Melting point	-20 ºC
Water Solubility	300 g/L (20 ºC)
Boiling point	160-162 ºC
Flash point	75 ºC
Density	1.131
Refractive index	1.444-1.446

Symbol(GHS)	Xn
Hazard Codes	R22;R36/37/38
SDS/MSDS	S36/37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Peer-Reviewed Papers

Putative denitrosylase activity of Cu,Zn-superoxide dismutase.Ayako Okado-Matsumoto et al.Free radical biology & medicine, 43(5), 830-836 (2007-08-01) Glyceraldehyde 3-phosphate dehydrogenase is unlikely to mediate hydrogen peroxide signaling: studies with a novel anti-dimedone sulfenic acid antibody.Claire Maller et al.Antioxidants & redox signaling, 14(1), 49-60 (2010-06-04) Reactivity of sulfenic acid in human serum albumin.Lucía Turell et al.Biochemistry, 47(1), 358-367 (2007-12-15) The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.Ryan D Michalek et al.Journal of immunology (Baltimore, Md. : 1950), 179(10), 6456-6467 (2007-11-06) Synthesis of symmetrical and non-symmetrical diimines from dimedone.Bahjat A Saeed et al.Molecules (Basel, Switzerland), 14(6), 2278-2285 (2009-06-26) Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.Chananat Klomsiri et al.Methods in enzymology, 473, 77-94 (2010-06-02) Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins.Kimberly J Nelson et al.Methods in enzymology, 473, 95-115 (2010-06-02) Synthesis of new nonclassical acridines, quinolines, and quinazolines derived from dimedone for biological evaluation.Osama I El-Sabbagh et al.Archiv der Pharmazie, 343(9), 519-527 (2010-09-04) Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.Julie A Reisz et al.The FEBS journal, 280(23), 6150-6161 (2013-10-10) Non-cytotoxic dimedone derivatives: structure, antiradical and UV protective studies.P V Joshi et al.Drug research, 63(12), 650-656 (2013-08-02) Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.Susan M Hutson et al.Methods in molecular biology (Clifton, N.J.), 476, 139-152 (2009-01-23) [The role of aldehydes in development of oxidative stress under rhabdomyolysis in rats].K O Tokarchuk et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 25-31 (2013-05-30) "Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigen-presenting cells.S N Lavergne et al.The Journal of pharmacology and experimental therapeutics, 331(2), 372-381 (2009-08-12) The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation.Katie E Crump et al.European journal of immunology, 42(8), 2152-2164 (2012-06-08) One-pot and efficient synthesis of triazolo[1,2-a]indazole-triones via reaction of arylaldehydes with urazole and dimedone catalyzed by silica nanoparticles prepared from rice husk.Hooshang Hamidian et al.Molecules (Basel, Switzerland), 16(11), 9041-9048 (2011-10-28) Quantification of protein sulfenic acid modifications using isotope-coded dimedone and iododimedone.Young Ho Seo et al.Angewandte Chemie (International ed. in English), 50(6), 1342-1345 (2011-02-04) Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans.Yuande Yang et al.Biochemical and biophysical research communications, 363(4), 1013-1019 (2007-10-12) Open season for hunting and trapping post-translational cysteine modifications in proteins and enzymes.Claus Jacob et al.Chembiochem : a European journal of chemical biology, 12(6), 841-844 (2011-03-30) Chemical dissection of an essential redox switch in yeast.Candice E Paulsen et al.Chemistry & biology, 16(2), 217-225 (2009-02-24) The Journal of Organic Chemistry, 58, 3960-3960 (1993) Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.Patrick M Dansette et al.Chemical research in toxicology, 23(7), 1268-1274 (2010-06-19) Agonist- and hydrogen peroxide-mediated oxidation of the β2 adrenergic receptor: evidence of receptor s-sulfenation as detected by a modified biotin-switch assay.Rebecca N Burns et al.The Journal of pharmacology and experimental therapeutics, 339(3), 914-921 (2011-09-16) Sphaeropsidones, phytotoxic dimedone methyl ethers produced by Diplodia cupressi: a structure-activity relationship study.Antonio Evidente et al.Journal of natural products, 74(4), 757-763 (2011-02-24) [Method for endogenous formaldehyde evaluation in animal organism].C H Shandrenko et al.Ukrains'kyi biokhimichnyi zhurnal (1999 ), 83(6), 110-115 (2012-03-01) Formation and reactions of sulfenic acid in human serum albumin.Beatriz Alvarez et al.Methods in enzymology, 473, 117-136 (2010-06-02) Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation.Joseph R Burgoyne et al.Biochemical Society transactions, 39(5), 1260-1267 (2011-09-23) Potential role of formaldehyde in the mechanism of action of ascorbigens on the basis of BioArena studies.György Kátay et al.Biomedical chromatography : BMC, 23(4), 412-418 (2008-11-29) Possibilities and pitfalls in quantifying the extent of cysteine sulfenic acid modification of specific proteins within complex biofluids.Douglas S Rehder et al.BMC biochemistry, 11, 25-25 (2010-07-03)

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