Melting point	158-164 ºC

Symbol(GHS)	Xn
Hazard Codes	R41;R42/43
SDS/MSDS	S22;S24;S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Estragole: a weak direct-acting food-borne genotoxin and potential carcinogen.Célia Martins et al.Mutation research, 747(1), 86-92 (2012-05-09) NTP 3-month toxicity studies of estragole (CAS No. 140-67-0) administered by gavage to F344/N rats and B6C3F1 mice.D W Bristol Toxicity report series, (82)(82), 1-111 (2011-03-30) The atmospheric chemistry of trace gases and particulate matter emitted by different land uses in Borneo.A R MacKenzie et al.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 366(1582), 3177-3195 (2011-10-19) In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling.Alicia Paini et al.Mutagenesis, 27(6), 653-663 (2012-07-31) Isolation, characterization and evaluation of antimicrobial and cytotoxic activity of estragole, obtained from the essential oil of croton zehntneri (euphorbiaceae)Andrade BCT, et al. Anais da Academia Brasileira de Ciencias, 87(1), 173-182 (2015) DNA adducts derived from safrole, estragole and related compounds, and from benzene and its metabolites.D H Phillips IARC scientific publications, (125)(125), 131-140 (1994-01-01) Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract.Heibatullah Kalantari et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 26-32 (2012-09-27) Fresh aromatic herbs containing methylchavicol did not exhibit the pro-oxidative effects of pure methylchavicol on a human hepatoma cell line, HepG2.M Bidri et al.Annales pharmaceutiques francaises, 70(5), 256-263 (2012-10-02) Induction of oxidative stress as a possible mechanism of the antifungal action of three phenylpropanoids.Amber Khan et al.FEMS yeast research, 11(1), 114-122 (2010-12-01) In vitro and in vivo antimalarial activity of essential oils and chemical components from three medicinal plants found in northeastern Brazil.Magaly L Mota et al.Planta medica, 78(7), 658-664 (2012-03-24) A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes.Alicia Paini et al.Toxicology and applied pharmacology, 245(1), 57-66 (2010-02-11) Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats.E Martati et al.Chemical research in toxicology, 24(6), 818-834 (2011-03-31) Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats.Yuta Suzuki et al.Archives of toxicology, 86(10), 1593-1601 (2012-05-12) Quantification of estragole in fennel herbal teas: implications on the assessment of dietary exposure to estragole.Antonio Raffo et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(2), 370-375 (2010-11-26) In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: implications for risk assessment.Ivonne M C M Rietjens et al.Molecular nutrition & food research, 54(2), 195-207 (2009-11-28) The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole.J A Miller et al.British journal of cancer, 48(1), 1-15 (1983-07-01) Chemical composition of the essential oil of Feronia elephantum Correa.Chitra Pande et al.Natural product research, 24(19), 1807-1810 (2010-11-26) Essential oil composition of Foeniculum vulgare Mill. fruits from pharmacies in different countries.Ain Raal et al.Natural product research, 26(13), 1173-1178 (2011-08-11) Comparative study of the anti-edematogenic effects of anethole and estragole.Edson L Ponte et al.Pharmacological reports : PR, 64(4), 984-990 (2012-10-23) Determination of Estragole in Pharmaceutical Products, Herbal Teas and Herbal Extracts Using GC-FIDIsmaiel AO, et al. Journal of Applied Pharmaceutical Science, 6(12), 144-150 (2016) Detection and quantification of specific DNA adducts by liquid chromatography-tandem mass spectrometry in the livers of rats given estragole at the carcinogenic dose.Yuji Ishii et al.Chemical research in toxicology, 24(4), 532-541 (2011-03-10) [Chemical composition of essential oil obtained from Romanian fennel fruits].M Băjan et al.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 115(2), 590-594 (2011-08-30) Isolation, characterization and evaluation of antimicrobial and cytotoxic activity of estragole, obtained from the essential oil of Croton zehntneri (Euphorbiaceae).Thallita C B Andrade et al.Anais da Academia Brasileira de Ciencias, 87(1), 173-182 (2015-03-20) [Effect of hepatocarcinogenicity of estragole on the glucocorticoid-mediated induction of liver-specific enzymes and the activity of the transcription factors FOXA and HNF4 in the liver of mouse and rat].V I Kaledin et al.Biofizika, 55(2), 326-335 (2010-05-01) Comparative evaluation of two different Artemisia dracunculus L. cultivars for blood sugar lowering effects in rats.Stefanie Weinoehrl et al.Phytotherapy research : PTR, 26(4), 625-629 (2011-09-29) Effects of land use on surface-atmosphere exchanges of trace gases and energy in Borneo: comparing fluxes over oil palm plantations and a rainforest.David Fowler et al.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 366(1582), 3196-3209 (2011-10-19) The natural basil flavonoid nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat.Wasma Alhusainy et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 28-34 (2014-09-15) A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core.Ross M Denton et al.Organic & biomolecular chemistry, 10(29), 5629-5635 (2012-06-22) Constituents of aromatic plants: II. Estragole.M De Vincenzi et al.Fitoterapia, 71(6), 725-729 (2000-11-15) Matrix modulation of the bioactivation of estragole by constituents of different alkenylbenzene-containing herbs and spices and physiologically based biokinetic modeling of possible in vivo effects.Wasma Alhusainy et al.Toxicological sciences : an official journal of the Society of Toxicology, 129(1), 174-187 (2012-06-01) Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice.Yuta Suzuki et al.Mutation research, 749(1-2), 23-28 (2012-08-14) [Fennel tea: risk assessment of the phytogenic monosubstance estragole in comparison to the natural multicomponent mixture].F Iten et al.Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine, 11(2), 104-108 (2004-05-13) Determination of estragole, safrole and eugenol methyl ether in food products.Siano F, et al. Food Chemistry, 81(3), 469-475 (2003) Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect.W Alhusainy et al.Toxicology and applied pharmacology, 245(2), 179-190 (2010-03-17)

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