没有数据	没有数据

没有数据	没有数据

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download

Synthetic Route

More

Name	CAS

More

Articles

Peer-Reviewed Papers

PIN-mediated polar auxin transport facilitates root-obstacle avoidance.Hyo-Jun Lee et al.The New phytologist, 225(3), 1285-1296 (2019-07-25) A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.Laura Orsatti et al.Journal of pharmaceutical and biomedical analysis, 107, 426-431 (2015-02-11) Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs.Soranobu Ninomiya et al.Blood, 125(25), 3905-3916 (2015-05-06) Tryptophan concentration is the main mediator of the capacity of adipose mesenchymal stromal cells to inhibit T-lymphocyte proliferation in vitro.Ramón Menta et al.Cytotherapy, 16(12), 1679-1691 (2014-09-23) Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.Linnéa Asp et al.Journal of inflammation (London, England), 8, 25-25 (2011-10-11) Involvement of kynurenines in Huntington's disease and stroke-induced brain damage.Stone TW, Forrest CM, et al. Journal of Neural Transmission. General Section, 119(2), 261-274 (2011) Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions.Chi-Hao Tsai et al.Biochimica et biophysica acta. Molecular cell research, 1867(2), 118564-118564 (2019-11-02) The Asymmetric Expression of SAUR Genes Mediated by ARF7/19 Promotes the Gravitropism and Phototropism of Plant Hypocotyls.Xiaoyi Wang et al.Cell reports, 31(3), 107529-107529 (2020-04-23) Examination of Kynurenine Toxicity on Corneal and Conjunctival Epithelium: In vitro and in vivo Studies.Anna Matysik-Woźniak et al.Ophthalmic research, 62(1), 24-35 (2019-04-11) 1,25(OH)2D3 Differently Affects Immunomodulatory Activities of Mesenchymal Stem Cells Depending on the Presence of TNF-α, IL-1β and IFN-γ.Christian Behm et al.Journal of clinical medicine, 8(12) (2019-12-19) Plant circadian rhythms regulate the effectiveness of a glyphosate-based herbicide.Fiona E Belbin et al.Nature communications, 10(1), 3704-3704 (2019-08-20) Noncanonical auxin signaling regulates cell division pattern during lateral root development.Rongfeng Huang et al.Proceedings of the National Academy of Sciences of the United States of America, 116(42), 21285-21290 (2019-10-02) Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.Zeqian Huang et al.Theranostics, 9(19), 5542-5557 (2019-09-20) The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways.Krishna Reddy Challa et al.PLoS genetics, 15(2), e1007988-e1007988 (2019-02-12) Single cell analysis of kynurenine and System L amino acid transport in T cells.Linda V Sinclair et al.Nature communications, 9(1), 1981-1981 (2018-05-19) Human Mesenchymal Stromal Cell Sheets Induce Macrophages Predominantly to an Anti-Inflammatory Phenotype.Panithi Sukho et al.Stem cells and development, 27(13), 922-934 (2018-05-09) Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects.Xue Jiang et al.International journal of immunopathology and pharmacology, 34, 2058738420950584-2058738420950584 (2020-09-24) Auxin and Gibberellins Are Required for the Receptor-Like Kinase ERECTA Regulated Hypocotyl Elongation in Shade Avoidance in Arabidopsis.Junbo Du et al.Frontiers in plant science, 9, 124-124 (2018-02-23) Determination of Kynurenine Enantiomers by Alpha-Cyclodextrin, Cationic-βeta-Cyclodextrin and Their Synergy Complemented with Stacking Enrichment in Capillary Electrophoresis.Aysha Sarfraz Rizvi et al.Journal of chromatography. A, 1622, 461128-461128 (2020-04-26) KynR, a Lrp/AsnC-type transcriptional regulator, directly controls the kynurenine pathway in Pseudomonas aeruginosa.Claire A Knoten et al.Journal of bacteriology, 193(23), 6567-6575 (2011-10-04) Application of the optimized and validated LC-MS method for simultaneous quantification of tryptophan metabolites in culture medium from cancer cells.Ilona Sadok et al.Journal of pharmaceutical and biomedical analysis, 176, 112805-112805 (2019-08-16) Determination of tryptophan derivatives in kynurenine pathway in fermented foods using liquid chromatography tandem mass spectrometry.Cemile Yılmaz et al.Food chemistry, 243, 420-427 (2017-11-18) Cellular apoptosis of HFF cells by inorganic nanoparticles not susceptible to modulation by Toxoplasma gondii infection in