Melting point	-13 ºC
Water Solubility	Insoluble
Boiling point	213-214 ºC
Flash point	82 ºC
Density	1.274
Refractive index	1.558-1.560

Symbol(GHS)	C;N
Hazard Codes	R20/21/22;R34;R50/53
SDS/MSDS	S26;S29;S36/37/39;S45

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Methyldibromoglutaronitrile (Euxyl K400): A new and important sensitizer in the United States?Jackson M.J, et al. Journal of the American Academy of Dermatology, 38, 934-937 (1998) Determination of bromothalonil residues and degradation in apple and soil by QuEChERS and GC-MS/MS.Huijun Liu et al.Bulletin of environmental contamination and toxicology, 92(4), 451-454 (2014-02-20) Occupational allergic contact dermatitis to methyldibromoglutaronitrile in hand degreasing toilet paper.M E Marcano et al.Contact dermatitis, 57(2), 126-127 (2007-07-14) [Contact sensitization to Euxyl K-400].M T Bordel-Gómez et al.Actas dermo-sifiliograficas, 100(3), 201-204 (2009-05-22) Applicability of amino acid derivative reactivity assay for prediction of skin sensitization by combining multiple alternative methods to evaluate key events.Yusuke Yamamoto et al.The Journal of toxicological sciences, 44(9), 585-600 (2019-09-03) Undisclosed methyldibromo glutaronitrile causing allergic contact dermatitis in a NSAID cream.Cristina Amaro et al.Contact dermatitis, 67(3), 173-174 (2012-08-18) NTP technical report on the toxicology and carcinogenesis studies of 1,2-dibromo-2,4-dicyanobutane (CAS No. 35691-65-7) in F344/N rats and B6C3F1 mice (dermal studies). National Toxicology Program technical report series, (555)(555), 1-171 (2010-08-21) Temporal trends of preservative allergy in Denmark (1985-2008).Jacob P Thyssen et al.Contact dermatitis, 62(2), 102-108 (2010-02-09) Methyldibromoglutaronitrile allergy: relationship between patch test and repeated open application test thresholds.L A Fischer et al.The British journal of dermatology, 159(5), 1138-1143 (2008-09-18) Proliferative responses in the local lymph node assay associated with concomitant exposure to 1,4-phenylenediamine and methyldibromo glutaronitrile: evidence for synergy?Ian R Jowsey et al.Contact dermatitis, 59(2), 90-95 (2008-09-02) Patch testing in allergic contact dermatitis: is it useful to perform the cosmetic series in addition to the European standard series?S Ada et al.Journal of the European Academy of Dermatology and Venereology : JEADV, 24(10), 1192-1196 (2010-03-20) Simple and rapid analysis of methyldibromo glutaronitrile in cosmetic products by gas chromatography mass spectrometry.Manuela Pellegrini et al.Journal of pharmaceutical and biomedical analysis, 56(5), 1112-1116 (2011-08-30) Repeated open application tests with methyldibromoglutaronitrile in dermatitis patients with and without hypersensitivity to methyldibromoglutaronitrile.Marléne Isaksson et al.Dermatitis : contact, atopic, occupational, drug, 18(4), 203-207 (2007-11-21) Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals.B C Carlsen et al.The British journal of dermatology, 160(1), 103-106 (2008-11-19) Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention.Jeanne D Johansen et al.Contact dermatitis, 59(1), 48-51 (2008-06-10) Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008.Cecilia Svedman et al.Contact dermatitis, 67(5), 312-314 (2012-10-09) Decreasing trends in methyldibromo glutaronitrile contact allergy?following regulatory interventionJohansen DJ, et al. Contact Dermatitis, 59, 48-51 (2008) An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.Kazutoshi Saito et al.Toxicology in vitro : an international journal published in association with BIBRA, 40, 11-25 (2016-12-15) Methyldibromoglutaronitrile in rinse?off products causes allergic contact dermatitis: an experimental studyJensen.DC, et al. British Journal of Dermatology, 150, 90-95 (2004) Contact hypersensitivity to epoxy resin, methyldibromoglutaronitrile, tixocortol pivalate and budesonide in Hungary: a study in 1448 patients.G Pónyai et al.Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 146(1), 53-56 (2011-02-15) New aspects in allergic contact dermatitis.Charlotte Gotthard Mortz et al.Current opinion in allergy and clinical immunology, 8(5), 428-432 (2008-09-05) Methyldibromoglutaronitrile (Euxyl K 400): an important "new" allergen in cosmetics.A C De Groot et al.Journal of the American Academy of Dermatology, 35(5 Pt 1), 743-747 (1996-11-01) Ethosome formulation of contact allergens may enhance patch test reactions in patients.Jakob Torp Madsen et al.Contact dermatitis, 63(4), 209-214 (2010-08-25) Quantitative repeated open application testing with a rinse-off product in methyldibromo glutaronitrile-sensitive patients: results of the IVDK.Annice Heratizadeh et al.Contact dermatitis, 62(6), 330-337 (2010-06-19) A further characteristic of susceptibility to contact allergy: sensitization to a weak contact allergen is associated with polysensitization. Results of the IVDK.Axel Schnuch et al.Contact dermatitis, 56(6), 331-337 (2007-06-20) Patch testing with methyldibromoglutaronitrile in a localized population in the United States.Srimanasi Javvaji et al.Dermatitis : contact, atopic, occupational, drug, 21(6), 321-326 (2010-12-15) Prevalence of delayed-type and immediate-type hypersensitivity in healthcare workers with hand eczema.Kristina S Ibler et al.Contact dermatitis, 75(4), 223-229 (2016-06-30) A dynamic landscape of allergen associations in delayed-type cutaneous hypersensitivity.M D Lynch et al.The British journal of dermatology, 176(1), 184-196 (2016-06-11) Hand dermatitis: a focus on allergic contact dermatitis to biocides.Lisa E Maier et al.Dermatologic clinics, 27(3), 251-264 (2009-07-08) The dose-response relationship between the patch test and ROAT and the potential use for regulatory purposes.Louise Arup Fischer et al.Contact dermatitis, 61(4), 201-208 (2009-10-15) Allergy to methyldibromoglutaronitrile/phenoxyethanol (Euxyl k 400): regulatory issues, epidemiology, clinical characteristics, and management.Angela E Aakhus et al.Dermatitis : contact, atopic, occupational, drug, 22(3), 127-140 (2011-05-17) Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment.David A Basketter Cutaneous and ocular toxicology, 29(1), 4-9 (2009-11-04) Patch testing with methyldibromoglutaronitrileGeier J, et al. American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, 11, 207-212 (2000) Determination of methyldibromoglutaronitrile in cosmetic products by high-performance liquid chromatography with electrochemical detection: Method validationRastogi CS, et al. Journal of Chromatography A, 1031(1-2), 315-317 (2004) Can exposure limitations for well-known contact allergens be simplified? An analysis of dose-response patch test data.Louise Arup Fischer et al.Contact dermatitis, 64(6), 337-342 (2011-05-04) Hyphenation of ultra performance liquid chromatography (UPLC) with inductively coupled plasma mass spectrometry (ICP-MS) for fast analysis of bromine containing preservatives.Lars Bendahl et al.Journal of pharmaceutical and biomedical analysis, 40(3), 648-652 (2006-01-19) [Current contact allergens].J Geier et al.Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 62(10), 751-756 (2011-09-09)

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