Melting point	43-46 ºC
Boiling point	173-183 ºC
Density	1503

Symbol(GHS)	C
Hazard Codes	R34
SDS/MSDS	S26;S36/37/39;S45

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

Combination azelaic acid therapy for acne vulgaris.G Webster Journal of the American Academy of Dermatology, 43(2 Pt 3), S47-S50 (2000-07-18) Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins.Yosuke Fukutani et al.Analytical biochemistry, 471, 1-8 (2014-12-03) The role of topical metronidazole in the treatment of rosacea.John E Wolf Cutis, 73(1 Suppl), 19-28 (2004-02-13) Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: effect of depigmenting agents.J F Hermanns et al.Dermatology (Basel, Switzerland), 201(2), 118-122 (2000-10-29) Management of dyschromias in ethnic skin.Rebat M Halder et al.Dermatologic therapy, 17(2), 151-157 (2004-04-29) The use of topical azelaic acid for common skin disorders other than inflammatory rosacea.James Q Del Rosso Cutis, 77(2 Suppl), 22-24 (2006-03-29) Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study.Leon H Kircik Journal of drugs in dermatology : JDD, 10(6), 586-590 (2011-06-04) Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic acid.Maria Zoeller et al.Plant physiology, 160(1), 365-378 (2012-07-24) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) Azelaic acid--a new topical treatment for acne. Drug and therapeutics bulletin, 31(13), 50-52 (1993-06-21) [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid].Wolf-Ingo Worret et al.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 4(4), 293-300 (2006-04-28) A clinical overview of azelaic acid.Boni Elewski et al.Cutis, 77(2 Suppl), 12-16 (2006-03-29) Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study.A Mayer-da-Silva et al.Acta dermato-venereologica. Supplementum, 143, 20-30 (1989-01-01) Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea.J Mark Jackson et al.Journal of drugs in dermatology : JDD, 12(3), 292-298 (2013-04-03) Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system.Ronald G Wheeland et al.Journal of drugs in dermatology : JDD, 10(6), 596-602 (2011-06-04) Management of acne.David C Liao The Journal of family practice, 52(1), 43-51 (2003-01-24) Rosacea: update on management and emerging therapies.Robyn S Fallen et al.Skin therapy letter, 17(10), 1-4 (2012-12-12) Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies.A S Breathnach Cutis, 57(1 Suppl), 36-45 (1996-01-01) Azelaic acid (15% gel) in the treatment of acne rosacea.Aditya K Gupta et al.International journal of dermatology, 46(5), 533-538 (2007-05-03) Azelaic acid 15% gel in the treatment of rosacea.Harald Gollnick et al.Expert opinion on pharmacotherapy, 9(15), 2699-2706 (2008-09-23) Effect of ionization and vehicle on skin absorption and penetration of azelaic acid.Nan Li et al.Drug development and industrial pharmacy, 38(8), 985-994 (2011-11-25) Melasma: a comprehensive update: part II.Vaneeta M Sheth et al.Journal of the American Academy of Dermatology, 65(4), 699-714 (2011-09-17) Modulation of colon cancer by nutmeg.Fei Li et al.Journal of proteome research, 14(4), 1937-1946 (2015-02-26) Azelaic acid gel 15% in the management of papulopustular rosacea: a status report on available efficacy data and clinical application.James Q Del Rosso et al.Cutis, 88(2), 67-72 (2011-09-16) [Chemical constituents of Halenia elliptica].Hongling Wang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(11), 1454-1457 (2012-07-12) Rosacea: pathophysiology and management principles.Nitin Chauhan et al.Facial plastic surgery clinics of North America, 21(1), 127-136 (2013-02-02) Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.Tsutomu Matsubara et al.Cell metabolism, 16(5), 634-644 (2012-11-13) Topical therapy for acne.J J Russell American family physician, 61(2), 357-366 (2000-02-12) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.Arun Sreekumar et al.Nature, 457(7231), 910-914 (2009-02-13) Azelaic acid therapy for acne.P S Mackrides et