Melting point	-5.5 ºC
Water Solubility	practically insoluble
Boiling point	234 ºC
Flash point	79 ºC
Density	0.756
Refractive index	1.424-1.426

SDS/MSDS	S24/25

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Peer-Reviewed Papers

Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.W H Tolleson et al.International journal of oncology, 14(5), 833-843 (1999-04-14) Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation.Arthur J L Cooper et al.Biochemical pharmacology, 65(2), 181-192 (2002-12-31) 3-Chloro-DL-alanine resistance by L-methionine-alpha-deamino-gamma-mercaptomethane-lyase activity.Mamiko Yoshimura et al.FEBS letters, 523(1-3), 119-122 (2002-07-19) Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn.Brooke S Wright et al.Archives of biochemistry and biophysics, 415(2), 184-192 (2003-07-02) A novel way of amino acid-specific assignment in 1 H-15 N HSQC spectra with a wheat germ cell-free protein synthesis systemMorita EH, et al. Journal of Biomolecular Nmr, 30(1), 37-45 (2004) Structural and mutational studies on substrate specificity and catalysis of Salmonella typhimurium D-cysteine desulfhydrase.Sakshibeedu R Bharath et al.PloS one, 7(5), e36267-e36267 (2012-05-11) Inositol phosphoceramide synthase is a regulator of intracellular levels of diacylglycerol and ceramide during the G1 to S transition in Saccharomyces cerevisiae.Jorge Cerbón et al.The Biochemical journal, 388(Pt 1), 169-176 (2004-11-25) Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growthBeuster G, et al. The Journal of Biological Chemistry, jbc-M110 (2011) Role of tyrosine 265 of alanine racemase from Bacillus stearothermophilus.A Watanabe et al.Journal of biochemistry, 125(6), 987-990 (1999-06-01) Entamoeba invadens: sphingolipids metabolic regulation is the main component of a PKC signaling pathway in controlling cell growth and proliferation.Jorge Cerbon et al.Experimental parasitology, 122(2), 106-111 (2009-03-03) Inhibition of skin sphingosine synthesis: enhanced percutaneous permeation of 5-fluorouracil.M Gupta et al.Die Pharmazie, 59(3), 212-216 (2004-04-13) N-chloroamino acids cause oxidative protein modifications in the erythrocyte membrane.Agnieszka Robaszkiewicz et al.Mechanisms of ageing and development, 129(10), 572-579 (2008-07-01) A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.Noriaki Shimizu et al.Nature communications, 6, 6693-6693 (2015-04-02) De novo synthesis and recycling pathways of sphingomyelin in rat Sertoli cells.A L Ziulkoski et al.Biochemical and biophysical research communications, 281(4), 971-975 (2001-03-10) Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis.Mariarita Bertoldi et al.Biochimica et biophysica acta, 1784(9), 1356-1362 (2008-05-22) Skin lipid synthesis inhibition: a possible means for enhancing percutaneous delivery of levodopa.Kumar Babita et al.Current drug delivery, 1(4), 397-403 (2005-11-25) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) The effect of beta-chloro D-alanine and L-cycloserine on the serine, phosphorus and palmitic acid uptake and metabolism of Tetrahymena lipids.P Kovács Acta biologica Hungarica, 50(4), 363-373 (2000-03-29) Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133Song Y, et al. Scientific Reports, 8(1), 16100-16100 (2018) Mitochondrial aspartate aminotransferase catalyses cysteine S-conjugate beta-lyase reactions.Arthur J L Cooper et al.The Biochemical journal, 368(Pt 1), 253-261 (2002-07-26) NMR assignment of protein side chains using residue-correlated labeling and NOE spectra.Geoffrey A Mueller et al.Journal of magnetic resonance (San Diego, Calif. : 1997), 165(2), 237-247 (2003-12-04) Enzymatic assay of gamma-cystathionase activity using pyruvate oxidase-peroxidase sequential reaction.Yuki Ogasawara et al.Journal of biochemical and biophysical methods, 51(2), 139-150 (2002-06-14) Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells: a novel evaluation system using an SPT-defective mammalian cell mutantHanada K, et al. Biochemical Pharmacology, 59(10), 1211-1216 (2000) Synergic activity of D-cycloserine and beta-chloro-D-alanine against Mycobacterium tuberculosis.S David The Journal of antimicrobial chemotherapy, 47(2), 203-206 (2001-02-07) L-alanine-glyoxylate aminotransferase II of rat kidney and liver mitochondria possesses cysteine S-conjugate beta-lyase activity: a contributing factor to the nephrotoxicity/hepatotoxicity of halogenated alkenes?Arthur J L Cooper et al.The Biochemical journal, 376(Pt 1), 169-178 (2003-07-16) [Regulation of key enzymes of L-alanine biosynthesis by Brevibacterium flavum producer strains].L O Melkonian et al.Prikladnaia biokhimiia i mikrobiologiia, 49(2), 144-148 (2013-06-26) Stereochemistry of reactions of the inhibitor/substrates L- and D-beta-chloroalanine with beta-mercaptoethanol catalysed by L-aspartate aminotransferase and D-amino acid aminotransferase respectively.Benjamin Adams et al.Organic & biomolecular chemistry, 3(18), 3357-3364 (2005-09-01) Serine 51 residue of Citrobacter freundii tyrosine phenol-lyase assists in C-alpha-proton abstraction and transfer in the reaction with substrateBarbolina MV, et al. Biochimie, 147(1), 63-69 (2018) Characterization of an alanine racemase gene from Lactobacillus reuteri.Arthur Thompson et al.Current microbiology, 44(4), 246-250 (2002-03-23) Reactions of serine palmitoyltransferase with serine and molecular mechanisms of the actions of serine derivatives as inhibitors.Hiroko Ikushiro et al.Biochemistry, 43(4), 1082-1092 (2004-01-28) Role of sphingosine synthesis inhibition in transcutaneous delivery of levodopa.Babita S Gupta et al.International journal of pharmaceutics, 238(1-2), 43-50 (2002-05-09) Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction.Subramanian Karthikeyan et al.Biochemistry, 43(42), 13328-13339 (2004-10-20) Affinity labeling of alanine aminotransferase by 3-chloro-L-alanine.Y Morino et al.The Journal of biological chemistry, 254(2), 279-285 (1979-01-25)

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