Melting point	83-85 ºC
Water Solubility	Insoluble
Boiling point	177-180 ºC (11 mmHg)

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
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TCI	View & Download

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Articles

Peer-Reviewed Papers

Voxelwise quantification of [(11)C](R)-rolipram PET data: a comparison between model-based and data-driven methods.Gaia Rizzo et al.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1032-1040 (2013-03-21) Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle.B R Choi et al.International journal of impotence research, 27(6), 225-232 (2015-10-09) Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.Xue-Qi Liu et al.Biochemical pharmacology, 180, 114132-114132 (2020-07-06) Phosphodiesterase Inhibitors Revert Axonal Dystrophy in Friedreich's Ataxia Mouse Model.Belén Mollá et al.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 16(2), 432-449 (2019-02-15) Phosphorylation of unique C-terminal sites of the mu-opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine.Sumita Chakrabarti et al.Journal of neurochemistry, 152(4), 449-467 (2019-09-04) The role of arachidonic acid/cyclooxygenase cascade, phosphodiesterase IV and Rho-kinase in HFatma Aydinoglu et al.Pharmacological reports : PR, 69(4), 610-615 (2017-05-16) Estradiol mediates relaxation of porcine lower esophageal sphincter.Ching-Chung Tsai et al.Steroids, 136, 56-62 (2018-05-08) Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs.Yaru Yang et al.Biochimie, 115, 59-70 (2015-05-10) Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts.Jingjing Ji et al.BMC cardiovascular disorders, 20(1), 242-242 (2020-05-26) Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.Pojeong Park et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(2), 622-631 (2016-01-14) Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival.Mara Massimi et al.Journal of cellular biochemistry, 118(6), 1401-1411 (2016-11-20) PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation.Mariya Y Radeva et al.PloS one, 9(9), e106733-e106733 (2014-09-05) Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus.Víctor Manuel Muñoz-Pérez et al.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(4), 429-437 (2017-07-15) GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.A Richard Rutter et al.The Journal of pharmacology and experimental therapeutics, 350(1), 153-163 (2014-05-03) Functional βAndré Luiz de Moura et al.Canadian journal of physiology and pharmacology, 95(9), 999-1008 (2017-05-02) Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.Leila Gobejishvili et al.The Journal of pharmacology and experimental therapeutics, 347(1), 80-90 (2013-07-28) PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3Mo SJ, et al. Biochemical and Biophysical Research Communications, 508(1), 52-59 (2019) Decrease of phosphorylated CREB and ERK in nucleus accumbens is associated with the incubation of heroin seeking induced by cues after withdrawal.Anna Sun et al.Neuroscience letters, 591, 166-170 (2015-02-26) Fatty Acid and Related Potassium Kv2 Channel Blockers: Toxicity and Physiological Actions on Mosquitoes.Fabien Démares et al.Insects, 9(4) (2018-11-06) Modification of levosimendan-induced suppression of atrial natriuretic peptide secretion in hypertrophied rat atria.Lamei Yu et al.European journal of pharmacology, 829, 54-62 (2018-04-14) A synthesized heterocyclic chalcone inhibits neutrophilic inflammation through K+ -dependent pH regulation.Shun-Chin Yang et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 7127-7143 (2020-04-11) Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation.Gopireddy Raghavender Reddy et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3458-3471 (2015-05-02) Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder.Zhuoran Wang et al.Aging, 10(9), 2394-2406 (2018-09-19) Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.Laura Rinaldi et al.Nature communications, 10(1), 2572-2572 (2019-06-14) N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury.Elisabeth Wigenstam et al.Toxicology, 328, 40-47 (2014-12-17) Inhibition of protein kinase A and GIRK channel reverses fentanyl-induced respiratory depression.Xiaonan Liang et al.Neuroscience letters, 677, 14-18 (2018-04-22) Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes.Shailesh R Agarwal et al.Frontiers in pharmacology, 9, 332-332 (2018-05-10) Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.Eva Bollen et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(11), 2497-2505 (2014-05-13) Modulation of signaling through GPCR-cAMP-PKA pathways by PDE4 depends on stimulus intensity: Possible implications for the pathogenesis of acrodysostosis without hormone resistance.Emmanuelle Motte et al.Molecular and cellular endocrinology, 442, 1-11 (2016-12-03) Modulation of proinflammatory cytokines and enzymes by polyherbal formulation Guggulutiktaka ghritam.Mohind C Mohan et al.Journal of Ayurveda and integrative medicine (2019-01-15) βTiina Keränen et al.Cytokine, 94, 1-7 (2017-02-07) Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness.Clementine J J van Zeijl et al.American journal of physiology. Endocrinology and metabolism, 307(6), E527-E537 (2014-08-15) The phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats.Miaojun Lai et al.The international journal of neuropsychopharmacology, 17(9), 1397-1407 (2014-05-17) The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice.Xin Liu et al.Psychopharmacology, 234(16), 2409-2419 (2017-05-10) Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease.Amy E Dunne et al.American journal of respiratory cell and molecular biology, 60(4), 445-453 (2018-11-06) The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs).Jolanta Wiejak et al.Biochimica et biophysica acta. Molecular cell research, 1866(2), 264-276 (2018-11-12) Beneficial effects of rolipram, a phosphodiesterase 4 specific inhibitor, on testicular torsion-detorsion injury in rats.Deniz Abat et al.Journal of pediatric surgery, 53(11), 2261-2265 (2018-05-19) Differential expressions and functions of phosphodiesterase enzymes in different regions of the rat heart.Mehmet Kürşat Derici et al.European journal of pharmacology, 844, 118-129 (2018-12-12) The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury.Sandra Marie Schaal et al.PloS one, 7(9), e43634-e43634 (2012-10-03) Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach.Artur Świerczek et al.Pharmaceutical research, 37(2), 19-19 (2020-01-04) Caffeine and rolipram affect Smad signalling and TGF-β1 stimulated CTGF and transgelin expression in lung epithelial cells.Markus Fehrholz et al.PloS one, 9(5), e97357-e97357 (2014-05-16) Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa.Loïze Maréchal et al.Biochimica et biophysica acta, 1861(2), 147-156 (2016-11-12) Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.Eva Degerman et al.Acta oto-laryngologica, 137(1), 8-15 (2016-09-30) Effects of intravenous phosphodiesterase inhibitors and corticosteroids on severe meconium aspiration syndrome.Ju-Ing Shao et al.Journal of the Chinese Medical Association : JCMA, 82(7), 568-575 (2019-07-06) Efficacy of phosphodiesterase-4 inhibitors in juvenile Batten disease (CLN3).Amy Aldrich et al.Annals of neurology, 80(6), 909-923 (2016-11-03) Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.Emilie Degagné et al.The Journal of clinical investigation, 124(12), 5368-5384 (2014-10-28) The phosphodiesterase-4 inhibitor Rolipram promotes cognitive function recovery in prenatal Escherichia coli infected offspring.Tao Zhu et al.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 33(13), 2166-2175 (2018-10-31) Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.M D Houslay et al.Biochemical Society transactions, 25(2), 374-381 (1997-05-01) Phosphodiesterase 4-targeted treatments for autoimmune diseases.Neal Kumar et al.BMC medicine, 11, 96-96 (2013-04-06) N-Docosahexaenoylethanolamine ameliorates ethanol-induced impairment of neural stem cell neurogenic differentiation.Mohammad Abdur Rashid et al.Neuropharmacology, 102, 174-185 (2015-11-21) Off-Target Effect of Sildenafil on Postsurgical Erectile Dysfunction: Alternate Pathways and Localized Delivery System.Amirali Salmasi et al.The journal of sexual medicine, 13(12), 1834-1843 (2016-11-16) Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice.Hee Jae Lee et al.International journal of molecular sciences, 20(17) (2019-08-30) PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts.Silja Meier et al.European journal of pharmacology, 812, 174-183 (2017-07-13) Paeoniflorin ameliorates