al.American family physician, 54(8), 2457-2459 (1996-12-01) Present and future rosacea therapy.John E Wolf Cutis, 75(3 Suppl), 4-7 (2005-04-07) Considerations for treating acne in ethnic skin.Valerie D Callender Cutis, 76(2 Suppl), 19-23 (2005-09-17) Therapeutic effects of minoxidil high extra combination therapy in patients with androgenetic alopecia.Hamidreza Pazoki-Toroudi et al.Skinmed, 10(5), 276-282 (2012-11-21) Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials.Rosemarie H Liu et al.Archives of dermatology, 142(8), 1047-1052 (2006-08-23) A status report on the medical management of rosacea: focus on topical therapies.James Q Del Rosso Cutis, 70(5), 271-275 (2002-12-10) Azelaic acid 15% gel: in the treatment of papulopustular rosacea.James E Frampton et al.American journal of clinical dermatology, 5(1), 57-64 (2004-02-26) Amelanotic lentigo maligna melanoma: report of a case and review of the literature.V Rocamora et al.Cutis, 64(1), 53-56 (1999-08-04) Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach.Zhonghua Wang et al.Journal of proteome research, 14(6), 2583-2593 (2015-05-21) Formulation and characterization of liquid crystal systems containing azelaic acid for topical delivery.Merve Aytekin et al.Drug development and industrial pharmacy, 39(2), 228-239 (2012-04-07) [Treatment of rosacea].A Parodi et al.Annales de dermatologie et de venereologie, 138 Suppl 2, S158-S162 (2011-09-13) Whole Grain Consumption Increases Gastrointestinal Content of Sulfate-Conjugated Oxylipins in Pigs - A Multicompartmental Metabolomics Study.Anne Krog Ingerslev et al.Journal of proteome research, 14(8), 3095-3110 (2015-07-03) Physiology and pathophysiology of organic acids in cerebrospinal fluid.G F Hoffmann et al.Journal of inherited metabolic disease, 16(4), 648-669 (1993-01-01) Formation of gels in the presence of metal ions.Nicola Castellucci et al.Amino acids, 41(3), 609-620 (2011-04-14) Systematic review of rosacea treatments.Esther J van Zuuren et al.Journal of the American Academy of Dermatology, 56(1), 107-115 (2006-12-28) Mussel-inspired bolaamphiphile sticky self-assemblies for the preparation of magnetic nanoparticles.Chaemyeong Lee et al.Colloids and surfaces. B, Biointerfaces, 127, 89-95 (2015-02-07) Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy.Maria Vinaixa et al.PloS one, 6(12), e29052-e29052 (2011-12-24) Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne.Q H Nguyen et al.International journal of dermatology, 34(2), 75-84 (1995-02-01) Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.F Guneral et al.Clinical chemistry, 40(6), 862-866 (1994-06-01) Face up to rosacea.Heather L Roebuck The Nurse practitioner, 30(9), 24-30 (2005-09-10) The evolution of azelaic acid.Alan B Fleischer Cutis, 77(2 Suppl), 4-6 (2006-03-29) Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.Wolfram Gronwald et al.Kidney international, 79(11), 1244-1253 (2011-03-11) The rigor of trials evaluating Rosacea treatments.Esther J van Zuuren et al.Cutis, 75(3 Suppl), 13-16 (2005-04-07) Managing acne vulgaris effectively.Greg Goodman Australian family physician, 35(9), 705-709 (2006-09-14) Acne vulgaris in children and adolescents.C Schnopp et al.Minerva pediatrica, 63(4), 293-304 (2011-09-13) Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis.G Hoffmann et al.Clinical chemistry, 35(4), 587-595 (1989-04-01) Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris.Diane Thiboutot Journal of drugs in dermatology : JDD, 7(1), 13-16 (2008-02-06) Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ.Stefania Briganti et al.Experimental dermatology, 22(1), 41-47 (2013-01-03) Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma.Susan Farshi Journal of cosmetic dermatology, 10(4), 282-287 (2011-12-14) Acne vulgaris.Sarah Purdy Clinical evidence, (15)(15), 2183-2201 (2006-09-16) Topical therapies for rosacea.Jennie B Nally et al.Journal of drugs in dermatology : JDD, 5(1), 23-26 (2006-02-14) Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice.Shanmugam Muthulakshmi et al.Molecular and cellular biochemistry, 377(1-2), 23-33 (2013-01-31) The rationale for advancing the formulation of azelaic acid vehicles.Zoe Diana Draelos Cutis, 77(2 Suppl), 7-11 (2006-03-29) The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin.Pei-Wen Hsieh et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(2), 369-378 (2012-04-04) Characteristic urine organic acid profile in peroxisomal biogenesis disorders.S H Korman et al.Journal of inherited metabolic disease, 23(4), 425-428 (2000-07-15) A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing.Eric M Jones et al.Cell systems, 8(3), 254-260 (2019-03-25) Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography-Mass Spectrometry Approach.Maryam Goudarzi et al.Journal of proteome research, 14(9), 4039-4049 (2015-08-12) Optimal management of papulopustular rosacea: rationale for combination therapy.Neal D Bhatia et al.Journal of drugs in dermatology : JDD, 11(7), 838-844 (2012-07-11) Acne vulgaris.Sarah Purdy Clinical evidence, (13)(13), 2038-2059 (2005-09-02) Heterogeneous reaction of suspended phosmet particles with NO3 radicals.Changgeng Liu et al.The journal of physical chemistry. A, 115(39), 10744-10748 (2011-08-30) Medical treatment of rosacea with emphasis on topical therapies.James Q Del Rosso Expert opinion on pharmacotherapy, 5(1), 5-13 (2003-12-19) The treatment of melasma: a review of clinical trials.Aditya K Gupta et al.Journal of the American Academy of Dermatology, 55(6), 1048-1065 (2006-11-14) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Topical agents used in the management of hyperpigmentation.R M Halder et al.Skin therapy letter, 9(6), 1-3 (2004-08-31) Hyperpigmentation: an overview of the common afflictions.Kimberly A Cayce et al.Dermatology nursing, 16(5), 401-406 (2004-12-31) Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders.A Fitton et al.Drugs, 41(5), 780-798 (1991-05-01) Inflammatory acne management with a novel prescription dietary supplement.Alan R Shalita et al.Journal of drugs in dermatology : JDD, 11(12), 1428-1433 (2013-02-05) Feasibility of detecting prostate cancer by ultraperformance liquid chromatography-mass spectrometry serum metabolomics.Xiaoling Zang et al.Journal of proteome research, 13(7), 3444-3454 (2014-06-13) Rosacea. An overview of diagnosis and management.Karol Burkhart Lindow Advance for nurse practitioners, 12(12), 27-32 (2004-12-24) Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne.Q H Nguyen et al.International journal of dermatology, 34(2), 75-84 (1995-02-01) LeciPlex, invasomes, and liposomes: A skin penetration study.Sanket M Shah et al.International journal of pharmaceutics, 490(1-2), 391-403 (2015-05-24) Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports.K Graupe et al.Cutis, 57(1 Suppl), 20-35 (1996-01-01) Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris.Hamidreza Pazoki-Toroudi et al.Cutaneous and ocular toxicology, 30(4), 286-291 (2011-05-27) Enhanced Cell Adhesion on a Nano-Embossed, Sticky Surface Prepared by the Printing of a DOPA-Bolaamphiphile Assembly Ink.Chaemyeong Lee et al.Scientific reports, 7(1), 13797-13797 (2017-10-25) Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris.J R Gibson Dermatology nursing, 9(5), 339-344 (1997-12-11) Cellulase applied to the leaves of sweet pepper (Capsicum annuum L. var. grossum) upregulates the production of salicylic and azelaic acids.Chizuru Sato et al.Bioscience, biotechnology, and biochemistry, 75(4), 761-763 (2011-04-23) [Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy].Joachim W Fluhr et al.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 8 Suppl 1, S24-S30 (2010-05-28) Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders.A Fitton et al.Drugs, 41(5), 780-798 (1991-05-01) Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel.Alvin B Coda et al.Journal of the American Academy of Dermatology, 69(4), 570-577 (2013-07-23)

Remarks