Melting point	111-115 ºC
Water Solubility	Insoluble
Boiling point	371 ºC

SDS/MSDS	S24/25

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
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TCI	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Cyclodextrin-modified micellar electrokinetic chromatography for enantioseparations.Wan Aini Wan Ibrahim et al.Methods in molecular biology (Clifton, N.J.), 970, 349-361 (2013-01-04) Ultrasound-enhanced surfactant-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography for determination of ketoconazole and econazole nitrate in human blood.Yating Xia et al.Analytical and bioanalytical chemistry, 402(3), 1241-1247 (2011-11-08) Econazole-releasing porous space maintainers for fungal periprosthetic joint infection.Alexander M Tatara et al.Journal of materials science. Materials in medicine, 29(5), 70-70 (2018-05-13) Future of Ionic Liquids for Chiral Separations in High-Performance Liquid Chromatography and Capillary Electrophoresis.Afzal Hussain et al.Critical reviews in analytical chemistry, 49(4), 289-305 (2018-12-26) Pickering emulsions based on cyclodextrins: A smart solution for antifungal azole derivatives topical delivery.Loïc Leclercq et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 82, 126-137 (2015-12-01) Assessing anti-T. cruzi candidates in vitro for sterile cidality.Monica Cal et al.International journal for parasitology. Drugs and drug resistance, 6(3), 165-170 (2016-10-23) Periocular rash.Huan J Chang JAMA, 306(11), 1263-1264 (2011-09-22) TRPM2 contributes to antigen-stimulated Ca²⁺ influx in mucosal mast cells.Satoshi Oda et al.Pflugers Archiv : European journal of physiology, 465(7), 1023-1030 (2013-02-02) Chitosan/sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for ocular drug delivery.Azza A Mahmoud et al.International journal of pharmaceutics, 413(1-2), 229-236 (2011-05-05) Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation.Poonam Verma et al.Nanomedicine : nanotechnology, biology, and medicine, 8(4), 489-496 (2011-08-16) Stability and toxicity studies for duloxetine and econazole on Spirodela polyrhiza using chiral capillary electrophoresis.Jesús Valimaña-Traverso et al.Journal of hazardous materials, 374, 203-210 (2019-04-20) Inhibition of bone resorption by econazole in rat osteoclast-like cells through suppressing TRPV5.Peng Yan et al.Archives of pharmacal research, 34(6), 1007-1013 (2011-07-05) Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway.Chao Dong et al.American journal of cancer research, 10(1), 263-274 (2020-02-18) Optimization of a High-Throughput 384-Well Plate-Based Screening Platform with Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 15442 Biofilms.Shella Gilbert-Girard et al.International journal of molecular sciences, 21(9) (2020-04-30) Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells.Chao Dong et al.Scientific reports, 7(1), 17987-17987 (2017-12-23) Microwave-assisted microemulsion technique for production of miconazole nitrate- and econazole nitrate-loaded solid lipid nanoparticles.Rohan M Shah et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 117, 141-150 (2017-04-16) An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae.Christopher R J Agnew et al.Antimicrobial agents and chemotherapy, 56(1), 391-402 (2011-11-01) Common features of periocular tinea.S Alison Finger Basak et al.Archives of ophthalmology (Chicago, Ill. : 1960), 129(3), 306-309 (2011-03-16) HPLC enantio-separation and chiral recognition mechanism of quinolones on vancomycin CSP.Zeid A ALOthman et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1157, 122335-122335 (2020-09-02) Hydroxypropyl β-cyclodextrin nanohybrid monoliths for use in capillary electrochromatography with UV detection: application to the enantiomeric separation of adrenergic drugs, anticholinergic drugs, antidepressants, azoles, and antihistamine.Li Zhou et al.Mikrochimica acta, 187(7), 381-381 (2020-06-11) A fabric phase sorptive extraction-High performance liquid chromatography-Photo diode array detection method for the determination of twelve azole antimicrobial drug residues in human plasma and urine.Marcello Locatelli et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1040, 192-198 (2016-11-20) Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue.Songhee Han et al.Molecules and cells, 39(3), 211-216 (2016-02-18) Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels.Gui-Lan Chen et al.British journal of pharmacology, 167(6), 1232-1243 (2012-06-01) Effect of phenethyl isothiocyanate on Ca2+ movement and viability in MDCK canine renal tubular cells.I S Chen et al.Human & experimental toxicology, 31(12), 1251-1261 (2012-06-02) The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules.Chris Hamman et al.Journal of chromatography. A, 1218(43), 7886-7894 (2011-09-24) Inhibitor screening assay for neurexin-LRRTM adhesion protein interaction involved in synaptic maintenance and neurological disorders.Sudeep Karki et al.Analytical biochemistry, 587, 113463-113463 (2019-10-02) Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole.Emna El Hammi et al.The FEBS journal, 279(24), 4565-4575 (2012-10-26) Enantioselective separation of eight antihistamines with α1-acid glycoprotein-based chiral stationary phase by HPLC: Development and validation for the enantiomeric quality control.Bolin Zhu et al.Journal of pharmaceutical and biomedical analysis, 176, 112803-112803 (2019-08-24) Effect of methoxychlor on Ca(2+) movement and viability in MDCK renal tubular cells.He-Hsiung Cheng et al.Basic & clinical pharmacology & toxicology, 111(4), 224-231 (2012-03-31) Antifungal activity of econazole nitrate/cyclodextrin complex: Effect of pH and formation of complex aggregates.Phatsawee Jansook et al.International journal of pharmaceutics, 574, 118896-118896 (2019-11-26) Complementarity of phosphorylated histones H2AX and H3 quantification in different cell lines for genotoxicity screening.Laure Khoury et al.Archives of toxicology, 90(8), 1983-1995 (2015-09-26) Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents.Suhyun Kim et al.Bioorganic & medicinal chemistry letters, 22(22), 6844-6847 (2012-10-13) Oleic acid inhibits store-operated calcium entry in human colorectal adenocarcinoma cells.Celia Carrillo et al.European journal of nutrition, 51(6), 677-684 (2011-10-01) A prototype antifungal contact lens.Joseph B Ciolino et al.Investigative ophthalmology & visual science, 52(9), 6286-6291 (2011-04-30) Culturable bacteria from two Portuguese salterns: diversity and bioactive potential.Eduarda Almeida et al.Antonie van Leeuwenhoek, 113(4), 459-475 (2019-11-14) Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells.Jin-Shiung Cheng et al.Archives of toxicology, 85(10), 1257-1266 (2011-03-17) HPLC METHOD FOR SEPARATING ENANTIOMERS OF IMIDAZOLE DERIVATIVES - ANTIFUNGAL COMPOUNDS.Marzena Podolska et al.Acta poloniae pharmaceutica, 74(3), 777-784 (2018-03-08) Flow-through silica: A potential matrix for fast chromatographic enantioseparation with high enantioselectivity.Xiao-Jing Mao et al.Talanta, 178, 583-587 (2017-11-16) Evaluation of topical econazole nitrate formulations with potential for treating Raynaud's phenomenon.Dherya Bahl et al.Pharmaceutical development and technology, 24(6), 689-699 (2019-02-05) Enantioselective determination of econazole in rat plasma and its application to a pharmacokinetic study.Junyuan Zhang et al.Analytical biochemistry, 602, 113791-113791 (2020-05-31) Ultrasound-mediated topical delivery of econazole nitrate with potential for treating Raynaud's phenomenon.Saloni Daftardar et al.International journal of pharmaceutics, 580, 119229-119229 (2020-03-19) Pharmacological inhibition of TRPM8-induced gene transcription.Gerald Thiel et al.Biochemical pharmacology, 170, 113678-113678 (2019-10-28) Binding free energies of inhibitors to iron porphyrin