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Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK.D Leshem-Lev et al.Molecular and cellular biochemistry, 345(1-2), 153-160 (2010-08-24) Functional selectivity of adenosine A1 receptor ligands?Ellen V Langemeijer et al.Purinergic signalling, 9(1), 91-100 (2012-10-12) Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration.Patrycja Koszałka et al.PloS one, 11(3), e0151420-e0151420 (2016-03-11) Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.Dovenia S Ponnoth et al.American journal of physiology. Heart and circulatory physiology, 299(1), H81-H87 (2010-04-20) Positive allosteric modulation of AFabrizio Vincenzi et al.Neuropharmacology, 111, 283-292 (2016-09-19) Functional changes in vascular reactivity to adenosine receptor activation in type I diabetic mice.Hicham Labazi et al.European journal of pharmacology, 820, 191-197 (2017-12-23) Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation.Luca Soattin et al.Frontiers in physiology, 11, 493-493 (2020-07-01) The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.Carolyn E Pritchett et al.Brain research, 1306, 85-92 (2009-10-14) Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.Loredana Cappellacci et al.Journal of medicinal chemistry, 51(14), 4260-4269 (2008-07-01) Drug-eluting stent for delivery of signal pathway-specific 1,3-dipropyl-8-cyclopentyl xanthine.Eunah Kang et al.Molecular pharmaceutics, 6(4), 1110-1117 (2009-05-13) Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.Romeo Romagnoli et al.European journal of medicinal chemistry, 101, 185-204 (2015-07-05) Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.Devon C Crawford et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(38), 13100-13110 (2012-09-21) Effect of Interaction between Adenosine and Nitric Oxide on Central Nervous System Oxygen Toxicity.Cheng-Wei Xie et al.Neurotoxicity research, 36(1), 193-203 (2019-03-31) Autocrine signaling via A(1) adenosine receptors causes downregulation of M(2) receptors in adult rat atrial myocytes in vitro.Christoph Littwitz et al.Pflugers Archiv : European journal of physiology, 461(1), 165-176 (2010-11-10) Adenosine receptors regulate exosome production.Nils Ludwig et al.Purinergic signalling, 16(2), 231-240 (2020-05-23) Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor.Dong Guo et al.British journal of pharmacology, 171(23), 5295-5312 (2014-07-22) Alkaline Phosphatase Inhibitors Attenuate Renovascular Responses to Norepinephrine.Edwin K Jackson et al.Hypertension (Dallas, Tex. : 1979), 69(3), 484-493 (2017-02-01) Functional coupling between adenosine A1 receptors and G-proteins in rat and postmortem human brain membranes determined with conventional guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding or [35S]GTPγS/immunoprecipitation assay.Yuji Odagaki et al.Purinergic signalling, 14(2), 177-190 (2018-03-02) Role of CD73 in Renal Sympathetic Neurotransmission in the Mouse Kidney.Edwin K Jackson et al.Physiological reports, 1(3) (2013-09-26) Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.Kenneth A Jacobson et al.Journal of medicinal chemistry, 48(26), 8103-8107 (2005-12-22) Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.Luca Antonioli et al.European journal of pharmacology, 650(2-3), 639-649 (2010-11-03) Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281.Scott J Hughes et al.Cellular signalling, 27(5), 1008-1018 (2015-03-01) A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice.Bunyen Teng et al.Journal of experimental pharmacology, 2011(3), 59-68 (2011-08-19) Systemic inflammatory response syndrome-related lymphopenia is associated with adenosine AReut Riff et al.Journal of leukocyte biology, 102(1), 95-103 (2017-05-13) Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes.A V Hinze et al.Journal of molecular and cellular cardiology, 53(5), 639-645 (2012-08-22) Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms.E Narimatsu et al.Acta anaesthesiologica Scandinavica, 52(10), 1415-1422 (2008-11-26) Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.Romeo Romagnoli et al.European journal of medicinal chemistry, 101, 185-204 (2015-07-05) Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT.N L D Smith et al.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(11), O960-O968 (2014-04-10) Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.Richard A Fenton et al.American journal of physiology. Heart and circulatory physiology, 297(2), H718-H725 (2009-06-16) Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.Romeo Romagnoli et al.Journal of medicinal chemistry, 51(18), 5875-5879 (2008-08-30) Positive allosteric modulation of AFabrizio Vincenzi et al.Neuropharmacology, 111, 283-292 (2016-09-19) Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration.Patrycja Koszałka et al.PloS one, 11(3), e0151420-e0151420 (2016-03-11) Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.Dovenia S Ponnoth et al.American journal of physiology. Heart and circulatory physiology, 299(1), H81-H87 (2010-04-20) Functional selectivity of adenosine A1 receptor ligands?Ellen V Langemeijer et al.Purinergic signalling, 9(1), 91-100 (2012-10-12) [Metallothionein mediates cardioprotection induced by delayed preconditioning with adenosine A1 receptor agonist in rabbits].Caijiao Xie et al.