Melting point	140-145 ºC

SDS/MSDS	S24/25

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Peer-Reviewed Papers

Photo-excitation of carotenoids causes cytotoxicity via singlet oxygen production.Hiroshi Yoshii et al.Biochemical and biophysical research communications, 417(1), 640-645 (2011-12-22) Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage.Soo-Jin Heo et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(9), 3336-3342 (2012-06-28) Fucoxanthin enhances cisplatin-induced cytotoxicity via NFκB-mediated pathway and downregulates DNA repair gene expression in human hepatoma HepG2 cells.Cheng-Ling Liu et al.Marine drugs, 11(1), 50-66 (2013-01-10) Antioxidant activity of Hawaiian marine algae.Dovi Kelman et al.Marine drugs, 10(2), 403-416 (2012-03-14) Isolation of fucoxanthin from edible brown algae by microwave-assisted extraction coupled with high-speed countercurrent chromatography.Xiaohua Xiao et al.Journal of separation science, 35(17), 2313-2317 (2012-07-19) Stark fluorescence spectroscopy reveals two emitting sites in the dissipative state of FCP antennas.Md Wahadoszamen et al.Biochimica et biophysica acta, 1837(1), 193-200 (2013-09-17) Defence chemistry modulation by light and temperature shifts and the resulting effects on associated epibacteria of Fucus vesiculosus.Mahasweta Saha et al.PloS one, 9(10), e105333-e105333 (2014-11-02) Hexane fraction from Laminaria japonica exerts anti-inflammatory effects on lipopolysaccharide-stimulated RAW 264.7 macrophages via inhibiting NF-kappaB pathway.Ji-Young Lee et al.European journal of nutrition, 52(1), 409-421 (2012-04-06) Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems.Mizuki Takashima et al.Free radical research, 46(11), 1406-1412 (2012-08-21) Fucoxanthin as a major carotenoid in Isochrysis aff. galbana: Characterization of extraction for commercial applicationKim SM, et al. Journal of the Korean Society for Applied Biological Chemistry, 55(4), 477-483 (2012) A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum.Sang Min Kim et al.Applied biochemistry and biotechnology, 166(7), 1843-1855 (2012-03-01) Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A(y) mice.Fumiaki Beppu et al.Lipids in health and disease, 11, 112-112 (2012-09-12) Fucoxanthin: A promising medicinal and nutritional ingredientZhang H, et al. Evidence-Based Complementary and Alternative Medicine : ECAM, 2015 (2015) In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Abeta1-42) toxicity and aggregationAlghazwi M, et al. Neurochemistry International, 124, 215-224 (2019) Fucoxanthinol, Metabolite of Fucoxanthin, Improves Obesity-Induced Inflammation in Adipocyte Cells.Hayato Maeda et al.Marine drugs, 13(8), 4799-4813 (2015-08-08) Marine carotenoids and oxidative stress.Graziano Riccioni Marine drugs, 10(1), 116-118 (2012-03-01) Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.Kil-Nam Kim et al.Environmental toxicology and pharmacology, 35(1), 39-46 (2012-12-12) Fucoxanthin induces GADD45A expression and G1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells.Yoshiko Satomi Anticancer research, 32(3), 807-813 (2012-03-09) Comparative effects between fucoxanthinol and its precursor fucoxanthin on viability and apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231.Arlette Rwigemera et al.Anticancer research, 35(1), 207-219 (2015-01-01) Fucoxantin: a treasure from the sea.Nicolantonio D'Orazio et al.Marine drugs, 10(3), 604-616 (2012-05-23) Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathwaysZhang L, et al. Scientific Reports, 7, 46763-46763 (2017) The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity.Mieko Kaneko et al.The Journal of toxicological sciences, 38(1), 115-126 (2013-01-30) Valorization of Sargassum muticum Biomass According to the Biorefinery Concept.Elena M Balboa et al.Marine drugs, 13(6), 3745-3760 (2015-06-26) Disruption-free imaging by Raman spectroscopy reveals a chemical sphere with antifouling metabolites around macroalgae.Katharina Grosser et al.Biofouling, 28(7), 687-696 (2012-07-13) Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.Sangeetha Ravi Kumar et al.Marine drugs, 11(12), 5130-5147 (2013-12-20) A stable and efficient nuclear transformation system for the diatom Chaetoceros gracilis.Kentaro Ifuku et al.Photosynthesis research, 123(2), 203-211 (2014-10-10) Gastrointestinal Bioaccessibility and Colonic Fermentation of Fucoxanthin from the Extract of the Microalga Nitzschia laevis.Bingbing Guo et al.Journal of agricultural and food chemistry, 68(7), 1844-1850 (2019-05-14) Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health.Juan Peng et al.Marine drugs, 9(10), 1806-1828 (2011-11-11) Fucoxanthin production by heterokont microalgaePetrushkina M, et al. Algal research, 24, 387-393 (2017) Fucoxanthin alleviates palmitate-induced inflammation in RAW 264.7 cells through improving lipid metabolism and attenuating mitochondrial dysfunction.Siyu Li et al.Food & function, 11(4), 3361-3370 (2020-04-02) Anti-neoplastic effects