ischemic neuronal damage in vitro via adenosine A1 receptor-mediated transactivation of epidermal growth factor receptor.Min Zhong et al.Acta pharmacologica Sinica, 36(3), 298-310 (2015-02-11) An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors.Chunxiang Jiang et al.ACS chemical neuroscience, 11(10), 1436-1446 (2020-04-24) ZGLP1 is a determinant for the oogenic fate in mice.So I Nagaoka et al.Science (New York, N.Y.), 367(6482) (2020-02-15) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.Euan Parnell et al.Biochimica et biophysica acta, 1853(7), 1749-1758 (2015-04-29) Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes.Sunil Yeruva et al.Frontiers in physiology, 11, 430-430 (2020-06-09) Pannexin-1 mediated ATP release in adipocytes is sensitive to glucose and insulin and modulates lipolysis and macrophage migration.Marco Tozzi et al.Acta physiologica (Oxford, England), 228(2), e13360-e13360 (2019-08-11) Pathophysiological effects of intravenous phosphodiesterase type 4 inhibitor in addition to surfactant lavage in meconium-injured newborn piglet lungs.Wei-Yu Chen et al.Pediatric pulmonology, 55(9), 2272-2282 (2020-06-02) A-Kinase Anchoring Proteins Diminish TGF-β1/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition.Haoxiao Zuo et al.Cells, 9(2) (2020-02-08) Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.Pojeong Park et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(2), 622-631 (2016-01-14) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.Euan Parnell et al.Biochimica et biophysica acta, 1853(7), 1749-1758 (2015-04-29) Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes.Sunil Yeruva et al.Frontiers in physiology, 11, 430-430 (2020-06-09) Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival.Mara Massimi et al.Journal of cellular biochemistry, 118(6), 1401-1411 (2016-11-20) PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation.Mariya Y Radeva et al.PloS one, 9(9), e106733-e106733 (2014-09-05) Preferential expression of PAPPA in human preadipocytes from omental fat.Caroline Davidge-Pitts et al.The Journal of endocrinology, 222(1), 87-97 (2014-05-02) The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation.Joseph R Hedde et al.Brain, behavior, and immunity, 64, 285-295 (2017-04-26) An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors.Chunxiang Jiang et al.ACS chemical neuroscience, 11(10), 1436-1446 (2020-04-24) ZGLP1 is a determinant for the oogenic fate in mice.So I Nagaoka et al.Science (New York, N.Y.), 367(6482) (2020-02-15) The role of arachidonic acid/cyclooxygenase cascade, phosphodiesterase IV and Rho-kinase in HFatma Aydinoglu et al.Pharmacological reports : PR, 69(4), 610-615 (2017-05-16) Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus.Víctor Manuel Muñoz-Pérez et al.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(4), 429-437 (2017-07-15) Protective effects of phosphodiesterase-4-specific inhibitor rolipram on acute ischemia-reperfusion injury in rat kidney.Emin Mammadov et al.Urology, 80(6), 1390-1390 (2012-09-27) Population-based input function and image-derived input function for [¹¹C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorder.Paolo Zanotti-Fregonara et al.NeuroImage, 63(3), 1532-1541 (2012-08-22) Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies.V Dal Piaz et al.European journal of medicinal chemistry, 35(5), 463-480 (2000-07-12) Amelioration of diabetes-induced cognitive impairment by Transient Receptor Potential Vanilloid 2 (TRPV2) channel inhibitor: Behavioral and mechanistic study.P Thapak et al.Neurochemistry international, 139, 104783-104783 (2020-07-12) Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of β1 and β3-adrenoceptor signalling.Sukanya Arcot Kannabiran et al.Molecular metabolism, 37, 100986-100986 (2020-04-05) CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts.Yasuhiko Koga et al.Allergology international : official journal of the Japanese Society of Allergology, 65(4), 406-413 (2016-04-28) Pannexin-1 mediated ATP release in adipocytes is sensitive to glucose and insulin and modulates lipolysis and macrophage migration.Marco Tozzi et al.Acta physiologica (Oxford, England), 228(2), e13360-e13360 (2019-08-11) Pathophysiological effects of intravenous phosphodiesterase type 4 inhibitor in addition to surfactant