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2,3,6-Trichlorophenol | CAS:933-75-5
2,3,6-Trichlorophenol
  • Name:2,3,6-Trichlorophenol
  • CAS:933-75-5
  • Synonyms:
  • Molecular Formula:C6H3Cl3O
  • Molecular Weight:197.45
  • EINESC:213-271-7

Description

Properties

Melting point 160-161 ºC***
Boiling point 272 ºC****
Flash point 78.9±0.0 ºC, 计算值*
Density 1.5 g/cm3**

Safety

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SDS

Source SDS/MSDS Samples
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Synthetic Route
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Articles
Peer-Reviewed Papers
Bevacizumab improves splenomegaly and decreases production of hyaluronic acid after L-OHP based chemotherapy.Yusuke Arakawa et al.Anticancer research, 34(4), 1953-1958 (2014-04-03) Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2.De-Shen Wang et al.Oncotarget, 5(12), 4529-4542 (2014-07-02) Splenic volume may be a useful indicator of the protective effect of bevacizumab against oxaliplatin-induced hepatic sinusoidal obstruction syndrome.K Imai et al.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(5), 559-566 (2014-01-07) Anti-proliferative and cytoskeleton-disruptive effects of icariin on HepG2 cells.Zhi-Min Wang et al.Molecular medicine reports, 12(5), 6815-6820 (2015-09-04) Huaier Augmented the Chemotherapeutic Sensitivity of Oxaliplatin via Downregulation of YAP in Hepatocellular Carcinoma.Yuquan Tao et al.Journal of Cancer, 9(21), 3962-3970 (2018-11-10) The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model.Tomoe Kanbara et al.Journal of pharmacological sciences, 126(3), 264-273 (2014-10-28) siRNA-mediated silencing of MDR1 reverses the resistance to oxaliplatin in SW480/OxR colon cancer cells.N Montazami et al.Cellular and molecular biology (Noisy-le-Grand, France), 61(2), 98-103 (2015-05-31) Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer.Ching-Wei Chang et al.International journal of molecular sciences, 21(2) (2020-01-16) The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery.Arancha Prada-Villaverde et al.Journal of surgical oncology, 110(7), 779-785 (2014-08-05) A phase I trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors.Syma Iqbal et al.Cancer chemotherapy and pharmacology, 72(1), 85-91 (2013-05-29) The role of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer.D Khayat et al.Oncology (Williston Park, N.Y.), 15(4), 415-429 (2001-05-12) Maintenance therapy for colorectal cancer.John L Marshall Oncology (Williston Park, N.Y.), 28(4), 322-322 (2014-05-21) Oxaliplatin enhances gap junction-mediated coupling in cell cultures of mouse trigeminal ganglia.Jeppe Nørgaard Poulsen et al.Experimental cell research, 336(1), 94-99 (2015-05-23) Efficacy and safety of the FOLFOX4 regimen versus doxorubicin in Chinese patients with advanced hepatocellular carcinoma: a subgroup analysis of the EACH study.Shukui Qin et al.The oncologist, 19(11), 1169-1178 (2014-09-17) Colorectal cancer surgery in portal hypertensive patients: does adjuvant oxaliplatin affect prognosis?Khaled M Madbouly et al.Diseases of the colon and rectum, 56(5), 577-585 (2013-04-12) Morphine and oxycodone, but not fentanyl, exhibit antinociceptive effects mediated by G-protein inwardly rectifying potassium (GIRK) channels in an oxaliplatin-induced neuropathy rat model.Tomoe Kanbara et al.Neuroscience letters, 580, 119-124 (2014-08-17) Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.Giovanna Bianchi et al.Oncotarget, 6(14), 11806-11819 (2015-04-25) Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent peritoneal metastases.Terence C Chua et al.Journal of surgical oncology, 108(2), 81-88 (2013-06-06) Oxaliplatin-induced hepatocellular injury and ototoxicity: a review of the literature and report of unusual side effects of a commonly used chemotherapeutic agent.Nicole O Vietor et al.