Water Solubility	slightly soluble
Boiling point	199 ºC
Flash point	78 ºC
Density	1.019
Refractive index	1.54-1.542

Symbol(GHS)	Xi
Hazard Codes	R36/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Peer-Reviewed Papers

Intrathecal gabapentin to treat chronic intractable noncancer pain.Richard Rauck et al.Anesthesiology, 119(3), 675-686 (2013-07-10) Clinical practice. Postherpetic neuralgia.Robert W Johnson et al.The New England journal of medicine, 371(16), 1526-1533 (2014-10-16) Gabapentin add-on for drug-resistant partial epilepsy.Sarah Al-Bachari et al.The Cochrane database of systematic reviews, 7(7), CD001415-CD001415 (2013-07-28) The effect of gabapentin versus intrathecal fentanyl on postoperative pain and morphine consumption in cesarean delivery: a prospective, randomized, double-blind study.Abdolreza Najafi Anaraki et al.Archives of gynecology and obstetrics, 290(1), 47-52 (2014-02-13) Clinical Inquiry: Do venlafaxine and gabapentin control hot flashes in women with a history of breast cancer?Angela Sarkissian et al.The Journal of family practice, 61(12), 759-772 (2013-01-15) Gabapentin Attenuates Oxidative Stress and Apoptosis in the Diabetic Rat Retina.Mohammad Shamsul Ola et al.Neurotoxicity research, 36(1), 81-90 (2019-03-05) The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.Hance Clarke et al.Anesthesia and analgesia, 115(2), 428-442 (2012-03-15) Painful diabetic neuropathy.Amanda Peltier et al.BMJ (Clinical research ed.), 348, g1799-g1799 (2014-05-08) Efficacy of gabapentin for treatment of adults with phantom limb pain.Kim Abbass The Annals of pharmacotherapy, 46(12), 1707-1711 (2012-12-13) Gabapentin and pregabalin in the management of postoperative pain after lumbar spinal surgery: a systematic review and meta-analysis.Lin Yu et al.Spine, 38(22), 1947-1952 (2013-08-08) Long-term safety of gastroretentive gabapentin in postherpetic neuralgia patients.Mark P Jensen et al.The Clinical journal of pain, 29(9), 770-774 (2013-02-02) Pharmacokinetics, efficacy, and tolerability of a once-daily gastroretentive dosage form of gabapentin for the treatment of postherpetic neuralgia.Cuiping Chen et al.Journal of pharmaceutical sciences, 102(4), 1155-1164 (2013-02-06) Latest guidelines and advances for treatment of restless legs syndrome.Christopher J Earley The Journal of clinical psychiatry, 75(4), e08-e08 (2014-05-13) Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis.Nada Alayed et al.Obstetrics and gynecology, 123(6), 1221-1229 (2014-05-09) Clinical study evaluating pregabalin efficacy and tolerability for pain management in patients undergoing laparoscopic cholecystectomy.Mohammad S Bekawi et al.The Clinical journal of pain, 30(11), 944-952 (2014-03-26) Peripheral neuropathy in HIV: an analysis of evidence-based approaches.Patrice K Nicholas et al.The Journal of the Association of Nurses in AIDS Care : JANAC, 25(4), 318-329 (2014-04-05) The effect of gabapentin on intensity and duration of hot flashes in postmenopausal women: a randomized controlled trial.Najmieh Saadati et al.Global journal of health science, 5(6), 126-130 (2013-11-01) The intestinal absorption mechanism of gabapentin makes it appropriate for gastroretentive delivery.Cuiping Chen et al.Current clinical pharmacology, 8(1), 67-72 (2012-09-06) Is there a role for gabapentin in preventing or treating pain following thoracic surgery?Mustafa Zakkar et al.Interactive cardiovascular and thoracic surgery, 17(4), 716-719 (2013-07-09) Comparison of two aerosol-based detectors for the analysis of gabapentin in pharmaceutical formulations by hydrophilic interaction chromatographyJia S, et al. Talanta, 85(5), 2301-2306 (2011) Clinical development of a once-daily gastroretentive formulation of gabapentin for treatment