lavage in meconium-injured newborn piglet lungs.Wei-Yu Chen et al.Pediatric pulmonology, 55(9), 2272-2282 (2020-06-02) Estradiol mediates relaxation of porcine lower esophageal sphincter.Ching-Chung Tsai et al.Steroids, 136, 56-62 (2018-05-08) Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.Leila Gobejishvili et al.The Journal of pharmacology and experimental therapeutics, 347(1), 80-90 (2013-07-28) PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3Mo SJ, et al. Biochemical and Biophysical Research Communications, 508(1), 52-59 (2019) Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems.Varun Balaji et al.Autophagy, 14(12), 2139-2154 (2018-08-28) Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.Seol-Ae Lee et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(6), 2301-2313 (2017-02-23) PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3.Seo Jung Mo et al.Biochemical and biophysical research communications, 508(1), 52-59 (2018-11-24) Plasma, blood and liver tissue sample preparation methods for the separate quantification of liposomal-encapsulated prednisolone phosphate and non-encapsulated prednisolone.Evelien A W Smits et al.Journal of liposome research, 25(1), 46-57 (2014-07-02) Rolipram improves renal perfusion and function during sepsis in the mouse.Joseph H Holthoff et al.The Journal of pharmacology and experimental therapeutics, 347(2), 357-364 (2013-09-11) GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.A Richard Rutter et al.The Journal of pharmacology and experimental therapeutics, 350(1), 153-163 (2014-05-03) Functional βAndré Luiz de Moura et al.Canadian journal of physiology and pharmacology, 95(9), 999-1008 (2017-05-02) Amelioration of diabetes-induced cognitive impairment by Transient Receptor Potential Vanilloid 2 (TRPV2) channel inhibitor: Behavioral and mechanistic study.P Thapak et al.Neurochemistry international, 139, 104783-104783 (2020-07-12) Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of β1 and β3-adrenoceptor signalling.Sukanya Arcot Kannabiran et al.Molecular metabolism, 37, 100986-100986 (2020-04-05) Effects of PDE4 pathway inhibition in rat experimental stroke.Fan Yang et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(3), 362-370 (2014-09-17) Evidence for global reduction in brain cyclic adenosine monophosphate signaling in depression.James M O'Donnell et al.Biological psychiatry, 72(7), 524-525 (2012-09-11) Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.Seol-Ae Lee et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(6), 2301-2313 (2017-02-23) PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3.Seo Jung Mo et al.Biochemical and biophysical research communications, 508(1), 52-59 (2018-11-24) Multiple cAMP Phosphodiesterases Act Together to Prevent Premature Oocyte Meiosis and Ovulation.Giulia Vigone et al.Endocrinology, 159(5), 2142-2152 (2018-04-03) Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper).Yefei Pang et al.General and comparative endocrinology, 265, 180-187 (2018-03-27) "Mixed" anionic and non-ionic micellar liquid chromatography for high-speed radiometabolite analysis of positron emission tomography radioligands.Ryuji Nakao et al.Journal of chromatography. A, 1281, 54-59 (2013-02-13) Reactivation of denervated Schwann cells by neurons induced from bone marrow-derived mesenchymal stem cells.Yani Zheng et al.Brain research bulletin, 139, 211-223 (2018-03-11) Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone.Rayudu Gopalakrishna et al.Biochemical and biophysical research communications, 523(3), 678-684 (2020-01-18) Population-based input function and image-derived input function for [¹¹C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorder.Paolo Zanotti-Fregonara et al.NeuroImage, 63(3), 1532-1541 (2012-08-22) Divergent off-target effects of RSK N-terminal and C-terminal kinase inhibitors in cardiac myocytes.Konstantina Stathopoulou et al.Cellular signalling, 63, 109362-109362 (2019-07-26) Identification and local delivery of vasodilators for the reduction of ureteral contractions.Christopher X Lee et al.Nature biomedical engineering, 4(1), 28-39 (2019-12-04) Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response.Marie-Victoire Cosson et al.Journal of molecular and cellular cardiology, 131, 132-145 (2019-04-23) New and cost