Boiling point	158-159 ºC
Flash point	62 ºC
Density	1.08
Refractive index	1.417-1.42

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Peer-Reviewed Papers

Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide.H Reynaldo López-Mirabal et al.FEMS yeast research, 7(3), 391-403 (2007-01-27) O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.F Peter Guengerich et al.Biochemistry, 42(37), 10965-10970 (2003-09-17) Synthesis and structural characterization of binuclear half-sandwich iridium, rhodium and ruthenium complexes containing 4,4'-dipyridyldisulfide (4DPDS) ligands.Ying-Feng Han et al.Dalton transactions (Cambridge, England : 2003), 39(30), 7119-7124 (2010-07-02) Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant.Tomoko Nishino et al.The Journal of biological chemistry, 280(26), 24888-24894 (2005-05-10) Characterization of the redox and metal binding activity of BsSco, a protein implicated in the assembly of cytochrome c oxidase.Iveta Imriskova-Sosova et al.Biochemistry, 44(51), 16949-16956 (2005-12-21) Identification and Quantitative Analysis of 2-Methyl-4-propyl-1,3-oxathiane in Wine.Liang Chen et al.Journal of agricultural and food chemistry, 66(41), 10808-10815 (2018-10-06) Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing.Yan Huang et al.Proceedings of the National Academy of Sciences of the United States of America, 117(7), 3543-3550 (2020-02-01) Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective.Judith Martini et al.Critical care (London, England), 12(2), R54-R54 (2008-04-22) Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide.H Reynaldo López-Mirabal et al.FEMS yeast research, 7(3), 391-403 (2007-01-27) Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells.Soong-Yu Kuo et al.Archives of toxicology, 77(11), 630-637 (2003-08-21) Mutations in the RAM network confer resistance to the thiol oxidant 4,4'-dipyridyl disulfide.H Reynaldo López-Mirabal et al.Molecular genetics and genomics : MGG, 279(6), 629-642 (2008-03-22) Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells.Soong-Yu Kuo et al.Archives of toxicology, 77(11), 630-637 (2003-08-21) Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition.Cynthia A Danquah et al.Scientific reports, 8(1), 1150-1150 (2018-01-20) Adsorption of 4,4'-Dithiodipyridine Axially Coordinated to Iron(II) Phthalocyanine on Au(111) as a New Strategy for Oxygen Reduction Electrocatalysis.Santiago Herrera et al.Chemphyschem : a European journal of chemical physics and physical chemistry, 19(13), 1599-1604 (2018-03-31) Identification of the reactive cysteine residues in yeast dipeptidyl peptidase III.Nina Jajcanin-Jozić et al.Biochimie, 92(1), 89-96 (2009-10-15) Porous Metal-Organic Frameworks Containing Reversible Disulfide Linkages as Cathode Materials for Lithium-Ion Batteries.Takeshi Shimizu et al.ChemSusChem, 13(9), 2256-2263 (2020-01-30) Biphasic modulation of ryanodine receptors by sulfhydryl oxidation in rat ventricular myocytes.Hong Xie et al.Biophysical journal, 91(8), 2882-2891 (2006-08-01) J. Vac. Sci. Technol. B, 12, 1486-1486 (1994) Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine.Christian K Riener et al.Analytical and bioanalytical chemistry, 373(4-5), 266-276 (2002-07-12) Involvement of amino-acid side chains of membrane proteins in the binding of glutathione to pig cerebral cortical membranes.András Hermann et al.Neurochemical research, 27(5), 389-394 (2002-06-18) A novel HPLC-MS/MS approach for the identification of biological thiols in vegetables.Silvia Millan et al.Food chemistry, 339, 127809-127809 (2020-09-03) Molecularly imprinted tunable binding sites based on conjugated prosthetic groups and