Melting point	62-65 ºC
Water Solubility	Insoluble

Symbol(GHS)	Xn
Hazard Codes	R20/21/22;R36/37/38
SDS/MSDS	S26;S36/37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Menière-like syndrome in Camurati-Engelmann disease.Lea Pollak The Israel Medical Association journal : IMAJ, 15(7), 390-391 (2013-08-16) Meniere's disease: an evidence based approach to assessment and management.I Syed et al.International journal of clinical practice, 66(2), 166-170 (2012-01-20) Benign paroxysmal positional vertigo (BPPV): influence of pharmacotherapy and rehabilitation therapy on patients' recovery rate and life quality.Sinisa Maslovara et al.NeuroRehabilitation, 31(4), 435-441 (2012-12-13) Involvement of histamine receptors in SAPK/JNK phosphorylation.Radhika D Dandekar et al.International immunopharmacology, 13(2), 190-196 (2012-04-11) [Prospects for the use of histaminergic preparations for the purpose of noise otoprotection].E I Matsnev et al.Vestnik otorinolaringologii, (3)(3), 59-64 (2011-07-02) Topical application of betahistine improves eustachian tube function in an animal model.Burkhard Franz et al.Acta oto-laryngologica, 131(11), 1155-1159 (2011-09-13) Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model.Chao Deng et al.Journal of psychopharmacology (Oxford, England), 26(9), 1271-1279 (2012-06-15) Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.Shigeru Hishinuma et al.Biochemical pharmacology, 91(2), 231-241 (2014-07-30) [Treatment of vestibular vertigo and Ménière syndrome in outpatient clinics].E V Kostenko et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(12), 36-40 (2013-02-08) The effects of betahistine in addition to epley maneuver in posterior canal benign paroxysmal positional vertigo.Enis Alpin Guneri et al.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 146(1), 104-108 (2011-08-20) Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo.Fritz Ihler et al.PloS one, 7(6), e39086-e39086 (2012-06-30) [Betahistine in the treatment of vestibular and coordination disturbances in multiple sclerosis].N F Popova et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 111(2 Pt 2), 77-81 (2011-09-16) Betahistine in the treatment of tinnitus in patients with vestibular disorders.Maurício Malavasi Ganança et al.Brazilian journal of otorhinolaryngology, 77(4), 499-503 (2011-08-24) High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series.Franziska Lezius et al.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 268(8), 1237-1240 (2011-06-01) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.G Desmadryl et al.British journal of pharmacology, 167(4), 905-916 (2012-05-26) Duplicate internal auditory canals with facial and vestibulocochlear nerve dysfunction.T Y Kew et al.The Journal of laryngology and otology, 126(1), 66-71 (2011-08-27) Betahistine or Cinnarizine for treatment of Meniere's disease.Jasminka Djelilovic-Vranic et al.Medical archives (Sarajevo, Bosnia and Herzegovina), 66(6), 396-398 (2013-02-16) [Vertigo: patient management tactics].I S Vasyl'chuk et al.Likars'ka sprava, (7)(7), 84-87 (2013-01-29) Transdermal delivery of betahistine hydrochloride using microemulsions: physical characterization, biophysical assessment, confocal imaging and permeation studies.Rania M Hathout et al.Colloids and surfaces. B, Biointerfaces, 110, 254-260 (2013-06-05) Effect of transtympanic low-pressure therapy in patients with unilateral Menière's disease unresponsive to betahistine: a randomised, placebo-controlled, double-blinded, clinical trial.R Gürkov et al.The Journal of laryngology and otology, 126(4), 356-362 (2012-03-01) [Clinical effectiveness and safety of sanchi tong shu capsule in the treatment of aural vertigo: a multi-center randomized controlled clinical trial].Juan Meng et al.Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 26(7), 295-299 (2012-06-29) Bayesian model selection techniques as decision support for shaping a statistical analysis plan of a clinical trial: an example from a vertigo phase III study with longitudinal count data as primary endpoint.Christine Adrion et al.BMC medical research methodology, 12, 137-137 (2012-09-12) [Efficacy of vestibo in the treatment of vertebrobasilar insufficiency].E I Chukanova et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(4), 53-56 (2012-07-20) Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study.Arne-Wulf Scholtz et al.Clinical drug investigation, 32(6), 387-399 (2012-04-18) Histamine and antipsychotic drug-induced weight gain.Gavin P Reynolds Journal of psychopharmacology (Oxford, England), 26(12), 1608-1609 (2012-11-30) Development of novel sustained release matrix pellets of betahistine dihydrochloride: effect of lipophilic surfactants and co-surfactants.Rehab Nabil Shamma et al.Pharmaceutical development and technology, 17(5), 583-593 (2011-07-21) Reducing antipsychotic-induced weight gain in schizophrenia: a double-blind placebo-controlled study of reboxetine-betahistine combination.Michael Poyurovsky et al.Psychopharmacology, 226(3), 615-622 (2012-12-15)

Remarks