of postherpetic neuralgia: an overview.Charles E Argoff et al.Expert opinion on drug delivery, 9(9), 1147-1160 (2012-07-20) Validated HPLC method for the determination of gabapentin in human plasma using pre-column derivatization with 1-fluoro-2,4-dinitrobenzene and its application to a pharmacokinetic study.Hassan Jalalizadeh et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 854(1-2), 43-47 (2007-05-23) Severe respiratory depression associated with perioperative opioid-sparing gabapentin use.D Ongley et al.Anaesthesia and intensive care, 42(1), 136-137 (2014-01-30) Recent advances in sleep research.Bernd Saletu et al.Psychiatria Danubina, 25(4), 426-434 (2013-11-20) Mechanisms of action of antiepileptic drugs.Piotr Czapiński et al.Current topics in medicinal chemistry, 5(1), 3-14 (2005-01-11) Quantitation of poloxamers in pharmaceutical formulations using size exclusion chromatography and colorimetric methodsMao Y, et al. Journal of Pharmaceutical and Biomedical Analysis, 35(5), 1127-1142 (2004) Implications and mechanism of action of gabapentin in neuropathic pain.Ankesh Kukkar et al.Archives of pharmacal research, 36(3), 237-251 (2013-02-26) Mechanisms of the antinociceptive action of gabapentin.Jen-Kun Cheng et al.Journal of pharmacological sciences, 100(5), 471-486 (2006-02-14) Colorimetric determination of gabapentin in pharmaceutical formulationAbdellatef HE and Khalil HM Journal of Pharmaceutical and Biomedical Analysis, 31(1), 209-214 (2003) Patient demographics and health plan paid costs in chronic inflammatory demyelinating polyneuropathy.Jeffrey T Guptill et al.Muscle & nerve, 50(1), 47-51 (2014-03-19) Use of gabapentin and pregabalin for hand surgery patients.Lance M Brunton et al.The Journal of hand surgery, 37(7), 1486-1488 (2012-06-23) Update on neuropathic pain treatment: ion channel blockers and gabapentinoids.Lucy Chen et al.Current pain and headache reports, 17(9), 359-359 (2013-07-28) Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain.Peter C Schmidt et al.Anesthesiology, 119(5), 1215-1221 (2013-09-21) Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults.Mattias Linde et al.The Cochrane database of systematic reviews, 6(6), CD010609-CD010609 (2013-06-26) Gabapentin therapy of hiccups.Dennis F Thompson et al.The Annals of pharmacotherapy, 47(6), 897-903 (2013-05-16) Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats.Carlos C Câmara et al.Neuroscience letters, 556, 93-98 (2013-10-22) Gabapentin in the prophylaxis of migraine: a double-blind randomized placebo-controlled study.G Di Trapani et al.La Clinica terapeutica, 151(3), 145-148 (2000-08-25) The effects of gabapentin on methadone based addiction treatment: a randomized controlled trial.Mohsen Saber Moghadam et al.Pakistan journal of pharmaceutical sciences, 26(5), 985-989 (2013-09-17) Drugs for neuropathic pain.Eija Kalso et al.BMJ (Clinical research ed.), 347, f7339-f7339 (2013-12-21) A randomized placebo-controlled trial of gabapentin for cocaine dependence.Adam Bisaga et al.Drug and alcohol dependence, 81(3), 267-274 (2005-09-20) Validated HPLC method for the determination of gabapentin in human plasma using pre-column derivatization with 1-fluoro-2, 4-dinitrobenzene and its application to a pharmacokinetic studyJalalizadeh H, et al. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 854, 43-47 (2007) Dorsal Root Ganglion Stimulation Alleviates Pain-related Behaviors in Rats with Nerve Injury and Osteoarthritis.Guoliang Yu et al.Anesthesiology, 133(2), 408-425 (2020-05-21) Gabapentin: a new addition to the armamentarium for alcohol dependence?Edward V Nunes JAMA internal medicine, 174(1), 78-79 (2013-11-06) The efficacy of nonestrogenic therapy to hot flashes in cancer patients under hormone manipulation therapy: a systematic review and meta-analysis.N Yamaguchi et al.Journal of cancer research and clinical oncology, 139(10), 1701-1707 (2013-08-27) Chronobiological characteristics of neuropathic pain: clinical predictors of diurnal pain rhythmicity.Ian Gilron et al.The Clinical journal of pain, 29(9), 755-759 (2013-02-02) Peripheral straightjacket (α2δ Ca2+ channel subunit) expression is required for neuropathic sensitization in Drosophila.Thang M Khuong et al.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 374(1785), 20190287-20190287 (2019-09-24) Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and p-acceptorsSiddiqui AF, et al. European Journal of Medicinal Chemistry, 45(7), 2761-2767 (2010) Strategies to prevent the neuropsychiatric side-effects of corticosteroids: a case report and review of the literature.Stephen West et al.Current opinion in organ transplantation, 19(2), 201-208 (2014-02-21) Gabapentin withdrawal: case report in an older adult and review of the literature.Linda Mah et al.Journal of the American Geriatrics Society, 61(9), 1635-1637 (2013-09-14) Asterixis related to gabapentin intake: a case report and review.Mervat Wahba et al.Postgraduate medicine, 125(5), 139-141 (2013-10-12) Gabapentin for pruritus in palliative care.Sheeba Anand The American journal of hospice & palliative care, 30(2), 192-196 (2012-05-05) The role of GABA in the pathophysiology and treatment of anxiety disorders.Charles B Nemeroff Psychopharmacology bulletin, 37(4), 133-146 (2004-05-08) The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.O A Petroff et al.Annals of neurology, 39(1), 95-99 (1996-01-01) Development and application of a validated HPLC method for the analysis of dissolution samples of gabapentin drug productsGupta A, et al. Journal of Pharmaceutical and Biomedical Analysis, 46, 181-186 (2008) Gabapentin for once-daily treatment of post-herpetic neuralgia: a review.Benjamin Beal et al.Clinical interventions in aging, 7, 249-255 (2012-08-07) Neuropathic pain following sagittal split ramus osteotomy of the mandible: prevalence, risk factors, and clinical course.Érica C Marchiori et al.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(12), 2115-2122 (2013-09-03) Bad medicine: gabapentin and pregabalin.Des Spence BMJ (Clinical research ed.), 347, f6747-f6747 (2013-11-12) Gabapentin treatment for alcohol dependence: a randomized clinical trial.Barbara J Mason et al.JAMA internal medicine, 174(1), 70-77 (2013-11-06) Interchangeability of gabapentin generic formulations in the Netherlands: a comparative bioavailability study.Y Yu et al.Clinical pharmacology and therapeutics, 94(4), 519-524 (2013-05-28) Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain.Hugo F Miranda et al.Journal of orofacial pain, 27(4), 361-366 (2013-10-31) 31-year-old woman with alopecia.Nicole M Loo et al.Mayo Clinic proceedings, 88(10), 1147-1150 (2013-10-02) Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study.Jennifer Y Xie et al.Pain, 160(8), 1847-1855 (2019-07-25) Gabapentin for the prophylaxis of episodic migraine in adults.Corey D Fogleman American family physician, 89(9), 714-715 (2014-05-03) Should anaesthetists routinely use a gabapentinoid perioperatively?G J Sanders British journal of hospital medicine (London, England : 2005), 75(1), 58-58 (2014-01-10) Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin.Stephanie Shiers et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(33), 7337-7350 (2018-07-22) Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial.Wirinda Chiravanich et al.Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 95(2), 186-190 (2012-03-23) Veterinary Pharmacology and Therapeutics (2009)

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