of fucoxanthin and its deacetylated product, fucoxanthinol, on Burkitt's and Hodgkin's lymphoma cells.Senji Tafuku et al.Oncology reports, 28(4), 1512-1518 (2012-08-04) Anti-cancer mechanism and possibility of nano-suspension formulations for a marine algae product fucoxanthin.Srinivasan Muthuirulappan et al.Asian Pacific journal of cancer prevention : APJCP, 14(4), 2213-2216 (2013-06-04) Compounds associated with algal surfaces mediate epiphytic colonization of the marine macroalga Fucus vesiculosus.Tim Lachnit et al.FEMS microbiology ecology, 84(2), 411-420 (2013-01-15) The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds.Kazuo Miyashita et al.Journal of the science of food and agriculture, 91(7), 1166-1174 (2011-03-25) In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.Jun Wang et al.Marine drugs, 10(9), 2055-2068 (2012-11-03) Fucoxanthin induces apoptosis in human cervical cancer cell line HeLa via PI3K/Akt pathway.Guoliu Ye et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11261-11267 (2014-08-13) Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways.Li Zhang et al.Scientific reports, 7, 46763-46763 (2017-04-22) Chlorophyll triplet quenching by fucoxanthin in the fucoxanthin-chlorophyll protein from the diatom Cyclotella meneghiniana.Marilena Di Valentin et al.Biochemical and biophysical research communications, 427(3), 637-641 (2012-10-03) Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans.Ekaterina Lashmanova et al.Pharmacological research, 100, 228-241 (2015-08-21) Isolation of fucoxanthin and highly unsaturated monogalactosyldiacylglycerol from brown alga Fucus evanescens C Agardh and in vitro investigation of their antitumor activity.Tatiana I Imbs et al.Marine biotechnology (New York, N.Y.), 15(5), 606-612 (2013-06-12) Characterization of gene clusters encoding the fucoxanthin chlorophyll proteins of the diatom Phaeodactylum tricornutum.D Bhaya et al.Nucleic acids research, 21(19), 4458-4466 (1993-09-25) Anticholinesterase and antioxidant activities of fucoxanthin purified from the microalga Phaeodactylum tricornutum.Arthitaya Kawee-ai et al.Natural product communications, 8(10), 1381-1386 (2013-12-21) Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis.Thamaraiselvan Rengarajan et al.Nutrients, 5(12), 4978-4989 (2013-12-11) Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats.Xiaojie Hu et al.Archives of biochemistry and biophysics, 519(1), 59-65 (2012-02-01) Marine algal fucoxanthin inhibits the metastatic potential of cancer cells.Tae-Wook Chung et al.Biochemical and biophysical research communications, 439(4), 580-585 (2013-09-17) Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPARγ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways.Ching-Shu Lai et al.Journal of agricultural and food chemistry, 60(4), 1094-1101 (2012-01-10) Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells.Lavinia-Lorena Pruteanu et al.PloS one, 15(9), e0239551-e0239551 (2020-09-19) Effect of an Introduced Phytoene Synthase Gene Expression on Carotenoid Biosynthesis in the Marine Diatom Phaeodactylum tricornutum.Takashi Kadono et al.Marine drugs, 13(8), 5334-5357 (2015-08-27) Simultaneous Determination of Fucoxanthin and Its Deacetylated Metabolite Fucoxanthinol in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry.Yiping Zhang et al.Marine drugs, 13(10), 6521-6536 (2015-10-30) Triplet-triplet energy transfer in fucoxanthin-chlorophyll protein from diatom Cyclotella meneghiniana: insights into the structure of the complex.Marilena Di Valentin et al.Biochimica et biophysica acta, 1827(10), 1226-1234 (2013-07-17) Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.Cheng-Ling Liu et al.Marine drugs, 10(1), 242-257 (2012-03-01) Biological Properties of Fucoxanthin in Oil Recovered from Two Brown Seaweeds Using Supercritical CO2 Extraction.Saravana Periaswamy Sivagnanam et al.Marine drugs, 13(6), 3422-3442 (2015-06-04) Stereocontrolled total synthesis of fucoxanthin and its polyene chain-modified derivative.Takayuki Kajikawa et al.Organic letters, 14(3), 808-811 (2012-01-20) Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase.Seong-Il Kang et al.Journal of agricultural and food chemistry, 60(13), 3389-3395 (2012-03-10) Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues.Kazuto Takahashi et al.Oncology letters, 10(3), 1463-1467 (2015-12-02) Fucoxanthin content and antioxidant properties of Undaria pinnatifida.Adah Fung et al.Food chemistry, 136(2), 1055-1062 (2012-11-06) Biological activities and potential health benefits of fucoxanthin derived from marine brown algae.Se-Kwon Kim et al.Advances in food and nutrition research, 64, 111-128 (2011-11-08) The charge-transfer properties of the S2 state of fucoxanthin in solution and in fucoxanthin chlorophyll-a/c2 protein (FCP) based on stark spectroscopy and molecular-orbital theory.Lavanya Premvardhan et al.The journal of physical chemistry. B, 112(37), 11838-11853 (2008-08-30)

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