Melting point	103-107 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Matrix	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.Cecilia L Speyer et al.Breast cancer research and treatment, 132(2), 565-573 (2011-06-18) Increased [³H]quisqualic acid binding density in the dorsal striatum and anterior insula of alcoholics: A post-mortem whole-hemisphere autoradiography study.Virpi Laukkanen et al.Psychiatry research. Neuroimaging, 287, 63-69 (2019-04-17) Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems.Mostafa El Mansari et al.Neuropharmacology, 99, 696-704 (2015-09-13) Involvement of glutamatergic mechanisms in the median preoptic nucleus in the dipsogenic response induced by angiotensinergic activation of the subfornical organ in rats.Akihiko Ushigome et al.Experimental brain research, 238(1), 73-80 (2019-12-01) The ferroptosis inducer erastin irreversibly inhibits system xMami Sato et al.Scientific reports, 8(1), 968-968 (2018-01-19) Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors.Lisa M Del Valle-Mojica et al.Planta medica, 78(16), 1719-1724 (2012-08-28) Optical recordings of Ca2+ signaling activities from identified inner ear cells in cochlear slices and hemicochleaeXi Lin Brain Res. Protoc., 11(2) (2003) Dietary glutamate: interactions with the enteric nervous system.Guo-Du Wang et al.Journal of neurogastroenterology and motility, 20(1), 41-53 (2014-01-28) Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Takashi Miyamoto et al.Molecular neurodegeneration, 12(1), 41-41 (2017-05-21) Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor.Brian G Salisbury et al.European journal of pharmacology, 579(1-3), 34-39 (2007-10-31) Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor.Sujeenthar Tharmalingam et al.Neuropharmacology, 63(4), 667-674 (2012-06-02) The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.Sandra M Holley et al.Biochemistry, 51(19), 4015-4027 (2012-04-20) Dermatomal scratching after intramedullary quisqualate injection: correlation with cutaneous denervation.Kori L Brewer et al.The journal of pain : official journal of the American Pain Society, 9(11), 999-1005 (2008-07-16) Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overloadPlotegher N, et al. Cell Death and Differentiation, 27(5), 1588-1603 (2020) Synergistic effect of aripiprazole and escitalopram in increasing serotonin but not norepinephrine neurotransmission in the rat hippocampus.Mohammad Ebrahimzadeh et al.Neuropharmacology, 146, 12-18 (2018-11-12) Structural insights into the activation of metabotropic glutamate receptors.Antoine Koehl et al.Nature, 566(7742), 79-84 (2019-01-25) Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 in Purkinje cells is regulated by calcium and actin filaments.Kazumi Fukatsu et al.Journal of neurochemistry, 114(6), 1720-1733 (2010-07-16) Rare excitatory amino acid from flowers of zonal geranium responsible for paralyzing the Japanese beetle.Christopher M Ranger et al.Proceedings of the National Academy of Sciences of the United States of America, 108(4), 1217-1221 (2011-01-06) Excitatory amino acids and mammalian CNS function. In.Lehmann, et al. et al.Ann. Rep. Med. Chem., 22 (1987) Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter.Jean-Louis G Etoga et al.Bioorganic & medicinal chemistry letters, 20(8), 2680-2683 (2010-03-23) Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7.Emanuelle Sagot et al.Journal of medicinal chemistry, 51(14), 4093-4103 (2008-06-27) Excitotoxic spinal cord injury induced dysesthesias are associated with enhanced intrinsic growth of sensory neurons.Sonja K Bareiss et al.Neuroscience letters, 542, 113-117 (2013-03-19) Molecular dynamic simulation of mGluR5 amino terminal domain: essential dynamics analysis captures the agonist or antagonist behaviour of ligands.Alessandro Casoni et al.Journal of molecular graphics & modelling, 41, 72-78 (2013-03-19) The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse.P Boden et al.Brain research, 385(2), 205-211 (1986-10-22) Retinal control of lens-induced astigmatism in chicks.Anca-Vanessa Popa et al.Experimental eye research, 194, 108000-108000 (2020-03-17) Selective and sustained α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation in cerebellum induces dystonia in mice.Xueliang Fan et al.The Journal of pharmacology and experimental therapeutics, 340(3), 733-741 (2011-12-16) Ronald Tasker Award: Intrathecal transplantation of a human neuronal cell line for the treatment of neuropathic pain in a spinal cord injury model.Stacey C Quintero Wolfe et al.Clinical neurosurgery, 54, 220-225 (2008-05-29) Regulatory roles of Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 2A on the quisqualic acid-induced K+-current response in identified