ion-paired cofactors.Kohei Takeda et al.Journal of the American Chemical Society, 131(25), 8833-8838 (2009-06-06) A SERRS/MRI multimodal contrast agent based on naked Au nanoparticles functionalized with a Gd(iii) loaded PEG polymer for tumor imaging and localized hyperthermia.Lucio Litti et al.Nanoscale, 10(3), 1272-1278 (2018-01-03) Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.Andrea Kocsis et al.Journal of immunology (Baltimore, Md. : 1950), 185(7), 4169-4178 (2010-09-08) The thiol oxidant dipyridyl disulfide can supply the PDI-Ero1p pathway with additional oxidative equivalents.H Reynaldo López-Mirabal et al.Antonie van Leeuwenhoek, 92(4), 463-472 (2007-06-15) Conformational change of the E-F interhelical loop in the M photointermediate of bacteriorhodopsin.Leonid S Brown et al.Journal of molecular biology, 317(3), 471-478 (2002-04-02) Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance.Angela Fago et al.The Journal of biological chemistry, 279(43), 44417-44426 (2004-08-10) Spectroelectrochemistry of cytochrome P450cam.Nikitas Bistolas et al.Biochemical and biophysical research communications, 314(3), 810-816 (2004-01-27) Oxidant resistance in a yeast mutant deficient in the Sit4 phosphatase.H Reynaldo López-Mirabal et al.Current genetics, 53(5), 275-286 (2008-03-22) Improving Functional Annotation in the DRE-TIM Metallolyase Superfamily through Identification of Active Site Fingerprints.Garima Kumar et al.Biochemistry, 55(12), 1863-1872 (2016-03-05) Mechanism of inhibitory actions of oxidizing agents on calcium-activated potassium current in cultured pigment epithelial cells of the human retina.Shwu-Jiuan Sheu et al.Investigative ophthalmology & visual science, 44(3), 1237-1244 (2003-02-26) Symmetry distortion in the human hemoglobin tetramer induced by asymmetric ligation.Naoya Shibayama FEBS letters, 586(1), 74-78 (2011-12-07) Aqueous solution properties of disulfide linked gemini and cleaved monomeric thiol surfactants.Tsuyoshi Asakawa et al.Journal of oleo science, 57(4), 243-249 (2008-03-12) Aldrichimica Acta, 4, 33-33 (1971) In vivo regulation of alcohol dehydrogenase and lactate dehydrogenase in Rhizopus oryzae to improve L-lactic acid fermentation.Sitanan Thitiprasert et al.Applied biochemistry and biotechnology, 164(8), 1305-1322 (2011-03-19) Oxidative stress and lipid peroxidation are upstream of amyloid pathology.Muriel Arimon et al.Neurobiology of disease, 84, 109-119 (2015-06-24) Straightforward preparation and assay of aspartyl protease substrates with an internal thioester linkage.Yazmín T Rosa-Bauzá et al.Chembiochem : a European journal of chemical biology, 8(9), 981-984 (2007-05-12) Preheat-stabilized pea proteins with anti-aggregation properties.Chao Wu et al.International journal of biological macromolecules, 155, 1288-1295 (2019-11-17) General method for facile intramolecular disulfide formation in synthetic peptides.Daniel J Cline et al.Analytical biochemistry, 335(1), 168-170 (2004-11-03) VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells.Chitra Mohan et al.eLife, 7 (2018-08-10) Selective perturbation of the intravesicular heme center of cytochrome b561 by cysteinyl modification with 4,4'-dithiodipyridine.Fusako Takeuchi et al.Journal of biochemistry, 138(6), 751-762 (2006-01-24) Unraveling the RNA Binding Properties of the Iron-Sulfur Zinc Finger Protein CPSF30.Jordan D Pritts et al.Biochemistry, 59(8), 970-982 (2020-02-07) Conjugation with 20 kDa dextran decreases the autoxidation rate of bovine hemoglobin.Jun Zhang et al.Artificial cells, nanomedicine, and biotechnology, 46(7), 1436-1443 (2017-09-09)

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