Melting point	9-11 ºC
Boiling point	88-90 ºC (76 mmHg)
Flash point	79 ºC
Density	1.512

Symbol(GHS)	T+;N
Hazard Codes	R25;R26;R34;R50/53
SDS/MSDS	S26;S36/37/39;S45;S60;S61

Source	SDS/MSDS Samples
Sigma-Aldrich	View & Download
TCI	View & Download
Matrix	View & Download

Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin.Ingo P Korndörfer et al.Journal of molecular biology, 330(2), 385-396 (2003-06-26) [Chemical constituents of Periploca forrestii].Xiuhai Gan et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(24), 3225-3228 (2010-04-01) Relationships Between Chemical Defenses of Common Toad (Bufo bufo) Tadpoles and Bacterial Community Structure of their Natural Aquatic Habitat.János Ujszegi et al.Journal of chemical ecology, 46(5-6), 534-543 (2020-05-30) Structure-activity relationships of saponins and cardiac glycosides. III. Beta-L-xylopyranosyl-(1-->6)-alpha- and -beta-D-glucopyranosides.M Takechi et al.Biological & pharmaceutical bulletin, 21(11), 1234-1235 (1998-12-16) Identification of anti-viral activity of the cardenolides, NaCheng-Wei Yang et al.Toxicology and applied pharmacology, 332, 129-137 (2017-04-26) Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs.Marie Jensen et al.Bioorganic & medicinal chemistry, 19(7), 2407-2417 (2011-03-23) Periplogenin, isolated from Lagenaria siceraria, ameliorates L-T₄-induced hyperthyroidism and associated cardiovascular problems.S Panda et al.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 43(3), 188-193 (2011-02-03) Inhibitory activity of a phytochemically characterized fraction from Streptocaulon juventas on lung cancer in nude mice.Na Han et al.Planta medica, 76(6), 561-565 (2009-11-18) Na+,K+-ATPase inhibitors in rat urine: origins and physiological significance.M Tamura et al.Clinical and experimental hypertension (New York, N.Y. : 1993), 20(5-6), 543-550 (1998-07-31) 17 alpha-O-(aminoalkyl)oxime derivatives of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane as inhibitors of Na(+),K(+)-ATPase at the digitalis receptor.M Gobbini et al.Journal of medicinal chemistry, 44(23), 3821-3830 (2001-11-02) Defective activity and isoform of the Na,K-ATPase in the dilated cardiomyopathic hamster.F Paganelli et al.Cellular and molecular biology (Noisy-le-Grand, France), 47(2), 255-260 (2001-05-17) A cardiac glucoside with in vitro anti-HIV activity isolated from Elaeodendron croceum.Gerhard Prinsloo et al.Natural product research, 24(18), 1743-1746 (2010-10-29) Assembly of digitoxin by gold(I)-catalyzed glycosidation of glycosyl o-alkynylbenzoates.Yuyong Ma et al.The Journal of organic chemistry, 76(23), 9748-9756 (2011-11-08) Periplogenin-3-O- -D-glucopyranosyl -(1-->6)- -D-glucopyaranosyl- -(1-->4) -D-cymaropyranoside, isolated from Aegle marmelos protects doxorubicin induced cardiovascular problems and hepatotoxicity in rats.Sunanda Panda et al.Cardiovascular therapeutics, 27(2), 108-116 (2009-05-12) Effects of AL 107, a novel semisynthetic cardiac glycoside, on the cardiovascular system in anaesthetized beagle dogs with pentobarbital-induced cardiac insufficiency.B Kögel et al.Arzneimittel-Forschung, 49(8), 679-684 (1999-09-14) Age- and environment-dependent changes in chemical defences of larval and post-metamorphic toads.Bálint Üveges et al.BMC evolutionary biology, 17(1), 137-137 (2017-06-15) Bioactive cardenolides from the stems and twigs of Nerium oleander.Ming Zhao et al.Journal of natural products, 70(7), 1098-1103 (2007-06-28) Changes in Toxin Quantities Following Experimental Manipulation of Toxin Reserves in Bufo bufo Tadpoles.Zoltán Tóth et al.Journal of chemical ecology, 45(3), 253-263 (2019-01-27) 19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.Thitima