neurons of Aplysia.Shingo Kimura et al.Neuroscience research, 60(1), 73-81 (2007-11-06) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Long-term potentiation in isolated dendritic spines.Amadou T Corera et al.PloS one, 4(6), e6021-e6021 (2009-06-24) Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.Cyril Barinka et al.Journal of medicinal chemistry, 50(14), 3267-3273 (2007-06-15) Recent advances in the pharmacology of excitatory amino acids.Watkins, et al. Neurol. Neurobiol., 24, 19-19 (1987) Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain.Mostafa El Mansari et al.Psychopharmacology, 232(13), 2343-2352 (2015-02-11) Posttraumatic syringomyelia.Michael G Fehlings et al.Journal of neurosurgery. Spine, 14(5), 570-572 (2011-03-11) Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.Marzia Castiglione et al.Neuropharmacology, 55(4), 560-567 (2008-07-08) Long-term administration of cariprazine increases locus coeruleus noradrenergic neurons activity and serotonin1A receptor neurotransmission in the hippocampus.Mostafa El Mansari et al.Journal of psychopharmacology (Oxford, England), 34(10), 1143-1154 (2020-07-21) Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine null Metabotropic and ionotropic glutamate receptors mediate the modulation of acetylcholine release at the frog neuromuscular junction.Andrei Tsentsevitsky et al.Journal of neuroscience research, 95(7), 1391-1401 (2016-10-23) Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.Charalambos Kaittanis et al.The Journal of experimental medicine, 215(1), 159-175 (2017-11-17) Predifferentiated GABAergic neural precursor transplants for alleviation of dysesthetic central pain following excitotoxic spinal cord injury.Jeung Woon Lee et al.Frontiers in physiology, 3, 167-167 (2012-07-04) Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines.Mary J Eaton et al.Pain research and treatment, 2012, 356412-356412 (2012-05-24) C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.L Giovannelli et al.Journal of neural transmission (Vienna, Austria : 1996), 105(8-9), 935-948 (1998-12-30) Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition.Rami Hamati et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(12), 2098-2105 (2020-05-31) Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.Lisa M Del Valle-Mojica et al.Evidence-based complementary and alternative medicine : eCAM, 2011, 403591-403591 (2011-05-18) Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons.Thibault Collin et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(29), 9281-9291 (2009-07-25) Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin.Pablo J Giraudi et al.PloS one, 6(12), e29078-e29078 (2012-01-05) Involvement of ERK2 in traumatic spinal cord injury.Chen-Guang Yu et al.Journal of neurochemistry, 113(1), 131-142 (2010-01-14) Quisqualis indica Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis.Charith Ub Wijerathne et al.Biological & pharmaceutical bulletin, 40(12), 2125-2133 (2017-09-26) Medical Laboratory Science : Theory And Practice (1990) Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.Klara Hlouchova et al.The FEBS journal, 276(16), 4448-4462 (2009-08-15) Deleterious GRM1 mutations in schizophrenia.Mohammed Akli Ayoub et al.PloS one, 7(3), e32849-e32849 (2012-03-27) Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.Alexander A Nicodemo et al.Molecular brain, 3, 4-4 (2010-02-26) Reaction of endogenous progenitor cells in a rat model of posttraumatic syringomyelia.Jian Tu et al.Journal of neurosurgery. Spine, 14(5), 573-582 (2011-03-11) Agonist-induced internalization of mGluR1alpha is mediated by caveolin.Yun Hwa Hong et al.Journal of neurochemistry, 111(1), 61-71 (2009-07-25) Subtype selective kainic acid receptor agonists: discovery and approaches to rational design.Lennart Bunch et al.Medicinal research reviews, 29(1), 3-28 (2008-07-16) The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease.Shogo Furutani et al.International journal for parasitology. Drugs and drug resistance, 8(2), 350-360 (2018-06-30) Clinical feasibility for cell therapy using human neuronal cell line to treat neuropathic behavioral hypersensitivity following spinal cord injury in rats.Mary J Eaton et al.Journal of rehabilitation research and development, 46(1), 145-165 (2009-06-18) Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators.Víctor Fernández-Dueñas et al.Molecules (Basel, Switzerland), 25(7) (2020-04-02) Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents.D Jantas et al.Neuropeptides, 43(5), 371-385 (2009-08-12) Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.Paola Scandroglio et al.Journal of biomolecular screening, 15(10), 1238-1247 (2010-09-03)

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