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3,5-Dinitroaniline | CAS:618-87-1
3,5-Dinitroaniline
  • Name:3,5-Dinitroaniline
  • CAS:618-87-1
  • Synonyms:
  • Molecular Formula:C6H5N3O4
  • Molecular Weight:183.12
  • EINESC:210-567-8

Description

Properties

Melting point 160-162 ºC

Safety

Symbol(GHS) T
Hazard Codes R23/24/25;R33
SDS/MSDS S28;S37;S45

SDS

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Peer-Reviewed Papers
Preparation and characterization of polylactic-co-glycolic acid/insulin nanoparticles encapsulated in methacrylate coated gelatin with sustained release for specific medical applications.Elham Akhavan Farid et al.Journal of biomaterials science. Polymer edition, 31(7), 910-937 (2020-02-06) Lactoferrin bioconjugated solid lipid nanoparticles: a new drug delivery system for potential brain targeting.Indu Singh et al.Journal of drug targeting, 24(3), 212-223 (2015-07-30) A novel approach for dry powder coating of pellets with Ethylcellulose. Part I: Evaluation of film formulation and process set up.Beatrice Albertini et al.International journal of pharmaceutics, 516(1-2), 380-391 (2016-11-30) Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers.Wenxi Wang et al.AAPS PharmSciTech, 18(2), 509-516 (2016-04-28) Advances in ophthalmic preparation: the role of drug nanocrystals and lipid-based nanosystems.Maria Christina Camasmie Peters et al.Journal of drug targeting, 28(3), 259-270 (2019-09-07) Actively-targeted LTVSPWY peptide-modified magnetic nanoparticles for tumor imaging.Li-Yong Jie et al.International journal of nanomedicine, 7, 3981-3989 (2012-08-07) Development and evaluation of topical formulations for a novel skin whitening agent (AP736) using Hansen solubility parameters and PEG-PCL polymers.Hong-Ju Shin et al.International journal of pharmaceutics, 552(1-2), 251-257 (2018-10-01) Fabrication of extended-dissolution divalproex tablets: a green solvent-free granulation technique.Amr Khaled et al.Drug development and industrial pharmacy, 46(6), 975-987 (2020-05-05) Development of a protective dermal drug delivery system for therapeutic DNAzymes.Kay Marquardt et al.International journal of pharmaceutics, 479(1), 150-158 (2014-12-30) Localized rosuvastatin via implantable bioerodible sponge and its potential role in augmenting bone healing and regeneration.Howida Kamal Ibrahim et al.Drug delivery, 23(9), 3181-3192 (2016-03-05) Rifampicin Lipid-Polymer hybrid nanoparticles (LIPOMER) for enhanced Peyer's patch uptake.Sagar S Bachhav et al.International journal of pharmaceutics, 532(1), 612-622 (2017-09-25) Folate receptor-targeted hybrid lipid-core nanocapsules for sequential delivery of doxorubicin and tanespimycin.Biki Gupta et al.Colloids and surfaces. B, Biointerfaces, 155, 83-92 (2017-04-15) Solid lipid nanoparticles of guggul lipid as drug carrier for transdermal drug delivery.Praveen Kumar Gaur et al.BioMed research international, 2013, 750690-750690 (2013-09-24) Ciprofloxacin hydrochloride-loaded glyceryl monostearate nanoparticle: factorial design of Lutrol F68 and Phospholipon 90G.Malay Shah et al.Journal of microencapsulation, 29(4), 331-343 (2012-01-19) Development and Efficacy Assessment of an Enteric Coated Porous Tablet Loaded With F4 Fimbriae for Oral Vaccination of Piglets against F4+ Escherichia coli Infections.Atul Srivastava et al.Current drug delivery, 13(1), 121-130 (2015-07-28) Transport mechanism of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan decorated coumarin-6 loaded nanostructured lipid carriers across the rabbit ocular.Jinyu Li et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 120, 89-97 (2017-09-05) Formulation development and in vitro evaluation of gastroretentive hollow microspheres of famotidine.Mayur A Chordiya et al.International journal of pharmaceutical investigation, 1(2), 105-111 (2011-04-01) A comparative study of the rheological and sensory properties of a petroleum-free and a petroleum-based cosmetic cream.Fan C Wang et al.Journal of cosmetic science, 68(2), 159-172 (2018-04-06) Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema.Shanshan Gao et al.International journal of nanomedicine, 14, 6135-6150 (2019-08-27) Impact