vitro.Oluyomi Stephen Adeyemi et al.Toxicology in vitro : an international journal published in association with BIBRA, 54, 280-285 (2018-10-26) Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase.Hyun Tae Kim et al.Cell chemical biology, 25(4), 426-438 (2018-02-13) The tryptophan derivative, tranilast, and conditioned medium with indoleamine 2,3-dioxygenase-expressing cells inhibit the proliferation of lymphoid malignancies.Shihoko Suwa et al.International journal of oncology, 46(3), 1369-1376 (2015-01-13) Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.Shankar S Iyer et al.Cell, 173(5), 1123-1134 (2018-05-19) Copper mediates auxin signalling to control cell differentiation in the copper moss Scopelophila cataractae.Toshihisa Nomura et al.Journal of experimental botany, 66(5), 1205-1213 (2014-11-28) Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging.Xuan Huang et al.Oncotarget, 8(29), 46900-46914 (2017-02-06) Epithelial-Mesenchymal Transition in Human Prostate Cancer Demonstrates Enhanced Immune Evasion Marked by IDO1 Expression.Kimberley Kolijn et al.Cancer research, 78(16), 4671-4679 (2018-06-21) Adipose-derived mesenchymal stem cells from infrapatellar fat pad of patients with rheumatoid arthritis and osteoarthritis have comparable immunomodulatory properties.Urszula Skalska et al.Autoimmunity, 49(2), 124-131 (2015-12-30) Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.Minh Truong Do et al.Toxicology and applied pharmacology, 280(1), 138-148 (2014-08-12) Endogenous auxin determines the pattern of adventitious shoot formation on internodal segments of ipecac.Imari Koike et al.Planta, 251(3), 73-73 (2020-03-07) Metabolomic adaptations and correlates of survival to immune checkpoint blockade.Haoxin Li et al.Nature communications, 10(1), 4346-4346 (2019-09-27) Indoleamine-2,3-Dioxygenase in Thyroid Cancer Cells Suppresses Natural Killer Cell Function by Inhibiting NKG2D and NKp46 Expression via STAT Signaling Pathways.Arum Park et al.Journal of clinical medicine, 8(6) (2019-06-20) Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice.Rooban B Nahomi et al.International journal of molecular sciences, 21(5) (2020-03-11) The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?Song Guo et al.Cephalalgia : an international journal of headache, 31(9), 1029-1038 (2011-05-20) Metabolomic adaptations and correlates of survival to immune checkpoint blockade.Haoxin Li et al.Nature communications, 10(1), 4346-4346 (2019-09-27) Indoleamine-2,3-Dioxygenase in Thyroid Cancer Cells Suppresses Natural Killer Cell Function by Inhibiting NKG2D and NKp46 Expression via STAT Signaling Pathways.Arum Park et al.Journal of clinical medicine, 8(6) (2019-06-20) Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imagingXuan Huang Oncotarget, 8(29), 46900-46914 (2017) Auxin transport and response requirements for root hydrotropism differ between plant species.Yusuke Nakajima et al.Journal of experimental botany, 68(13), 3441-3456 (2017-06-22) Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation.Yan-Heng Zhou et al.mBio, 10(6) (2019-12-19) Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism.Chang Qu et al.Pharmacological research, 121, 70-82 (2017-05-01) Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats.Sarah Beggiato et al.Progress in neuro-psychopharmacology & biological psychiatry, 100, 109883-109883 (2020-02-08) A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis.Ying Zhu et al.The Journal of biological chemistry, 294(52), 19923-19933 (2019-11-17) Kynuramines induce overexpression of heat shock proteins in pancreatic cancer cells via 5-hydroxytryptamine and MT1/MT2 receptors.A Leja-Szpak et al.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 66(5), 711-718 (2015-11-19) IPyA glucosylation mediates light and temperature signaling to regulate auxin-dependent hypocotyl elongation in Arabidopsis.Lu Chen et al.Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6910-6917 (2020-03-11) Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory.Jillian M Heisler et al.Brain, behavior, and immunity, 50, 115-124 (2015-07-02) Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.Xiaojing Liu et al.Cell, 175(2), 502-513 (2018-09-25) Salicylic Acid Suppresses Apical Hook Formation via NPR1-Mediated Repression of EIN3 and EIL1 in Arabidopsis.Peixin Huang et al.The Plant cell, 32(3), 612-629 (2020-01-01) Interferon-Induced IDO1 Mediates Radiation Resistance and Is a Therapeutic Target in Colorectal Cancer.Baosheng Chen et al.Cancer immunology research, 8(4), 451-464 (2020-03-05) Influence of Cyclooxygenase-2 Inhibitors on Kynurenic Acid Production in Rat Brain in Vitro.Izabela Zakrocka et al.Neurotoxicity research, 35(1), 244-254 (2018-09-05) Targeting the kynurenine pathway-related alterations in Alzheimer's disease: a future therapeutic strategy.Imola Plangár et al.Journal of Alzheimer's disease : JAD, 24 Suppl 2, 199-209 (2011-03-29) Establishment of human retinal mitoscriptome gene expression signature for diabetic retinopathy using cadaver eyes.Gowthaman Govindarajan et al.Mitochondrion, 36, 150-181 (2017-07-22) Antibacterial lysine analogs that target lysine riboswitches.Kenneth F Blount et al.Nature chemical biology, 3(1), 44-49 (2006-12-05) Inhibition of indoleamine 2,3-dioxygenase by stereoisomers of 1-methyl tryptophan in an experimental graft-versus-tumor model.Ji-Young Lim et al.Experimental hematology, 42(10), 862-866 (2014-06-28) Synovial Fibroblasts Selectively Suppress Th1 Cell Responses through IDO1-Mediated Tryptophan Catabolism.Lars-Oliver Tykocinski et al.Journal of immunology (Baltimore, Md. : 1950), 198(8), 3109-3117 (2017-03-08) Light exposure accelerates oxidative protein polymerization in beef stored in high oxygen atmosphere.Mohd Asraf Mohd Zainudin et al.Food chemistry, 299, 125132-125132 (2019-07-13) Inhibition of indoleamine 2,3-dioxygenase attenuates endotoxin-mediated tolerance in granulosa cells through kynurenine pathway.Sunita Dahiya et al.Journal of cellular biochemistry (2019-04-16) Determination of tryptophan metabolism from biological tissues and fluids using high performance liquid chromatography with simultaneous dual electrochemical detection.Emily L Brooks et al.The Analyst, 144(20), 6011-6018 (2019-09-21) Local auxin biosynthesis is required for root regeneration after wounding.Rotem Matosevich et al.Nature plants, 6(8), 1020-1030 (2020-08-05) Differential Immunomodulatory Effects of Human Bone Marrow-Derived Mesenchymal Stromal Cells on Natural Killer Cells.Chia-Hsuan Donna Hu et al.Stem cells and development, 28(14), 933-943 (2019-05-28) Kynurenine Pathway Metabolites in Humans: Disease and Healthy StatesYiquan Chen International Journal of Tryptophan Research : IJTR, 2, 1-19 (2009) A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor.Jinlei Yu et al.The Journal of allergy and clinical immunology, 143(6), 2108-2119 (2018-12-24) Essential and Non-Essential Metals Metabolites with Antibiotic Activity Pharmacology of Benzodiazepines Interferon Gamma Research (2012) The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's DiseaseAnna Zinger Parkinson's Disease (2011) Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.Joyce A Ibana et al.Infection and immunity, 79(11), 4425-4437 (2011-09-14) Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified.Yuhei Shibata et al.Hematological oncology, 35(4), 637-644 (2016-06-25) 5-Hydroxytryptophan, a major product of tryptophan degradation, is essential for optimal replication of human parainfluenza virus.M A G Rabbani et al.Virology, 503, 46-51 (2017-01-24) Involvement of miR-30b in kynurenine-mediated lysyl oxidase expression.Zhiqing Duan et al.Journal of physiology and biochemistry, 75(2), 135-142 (2019-05-17) Simultaneous voltammetric analysis of tryptophan and kynurenine in culture medium from human cancer cells.Ilona Sadok et al.Talanta, 209, 120574-120574 (2020-01-02) E3 ubiquitin ligase SOR1 regulates ethylene response in rice root by modulating stability of Aux/IAA protein.Hui Chen et al.Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4513-4518 (2018-04-11) Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex.D M Bortz et al.Neuropharmacology, 121, 69-78 (2017-04-19) Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment.Cara C Schafer et al.Oncotarget, 7(46), 75407-75424 (2016-10-06) Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase.Xiaoxia Zhu et al.Journal of ethnopharmacology, 160, 86-93 (2014-12-02) Human renal tubular epithelial cells suppress alloreactive T cell proliferation.M W H J Demmers et al.Clinical and experimental immunology, 179(3), 509-519 (2014-10-15) The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function.Dennis Awuah et al.Journal of immunology (Baltimore, Md. : 1950), 203(1), 148-157 (2019-05-24) The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1).Anna Leja-Szpak et al.Anti-cancer agents in medicinal chemistry, 19(17), 2079-2090 (2019-04-17) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.Nobuhiko Nakamura et al.International journal of hematology, 102(3), 327-334 (2015-08-06) Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.Toshihiro Sato et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4), 475-484 (2015-01-13) IDO1 Maintains Pluripotency of Primed Human Embryonic Stem Cells by Promoting Glycolysis.Xin Liu et al.Stem cells (Dayton, Ohio), 37(9), 1158-1165 (2019-05-31) Modulation of multidrug resistance-associated proteins function in erythrocytes in glycerol-induced acute renal failure rats.Aoi Matsushima et al.The Journal of pharmacy and pharmacology, 69(2), 172-181 (2016-11-20) A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer.Nicholas C D'Amato et al.Cancer research, 75(21), 4651-4664 (2015-09-13) Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine.Petr Tomek et al.Biochimica et biophysica acta, 1850(9), 1772-1780 (2015-04-25) Exploring Amino Acid-Capped Nanoparticles for Selective Anti-Parasitic Action and Improved Host Biocompatibility.Oluyomi Stephen Adeyemi et al.Journal of biomedical nanotechnology, 14(5), 847-867 (2018-06-09) Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists.Edina Szűcs et al.Biomolecules, 10(2) (2020-02-16) Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss.Mona El Refaey et al.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32(11), 2182-2193 (2017-07-21) A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats.Ajeesh Koshy Cherian et al.Neuropharmacology, 82, 41-48 (2014-03-22) Contrasting growth responses in lamina and petiole during neighbor detection depend on differential auxin responsiveness rather than different auxin levels.Mieke de Wit et al.The New phytologist, 208(1), 198-209 (2015-05-13) Characterization of the In Vitro Chlamydia pecorum Response to Gamma Interferon.M Mominul Islam et al.Infection and immunity, 86(4) (2018-01-24) Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.Paras S Minhas et al.Nature immunology, 20(1), 50-63 (2018-11-28) Molecular State of the Membrane-Active Antibiotic Daptomycin.Ming-Tao Lee et al.Biophysical journal, 113(1), 82-90 (2017-07-13) The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases.Ewa Kuca-Warnawin et al.Cells, 8(12) (2019-12-22) Regulatory Diversification of INDEHISCENT in the Capsella Genus Directs Variation in Fruit Morphology.Yang Dong et al.Current biology : CB, 29(6), 1038-1046 (2019-03-05) Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.Katsumi Shibata et al.Bioscience, biotechnology, and biochemistry, 79(1), 103-108 (2014-09-26) Quantitative analysis of phenylalanine, tyrosine, tryptophan and kynurenine in rat model for tauopathies by ultra-high performance liquid chromatography with fluorescence and mass spectrometry detection.Jaroslav Galba et al.Journal of pharmaceutical and biomedical analysis, 117, 85-90 (2015-09-08) Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds.K R Jacobs et al.SLAS discovery : advancing life sciences R & D, 23(6), 554-560 (2018-02-09) Respiratory syncytial virus induces indoleamine 2,3-dioxygenase activity: a potential novel role in the development of allergic disease.F Ajamian et al.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 45(3), 644-659 (2015-01-30) Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity.Santiago Lima et al.Journal of medicinal chemistry, 52(2), 389-396 (2009-01-16) Salicylic Acid Affects Root Meristem Patterning via Auxin Distribution in a Concentration-Dependent Manner.Taras Pasternak et al.Plant physiology, 180(3), 1725-1739 (2019-05-01) The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.Katsumi Shibata et al.Journal of nutritional science and vitaminology, 60(4), 261-268 (2014-10-10)

Remarks