complex as a model for Cytochrome P450.Joo Yun Lee et al.Biopolymers, 97(4), 219-228 (2011-11-25) Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes.Celia Carrillo et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 27(3-4), 373-380 (2011-04-08) Clotrimazole and econazole inhibit Streptococcus mutans biofilm and virulence in vitro.Wei Qiu et al.Archives of oral biology, 73, 113-120 (2016-10-21) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression.Brygida Bisikirska et al.Cancer research, 76(3), 664-674 (2015-11-22) Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis.Victoria Díaz-Tomé et al.Journal of pharmaceutical sciences, 107(5), 1342-1351 (2018-01-07) Comparative studies of immobilized chiral stationary phases based on polysaccharide derivatives for enantiomeric separation of 15 azole compounds.Bolin Zhu et al.Electrophoresis, 39(16), 2107-2116 (2018-05-19) A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.Pénélope A Andreux et al.Scientific reports, 4, 5285-5285 (2014-06-14) Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis.Sandra Ortega Ugalde et al.SLAS discovery : advancing life sciences R & D, 24(7), 745-754 (2019-06-19) Uncovering malathion (an organophosphate insecticide) action on Ca2+ signal transduction and investigating the effects of BAPTA-AM (a cell-permeant Ca2+ chelator) on protective responses in glial cells.Shu-Shong Hsu et al.Pesticide biochemistry and physiology, 157, 152-160 (2019-06-04) New Species of the Genus Curvularia: C. tamilnaduensis and C. coimbatorensis from Fungal Keratitis Cases in South India.Noémi Kiss et al.Pathogens (Basel, Switzerland), 9(1) (2019-12-22) Screening for potent and selective anticlostridial leads among FDA-approved drugs.Ahmed AbdelKhalek et al.The Journal of antibiotics, 73(6), 392-409 (2020-03-07) A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy.S Li et al.Skin pharmacology and physiology, 25(5), 257-268 (2012-07-27) Effect of oleic acid on store-operated calcium entry in immune-competent cells.Celia Carrillo et al.European journal of nutrition, 56(3), 1077-1084 (2016-02-03) Enantiomer stability and combined toxicity of duloxetine and econazole on Daphnia magna using real concentrations determined by capillary electrophoresis.Jesús Valimaña-Traverso et al.The Science of the total environment, 670, 770-778 (2019-03-29) Controlled study on thymol + eugenol vaginal douche versus econazole in vaginal candidiasis and metronidazole in bacterial vaginosis.Francesco Sosto et al.Arzneimittel-Forschung, 61(2), 126-131 (2011-03-25) Skin permeation of econazole nitrate formulated in an enhanced hydrophilic multiple emulsion.Joaquim Suñer-Carbó et al.Mycoses, 60(3), 166-177 (2016-10-21) Development of thermodynamically stable nanostructured lipid carrier system using central composite design for zero order permeation of econazole nitrate through epidermis.Lav Keshri et al.Pharmaceutical development and technology, 18(3), 634-644 (2012-02-22) In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation.Esra Baloglu et al.The Journal of pharmacy and pharmacology, 63(10), 1274-1282 (2011-09-09) Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba.Scott Thomson et al.Scientific reports, 7(1), 8247-8247 (2017-08-16) Characterization of the phase I and phase II metabolic profile of tolvaptan by in vitro studies and liquid chromatography-mass spectrometry profiling: Relevance to doping control analysis.Monica Mazzarino et al.Journal of pharmaceutical and biomedical analysis, 145, 555-568 (2017-08-02) Distribution, behavior and fate of azole antifungals during mechanical, biological, and chemical treatments in sewage treatment plants in China.Xianzhi Peng et al.The Science of the total environment, 426, 311-317 (2012-04-24) Econazole: a review of its antifungal activity and therapeutic efficacy.R C Heel et al.Drugs, 16(3), 177-201 (1978-09-01)

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