Melting point	164 ºC
Water Solubility	116 g/L (30 ºC)

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
TCI	View & Download
Acros-Organics	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.R Scott Obach et al.Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1385-1405 (2008-04-23) Measurement of unbound bilirubin by the peroxidase test using Zone Fluidics.Charles E Ahlfors et al.Clinica chimica acta; international journal of clinical chemistry, 365(1-2), 78-85 (2005-09-20) Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Lourdes Santana et al.Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07) Factors influencing the protein binding of IQO4, a new isoquinolinedione derivative.Y J Moon et al.Research communications in molecular pathology and pharmacology, 108(3-4), 167-177 (2002-03-27) [Bacteriology and response to treatment with erythromycin-sulfisoxazole in children with acute otitis media].R S Rodríguez et al.Boletin medico del Hospital Infantil de Mexico, 44(12), 728-734 (1987-12-01) Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.Manthena V S Varma et al.Journal of medicinal chemistry, 53(3), 1098-1108 (2010-01-15) The effect of pH and triethanolamine on sulfisoxazole complexation with hydroxypropyl-beta-cyclodextrin.Granero Gladys et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 20(3), 285-293 (2003-11-01) Sulfafurazole (sulphisoxazole). IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 24, 275-284 (1980-01-01) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) New Ni(II)-sulfonamide complexes: synthesis, structural characterization and antibacterial properties. X-ray diffraction of [Ni(sulfisoxazole)2(H2O)4].2H2O and [Ni(sulfapyridine)2].Melina Mondelli et al.Journal of inorganic biochemistry, 102(2), 285-292 (2007-11-03) UDP-glucuronosyltransferases and clinical drug-drug interactions.Tony K L Kiang et al.Pharmacology & therapeutics, 106(1), 97-132 (2005-03-23) Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole.Hanne Tegnander Soligard et al.Phytotherapy research : PTR, 25(7), 1068-1072 (2011-02-01) Methyl gallate from Galla rhois successfully controls clinical isolates of Salmonella infection in both in vitro and in vivo systems.Jang-Gi Choi et al.PloS one, 9(7), e102697-e102697 (2014-07-23) The impact of hepatic uptake on the pharmacokinetics of organic anions.Philip Gardiner et al.Drug metabolism and disposition: the biological fate of chemicals, 39(10), 1930-1938 (2011-07-23) Antimicrobial susceptibility of Listeria monocytogenes isolated from meningoencephalitis in sheep.A I Vela et al.International journal of antimicrobial agents, 17(3), 215-220 (2001-04-03) Pharmacokinetic of sulfisoxazole in aqueous humor after topical and subconjunctival application in dogs.Gokhan Eraslan et al.Pakistan journal of biological sciences : PJBS, 10(22), 4168-4170 (2008-12-19) [Determination of 12 sulfonamides in cosmetics by ultra performance liquid chromatography].Hehui Zheng et al.Se pu = Chinese journal of chromatography, 25(2), 238-240 (2007-06-22) Computational aqueous solubility prediction for drug-like compounds in congeneric series.Lei Du-Cuny et al.European journal of medicinal chemistry, 43(3), 501-512 (2007-06-19) Chemometric and derivative methods as flexible spectrophotometric approaches for dissolution and assaying tests in multicomponent tablets.Catherine K Markopoulou et al.Farmaco (Societa chimica italiana : 1989), 59(8), 627-636 (2004-07-21) Adenoidectomy versus chemoprophylaxis and placebo for recurrent acute otitis media in children aged under 2 years: randomised controlled trial.Petri Koivunen et al.BMJ (Clinical research ed.), 328(7438), 487-487 (2004-02-11) Rapid analysis of multiclass antibiotic residues and some of their metabolites in hospital, urban wastewater and river water by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometryGros M, et al. Journal of Chromatography A, 1292(1), 173-188 (2013) Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.Xiaoning Lei et al.Environmental science and pollution research international, 22(3), 1670-1678 (2014-05-09) Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.Yong-Gang Zhao et al.Journal of chromatography. A, 1345, 17-28 (2014-05-02) Simultaneous determination of sulfonamides and metabolites in manure samples by one-step ultrasound/microwave-assisted