial epilepsy.Karla Hemming et al.The Cochrane database of systematic reviews, 1(1), CD007302-CD007302 (2013-02-27) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) Mechanism of action of vigabatrin: correcting misperceptions.E Ben-Menachem Acta neurologica Scandinavica. Supplementum, (192)(192), 5-15 (2011-11-09) Vigabatrin: 2008 update.L James Willmore et al.Epilepsia, 50(2), 163-173 (2009-02-21) Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice.Dorota Nieoczym et al.Progress in neuro-psychopharmacology & biological psychiatry, 39(1), 129-135 (2012-06-12) Balancing clinical benefits of vigabatrin with its associated risk of vision loss.J M Pellock Acta neurologica Scandinavica. Supplementum, (192)(192), 83-91 (2011-11-09) [Pharmacological treatment of spasticity in multiple sclerosis].O Heinzlef et al.Revue neurologique, 168 Suppl 3, S62-S68 (2012-06-29) Vigabatrin for partial-onset seizure treatment in patients with tuberous sclerosis complex.Daniel Friedman et al.Epilepsy & behavior : E&B, 27(1), 118-120 (2013-02-13) Vigabatrin: a comprehensive review of drug properties including clinical updates following recent FDA approval.Justin A Tolman et al.Expert opinion on pharmacotherapy, 10(18), 3077-3089 (2009-12-04) Vigabatrin and mental retardation in tuberous sclerosis: infantile spasms versus focal seizures.Mi-Sun Yum et al.Journal of child neurology, 28(3), 308-313 (2012-07-04) Effects of vigabatrin on the skeletal system of young rats.Barbara Nowińska et al.Acta poloniae pharmaceutica, 69(2), 327-334 (2012-05-10) Non-vision adverse events with vigabatrin therapy.S D Walker et al.Acta neurologica Scandinavica. Supplementum, (192)(192), 72-82 (2011-11-09) Vigabatrin-associated retinal damage: potential biochemical mechanisms.M K Heim et al.Acta neurologica Scandinavica, 126(4), 219-228 (2012-05-29) Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.Yun W Alelyunas et al.Bioorganic & medicinal chemistry letters, 20(24), 7312-7316 (2010-11-09) Understanding and interpreting vision safety issues with vigabatrin therapy.G T Plant et al.Acta neurologica Scandinavica. Supplementum, (192)(192), 57-71 (2011-11-09) Animal models of the epilepsies.R S Fisher Brain research. Brain research reviews, 14(3), 245-278 (1989-07-01) Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents.James W Wheless et al.BMC pediatrics, 12, 108-108 (2012-07-27) Long-term outcome in children with infantile spasms treated with vigabatrin: a cohort of 180 patients.Milena Djuric et al.Epilepsia, 55(12), 1918-1925 (2014-11-08)

Remarks