Melting point	65 ºC**
Boiling point	259.7±9.0 ºC (760 Torr
Flash point	120.8±13.4 ºC, 计算值*
Density	1.114±0.06 g/cm3 (20 º
Refractive index	1.53 (589.3 nm 20 ºC)****

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study.Laura Obici et al.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 19 Suppl 1, 34-36 (2012-05-04) Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells.Eun Sang Lee et al.Biochemical and biophysical research communications, 450(2), 1005-1009 (2014-06-29) Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.Xinyu Qi et al.Nature medicine, 25(8), 1225-1233 (2019-07-25) Progressive stages of mitochondrial destruction caused by cell toxic bile salts.Sabine Schulz et al.Biochimica et biophysica acta, 1828(9), 2121-2133 (2013-05-21) FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis.Katrin Panzitt et al.Journal of hepatology, 72(6), 1122-1131 (2020-02-01) Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cellsBerger, E. and D. Haller Biochemical and Biophysical Research Communications, 409, 6-6 (2011) Endoplasmic reticulum stress regulates epithelial‑mesenchymal transition in human lens epithelial cells.Sheng Zhou et al.Molecular medicine reports, 21(1), 173-180 (2019-11-21) Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling.Hongtu Zheng et al.BioMed research international, 2020, 5958272-5958272 (2020-02-23) Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts.Akitoshi Nakashima et al.Scientific reports, 9(1), 11466-11466 (2019-08-09) Optimizing treatment of tauroursodeoxycholic acid to improve embryonic development after in vitro maturation of cumulus-free oocytes in mice.Masato Mochizuki et al.PloS one, 13(8), e0202962-e0202962 (2018-08-28) Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut.Susan A Joyce et al.Proceedings of the National Academy of Sciences of the United States of America, 111(20), 7421-7426 (2014-05-07) Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals.Zhejun Cai et al.Arteriosclerosis, thrombosis, and vascular biology, 33(10), 2345-2354 (2013-08-10) Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages.Junichi Ishiyama et al.Journal of lipid research, 52(2), 299-307 (2010-11-17) Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model.Runbin Sun et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 123, 109721-109721 (2019-12-23) Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity.Jianbo Fu et al.The Journal of toxicological sciences, 41(6), 745-756 (2016-11-18) Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells.Yanyang Chen et al.Oncology reports, 40(4), 2260-2268 (2018-08-15) Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver.Vanessa Dubois et al.Molecular systems biology, 16(5), e9156-e9156 (2020-05-15) TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice.Ana F Nunes et al.Molecular neurobiology, 45(3), 440-454 (2012-03-23) Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation.Marta B Fernandes et al.Frontiers in cell and developmental biology, 8, 335-335 (2020-06-26) Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats.S Kinbara et al.Scandinavian journal of gastroenterology, 32(9), 947-952 (1997-09-23) Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells.Meghan S Soustek et al.Cell death & disease, 9(6), 658-658 (2018-06-02) Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage.Naoko Takeda et al.The American journal of pathology, 183(3), 774-785 (2013-07-23) Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.Vasiliki Delitsikou et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2087-2104 (2020-01-08) Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet.Cho EJ, Yoon JH, Kwak MS, et al. Digestive Diseases and Sciences, 59(7), 1461-1474 (2014) Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death.Debby Laukens et al.Laboratory investigation; a journal of technical methods and pathology, 94(12), 1419-1430 (2014-10-14) Cell-autonomous cytotoxicity of type I interferon responseChrysovalantou Mihailidou et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(12), 5432-5439 (2017-08-20) High fat diet induces microbiota-dependent silencing of enteroendocrine cells.Lihua Ye et al.eLife, 8 (2019-12-04) Lysosomes and unfolded protein response, determinants of differential resistance of melanoma cells to vinca alkaloids.Laure-Anais Vincent et al.Fundamental & clinical pharmacology, 29(2), 164-177 (2015-01-21)

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