Boiling point	152 ºC (15 mmHg)
Density	2.524
Refractive index	1.7176

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S24/25

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.A M Filppula et al.Clinical pharmacology and therapeutics, 94(3), 383-393 (2013-05-10) Over-the-counter fish oil use in a county hospital: Medication use evaluation and efficacy analysis.Amulya Tatachar et al.Journal of clinical lipidology, 9(3), 326-333 (2015-06-16) Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.Manthena V S Varma et al.Pharmaceutical research, 29(10), 2860-2873 (2012-05-29) Formation kinetics of gemfibrozil chlorination reaction products: analysis and application.Wendy H Krkosek et al.Water environment research : a research publication of the Water Environment Federation, 86(7), 654-662 (2014-08-13) Gemfibrozil, a lipid-lowering drug, induces suppressor of cytokine signaling 3 in glial cells: implications for neurodegenerative disorders.Arunava Ghosh et al.The Journal of biological chemistry, 287(32), 27189-27203 (2012-06-12) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma.Poonam Sonawane et al.British journal of pharmacology, 171(23), 5330-5344 (2014-07-22) Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier.M Grabacka et al.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 66(2), 233-247 (2015-04-24) Pharmaceutically active compounds in sludge stabilization treatments: anaerobic and aerobic digestion, wastewater stabilization ponds and composting.Julia Martín et al.The Science of the total environment, 503-504, 97-104 (2014-06-10) Removal of trace organic chemical contaminants by a membrane bioreactor.T Trinh et al.Water science and technology : a journal of the International Association on Water Pollution Research, 66(9), 1856-1863 (2012-08-29) Effects of gemfibrozil and other fibric acid derivatives on blood lipids and lipoproteins.P Zimetbaum et al.Journal of clinical pharmacology, 31(1), 25-37 (1991-01-01) Gemfibrozil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia.P A Todd et al.Drugs, 36(3), 314-339 (1988-09-01) Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β.Malabendu Jana et al.Neurochemical research, 37(8), 1718-1729 (2012-04-25) Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism.R Preston Mason et al.Biochimica et biophysica acta, 1848(2), 502-509 (2014-12-03) Gemfibrozil. IARC monographs on the evaluation of carcinogenic risks to humans, 66, 427-444 (1996-01-01) A neutral risk on the development of new-onset diabetes mellitus (NODM) in Taiwanese patients with dyslipidaemia treated with fibrates.Chien-Ying Lee et al.TheScientificWorldJournal, 2012, 392734-392734 (2012-08-25) Solubilizing properties of new surface-active agents, products of selective oxyethylation of cholic acid. Part I.Marian Mikołaj Zgoda et al.Polimery w medycynie, 37(4), 21-38 (2008-06-25) Bio-generation of stable isotope-labeled internal standards for absolute and relative quantitation of phase II drug metabolites in plasma samples using LC-MS/MS.Pei Li et al.Analytical and bioanalytical chemistry, 407(14), 4053-4063 (2015-03-26) [Gemfibrozil in the differential therapy of disorders of fat metabolism].F Ebner Fortschritte der Medizin, 110(28), 523-526 (1992-10-10) [Evaluation of the therapeutic efficacy of pravastatin in monothereapy and in association with gemfibrozil in hypercholesterolemia associated with moderate hyperglyceridemia].C Napoli et al.Cardiologia (Rome, Italy), 37(11), 761-768 (1992-11-01) Gemfibrozil, stretching arms beyond lipid lowering.Avik Roy et al.Immunopharmacology and immunotoxicology, 31(3), 339-351 (2009-08-22) Analytical and biological characterization of halogenated gemfibrozil produced through chlorination of wastewater.Daryl N Bulloch et al.Environmental science & technology, 46(10), 5583-5589 (2012-04-13) Gemfibrozil prevents major coronary events by increasing HDL-cholesterol and more.S A Doggrell Expert opinion on pharmacotherapy, 2(7), 1187-1189 (2001-10-05) Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β.Malabendu Jana et al.The Journal of biological chemistry, 287(41), 34134-34148 (2012-08-11) Persistent use of against-label statin-fibrate combinations from 2003-2009 despite United States Food and Drug Administration dose restrictions.Julie C Alford et al.Pharmacotherapy, 32(7), 623-630 (2012-05-10) Interaction between gemfibrozil and warfarin: case report and review of the literature.Dave L Dixon et al.Pharmacotherapy, 29(6), 744-748 (2009-05-30) Gemfibrozil-induced myopathy.G J