of potatoes deep-frying on common monounsaturated-rich vegetable oils: a comparative study.Carla S P Santos et al.Journal of food science and technology, 56(1), 290-301 (2019-02-08) Ellagic Acid Containing Nanostructured Lipid Carriers for Topical Application: A Preliminary Study.Supandeep Singh Hallan et al.Molecules (Basel, Switzerland), 25(6) (2020-03-27) Development of sustained-release microparticles containing tamsulosin HCl for orally disintegrating tablet using melt-adsorption method.Cheol-Hee Cho et al.Drug delivery and translational research, 8(3), 552-564 (2018-01-24) Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design.Jifu Hao et al.International journal of nanomedicine, 6, 683-692 (2011-05-11) Asymmetric lipid-polymer particles (LIPOMER) by modified nanoprecipitation: role of non-solvent composition.Anil B Jindal et al.International journal of pharmaceutics, 489(1-2), 246-251 (2015-05-03) Topical phenytoin nanostructured lipid carriers: design and development.Amira Motawea et al.Drug development and industrial pharmacy, 44(1), 144-157 (2017-09-29) Development and Evaluation of Lipid Nanoparticles for Drug Delivery: Study of Toxicity In, Vitro and In Vivo.Evelyn Winter et al.Journal of nanoscience and nanotechnology, 16(2), 1321-1330 (2016-07-20) Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies.Dnyandev G Gadhave et al.Drug development and industrial pharmacy, 45(5), 839-851 (2019-02-01) Quality by Design (QbD)-enabled development of aceclofenac loaded-nano structured lipid carriers (NLCs): An improved dermatokinetic profile for inflammatory disorder(s).Neeraj K Garg et al.International journal of pharmaceutics, 517(1-2), 413-431 (2016-12-14) Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations.Lin Wang et al.AIDS research and therapy, 8, 12-12 (2011-03-10) In vivo evaluation of porous silicon and porous silicon solid lipid nanocomposites for passive targeting and imaging.Annukka M Kallinen et al.Molecular pharmaceutics, 11(8), 2876-2886 (2014-07-01) Tacrolimus-loaded nanostructured lipid carriers for oral delivery - Optimization of production and characterization.Saba Khan et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 108, 277-288 (2016-07-28) An emerging technology in lipid research for targeting hydrophilic drugs to the skin in the treatment of hyperpigmentation disorders: kojic acid-solid lipid nanoparticles.Khadijeh Khezri et al.Artificial cells, nanomedicine, and biotechnology, 48(1), 841-853 (2020-05-28) Novel biosurfactant and lipid core-shell type nanocapsular sustained release system for intravenous application of methotrexate.Sameer S Katiyar et al.International journal of pharmaceutics, 557, 86-96 (2018-12-26) A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: Preparation, characterization and in vivo evaluation.Nancy Abdel Hamid Abou Youssef et al.International journal of pharmaceutics, 548(1), 609-624 (2018-07-24) Halloysite Tubes as Nanocontainers for Herbicide and Its Controlled Release in Biodegradable Poly(vinyl alcohol)/Starch Film.Bangchao Zhong et al.Journal of agricultural and food chemistry, 65(48), 10445-10451 (2017-11-14) Redox-responsive and pH-sensitive nanoparticles enhanced stability and anticancer ability of erlotinib to treat lung cancer in vivo.Sheng Tan et al.Drug design, development and therapy, 11, 3519-3529 (2017-12-22) Formulation of piperine solid lipid nanoparticles (SLN) for treatment of rheumatoid arthritis.Mangesh R Bhalekar et al.Drug development and industrial pharmacy, 43(6), 1003-1010 (2017-02-07) Preparation and Characterization of Nanostructured Lipid Carriers for Improved Topical Drug Delivery: Evaluation in Cutaneous Leishmaniasis and Vaginal Candidiasis Animal Models.Amina Riaz et al.AAPS PharmSciTech, 21(5), 185-185 (2020-07-08) Optimisation of chloroquine phosphate loaded nanostructured lipid carriers using Box-Behnken design and its antimalarial efficacy.Uday Krishna Baruah et al.Journal of drug targeting, 26(7), 576-591 (2017-10-24) Pseudoceramide-containing physiological lipid mixture reduces adverse effects of topical steroids.Hyun Jung Kim et al.Allergy, asthma & immunology research, 3(2), 96-102 (2011-04-05) Cytotoxic