Boiling point	121-122 ºC (30 mmHg)
Flash point	62 ºC
Density	1.129
Refractive index	1.407

Symbol(GHS)	C
Hazard Codes	R34
SDS/MSDS	S25;S36/37/39;S45

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
Acros-Organics	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Simultaneous determination of sulpiride and mebeverine by HPLC method using fluorescence detection: application to real human plasmaWalash IM, et al. Chemistry Central Journal, 6(1), 1192-1200 (2012) First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma.M Walash et al.Journal of fluorescence, 20(6), 1275-1285 (2010-07-08) Validated LC-MS/MS method for determination of Alverine and one of its hydroxy metabolites in human plasma along with its application to a bioequivalence study.Noel A Gomes et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(3), 197-206 (2008-12-27) Colloids as a sink for certain pharmaceuticals in the aquatic environment.Khalid Maskaoui et al.Environmental science and pollution research international, 17(4), 898-907 (2009-12-22) [Significance of biliary dysfunction in the pathogenesis of gallstone disease].I A Il'chenko et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (7)(7), 70-78 (2012-03-01) Support vector regression and artificial neural network models for stability indicating analysis of mebeverine hydrochloride and sulpiride mixtures in pharmaceutical preparation: a comparative study.Ibrahim A Naguib et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 86, 515-526 (2011-12-06) A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome.Mahnaz Darvish-Damavandi et al.World journal of gastroenterology, 16(5), 547-553 (2010-02-04) [The effectiveness of spasmolytic therapy in chronic acalculous cholecystitis].O V Shaĭkhutdinova et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (2)(2), 115-118 (2009-06-26) Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.Eglal Adelhamid Abdelaleem et al.Pakistan journal of pharmaceutical sciences, 26(1), 175-183 (2012-12-25) Development and validation of stability indicating HPLC and HPTLC methods for determination of sulpiride and mebeverine hydrochloride in combination.Ibrahim A Naguib et al.European journal of medicinal chemistry, 45(9), 3719-3725 (2010-06-12) [How to raise efficacy of gastroesophageal reflux disease treatment].Ia M Vakhrushev et al.Terapevticheskii arkhiv, 81(2), 27-30 (2009-04-02) Fiber-based liquid-phase micro-extraction of mebeverine enantiomers followed by chiral high-performance liquid chromatography analysis and its application to pharmacokinetics study in rat plasma.Mehdi Hatami et al.Chirality, 24(8), 634-639 (2012-06-16) Quality of life in patients with irritable bowel syndrome.Hubert Mönnikes Journal of clinical gastroenterology, 45 Suppl, S98-101 (2011-07-14) [A method for non-medicamentous treatment of irritated bowel syndrome].D Iu Sobin et al.Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury, (3)(3), 19-22 (2009-07-30) Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.Ghassan Z Abdullah et al.Pharmaceutical development and technology, 16(4), 331-342 (2010-05-01) Validated HPLC determination of the two fixed dose combinations (chlordiazepoxide hydrochloride and mebeverine hydrochloride; carvedilol and hydrochlorothiazide) in their tablets.Rim S Haggag et al.Journal of AOAC International, 93(4), 1192-1200 (2010-10-07) [Modern approaches to the therapy of biliary system diseases].A R Galiullin et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (4)(4), 109-113 (2010-07-14) Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.Manal S Elmasry et al.Journal of pharmaceutical and biomedical analysis, 54(4), 646-652 (2010-11-26) [Efficacy of duspatalin in the treatment and prophylaxis of postcholecystectomic syndrome].E M Lipnitskiĭ et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (3)(3), 86-93 (2009-01-17) [Chronic pancreatitis: microbe-intestinal tissue complex and systemic inflammatory response].V B Grinevich et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (7)(7), 13-17 (2012-03-01) Predictors of treatment outcome after cognitive behavior therapy and antispasmodic treatment for patients with irritable bowel syndrome in primary care.Silje Endresen Reme et al.Journal of psychosomatic research, 68(4), 385-388 (2010-03-24) Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial).Hazel A Everitt et al.BMC gastroenterology, 10, 136-136 (2010-11-23) [Effectiveness of duspatalin therapy in the treatment and prevention of post-cholecystectomy syndrome].E M Lipnitskiĭ et al.Vestnik Rossiiskoi akademii meditsinskikh nauk, (1)(1), 7-11 (2011-03-15) Spatiotemporal distributions, source apportionment and potential risks of 15 pharmaceuticals and personal care products (PPCPs) in Qinzhou Bay, South China.Yefeng Cui et al.Marine pollution bulletin, 141, 104-111 (2019-04-09) Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: a multicenter, randomized clinical trial, compared with mebeverine.K J Lee et al.Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 23(12), 1098-1104 (2011-09-17) [The pain problem as a historic aspect. Pain at the biliary pathology. Mebeverine hydrochloride as a part of complex therapy].A I Paltsev et al.Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (2)(2), 83-94 (2006-07-27) Novel quality by design tools for concentrated drug suspensions: surface energy profiling and the fractal concept of flocculation.Jan Kendall de Kruif et al.Journal of pharmaceutical sciences, 102(3), 994-1007 (2013-01-03) Core/shell poly(ethylene oxide)/Eudragit fibers for site-specific release.Dong Jia et al.International journal of pharmaceutics, 523(1), 376-385 (2017-03-28) Treatment of IBS-D with 5-HT3 receptor antagonists vs spasmolytic agents: similar therapeutical effects from heterogeneous pharmacological targets.Pere Clavé Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 23(12), 1051-1055 (2011-11-19)

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