Magarian et al.Archives of internal medicine, 151(9), 1873-1874 (1991-09-01) Sorption and degradation of pharmaceuticals and personal care products (PPCPs) in soils.Yong Yu et al.Environmental science and pollution research international, 20(6), 4261-4267 (2013-01-08) Gemfibrozil pretreatment affecting antioxidant defense system and inflammatory, but not Nrf-2 signaling pathways resulted in female neuroprotection and male neurotoxicity in the rat models of global cerebral ischemia-reperfusion.Fatemeh Mohagheghi et al.Neurotoxicity research, 23(3), 225-237 (2012-07-10) Severe rhabdomyolysis associated with the cerivastin-gemfibrozil combination therapy: report of a case.T K Lau et al.Texas Heart Institute journal, 28(2), 142-145 (2001-07-17) Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.David E Moody et al.Journal of analytical toxicology, 39(5), 374-386 (2015-04-15) HDL cholesterol--how do I raise my patients good cholesterol?Quratulain Shaikh et al.JPMA. The Journal of the Pakistan Medical Association, 62(6), 623-624 (2012-07-05) Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil.Ana Maria Sierra Villar et al.International journal of pharmaceutics, 431(1-2), 161-175 (2012-04-14) CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects.Andreas Holstein et al.Expert opinion on drug metabolism & toxicology, 8(12), 1549-1563 (2012-11-17) The role of microbial adaptation and biodegradable dissolved organic carbon on the attenuation of trace organic chemicals during groundwater recharge.Christiane Hoppe-Jones et al.The Science of the total environment, 437, 137-144 (2012-09-04) [Rhabdomyolysis and anuric kidney failure induced by the treatment with a gemfibrozil-cerivastatin combination].A E Sirvent et al.Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 21(5), 497-500 (2002-01-25) Identification of environmental chemicals that induce yolk malabsorption in zebrafish using automated image segmentation.Sharanya Maanasi Kalasekar et al.Reproductive toxicology (Elmsford, N.Y.), 55, 20-29 (2014-12-03) Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry.Fangfang Chen et al.Journal of chromatography. A, 1383, 104-111 (2015-02-03) Effect of transpiration on plant accumulation and translocation of PPCP/EDCs.Laurel K Dodgen et al.Environmental pollution (Barking, Essex : 1987), 198, 144-153 (2015-01-17) Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy.Arunava Ghosh et al.The Journal of biological chemistry, 287(46), 38922-38935 (2012-09-20) Comparative effectiveness of fish oil versus fenofibrate, gemfibrozil, and atorvastatin on lowering triglyceride levels among HIV-infected patients in routine clinical care.Monica A Muñoz et al.Journal of acquired immune deficiency syndromes (1999), 64(3), 254-260 (2013-07-31) Peroxisome proliferator-activated receptor ɑ (PPARɑ)-cytochrome P450 epoxygenases-soluble epoxide hydrolase axis in ER + PR + HER2- breast cancer.Zdenek Tauber et al.Medical molecular morphology, 53(3), 141-148 (2019-12-12) Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure.Jason P Cooper et al.British journal of pharmacology, 163(6), 1263-1275 (2011-03-12) [Gemfibrozil: new aspects in clinical use].N Tada Nihon rinsho. Japanese journal of clinical medicine, 59 Suppl 3, 625-630 (2001-05-12) Impact of the CYP2C8 *3 polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone.Christina L Aquilante et al.British journal of clinical pharmacology, 75(1), 217-226 (2012-05-26) Severe rhabdomyolysis and cerivastatin-gemfibrozil combination therapy.Bernardino Roca et al.The Annals of pharmacotherapy, 36(4), 730-731 (2002-04-09) Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine.Scott A Hoose et al.PloS one, 7(5), e36503-e36503 (2012-05-09) Effect of gemfibrozil on the metabolism of brivaracetam in vitro and in human subjects.J-M Nicolas et al.Drug metabolism and disposition: the biological fate of chemicals, 40(8), 1466-1472 (2012-04-28) Risk of hospitalized rhabdomyolysis associated with lipid-lowering drugs in a real-world clinical setting.Mark J Cziraky et al.Journal of clinical lipidology, 7(2), 102-108 (2013-02-19) Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation.Chin Fung Kelvin Kan et al.Journal of lipid research, 55(8), 1657-1667 (2014-06-01) Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins.Pradeep Sharma et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(1), 244-255 (2012-04-28) Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan.Gordon C C Yang et al.Journal of hazardous materials, 277, 53-61 (2014-04-08) A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.Faraz Kazmi et al.Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18) [Severe rhabdomyolysis associated with cerivastatin and gemfibrozil].J J de Arriba Méndez et al.Medicina clinica, 117(7), 278-279 (2001-09-20) The significant inhibition on CYP3A caused by radix Aconiti single herb is not observed in the Wutou decoction: The necessity of combination therapy of radix Aconiti.Jinjun Wu et al.Journal of ethnopharmacology, 170, 251-254 (2015-05-24) An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver.Yusuke Ito et al.Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2109-2116 (2014-09-14) Screening, monitoring, and treatment of stage 1 to 3 chronic kidney disease: A clinical practice guideline from the American College of Physicians.Amir Qaseem et al.Annals of internal medicine, 159(12), 835-847 (2013-10-23) Stimulating effect of normal-dosing of fibrates on cell proliferation: word of warning.Katerina Cizkova et al.Lipids in health and disease, 15(1), 164-164 (2016-09-24) Effects of chronic, parental pharmaceutical exposure on zebrafish (Danio rerio) offspring.Michal Galus et al.Aquatic toxicology (Amsterdam, Netherlands), 151, 124-134 (2014-02-15) Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.Manthena V S Varma et al.Pharmaceutical research, 30(4), 1188-1199 (2013-01-12) Challenges in the pharmacologic management of obesity and secondary dyslipidemia in children and adolescents.Mary Jayne Kennedy et al.Paediatric drugs, 15(5), 335-342 (2013-05-17) Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes: studies with human THP-1 monocytes and J774 murine macrophages.Frédéric Peyrusson et al.Antimicrobial agents and chemotherapy, 59(9), 5747-5760 (2015-07-15) CCR5 controls immune and metabolic functions during Toxoplasma gondii infection.Giuliano Bonfá et al.PloS one, 9(8), e104736-e104736 (2014-08-15) Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense.Grant T Corbett et al.Journal of immunology (Baltimore, Md. : 1950), 189(2), 1002-1013 (2012-06-19) Gemfibrozil. A reappraisal of its pharmacological properties and place in the management of dyslipidaemia.C M Spencer et al.Drugs, 51(6), 982-1018 (1996-06-01) Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions.Anna Vildhede et al.Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1210-1218 (2014-05-07) Effects of gemfibrozil on lipid metabolism, steroidogenesis, and reproduction in the fathead minnow (Pimephales promelas).Sarah Y Skolness et al.Environmental toxicology and chemistry, 31(11), 2615-2624 (2012-08-23) Management of hyperlipidemia among patients with rheumatoid arthritis in the primary care setting.Kashif Jafri et al.BMC musculoskeletal disorders, 16, 237-237 (2015-09-05) Summaries for patients. Screening, monitoring, and treatment of early stage chronic kidney disease: recommendations from the American College of Physicians. Annals of internal medicine, 159(12), I-28 (2013-10-23) Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.Thomas H Miller et al.The Science of the total environment, 511, 153-160 (2014-12-30) Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.Toshiyuki Kudo et al.Drug metabolism and disposition: the biological fate of chemicals, 41(2), 362-371 (2012-11-10) Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action.Gianluca Miglio et al.British journal of pharmacology, 167(3), 641-653 (2012-05-19) Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes.Norimasa Jinno et al.Xenobiotica; the fate of foreign compounds in biological systems, 44(8), 677-686 (2014-03-01) Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore's marine environment: influence of hydrodynamics and physical-chemical properties.Stéphane Bayen et al.Environmental pollution (Barking, Essex : 1987), 182, 1-8 (2013-07-31) Ionization suppression effects with condensed phase membrane introduction mass spectrometry: methods to increase the linear dynamic range and sensitivity.Kyle D Duncan et al.Journal of mass spectrometry : JMS, 50(3), 437-443 (2015-03-25) Validated spectrofluorometric method for determination of gemfibrozil in self nanoemulsifying drug delivery systems (SNEDDS).Ana M Sierra Villar et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 113, 22-27 (2013-05-28) Ultra-high-performance liquid chromatography-Time-of-flight high resolution mass spectrometry to quantify acidic drugs in wastewater.Mercedes Becerra-Herrera et al.Journal of chromatography. A, 1423, 96-103 (2015-11-13)

Remarks