Specific optical rotation	32.5 º (c=10, 1N NaOH)
Density	1.954

SDS/MSDS	S24/25

Source	SDS/MSDS Samples
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Acros-Organics	View & Download

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Peer-Reviewed Papers

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.Ana Martinez et al.Journal of medicinal chemistry, 48(23), 7103-7112 (2005-11-11) Rhodanine: a selective inhibitor of the multiplication of echovirus 12.H J Eggers et al.Science (New York, N.Y.), 167(3916), 294-297 (1970-01-16) Simultaneous trace-levels determination of Hg(II) and Pb(II) ions in various samples using a modified carbon paste electrode based on multi-walled carbon nanotubes and a new synthesized Schiff base.Abbas Afkhami et al.Analytica chimica acta, 746, 98-106 (2012-09-15) Molecular cloning and characterization of Schistosoma japonicum aldose reductase.Jian Liu et al.Parasitology research, 112(2), 549-558 (2012-11-20) Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.Xin Jin et al.European journal of medicinal chemistry, 56, 203-209 (2012-09-18) Supramolecular structure and spectral studies on mixed-ligand complexes derived from β-diketone with azodye rhodanine derivatives.A Z El-Sonbati et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 99, 353-360 (2012-10-06) Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111).Liping Zhang et al.FEBS letters, 587(22), 3681-3686 (2013-10-09) Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads.William Sinko et al.Journal of medicinal chemistry, 57(13), 5693-5701 (2014-05-16) Versatile routes to marine sponge metabolites through benzylidene rhodanines.Suresh K Kottakota et al.Organic letters, 14(24), 6310-6313 (2012-12-14) Impact of ductal plate malformation on survival with native liver in children with biliary atresia.Mohamed Safwan et al.Pediatric surgery international, 31(9), 837-843 (2015-07-05) Structural determinants of Tau aggregation inhibitor potency.Kelsey N Schafer et al.The Journal of biological chemistry, 288(45), 32599-32611 (2013-09-28) Asymmetric Michael addition of substituted rhodanines to α,β-unsaturated ketones catalyzed by bulky primary amines.Feng Yu et al.Organic letters, 14(8), 2038-2041 (2012-04-10) [Protective effect of epalrestat against high glucose-induced endothelial cell injuries].Fang Wang et al.Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 32(7), 940-943 (2012-07-24) [Recent advances in treatment of diabetic polyneuropathy].Masayuki Baba Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 5, 451-457 (2012-11-20) Development of an ESI-LC-MS-based assay for kinetic evaluation of Mycobacterium tuberculosis shikimate kinase activity and inhibition.Johayra Simithy et al.Analytical chemistry, 87(4), 2129-2136 (2015-01-30) Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors.Axel Hollmann et al.The Biochemical journal, 459(1), 161-170 (2014-01-25) Rhodanine as a privileged scaffold in drug discovery.T Tomasić et al.Current medicinal chemistry, 16(13), 1596-1629 (2009-05-16) Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein.Huan-qiu Li et al.Bioorganic & medicinal chemistry, 20(14), 4194-4200 (2012-06-29) Disruption of copper-dependent signaling pathway in the nitrofen-induced congenital diaphragmatic hernia.Toshiaki Takahashi et al.Pediatric surgery international, 31(1), 31-35 (2014-10-17) Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.W T Sing et al.Bioorganic & medicinal chemistry letters, 11(2), 91-94 (2001-02-24) Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation.Tihomir Tomašić et al.Expert opinion on drug discovery, 7(7), 549-560 (2012-05-23) Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis.Mohammad Hosein Farzaei et al.Pharmaceutical biology, 53(3), 429-436 (2014-12-05) Pro-apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells.Gwangbeom Heo et al.Oncology letters, 18(3), 3256-3264 (2019-08-28) Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine.Wenbin Wu et al.Chemical communications (Cambridge, England), 48(73), 9180-9182 (2012-08-07) Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells.Xiaolong Wang et al.Oncology reports, 33(6), 3038-3044 (2015-04-16) Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy.Hyeseung Song et al.Bioorganic & medicinal chemistry letters, 22(17), 5668-5674 (2012-08-04) In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B.Matjaž Brvar et al.Bioorganic & medicinal chemistry, 20(8), 2572-2580 (2012-03-27) Synthesis and bioactivity evaluation of rhodanine derivatives as potential anti-bacterial agents.Ming-Xia Song et al.European journal of medicinal chemistry, 54, 403-412 (2012-06-19) 5-benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials.Ondrej Zvarec et al.Bioorganic & medicinal chemistry letters, 22(8), 2720-2722 (2012-03-27) Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines.Chang-Ji Zheng et al.European journal of medicinal chemistry, 58, 112-116 (2012-11-06) Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.Chang-Ji Zheng et al.Bioorganic & medicinal chemistry letters, 22(23), 7024-7028 (2012-10-27) A rhodanine derivative CCR-11 inhibits bacterial proliferation by inhibiting the assembly and GTPase activity of FtsZ.Parminder Singh et al.Biochemistry, 51(27), 5434-5442 (2012-06-19) An antitubulin agent BCFMT inhibits proliferation of cancer cells and induces cell death by inhibiting microtubule dynamics.Ankit Rai et al.PloS one, 7(8), e44311-e44311 (2012-09-07) Optical survey of vagus nerve-related neuronal circuits in the embryonic rat brainstem.Yoko Momose-Sato et al.Neuroscience letters, 535, 140-145 (2012-12-26) Rhodanine derivatives as inhibitors of JSP-1.Neil S Cutshall et al.Bioorganic & medicinal chemistry letters, 15(14), 3374-3379 (2005-06-18) Revisiting the topic of histochemically detectable copper in various liver diseases with special focus on venous outflow impairment.Taofic Mounajjed et al.American journal of clinical pathology, 139(1), 79-86 (2012-12-29) Culture conditions for the production of a tannase of Aspergillus tamarii IMI388810 (B).Enemuor SC and Odibo FJC. African Journal of Biotechnology, 8(11), 2554-2557 (2009) Epalrestat improves diabetic wound healing via increased expression of nerve growth factor.O Nakagaki et al.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 121(2), 84-89 (2013-02-22) Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry.Thomas Mendgen et al.Journal of medicinal chemistry, 55(2), 743-753 (2011-11-15) Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on progression of diabetic neuropathy and other microvascular complications: multivariate epidemiological analysis based on patient background factors and severity of diabetic neuropathy.N Hotta et al.Diabetic medicine : a journal of the British Diabetic Association, 29(12), 1529-1533 (2012-04-18) Supramolecular structure, mixed ligands and substituents effect on the spectral studies of oxovanadium(IV) complexes of bioinorganic and medicinal relevance.A Z El-Sonbati et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 95, 627-636 (2012-05-15) Ischemic postconditioning during reperfusion attenuates oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose reductase.Shi-Hong Wen et al.Surgery, 153(4), 555-564 (2012-12-12)

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