effective cell-based assay for Dialyzed Leukocyte Extract (DLE)-induced Jurkat cells proliferation under azathioprine treatment.F M Cardoso et al.Journal of pharmaceutical and biomedical analysis, 138, 100-108 (2017-02-13) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.Beatriz Merino et al.PloS one, 10(7), e0132884-e0132884 (2015-07-30) Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury.Matthew J Grosso et al.Neurosurgery, 75(4), 461-471 (2014-05-30) A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms.Katarzyna Lepeta et al.EMBO molecular medicine, 9(8), 1100-1116 (2017-06-18) Anti-inflammatory potential of hentriacontane in LPS stimulated RAW 264.7 cells and mice model.Vidushi Khajuria et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 92, 175-186 (2017-05-27) Evaluation of anti-inflammatory effect of Varanadi Kashayam (decoction) in THP-1-derived macrophages.J U Chinchu et al.Ayu, 39(4), 243-249 (2019-08-02) Inhibition of Tumor Necrosis Factor-α and Interleukin-1β Production in Lipopolysaccharide-Stimulated Monocytes by Methanolic Extract of Elephantopus scaber Linn and Identification of Bioactive Components.Anu P Abhimannue et al.Applied biochemistry and biotechnology, 179(3), 427-443 (2016-02-15) Habenular TCF7L2 links nicotine addiction to diabetes.Alexander Duncan et al.Nature, 574(7778), 372-377 (2019-10-18) Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems.Varun Balaji et al.Autophagy, 14(12), 2139-2154 (2018-08-28) Systemic inflammatory response syndrome-related lymphopenia is associated with adenosine AReut Riff et al.Journal of leukocyte biology, 102(1), 95-103 (2017-05-13) Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop.Jessie W Yester et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4853-4865 (2015-08-08) The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition.Xia Zhu et al.Neuropharmacology, 153, 20-31 (2019-04-27) Activity-dependent expression of Channelrhodopsin at neuronal synapses.Francesco Gobbo et al.Nature communications, 8(1), 1629-1629 (2017-11-22) Synergistic effect of caffeine and glucocorticoids on expression of surfactant protein B (SP-B) mRNA.Markus Fehrholz et al.PloS one, 7(12), e51575-e51575 (2012-12-29) Pharmacological basis for medicinal use of Lens culinaris in gastrointestinal and respiratory disorders.Munasib Khan et al.Phytotherapy research : PTR, 28(9), 1349-1358 (2014-03-13) Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.Alexandra Borodovsky et al.Journal for immunotherapy of cancer, 8(2) (2020-07-31) The antidepressant and antiinflammatory effects of rolipram in the central nervous system.J Zhu et al.CNS drug reviews, 7(4), 387-398 (2002-02-07) Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.Nazari Polidovitch et al.Journal of molecular and cellular cardiology, 132, 60-70 (2019-05-06) Regio- and enantioselective palladium-catalyzed allylic alkylation of nitromethane with monosubstituted allyl substrates: synthesis of (R)-rolipram and (R)-baclofen.Xiao-Fei Yang et al.The Journal of organic chemistry, 77(20), 8980-8985 (2012-09-21) NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control.Laurie P Sutton et al.PLoS biology, 17(10), e3000477-e3000477 (2019-10-11) Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism.Elisa Canepa et al.IUBMB life, 65(2), 127-133 (2013-01-09) The diacylglycerol kinase α (DGKα)/Akt/NF-κB feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner.Jie Chen et al.Oncogene, 38(14), 2533-2550 (2018-12-12) CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines.Matylda Roszkowska et al.Molecular biology of the cell, 27(25), 4055-4066 (2016-11-01) Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach.Sven Akkerman et al.Learning & memory (Cold Spring Harbor, N.Y.), 23(1), 29-37 (2015-12-17) Luteolin Partially Inhibits LFA-1 Expression in Neutrophils Through the ERK Pathway.Yanan Wang et al.Inflammation, 42(1), 365-374 (2018-09-27) Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression.Tyler J Alban et al.Frontiers in immunology, 11, 1191-1191 (2020-07-07) Phosphodiesterase type 4 blockade prevents platelet-mediated neutrophil recruitment at the site of vascular injury.Licia Totani et al.Arteriosclerosis, thrombosis, and vascular biology, 34(8), 1689-1696 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