Melting point	215 ºC**
Boiling point	225.1±23.0 ºC (760 Tor
Flash point	90.0±22.6 ºC, 计算值*
Density	1.159±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Multiple actions of the coumarine derivative cloricromene and its protective effects on ischemic brain injury.G Calapai et al.Naunyn-Schmiedeberg's archives of pharmacology, 351(2), 209-215 (1995-02-01) Differential inhibition of polymorphonuclear leucocyte functions by cloricromene.A Zatta et al.Pharmacological research, 40(6), 525-533 (2000-02-08) Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats.Claudio Bucolo et al.Investigative ophthalmology & visual science, 44(3), 1178-1184 (2003-02-26) Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats.Carmelo Muià et al.Naunyn-Schmiedeberg's archives of pharmacology, 373(1), 51-59 (2006-03-31) The Mitochondrial Small Heat Shock Protein HSP22 from Pea is a Thermosoluble Chaperone Prone to Co-Precipitate with Unfolding Client Proteins.Marie-Hélène Avelange-Macherel et al.International journal of molecular sciences, 21(1) (2019-12-28) In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form.Eliana Leo et al.International journal of pharmaceutics, 278(1), 133-141 (2004-05-26) Stimulated Adsorption of Humic Acids on Capped Plasmonic Ag Nanoparticles Investigated by Surface-Enhanced Optical Techniques.Ornella Francioso et al.Langmuir : the ACS journal of surfaces and colloids, 35(13), 4518-4526 (2019-02-15) Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation.E Ribaldi et al.British journal of pharmacology, 118(6), 1351-1358 (1996-07-01) Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene.Rosario Pignatello et al.AAPS PharmSciTech, 7(1), E27-E27 (2006-04-06) Cloricromene in endotoxemia: role of NF-kappaB.A Ianaro et al.Naunyn-Schmiedeberg's archives of pharmacology, 370(2), 140-145 (2004-08-24) Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.D Altavilla et al.The American journal of physiology, 268(4 Pt 2), H1412-H1417 (1995-04-01) Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.Xinan Shi et al.Oncology reports, 40(3), 1592-1600 (2018-06-30) Effect of cloricromene on intermittent claudication. A randomized, double-blind, placebo-controlled trial in patients treated with aspirin: effect on claudication distance and quality of life. CRAMPS Investigator Group. Cloricromene Randomized Arteriopathy Multicenter Prospective Study.P Gresele et al.Vascular medicine (London, England), 5(2), 83-89 (2000-08-16) Liquefying Compounds by Forming Deep Eutectic Solvents: A Case Study for Organic Acids and Alcohols.Dinis O Abranches et al.The journal of physical chemistry. B, 124(20), 4174-4184 (2020-04-24) Cloricromene, a semi-synthetic coumarin derivative, inhibits tumor necrosis factor-alpha production at a pre-transcriptional level.E Corsini et al.European journal of pharmacology, 418(3), 231-237 (2001-05-10) Enhancement of availability of cloricromene at brain level by a lipophilic prodrug.R Pignatello et al.The Journal of pharmacy and pharmacology, 58(7), 1001-1005 (2006-06-30) Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene.Claudio Bucolo et al.The Journal of pharmacy and pharmacology, 56(7), 841-846 (2004-07-06) Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits.Eugenio Ragazzi et al.Life sciences, 78(8), 785-794 (2005-08-30) Comprehensive characterization of T-DNA integration induced chromosomal rearrangement in a birch T-DNA mutant.Huixin Gang et al.BMC genomics, 20(1), 311-311 (2019-04-25) Simultaneous determination of cloricromene and its active metabolite in rabbit aqueous humor by high-performance liquid chromatography.Adriana Maltese et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 767(1), 153-158 (2002-02-28) Intradermal injection vs. oral treatment of tinnitus.M Savastano et al.Therapie, 56(4), 403-407 (2001-10-27) A protective effect of the synthetic coumarine derivative Cloricromene against DNB-colitis in the rat.Walter Fries et al.Life sciences, 74(22), 2749-2756 (2004-03-27) Effects of cloricromene on the levels of endothelin and on the microcirculatory function in peripheral atherosclerotic arteriopathies.A Saitta et al.Pharmacology, 52(1), 8-15 (1996-01-01) Retinal and systemic pharmacokinetics of the anti-inflammatory drug cloricromene following oral administration in the rat and rabbit.Claudio Bucolo et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 23(3), 257-263 (2007-06-27) Cloricromene reduces myocardial infarct size in rabbits when administered during the early reperfusion period.D A Zvara et al.Anesthesia and analgesia, 84(2), 266-270 (1997-02-01) Participation of tumour necrosis factor and nitric oxide in the mediation of vascular dysfunction in splanchnic artery occlusion shock.F Squadrito et al.British journal of pharmacology, 113(4), 1153-1158 (1994-12-01) Preparation and characterization of solid lipid nanoparticles containing cloricromene.M L Bondì et al.Drug delivery, 10(4), 245-250 (2003-11-13) Protective effects of a coumarin derivative in diabetic rats.Claudio Bucolo et al.Investigative ophthalmology & visual science, 50(8), 3846-3852 (2009-03-13) Cloricromene reduces infarct size and alters postischaemic blood flow defects in dog myocardium.L Groban et al.Clinical and experimental pharmacology & physiology, 25(6), 417-423 (1998-07-23)

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