Melting point	-60 ºC
Water Solubility	3.4 g/L (20 ºC)
Boiling point	182 ºC
Flash point	63 ºC
Density	0.865
Refractive index	1.4405-1.4425

Symbol(GHS)	Xn
Hazard Codes	R22;R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Articles

Peer-Reviewed Papers

A strategy for detecting optimal ratio of cardioprotection-dependent three compounds as quality control of guan-xin-er-hao formula.Yang Wang et al.Journal of ethnopharmacology, 133(2), 735-742 (2010-11-16) [Determination of tanshinol and protocatechuic aldehyde in shenkangling granula by HPLC].Kedan Chu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(13), 1699-1701 (2010-09-25) The contribution of activating transcription factor 3 to apoptosis of human colorectal cancer cells by protocatechualdehyde, a naturally occurring phenolic compound.Jeong Rak Lee et al.Archives of biochemistry and biophysics, 564, 203-210 (2014-12-03) [Capillary electrophoresis with field-enhanced stacking for determination of water-soluble active principles in Salvia miltiorrhiza var. miltiorrhiza f. alba].Yuqin Li et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(11), 1466-1470 (2012-07-12) The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting α-glucosidase while other phenolics modulate salivary α-amylase, glucose uptake and sugar transporters.Sisir Kumar Barik et al.The Journal of nutritional biochemistry, 78, 108325-108325 (2020-01-18) In vitro antioxidant and anti-inflammatory activities of protocatechualdehyde isolated from Phellinus gilvus.Zhi-Qiang Chang et al.Journal of nutritional science and vitaminology, 57(1), 118-122 (2011-04-23) Protocatechuic aldehyde protects against experimental sepsis in vitro and in vivo.Yong Xu et al.Basic & clinical pharmacology & toxicology, 110(4), 384-389 (2011-11-05) Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster.Yuzo Nakagawa-Yagi et al.BMC complementary and alternative medicine, 12, 101-101 (2012-07-20) Synthesis and electroluminescence of novel copolymers containing crown ether spacers.Sun Q, et al. Journal of Materials Chemistry, 13(4), 800-806 (2003) [Studies on the chemical constituents of marine sponge Iotrochota sp].Yun-Qiu Li et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(4), 545-546 (2010-09-18) Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.Souichi Nakashima et al.Bioorganic & medicinal chemistry, 18(6), 2337-2345 (2010-03-02) [Study on the chemical constituents from Cyathea spinulosa].Jian-Shuang Jiang et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(4), 568-570 (2012-10-02) Synthesis of new bioactive venlafaxine analogs: Novel thiazolidin-4-ones as antimicrobials.Kavitha CV, et al. Bioorganic & Medicinal Chemistry, 14(7), 2290-2299 (2006) Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study.Di Zhao et al.European journal of mass spectrometry (Chichester, England), 17(4), 395-403 (2011-10-19) Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway.Liang Zhang et al.Toxicology and applied pharmacology, 283(1), 50-56 (2015-01-15) DJ-1-Mediated protective effect of protocatechuic aldehyde against oxidative stress in SH-SY5Y cells.Jian-Wei Gao et al.Journal of pharmacological sciences, 115(1), 36-44 (2010-12-17) [Dynamic changes of content of salvianolic acid in vegetative organs of Salvia miltiorrhiza].Hai-Yan Qin et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 32(8), 1199-1201 (2009-12-08) Protocatechualdehyde synergizes with aspirin at the platelet cyclooxygenase-1 level.Shiqing Sun et al.Planta medica, 77(17), 1898-1904 (2011-07-06) [Study on the chemical constituents of Antipathes dichotoma].Jie-Hong Ge et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(9), 1403-1405 (2011-01-20) 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout.Jian-Ming Lü et al.Biochemical pharmacology, 86(9), 1328-1337 (2013-09-03) Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation.Masahiko Imai et al.Bioorganic & medicinal chemistry, 23(13), 3788-3795 (2015-04-26) Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines.Catriona G Mortimer et al.Journal of medicinal chemistry, 49(1), 179-185 (2006-01-06) [Capillary electrophoresis fingerprints of compound Danshen Dropping Pill].Guoxiang Sun et al.Se pu = Chinese journal of chromatography, 27(4), 494-498 (2009-11-27) 3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.Chao-Bin Xue et al.Bioorganic & medicinal chemistry, 15(5), 2006-2015 (2007-01-30) Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells.Jin Boo Jeong et al.Biochemical and biophysical research communications, 430(1), 381-386 (2012-11-20) Protocatechuic aldehyde inhibits migration and proliferation of vascular smooth muscle cells and intravascular thrombosis.Chang Yoon Moon et al.Biochemical and biophysical research communications, 423(1), 116-121 (2012-05-30) Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats.Bo-bo Chang et al.Acta pharmacologica Sinica, 31(5), 638-646 (2010-04-07) Analysis of polyphenolic metabolites from in vitro gastrointestinal digested soft fruit extracts identify malvidin-3-glucoside as an inhibitor of PTP1B.Sisir Kumar Barik et al.Biochemical pharmacology, 178, 114109-114109 (2020-06-23) Synthesis and accumulation of aromatic aldehydes in an engineered strain of Escherichia coli.Aditya M Kunjapur et al.Journal of the American Chemical Society, 136(33), 11644-11654 (2014-07-31) White emission magnetic nanoparticles as chemosensors for sensitive colorimetric and ratiometric detection, and degradation of ClO⁻ and SCN⁻ in aqueous solutions based on a logic gate approach.Lihua Zhi et al.Nanoscale, 7(27), 11712-11719 (2015-06-24) Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III.Muhammed Alzweiri et al.Journal of enzyme inhibition and medicinal chemistry, 30(3), 420-429 (2014-07-30) The theoretical and experimental study on dicalcium phosphate dehydrate loading with protocatechuic aldehyde.Yuehua Guo et al.Journal of molecular modeling, 16(7), 1187-1194 (2009-12-19) Synthesis, characterization and biological evaluation of Fe (III), Co (II), Ni(II), Cu(II), and Zn(II) complexes with tetradentate Schiff base ligand derived from protocatechualdehyde with 2-aminophenol.A M Hassan et al.Applied biochemistry and biotechnology, 167(3), 581-594 (2012-05-12) Anti-tumor-initiating effects of phenolic compounds isolated from the bark of Picea jezoensis var. jezoensis.Shun-ichi Wada et al.Bioorganic & medicinal chemistry, 17(17), 6414-6421 (2009-08-04) Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis.In-Kyoung Lee et al.Bioorganic & medicinal chemistry letters, 16(21), 5621-5624 (2006-08-16) Structures and radical-scavenging activities of phenolic constituents from the bark of Picea jezoensis var. jezoensis.Shun-ichi Wada et al.Journal of natural products, 70(10), 1605-1610 (2007-10-03) Effects of ortho substituent groups of protocatechualdehyde derivatives on binding to the C1 domain of novel protein kinase C.Narsimha Mamidi et al.The journal of physical chemistry. B, 116(35), 10684-10692 (2012-08-07) Synthesis of bis-Schiff bases of isatins and their antiglycation activity.Khan KM, et al. Bioorganic & Medicinal Chemistry, 17(22), 7795-7801 (2009) [Multi-component of Cibotium baronetz decoction pieces via 1H-NMR spectroscopic analysis].Yi Sha et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(3), 371-375 (2013-05-15) Ethnobotanical survey, chemical composition, and antioxidant capacity of methanolic extract of the root bark of Annona cuneata Oliv.Farid Khallouki et al.Journal of medicinal food, 14(11), 1397-1402 (2011-08-30) Pharmacokinetics of phenolic compounds of Danshen extract in rat blood and brain by microdialysis sampling.Yun-Jing Zhang et al.Journal of ethnopharmacology, 136(1), 129-136 (2011-04-30) Protocatechuic aldehyde inhibits lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis via regulation of caspase-3.Ya-Ling Xing et al.Phytotherapy research : PTR, 26(9), 1334-1341 (2012-02-03)

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