effects of gemcitabine-loaded solid lipid nanoparticles in pancreatic cancer cells.Kevin O Affram et al.Journal of drug delivery science and technology, 55 (2020-01-07) Skin surface lipid composition in women: increased 2,3-oxidosqualene correlates with older age.Aline Rigal et al.European journal of dermatology : EJD (2020-04-14) Rivastigmine-loaded in situ gelling nanostructured lipid carriers for nose to brain delivery.Preeti R Wavikar et al.Journal of liposome research, 25(2), 141-149 (2014-09-10) Cascaded Aptamers-Governed Multistage Drug-Delivery System Based on Biodegradable Envelope-Type Nanovehicle for Targeted Therapy of HER2-Overexpressing Breast Cancer.Tingxizi Liang et al.ACS applied materials & interfaces, 10(40), 34050-34059 (2018-09-13) Development and evaluation of an omeprazole-based delayed-release liquid oral dosage form.Federica Ronchi et al.International journal of pharmaceutics, 567, 118416-118416 (2019-06-09) Preventive effects of multi-lamellar emulsion on low potency topical steroid induced local adverse effect.Geun Dong Sul et al.Annals of dermatology, 25(1), 5-11 (2013-03-08) An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect.Mohamed Hamdi et al.PloS one, 15(1), e0227231-e0227231 (2020-01-11) Long-term anesthetic analgesic effects: Comparison of tetracaine loaded polymeric nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers in vitro and in vivo.Xiaoli Liu et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 117, 109057-109057 (2019-06-17) Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy.Amrita Kadari et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 132, 168-179 (2018-09-24) Evaluation of solubility and dissolution of lamotrigine using lipid based microparticulate carriers: An in-vitro analysis.Nayyer Islam et al.Pakistan journal of pharmaceutical sciences, 33(1(Supplementary)), 299-306 (2020-03-04) Development of podophyllotoxin‑loaded nanostructured lipid carriers for the treatment of condyloma acuminatum.Yan Gao et al.Molecular medicine reports, 17(5), 6506-6514 (2018-03-08) Lipid and TPGS based novel core-shell type nanocapsular sustained release system of methotrexate for intravenous application.Sameer S Katiyar et al.Colloids and surfaces. B, Biointerfaces, 174, 501-510 (2018-11-30) Use of thermal and non thermal techniques for assessing compatibility between mirtazapine and solid lipids.Randeep Kaur et al.Journal of pharmaceutical and biomedical analysis, 161, 144-158 (2018-08-28) Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System.Maria Chountoulesi et al.Brain sciences, 10(6) (2020-06-06) LC-APCI-MS/MS Quantification and Topical Bioavailability of Chloroacetamide in Rats.Tae Hwan Kim et al.Journal of chromatographic science, 53(7), 1100-1106 (2014-12-20) Formulation and in vitro evaluation of rifampicin loaded porous microspheres.Satish Balakrishna Bhise et al.Scientia pharmaceutica, 78(2), 291-302 (2010-12-24) Surface modified kokum butter lipid nanoparticles for the brain targeted delivery of nevirapine.Sunita Lahkar et al.Journal of microencapsulation, 35(7-8), 680-694 (2019-02-01) Improved pharmacokinetics and antihyperlipidemic efficacy of rosuvastatin-loaded nanostructured lipid carriers.Md Rizwanullah et al.Journal of drug targeting, 25(1), 58-74 (2016-05-18) Film-forming formulations containing porous silica for the sustained delivery of actives to the skin.Rouven Heck et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 108, 1-8 (2016-08-25) In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes.Friederike Folttmann et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 931-938 (2014-12-03) Detecting active ingredients of insect repellents and sunscreens topically in skin by Raman spectroscopy.Michele Marin da Costa et al.Journal of biomedical optics, 23(10), 1-11 (2018-10-24) Development of Bioactive PEGylated Nanostructured Platforms for Sequential Delivery of Doxorubicin and Imatinib to Overcome Drug Resistance in Metastatic Tumors.Biki Gupta et al.ACS applied materials & interfaces, 9(11), 9280-9290 (2017-02-28) Lipid and TPGS based novel core-shell type nanocapsular sustained release system of methotrexate for intravenous