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 18(3), 355-359 (2012-02-16) Apoptotic Effect of Extract from Medicinal Mushroom from Taiwan Taiwanofungus salmoneus (Higher Basidiomycetes) Mycelium Combined with or without Cisplatin on Hepatocellular Carcinoma Cells.Rao-Chi Chien et al.International journal of medicinal mushrooms, 17(6), 567-577 (2015-09-10) Oxaliplatin-induced lung toxicity. Case report and review of the literature.Tiziana Prochilo et al.Current drug safety, 7(2), 179-182 (2012-08-10) A randomized phase II study of weekly docetaxel/cisplatin versus weekly docetaxel/oxaliplatin as first-line therapy for patients with advanced gastric cancer.Young Saing Kim et al.Cancer chemotherapy and pharmacology, 73(1), 163-169 (2013-11-10) A pragmatic definition of therapeutic synergy suitable for clinically relevant in vitro multicompound analyses.Muhammad Kashif et al.Molecular cancer therapeutics, 13(7), 1964-1976 (2014-04-24) Toxicity study of gemcitabine, oxaliplatin, and bevacizumab, followed by 5-fluorouracil, oxaliplatin, bevacizumab, and radiotherapy, in patients with locally advanced pancreatic cancer.Davendra P S Sohal et al.Cancer chemotherapy and pharmacology, 71(6), 1485-1491 (2013-03-28) Differential toxicity biomarkers for irinotecan- and oxaliplatin-containing chemotherapy in colorectal cancer.Lucía Cortejoso et al.Cancer chemotherapy and pharmacology, 71(6), 1463-1472 (2013-04-02) Oxaliplatin as a radiosensitiser for upper and lower gastrointestinal tract malignancies: what have we learned from a decade of translational research?Esme J Hill et al.Critical reviews in oncology/hematology, 83(3), 353-387 (2012-02-09) Oxaliplatin-induced thrombotic thrombocytopenic purpura: case report and literature review.Jiaxin Niu et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(31), e312-e314 (2012-09-19) Drug-Resistant Urothelial Cancer Cell Lines Display Diverse Sensitivity Profiles to Potential Second-Line Therapeutics.Stefan Vallo et al.Translational oncology, 8(3), 210-216 (2015-06-10) Current strategies to minimize toxicity of oxaliplatin: selection of pharmacogenomic panel tests.Raffaele Di Francia et al.Anti-cancer drugs, 24(10), 1069-1078 (2013-09-13) Milnacipran inhibits oxaliplatin-induced mechanical allodynia through spinal action in mice.Tsugunobu Andoh et al.Biological & pharmaceutical bulletin, 38(1), 151-154 (2015-03-07) FOLFIRI + bevacizumab as second-line therapy for metastatic colorectal cancer pretreated with oxaliplatin: a pooled analysis of published trials.Giordano Domenico Beretta et al.Medical oncology (Northwood, London, England), 30(1), 486-486 (2013-02-13) C-reactive protein is a negative independent factor in patients with stage IV colorectal cancer undergoing oxaliplatin-based chemotherapy.Minoru Fukuchi et al.Anticancer research, 33(11), 5051-5055 (2013-11-14) Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.Keita Fukushima et al.Cancer science, 106(8), 1000-1007 (2015-05-29) EF24 and RAD001 potentiates the anticancer effect of platinum-based agents in human malignant pleural mesothelioma (MSTO-211H) cells and protects nonmalignant mesothelial (MET-5A) cells.H I Onen et al.Human & experimental toxicology, 34(2), 117-126 (2014-07-17) High-throughput RNAi screening of human kinases identifies predictors of clinical outcome in colorectal cancer patients treated with oxaliplatin.Moubin Lin et al.Oncotarget, 6(18), 16774-16785 (2015-04-24) miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4.Ji Cheng et al.Oncology reports, 34(4), 1923-1932 (2015-08-05) Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death.K Moriwaki et al.Cell death & disease, 6, e1636-e1636 (2015-02-13) IFN-γ selectively exerts pro-apoptotic effects on tumor-initiating label-retaining colon cancer cells.Chao Ni et al.Cancer letters, 336(1), 174-184 (2013-05-07) miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer.Xu-Qin Xie et al.Molecular therapy oncolytics, 17, 320-331 (2020-05-10) The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells.Abbas Pirpour Tazehkand et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 103, 755-766 (2018-04-24) Randomized, placebo-controlled trial of K1 acupoint acustimulation to prevent cisplatin-induced or oxaliplatin-induced nausea.Yehua Shen et al.Cancer, 121(1), 84-92 (2014-09-11) VGluT3⁺ primary afferents play distinct roles in mechanical and cold hypersensitivity depending on pain etiology.Peter Draxler et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12015-12028 (2014-09-05) Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin.Ya-Jie Zhang et al.World journal of gastroenterology, 20(25), 8229-8236 (2014-07-11) Sensitization of mesothelioma cells to platinum-based chemotherapy by GSTπ knockdown.Jianli Chen et al.Biochemical and biophysical research communications, 447(1), 77-82 (2014-04-03) Oxaliplatin-related thrombocytopenia.D L Jardim et al.Annals of oncology : official journal of the European Society for Medical Oncology, 23(8), 1937-1942 (2012-04-27) Gc-protein-derived macrophage activating factor counteracts the neuronal damage induced by oxaliplatin.Gabriele Morucci et al.Anti-cancer drugs, 26(2), 197-209 (2014-10-12) Randomized clinical control study of locoregional therapy combined with arsenic trioxide for the treatment of hepatocellular carcinoma.Hui Wang et al.Cancer, 121(17), 2917-2925 (2015-06-03) Complete remission of recurrent and refractory ovarian cancers using weekly administration of bevacizumab and gemcitabine/oxaliplatin: report of two cases.M Takano et al.European journal of gynaecological oncology, 34(1), 90-93 (2013-04-18) [A case of bleeding stomal varices during the course of oxaliplatin-based chemotherapy for recurrent rectal cancer].Naruyuki Kobayashi et al.Gan to kagaku ryoho. Cancer & chemotherapy, 41(7), 905-907 (2014-08-19) [Preventive trial of preheating administration of oxaliplatin-diluted solution in combination with a hot compress for oxaliplatin-induced venous pain].Risa Miyajima et al.Gan to kagaku ryoho. Cancer & chemotherapy, 40(4), 537-540 (2013-07-16) Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer.Tingting Hu et al.PloS one, 10(5), e0125281-e0125281 (2015-05-02) Transcriptomic analysis predicts survival and sensitivity to anticancer drugs of patients with a pancreatic adenocarcinoma.Pauline Duconseil et al.The American journal of pathology, 185(4), 1022-1032 (2015-03-15) Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain.Dongxing Li et al.Toxins, 7(7), 2422-2434 (2015-07-02) Defective mismatch repair and benefit from bevacizumab for colon cancer: findings from NSABP C-08.Kay Pogue-Geile et al.Journal of the National Cancer Institute, 105(13), 989-992 (2013-07-04) Nicotinic Acetylcholine Receptors Mediate the Suppressive Effect of an Injection of Diluted Bee Venom into the GV3 Acupoint on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats.Heera Yoon et al.Biological & pharmaceutical bulletin, 38(5), 710-714 (2015-03-11) Provider-based research networks may improve early access to innovative colon cancer treatment for African Americans treated in the community.Dolly C Penn et al.Cancer, 121(1), 93-101 (2014-09-12) Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice.Tania E Schwingel et al.Naunyn-Schmiedeberg's archives of pharmacology, 387(9), 837-848 (2014-06-09) Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells--A Key Role for Heat-Shock Protein 70 and Receptor CD91.Josephine Salimu et al.Cancer immunology research, 3(6), 678-688 (2015-02-14) Effect of the norepinephrine transporter (NET) inhibition on μ-opioid receptor (MOR)-induced anti-nociception in a bone cancer pain model.Hiroko Ono et al.Journal of pharmacological sciences, 125(3), 264-273 (2014-06-27) [Basic evidence for efficacy of Goshajinkigan on oxaliplatin-induced neuropathy].Soichiro Ushio et al.Nihon yakurigaku zasshi. 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Cancer & chemotherapy, 40(12), 1834-1836 (2014-01-08) Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin.Jennifer R Deuis et al.Neuro-oncology, 16(10), 1324-1332 (2014-04-10) Hyperthermic intraperitoneal chemotherapy using a combination of mitomycin C,5-fluorouracil, and oxaliplatin in patients at high risk of colorectal peritoneal metastasis: A Phase I clinical study.T Shimizu et al.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(5), 521-528 (2014-01-07) Cisplatin, oxaliplatin, and carboplatin unequally inhibit in vitro mRNA translation.Jonas Philipp Becker et al.Toxicology letters, 225(1), 43-47 (2013-11-28) [Evaluation of usability of an anticancer drug after changing it to liquid formulation].Kumi Nakamura et al.Gan to kagaku ryoho. 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