Lhinhatrakool et al.Journal of natural products, 69(8), 1249-1251 (2006-08-29) Profiling and structural analysis of cardenolides in two species of Digitalis using liquid chromatography coupled with high-resolution mass spectrometry.Baradwaj Gopal Ravi et al.Journal of chromatography. A, 1618, 460903-460903 (2020-02-10) Cardenolide genin pattern in Isoplexis plants and shoot cultures.Frank Schaller et al.Planta medica, 72(12), 1149-1156 (2006-08-12) Synthesis and biological evaluation of 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin.M Gobbini et al.Bioorganic & medicinal chemistry, 6(10), 1889-1894 (1998-12-05) Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis.Cheng-Wei Yang et al.Biochemical pharmacology, 180, 114122-114122 (2020-06-28) The crystal structure of digitoxigenin, C23H34O4Isabella Karle and J. Karle Acta Crystallographica Section B, Structural Crystallography and Crystal Chemistry, B25, 434-434 (1969) Na(+) transport, and the E(1)P-E(2)P conformational transition of the Na(+)/K(+)-ATPase.A Babes et al.Biophysical journal, 79(5), 2557-2571 (2000-10-29) The current produced by the E779A mutant rat Na(+)/K(+) pump alpha1-subunit expressed in HEK 293 cells.S Zillikens et al.Biochimica et biophysica acta, 1509(1-2), 155-166 (2000-12-19) C3'/C4'-Stereochemical Effects of Digitoxigenin α-L-/α-D-Glycoside in Cancer Cytotoxicity.John W Hinds et al.ChemMedChem, 8(1), 63-69 (2012-11-10) Effect of the digitoxigenin derivative, INCICH-D7, on Na+, K+-ATPase.Margarita Ramirez et al.Biochemical pharmacology, 70(6), 851-857 (2005-08-06) The asymmetric syntheses of methyl D-digitoxoside, L-oleandrose and L-cymarose from methyl sorbate, an achiral precursor.Machiko Ono et al.Chemical & pharmaceutical bulletin, 60(8), 1076-1082 (2012-08-07) A stereoselective synthesis of digitoxin and digitoxigen mono- and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylation.Maoquan Zhou et al.Organic letters, 8(19), 4339-4342 (2006-09-08) Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.Miguel López-Lázaro et al.Journal of natural products, 68(11), 1642-1645 (2005-11-29) An LC-MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies.Xinchi Feng et al.Journal of pharmaceutical and biomedical analysis, 138, 378-385 (2017-02-01) Voltage dependence of the apparent affinity for external Na(+) of the backward-running sodium pump.P De Weer et al.The Journal of general physiology, 117(4), 315-328 (2001-03-30) Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.Raymond W Wong et al.Scientific reports, 8(1), 850-850 (2018-01-18) Measurement of serum digitoxin in patients by radioimmunoassay using specific antiserum.Y Ikeda et al.Clinica chimica acta; international journal of clinical chemistry, 314(1-2), 245-247 (2001-11-24) Cardenolide and oxypregnane glycosides from the root of Asclepias incarnata L.T Warashina et al.Chemical & pharmaceutical bulletin, 48(4), 516-524 (2000-04-27) A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis.Rodrigo M Pádua et al.Steroids, 73(4), 458-465 (2008-02-06) Cytotoxic principles from the formosan milkweed, Asclepias curassavica.Michael C Roy et al.Journal of natural products, 68(10), 1494-1499 (2005-10-29) Calcium-independent release of [3H]spermine from chick retina.F Calderón et al.Brain research, 854(1-2), 1-5 (2000-04-28) Efficient synthesis of 3-aminodigoxigenin and 3-aminodigitoxigenin probes.M Adamczyk et al.Bioorganic & medicinal chemistry letters, 9(5), 771-774 (1999-04-14) Integrating high-content screening and ligand-target prediction to identify mechanism of action.Daniel W Young et al.Nature chemical biology, 4(1), 59-68 (2007-12-11)

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