application.Sameer S Katiyar et al.Colloids and surfaces. B, Biointerfaces, 174, 501-510 (2018-11-30) Targeted paclitaxel delivery to tumors using cleavable PEG-conjugated solid lipid nanoparticles.Jie Zheng et al.Pharmaceutical research, 31(8), 2220-2233 (2014-03-07) Film-forming formulations containing porous silica for the sustained delivery of actives to the skin.Rouven Heck et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 108, 1-8 (2016-08-25) Improved pharmacokinetics and antihyperlipidemic efficacy of rosuvastatin-loaded nanostructured lipid carriers.Md Rizwanullah et al.Journal of drug targeting, 25(1), 58-74 (2016-05-18) Formulation and In-vitro Evaluation of Tretinoin Microemulsion as a Potential Carrier for Dermal Drug Delivery.Seyed Alireza Mortazavi et al.Iranian journal of pharmaceutical research : IJPR, 12(4), 599-609 (2014-02-14) Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine.Yuan Hong et al.Drug design, development and therapy, 14, 2263-2274 (2020-07-02) Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers.I Nešić et al.International journal of cosmetic science, 41(3), 300-310 (2019-05-06) Inhibitory activity of monoacylglycerols on biofilm formation in Aeromonas hydrophila, Streptococcus mutans, Xanthomonas oryzae, and Yersinia enterocolitica.Youngseok Ham et al.SpringerPlus, 5(1), 1526-1526 (2016-09-22) In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes.Friederike Folttmann et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 931-938 (2014-12-03) Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System.Maria Chountoulesi et al.Brain sciences, 10(6) (2020-06-06) Fabrication of solid lipid nanoparticles of lurasidone HCl for oral delivery: optimization, in vitro characterization, cell line studies and in vivo efficacy in schizophrenia.Mitali H Patel et al.Drug development and industrial pharmacy, 45(8), 1242-1257 (2019-03-19) Structural and mechanical properties of organogels: Role of oil and gelator molecular structure.Miguel A Cerqueira et al.Food research international (Ottawa, Ont.), 96, 161-170 (2017-05-22) Use of thermal and non thermal techniques for assessing compatibility between mirtazapine and solid lipids.Randeep Kaur et al.Journal of pharmaceutical and biomedical analysis, 161, 144-158 (2018-08-28) LC-APCI-MS/MS Quantification and Topical Bioavailability of Chloroacetamide in Rats.Tae Hwan Kim et al.Journal of chromatographic science, 53(7), 1100-1106 (2014-12-20) Formulation and in vitro evaluation of rifampicin loaded porous microspheres.Satish Balakrishna Bhise et al.Scientia pharmaceutica, 78(2), 291-302 (2010-12-24) Effect of lipid and cellulose based matrix former on the release of highly soluble drug from extruded/spheronized, sintered and compacted pellets.Madiha Maboos et al.Lipids in health and disease, 17(1), 136-136 (2018-06-11) In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations.Lucia Montenegro et al.Pharmaceutics, 10(1) (2018-03-03) Small peptide-modified nanostructured lipid carriers distribution and targeting to EGFR-overexpressing tumor in vivo.Cuiyan Han et al.Artificial cells, nanomedicine, and biotechnology, 42(3), 161-166 (2013-06-05) Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.Vincent O Oninla et al.Journal of lipid research, 55(12), 2606-2619 (2014-10-24) Surface modified kokum butter lipid nanoparticles for the brain targeted delivery of nevirapine.Sunita Lahkar et al.Journal of microencapsulation, 35(7-8), 680-694 (2019-02-01) Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Carlo Spirli et al.Hepatology (Baltimore, Md.), 62(6), 1828-1839 (2015-08-28) Fabrication and Evaluation of Curcumin-loaded Nanoparticles Based on Solid Lipid as a New Type of Colloidal Drug Delivery System.J Chen et al.Indian journal of pharmaceutical sciences, 75(2), 178-184 (2013-09-11) The encapsulation effect of UV molecular absorbers into biocompatible lipid nanoparticles.Ioana Lacatusu et al.Nanoscale research letters, 6(1), 73-73 (2011-06-30) OPTICORE™, an innovative and accurate colonic targeting technology.Felipe Varum et al.International journal of pharmaceutics, 583, 119372-119372 (2020-04-29) Accelerate development of topical cream