Boiling point	135 ºC
Flash point	69 ºF
Density	0.753
Refractive index	1.41

Symbol(GHS)	F;C
Hazard Codes	R11;R20/21/22;R34
SDS/MSDS	S16;S26;S27;S33;S36/37/39;S45

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

[Separation of oxetacaine and its metabolites] .B Unterhalt et al.Die Pharmazie, 56(1), 58-60 (2001-02-24) Effects of cholecystokinin and caerulein on gastric emptying.M S Anika European journal of pharmacology, 85(2), 195-199 (1982-11-19) Oxethazaine as the source of mephentermine and phentermine in athlete's urine.Mei-Chich Hsu et al.Forensic science international, 185(1-3), e1-e5 (2009-01-23) A preliminary report using oxethazaine--a potential new dental local anaesthetic.P A Brennan et al.The British journal of oral & maxillofacial surgery, 28(1), 26-28 (1990-02-01) Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers.Yasusuke Masuda et al.Journal of pharmacological sciences, 98(2), 181-184 (2005-06-09) [Clinical study on the pharmacological treatment of hemorrhoids with 0.25% oxethacaine chlorhydrate].G Gioiella et al.La Clinica terapeutica, 155(10), 443-445 (2005-02-11) Neural mechanisms in basal and meal-stimulated ileal absorption.M K Barry et al.The Journal of surgical research, 58(4), 425-431 (1995-04-01) Inhibitory mechanism of oxethazaine on release of endogenous secretin and pancreatic response in dogs.Y Yamazaki Digestive diseases and sciences, 27(9), 821-827 (1982-09-01) Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells.Yasusuke Masuda et al.Biochemical pharmacology, 64(4), 677-687 (2002-08-09) [The combination of contact anesthetic and antacid in the therapy of heartburn during pregnancy].V Brunclik et al.Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 77(21), 587-591 (1988-05-24) Effect of atropine on different phases of pancreatic secretion in conscious rats.A Pap et al.Acta medica Academiae Scientiarum Hungaricae, 37(3), 305-313 (1980-01-01) The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal modelsLee Y-S, et al. Pharmacology, Biochemistry, and Behavior, 105(3), 98-104 (2013) Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis.Wei-Hsun Huang et al.Journal of analytical toxicology, 34(2), 73-77 (2010-03-13) Complexation of oxethazaine with 2-hydroxypropyl-β-cyclodextrin: increased drug solubility, decreased cytotoxicity and analgesia at inflamed tissues.Andressa R Prado et al.The Journal of pharmacy and pharmacology, 69(6), 652-662 (2017-02-18) Adverse drug reaction to oxethazine: a case report.D Ruttenberg The New Zealand medical journal, 108(1008), 394-394 (1995-09-22) Effect of procaine and oxethazaine on muscarinic receptors of parietal cells.N Tani et al.The Tokai journal of experimental and clinical medicine, 22(3), 103-109 (1998-06-10) Influence of topical anesthetic, anticholinergic and ganglionic blocking agents on endogenous secretin release and pancreatic secretion in dogs.Y Yamazaki et al.Gastroenterologia Japonica, 17(1), 10-14 (1982-01-01) Is mucaine an appropriate medication for the relief of heartburn during pregnancy?G T Kovacs et al.Asia-Oceania journal of obstetrics and gynaecology, 16(4), 357-362 (1990-12-01) Meal-induced jejunal absorption requires intact neural pathways.G J Anthone et al.American journal of surgery, 163(1), 150-156 (1992-01-01) Alteration of hepatic microcirculation by oxethazaine and some vasoconstrictors in the perfused rat liver.Y Masuda et al.Biochemical pharmacology, 53(12), 1779-1787 (1997-06-15) Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis.Claire Barber et al.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 15(4), 427-440 (2006-11-30) The metabolic and hemodynamic effects of oxethazaine in the perfused rat liver.Y Masuda et al.Japanese journal of pharmacology, 70(3), 243-252 (1996-03-01) A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration.A Zanni et al.Current medical research and opinion, 10(2), 128-134 (1986-01-01) Postprandial celiac and superior mesenteric blood flows in conscious dogs.T Takagi et al.The American journal of physiology, 255(4 Pt 1), G522-G528 (1988-10-01) Ca2+ enhancement of hemolysis induced by the topical anesthetic oxethazaine in vitro.R Yasuno et al.Biological & pharmaceutical bulletin, 21(12), 1294-1299 (1999-01-09) Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity.Yasusuke Masuda Journal of pharmacological sciences, 100(3), 167-174 (2006-03-07) [Resorption of cyclosporin administered by oral route to renal transplant patients. Influence of breakfast and an antacid drug].F Penouil et al.Therapie, 43(1), 15-19 (1988-01-01)

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