solid-liquid-solid dispersive extraction and liquid chromatography-mass spectrometry.Hui-zhen Wu et al.Analytical and bioanalytical chemistry, 407(13), 3545-3554 (2015-03-04) Prevalence of Salmonella cerro in laboratory-based submissions of cattle and comparison with human infections in Pennsylvania, 2005-2010.Deepanker Tewari et al.Foodborne pathogens and disease, 9(10), 928-933 (2012-09-08) Involvement of imidazoline and opioid receptors in the enhancement of clonidine-induced analgesia by sulfisoxazole.Mustufa Boxwalla et al.Canadian journal of physiology and pharmacology, 88(5), 541-552 (2010-06-18) High-throughput multiclass method for antibiotic residue analysis by liquid chromatography-tandem mass spectrometryChico J, et al. Journal of Chromatography A, 1213(2), 189-199 (2008) Displacement of bilirubin from albumin by ibuprofen in vitro.Hanne T Soligard et al.Pediatric research, 67(6), 614-618 (2010-03-11) Human metapneumovirus: an emerging respiratory pathogen.Joseph P Mazzoncini et al.The Journal of emergency medicine, 38(4), 456-459 (2008-07-01) Rescue of pulmonary hypertension with an oral sulfonamide antibiotic sulfisoxazole by endothelin receptor antagonistic actions.Tomoko Uchino et al.Hypertension research : official journal of the Japanese Society of Hypertension, 31(9), 1781-1790 (2008-10-31) Antibiotic resistance in Escherichia coli isolated from retail raw chicken meat in Taif, Saudi Arabia.Abdullah D Altalhi et al.Foodborne pathogens and disease, 7(3), 281-285 (2009-11-17) Effect of ibuprofen on bilirubin-albumin binding.Charles E Ahlfors The Journal of pediatrics, 144(3), 386-388 (2004-03-06) Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.Alfonso Pérez-Garrido et al.Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06) The use of sequential studies in a salmonellosis outbreak linked to continental custard cakes.B Ward et al.Epidemiology and infection, 129(2), 287-293 (2002-10-31) A simple, fast and cheap non-SPE screening method for antibacterial residue analysis in milk and liver using liquid chromatography-tandem mass spectrometry.Magda Targa Martins et al.Talanta, 129, 374-383 (2014-08-17) Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.Ilaria Massarelli et al.European journal of medicinal chemistry, 44(9), 3658-3664 (2009-03-11) Genotyping and antimicrobial resistance patterns of Escherichia coli O157 originating from cattle farms.Katrijn Cobbaut et al.Foodborne pathogens and disease, 8(6), 719-724 (2011-03-09) Application of ion-exchange cartridge clean-up in food analysis: V. Simultaneous determination of sulphonamide antibacterials in animal liver and kidney using high-performance liquid chromatography with ultraviolet and mass spectrometric detectionIto Y, et al. Journal of Chromatography A, 898(1), 95-102 (2000) Solvatochromic and fluorescence behavior of sulfisoxazole.Abdulilah Dawoud Bani-Yaseen Journal of fluorescence, 21(3), 1061-1067 (2010-12-25) Physicochemical determinants of human renal clearance.Manthena V S Varma et al.Journal of medicinal chemistry, 52(15), 4844-4852 (2009-05-19) Characterization of antimicrobial resistance and seasonal prevalence of Escherichia coli O157:H7 recovered from commercial feedlots in Alberta, Canada.M Aslam et al.Letters in applied microbiology, 50(3), 320-326 (2010-01-28) Sulfisoxazole, an endothelin receptor antagonist, protects retinal neurones from insults of ischemia/reperfusion or lipopolysaccharide.Husnain Syed et al.Neurochemistry international, 48(8), 708-717 (2006-02-09) Quantitative analysis of twelve sulfonamides in honey after acidic hydrolysis by high-performance liquid chromatography with post-column derivatization and fluorescence detectionMaudens KE, et al. Journal of Chromatography A, 1047(1), 85-92 (2004) An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.Helen Hurst et al.Reproductive toxicology (Elmsford, N.Y.), 28(4), 503-510 (2009-08-04) Comprehensive fast multiresidue screening of 150 veterinary drugs in milk by ultra-performance liquid chromatography coupled to time of flight mass spectrometryOrtelli D, et al. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877(23), 2363-2374 (2009) Antimicrobial prophylaxis for infants at risk for recurrent acute otitis media.D W Teele et al.Vaccine, 19 Suppl 1, S140-S143 (2001-02-13)

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