Melting point	-74 ºC
Water Solubility	slightly soluble
Boiling point	121 ºC
Flash point	35 ºC
Density	0.842
Refractive index	1.3923

Symbol(GHS)	Xi
Hazard Codes	R10;R37/38;R41
SDS/MSDS	S16;S26;S36

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Two cases of airborne allergic contact dermatitis caused by methylisothiazolinone in paint.Michael D Lundov et al.Contact dermatitis, 65(3), 176-179 (2011-08-11) Contact sensitization to methylisothiazolinone in Finland--a multicentre study.Leena Ackermann et al.Contact dermatitis, 64(1), 49-53 (2010-12-21) Mechanistic assessment of peptide reactivity assay to predict skin allergens with Kathon CG isothiazolinones.Julien Mutschler et al.Toxicology in vitro : an international journal published in association with BIBRA, 23(3), 439-446 (2009-05-16) Allergic contact dermatitis caused by methylisothiazolinone from different sources, including 'mislabelled' household wet wipes.Lucie Vanneste et al.Contact dermatitis, 69(5), 311-312 (2013-10-15) Topography and extent of pulmonary vagus nerve supply with respect to transthoracic oesophagectomy.Teus J Weijs et al.Journal of anatomy, 227(4), 431-439 (2015-09-10) Methylisothiazolinone contact allergy--growing epidemic.Michael D Lundov et al.Contact dermatitis, 69(5), 271-275 (2013-10-15) Identifying the optimal patch test concentration for methylchloroisothiazolinone and methylisothiazolinone.E Davies et al.Contact dermatitis, 60(5), 288-289 (2009-04-29) Presumed primary contact sensitization to methylisothiazolinone from paint: a chemical that became airborne.Jeanette Kaae et al.Contact dermatitis, 66(6), 341-342 (2012-05-10) Methylisothiazolinone contact allergy: a review.M D Lundov et al.The British journal of dermatology, 165(6), 1178-1182 (2011-07-23) Methylisothiazolinone: dermal and respiratory immune responses in mice.Fien C Devos et al.Toxicology letters, 235(3), 179-188 (2015-04-25) Methylchloroisothiazolinone and methylisothiazolinone allergic contact dermatitis and the effect of patch test concentration.Eleanor Higgins et al.Dermatitis : contact, atopic, occupational, drug, 24(2), 73-76 (2013-03-12) Delayed hypersensitivity to methylchloroisothiazolinone/methylisothiazolinone not detected by the baseline series of the Spanish group.Laura Cuesta et al.Contact dermatitis, 62(4), 250-251 (2010-05-04) Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008.Cecilia Svedman et al.Contact dermatitis, 67(5), 312-314 (2012-10-09) Methylisothiazolinone.Mari Paz Castanedo-Tardana et al.Dermatitis : contact, atopic, occupational, drug, 24(1), 2-6 (2013-01-24) Determination of preservatives in cosmetics, cleaning agents and pharmaceuticals using fast liquid chromatography.Irena Baranowska et al.Journal of chromatographic science, 52(1), 88-94 (2013-01-18) Effects of 5-chloro-2-methyl-4-isothiazolin-3-one and other candidate biodiesel biocides on rat alveolar macrophages and NR8383 cells.R Poon et al.Archives of toxicology, 85(11), 1419-1427 (2011-03-30) Recommendation to include methylisothiazolinone in the European baseline patch test series--on behalf of the European Society of Contact Dermatitis and the European Environmental and Contact Dermatitis Research Group.Magnus Bruze et al.Contact dermatitis, 69(5), 263-270 (2013-10-15) Occupational contact dermatitis in painters: an analysis of patch test data from the Danish Contact Dermatitis Group.Anja P Mose et al.Contact dermatitis, 67(5), 293-297 (2012-05-04) Concomitant contact allergy to methylchloroisothiazolinone/methylisothiazolinone and formaldehyde-releasing preservatives.Barry N Statham et al.Contact dermatitis, 62(1), 56-57 (2010-02-09) The hazards of moist toilet paper: allergy to the preservative methylchloroisothiazolinone/methylisothiazolinone.Kevin H Gardner et al.Archives of dermatology, 146(8), 886-890 (2010-06-23) Recent increase in allergic reactions to methylchloroisothiazolinone/methylisothiazolinone: is methylisothiazolinone the culprit?Johannes Geier et al.Contact dermatitis, 67(6), 334-341 (2012-09-22) Moist toilet paper: allergy to the nonhalogenated derivative methylisothiazolinone preservative alone.Juan García-Gavín et al.Archives of dermatology, 146(10), 1186-1186 (2010-10-20) Methylisothiazolinone, an emerging allergen in cosmetics?Juan García-Gavín et al.Contact dermatitis, 63(2), 96-101 (2010-07-16) Airborne exposure to preservative methylisothiazolinone causes severe allergic reactions.Michael Dyrgaard Lundov et al.BMJ (Clinical research ed.), 345, e8221-e8221 (2012-12-06) Contact allergy to methylisothiazolinone in a deodorant.Cristina Amaro et al.Contact dermatitis, 64(5), 298-299 (2011-04-13) Ubiquitous preservative blamed for rash of skin allergies.Catherine Cross CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 185(15), E712-E712 (2013-09-18) Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a contact dermatitis unit.Paula Maio et al.Cutaneous and ocular toxicology, 31(2), 151-153 (2011-11-05) Airborne exposure to methylchloroisothiazolinone and methylisothiazolinone from a toilet cleaner.Michael D Lundov et al.Contact dermatitis, 68(4), 252-253 (2013-03-21) Sensitization to methylisothiazolinone in a group of methylchloroisothiazolinone/methylisothiazolinone allergic patients.Vasco Coelho Macias et al.Cutaneous and ocular toxicology, 32(2), 99-101 (2012-08-11) Methylisothiazolinone contact allergy and dose-response relationships.Michael D Lundov et al.Contact dermatitis, 64(6), 330-336 (2011-04-21) Airborne and systemic dermatitis, mimicking atopic dermatitis, caused by methylisothiazolinone in a young child.Olivier Aerts et al.Contact dermatitis, 68(4), 250-251 (2013-03-21) Allergic contact dermatitis caused by methylisothiazolinone from a 'waist reduction belt'.Wolfgang Uter et al.Contact dermatitis, 66(6), 347-348 (2012-05-10) Methylchloroisothiazolinone/methylisothiazolinone contact sensitization: diverging trends in subgroups of IVDK patients in a period of 19 years.Wolfgang Uter et al.Contact dermatitis, 67(3), 125-129 (2012-05-09) Methylchloroisothiazolinone and methylisothiazolinone contact allergy: a new 'epidemic'.Rachel Urwin et al.Contact dermatitis, 68(4), 253-255 (2013-03-21) Abnormal visual processing and increased seizure susceptibility result from developmental exposure to the biocide methylisothiazolinone.A Spawn et al.Neuroscience, 205, 194-204 (2012-01-17) Final report of the safety assessment of methylisothiazolinone.Christina L Burnett et al.International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22) Methylisothiazolinone is categorised as a strong sensitiser in the Murine Local Lymph Node Assay.David W Roberts Contact dermatitis, 69(5), 261-262 (2013-10-15)

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