drug product using a common platform base formulation.Dimple Modi et al.Pharmaceutical development and technology, 25(6), 767-778 (2020-03-17) Combination lung cancer chemotherapy: Design of a pH-sensitive transferrin-PEG-Hz-lipid conjugate for the co-delivery of docetaxel and baicalin.Shuang Li et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 95, 548-555 (2017-09-05) Assessment of viscoelasticity and hydration effect of herbal moisturizers using bioengineering techniques.Shweta Kapoor et al.Pharmacognosy magazine, 6(24), 298-304 (2010-12-02) Spray congealed solid lipid microparticles as a sustained release delivery system for Gonadorelin [6-D-Phe]: Production, optimization and in vitro release behavior.Kerstin Traub-Hoffmann et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 154, 18-32 (2020-07-01) Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line.Himanshu Bhatt et al.Current drug delivery, 15(9), 1271-1283 (2018-05-08) Local anesthetic lidocaine delivery system: chitosan and hyaluronic acid-modified layer-by-layer lipid nanoparticles.Laizhu Zhang et al.Drug delivery, 23(9), 3529-3537 (2016-06-25) Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting.Rajan Swami et al.International journal of pharmaceutics, 486(1-2), 287-296 (2015-04-04) In vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration.Min Fang et al.International journal of nanomedicine, 7, 5395-5404 (2012-10-24) Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH.Supandeep Singh Hallan et al.Artificial cells, nanomedicine, and biotechnology, 45(8), 1631-1639 (2017-01-11) OPTICORE™, an innovative and accurate colonic targeting technology.Felipe Varum et al.International journal of pharmaceutics, 583, 119372-119372 (2020-04-29) Fabrication and Evaluation of Curcumin-loaded Nanoparticles Based on Solid Lipid as a New Type of Colloidal Drug Delivery System.J Chen et al.Indian journal of pharmaceutical sciences, 75(2), 178-184 (2013-09-11) Properties of lotus seed starch-glycerin monostearin complexes formed by high pressure homogenization.Bingyan Chen et al.Food chemistry, 226, 119-127 (2017-03-04) Pressurized liquid extraction-gas chromatography-mass spectrometry for confirming the photo-induced generation of dioxin-like derivatives and other cosmetic preservative photoproducts on artificial skin.Gerardo Alvarez-Rivera et al.Journal of chromatography. A, 1440, 37-44 (2016-03-08) Dual alginate-lipid nanocarriers as oral delivery systems for amphotericin B.Juliana Perdiz Senna et al.Colloids and surfaces. 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Extract by Nanostructured Lipid Carriers.Wantida Chaiyana et al.Pharmaceutics, 12(4) (2020-04-03) The influence of surface charge and photo-reactivity on skin-permeation enhancer property of nano-TiO₂ in ex vivo pig skin model under indoor light.Elena Peira et al.International journal of pharmaceutics, 467(1-2), 90-99 (2014-04-03) Dynamic-mechanical thermoanalysis test as a high-performance alternative for accelerated freeze-thaw stability testing: a case study of O/W emulsions.Nebojsa D Cekic et al.Drug development and industrial pharmacy, 46(3), 505-520 (2020-02-15) Beta-carotene-Encapsulated Solid Lipid Nanoparticles (BC-SLNs) as Promising Vehicle for Cancer: an Investigative Assessment.Ashay Jain et al.AAPS PharmSciTech, 20(3), 100-100 (2019-02-06) Beeswax-Modified Textiles: Method of Preparation and Assessment of Antimicrobial Properties.Justyna Szulc et al.Polymers, 12(2) (2020-02-09) Atorvastatin Solid Lipid Nanoparticles as a Promising Approach for Dermal Delivery and an Anti-inflammatory Agent.Seyed Sadegh Shahraeini et al.AAPS PharmSciTech, 21(7), 263-263 (2020-09-27) An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs.Shuo Wang et al.Nanoscale research letters, 7(1), 219-219 (2012-04-17) An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells.A Tito et al.International journal of cosmetic science, 37(6), 588-594 (2015-05-06) Improving Efficacy, Oral Bioavailability, and Delivery of Paclitaxel Using Protein-Grafted Solid Lipid Nanoparticles.Deep Pooja et al.Molecular pharmaceutics, 13(11), 3903-3912 (2016-10-05)
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