Melting point	91-94 ºC
Water Solubility	Insoluble
Boiling point	223 ºC
Flash point	108 ºC

Symbol(GHS)	Xn
Hazard Codes	R20/22;R36/37/38
SDS/MSDS	S23;S26;S36

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Genotoxic effects of selected biocides on RTG-2 fish cells by means of a modified Fast Micromethod Assay.S Sánchez-Fortún et al.Aquatic toxicology (Amsterdam, Netherlands), 73(1), 55-64 (2005-05-17) Comparative hyperthermia effects of silica-gold nanoshells with different surface coverage of gold clusters on epithelial tumor cells.Sang-Eun Park et al.International journal of nanomedicine, 10(Spec Iss), 261-271 (2015-10-02) Synthesis of multivalent silica nanoparticles combining both enthalpic and entropic patchiness.Céline Hubert et al.Faraday discussions, 181, 139-146 (2015-04-30) Preliminary studies on the role and reactions of tetrakis(hydroxymethyl)phosphonium chloride in polyacrylamide gel dosimeters.Mahbod Sedaghat et al.Physics in medicine and biology, 57(19), 5981-5994 (2012-09-12) Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities.Nicole H Romano et al.Small (Weinheim an der Bergstrasse, Germany), 11(6), 722-730 (2014-10-16) β-Cyclodextrin coated SiO₂@Au@Ag core-shell nanoparticles for SERS detection of PCBs.Yilin Lu et al.Physical chemistry chemical physics : PCCP, 17(33), 21149-21157 (2014-12-06) [Use of sensitizers and photo laser for diagnosis and treatment of malignant tumors].B Latkowski et al.Otolaryngologia polska = The Polish otolaryngology, 49 Suppl 20, 205-208 (1995-01-01) Tetrakis(hydroxymethyl) phosphonium salts. IARC monographs on the evaluation of carcinogenic risks to humans, 48, 95-107 (1990-01-01) Uptake and phototoxicity of meso-tetrahydroxyphenyl chlorine are highly variable in human biliary tract cancer cell lines and correlate with markers of differentiation and proliferation.Tobias Kiesslich et al.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 9(5), 734-743 (2010-04-02) The characterisation of three substituted zinc phthalocyanines of differing charge for use in photodynamic therapy. A comparative study of their aggregation and photosensitising ability in relation to mTHPC and polyhaematoporphyrin.D J Ball et al.Journal of photochemistry and photobiology. B, Biology, 45(1), 28-35 (1998-11-20) Basic investigations on the performance of a normoxic polymer gel with tetrakis-hydroxy-methyl-phosphonium chloride as an oxygen scavenger: reproducibility, accuracy, stability, and dose rate dependence.Christian Bayreder et al.Medical physics, 33(7), 2506-2518 (2006-08-11) [Pharmacokinetics of photosensitizer m-THPC in rat models of liver cancer via orthotropic implantation using Walker-256].Jian-dong Wang et al.Zhonghua wai ke za zhi [Chinese journal of surgery], 49(4), 341-345 (2011-05-27) New photosensitizers for photodynamic therapy in gastroenterology.S G Bown et al.Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 13(5), 389-392 (1999-06-23) Tetrakis(hydroxymethyl)phosphonium salts. IARC monographs on the evaluation of carcinogenic risks to humans, 71 Pt 3, 1529-1532 (1999-09-07) Facile preparation of water-soluble fluorescent gold nanoclusters for cellular imaging applications.Shang L, et al. Nanoscale, 3(5), 2009-2014 (2011) Tetrakis(hydroxymethyl) phosphonium chloride as a covalent cross-linking agent for cell encapsulation within protein-based hydrogels.Cindy Chung et al.Biomacromolecules, 13(12), 3912-3916 (2012-11-16) Clinical feasibility of monitoring m-THPC mediated photodynamic therapy by means of fluorescence differential path-length spectroscopy.Baris Karakullukcu et al.Journal of biophotonics, 4(10), 740-751 (2011-08-24) Investigation of the PAGAT polymer gel dosimeter using magnetic resonance imaging.A J Venning et al.Physics in medicine and biology, 50(16), 3875-3888 (2005-08-04) Photodynamic therapy for esophageal diseases: a clinical update.R L Prosst et al.Endoscopy, 35(12), 1059-1068 (2003-12-04) Investigating the potential of polymer gel dosimetry for interventional radiology: first results.P E Antoniou et al.Physics in medicine and biology, 53(8), N127-N136 (2008-03-28) Beyond gold: rediscovering tetrakis-(hydroxymethyl)-phosphonium chloride (THPC) as an effective agent for the synthesis of ultra-small noble metal nanoparticles and Pt-containing nanoalloysHueso J L, et al. Royal Society of Chemistry Advances, 3(26), 10427-10433 (2013) The mutagenic evaluation of tetrakis (hydroxymethyl) phosphonium sulfate using a combined testing protocol approach.T H Connor et al.Journal of environmental pathology and toxicology, 4(1), 145-158 (1980-08-01) Effects of selected biocides used in the disinfection of cooling towers on toxicity and bioaccumulation in Artemia larvae.María Carmen Bartolomé et al.Environmental toxicology and chemistry, 24(12), 3137-3142 (2006-02-01) Comment on: "Basic investigations on the performance of a normoxic polymer gel with tetrakis-hydroxy-methyl-phosphonium chloride as an oxygen scavenger: reproducibility, accuracy, stability, and dose rate dependence" [Med. Phys. 33, 2506-2518 (2006)].N D MacDougall et al.Medical physics, 34(1), 366-366 (2007-02-07) Ferromagnetism exhibited by nanoparticles of noble metals.Urmimala Maitra et al.Chemphyschem : a European journal of chemical physics and physical chemistry, 12(12), 2322-2327 (2011-07-12) Investigation of tetrakis hydroxymethyl phosphonium chloride as an antioxidant for use in x-ray computed tomography polyacrylamide gel dosimetry.A Jirasek et al.Physics in medicine and biology, 51(7), 1891-1906 (2006-03-23)

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