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 34(7), 603-607 (2009-08-04) Activating adenosine A1 receptor accelerates PC12 cell injury via ADORA1/PKC/KATP pathway after intermittent hypoxia exposure.Hong-Fang Mei et al.Molecular and cellular biochemistry, 446(1-2), 161-170 (2018-01-31) Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats.Andreas K Dacho et al.Head & neck, 34(8), 1100-1105 (2011-11-01) Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes.Zhaogang Yang et al.Biochimica et biophysica acta, 1793(12), 1868-1875 (2009-11-03) Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.H Sandeep Prakasam et al.American journal of physiology. Renal physiology, 303(2), F279-F292 (2012-05-04) Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration.Ruzanna Shkhyan et al.Journal of molecular medicine (Berlin, Germany), 96(10), 1049-1060 (2018-08-09) Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.Sheng Hu et al.Brain research, 1459, 81-90 (2012-05-09) NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization.Mark Soave et al.SLAS discovery : advancing life sciences R & D, 25(2), 186-194 (2019-10-05) Adenosine AHitesh Soni et al.American journal of physiology. Renal physiology, 313(6), F1216-F1222 (2017-09-01) Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.Athena M Klutz et al.Journal of nanobiotechnology, 6, 12-12 (2008-10-25) Acute down-regulation of adenosine A(1) receptor activity in status epilepticus.Nicola E Hamil et al.Epilepsia, 53(1), 177-188 (2011-12-14) Adenosine A1-Receptors Modulate mTOR Signaling to Regulate White Matter Inflammatory Lesions Induced by Chronic Cerebral Hypoperfusion.Pengfei Cheng et al.Neurochemical research, 41(12), 3272-3277 (2016-09-25) 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.Loredana Cappellacci et al.Bioorganic & medicinal chemistry, 16(1), 336-353 (2007-10-16) Acute hyperglycemia abolishes ischemic preconditioning by inhibiting Akt phosphorylation: normalizing blood glucose before ischemia restores ischemic preconditioning.Zequan Yang et al.Oxidative medicine and cellular longevity, 2013, 329183-329183 (2013-12-29) Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia.Alberto Martire et al.Journal of neurochemistry, 149(2), 211-230 (2019-01-08) Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors.Sam A Booker et al.Neuropharmacology, 93, 103-115 (2015-02-07) Elevated levels of the neutrophil chemoattractant pro-platelet basic protein in macrophages from individuals with chronic and allergic aspergillosis.Nicola L D Smith et al.The Journal of infectious diseases, 211(4), 651-660 (2014-09-07) Hypothermia in mouse is caused by adenosine AJesse Lea Carlin et al.Neuropharmacology, 114, 101-113 (2016-12-05) Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.Antonioli L, Fornai M, Colucci R, et al. Journal of Physiology And Pharmacology, 650, 639-649 (2011) Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.Lorenz Bott-Flügel et al.PloS one, 6(3), e18048-e18048 (2011-04-06) Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse.M M Santafe et al.The European journal of neuroscience, 42(2), 1775-1787 (2015-04-22) Endogenous purines modulate K+ -evoked ACh secretion at the mouse neuromuscular junction.Juan F Guarracino et al.Journal of neuroscience research, 96(6), 1066-1079 (2018-02-13) Missing Link Prediction using Common Neighbor and Centrality based Parameterized Algorithm.Iftikhar Ahmad et al.Scientific reports, 10(1), 364-364 (2020-01-17) Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.Sang W Park et al.Kidney international, 82(8), 878-891 (2012-06-15) Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice.Yichun Zhang et al.Frontiers in cellular neuroscience, 14, 202-202 (2020-08-01) Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells.Mariachiara Zuccarini et al.Purinergic signalling, 13(4), 429-442 (2017-06-16) Utility of Serum and Bronchoalveolar Lavage Fluid Galactomannan in Diagnosis of Chronic Pulmonary Aspergillosis.Inderpaul Singh Sehgal et al.Journal of clinical microbiology, 57(3) (2019-01-11) Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats.L Jolly et al.British journal of pharmacology, 154(8), 1600-1610 (2008-05-27) IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.Joo Yun Kim et al.Journal of the American Society of Nephrology : JASN, 24(10), 1558-1570 (2013-07-03) Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron.Marla Rivera-Oliver et al.Molecular neurobiology, 56(2), 797-811 (2018-05-26) Guanosine Anxiolytic-Like Effect Involves Adenosinergic and Glutamatergic Neurotransmitter Systems.Roberto Farina Almeida et al.Molecular neurobiology, 54(1), 423-436 (2016-01-09) Adenosine A1 receptor blockage mediates theophylline-associated seizures.Mitsumasa Fukuda et al.Epilepsia, 51(3), 483-487 (2009-10-23) Anti-inflammatory preconditioning by agonists of adenosine A1 receptor.Sigal Nakav et al.PloS one, 3(5), e2107-e2107 (2008-05-08) Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.Guoping Liu et al.Brain research, 1700, 47-55 (2018-06-24) Norisoboldine attenuates inflammatory pain via the adenosine A1 receptor.X Gao et al.European journal of pain (London, England), 18(7), 939-948 (2014-01-08) Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts.Pitchai Balakumar et al.Journal of cardiovascular pharmacology, 54(3), 204-212 (2009-07-02) Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation.Adam G Walker et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(13), 2553-2566 (2017-07-01) A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis.N L D Smith et al.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(8), O480-O488 (2013-11-28) Crosstalk between adenosine A1 and β1-adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes.Satoshi Komatsu et al.Journal of cellular physiology, 227(9), 3201-3207 (2011-11-23) Chronic pharmacological preconditioning against ischemia.Mary Clare Luca et al.Clinical hemorheology and microcirculation, 49(1-4), 287-293 (2012-01-05) An adenosine A1 agonist 2-chloro-N6 cyclopentyladenosine inhibits the angiotensin II-induced cardiomyocyte hypertrophy through the calcineurin pathway.Xingliang Zhang et al.Cardiology, 129(3), 153-162 (2014-10-04) Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.Ann Chi Yan Wong et al.Hearing research, 260(1-2), 81-88 (2009-12-10)

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