Boiling point	257 ºC
Flash point	124 ºC
Density	1.159

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Source	SDS/MSDS Samples
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Synthetic Route

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Peer-Reviewed Papers

Infra-red absorption spectra of metal chelates derived from 8-hydroxyquinoline, 2-methyl-8-hydroxyquinoline, and 4-methyl-8-hydroxyquinoline. Charles RG, et al. Spectrochimica Acta Part A: Molecular Spectroscopy, 8(1), 1-8 (1956) Self-assembled polymeric chelate nanoparticles as potential theranostic agents.M Škodová et al.Chemphyschem : a European journal of chemical physics and physical chemistry, 13(18), 4244-4250 (2012-11-08) Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes.Donald J Messner et al.Digestive diseases and sciences, 58(7), 1899-1908 (2013-04-06) Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug.Tomoko Fukuuchi et al.Bioorganic & medicinal chemistry letters, 16(23), 5982-5987 (2006-09-22) Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.Saverio Tardito et al.Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo.G L Apostoli et al.Journal of thrombosis and haemostasis : JTH, 12(11), 1880-1889 (2014-08-29) Synthesis, antimicrobial, and antiviral activities of some new 5-sulphonamido-8-hydroxyquinoline derivatives.Emad M Kassem et al.Archives of pharmacal research, 35(6), 955-964 (2012-08-09) Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.Markus A Altmeyer et al.Bioorganic & medicinal chemistry letters, 20(14), 4038-4044 (2010-07-14) Synthesis and investigation of antimicrobial activity and spectrophotometric and dyeing properties of some novel azo disperse dyes based on naphthalimides.Hanieh Shaki et al.Biotechnology progress, 31(4), 1086-1095 (2015-05-15) Biosorption of Al(+3) and Cd(+2) by an exopolysaccharide from Lactobacillus rhamnosus.Magdalena Polak-Berecka et al.Journal of food science, 79(11), T2404-T2408 (2014-10-14) Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays.Mahmud Tareq Hassan Khan et al.Journal of medicinal chemistry, 52(1), 48-61 (2008-12-17) Evaluation of different buffered peptone water (BPW) based enrichment broths for detection of Gram-negative foodborne pathogens from various food matrices.H Margot et al.International journal of food microbiology, 214, 109-115 (2015-08-13) Synthesis of a monofunctional platinum compound and its activity alone and in combination with phytochemicals in ovarian tumor models.Laila Arzuman et al.Anticancer research, 34(12), 7077-7090 (2014-12-17) Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.Erik H J G Aarntzen et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06) High-throughput bone and cartilage micropellet manufacture, followed by assembly of micropellets into biphasic osteochondral tissue.Betul Kul Babur et al.Cell and tissue research, 361(3), 755-768 (2015-05-01) CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes.Nadia A Al-Banna et al.European journal of immunology, 44(6), 1633-1643 (2014-04-05) Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.Nidhi Puri et al.European journal of medicinal chemistry, 45(11), 4813-4826 (2010-08-27) Synthesis and characterization of binary and ternary complexes of Co(II), Ni(II), Cu(II) and Zn(II) ions based on 4-aminotoluene-3-sulfonic acid.Abeer A Faheim et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 109-124 (2013-01-09) In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.Poonpilas Hongmanee et al.Antimicrobial agents and chemotherapy, 51(3), 1105-1106 (2006-12-21) Synthesis, spectral, thermal and antibacterial investigations of mixed ligand complexes of thorium(IV) derived from 8-hydroxyquinoline and some amino acids.Sunil S Patil et al.Acta poloniae pharmaceutica, 69(6), 1087-1093 (2013-01-05) (111)Indium-oxine labelling for evaluating the homing process of autologous osteoblasts implanted percutaneously in atrophic nonunion fractures.Jean-Philippe Hauzeur et al.International orthopaedics, 37(1), 131-136 (2012-11-28) Characterization of 8-hydroxyquinoline derivatives containing aminobenzothiazole as inhibitors of dengue virus type 2 protease in vitro.Huiguo Lai et al.Antiviral research, 97(1), 74-80 (2012-11-07) Genomic affinities revealed by GISH suggests intergenomic restructuring between parental genomes of the paleopolyploid genus Zea.Graciela Esther González et al.Genome, 58(10), 433-439 (2015-10-28) Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.Oleg V Larionov et al.Organic letters, 16(3), 864-867 (2014-01-15) Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.Gamze Bora-Tatar et al.Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13) Analytical performance of a lab-made concomitant metal analyzer to generate volatile species of Ag, Au, Cd, Cu, Ni, Sn and Zn using 8-hydroxyquinoline as a reaction media.Julia Villanueva-Alonso et al.Talanta, 100, 45-50 (2012-11-13) [Synthesis and antimicrobial ivestigation of 8-quinolinols glucosaminides].T A Chupakhina et al.Bioorganicheskaia khimiia, 38(4), 482-488 (2012-11-30) A new metallostar complex based on an aluminum(III) 8-hydroxyquinoline core as a potential bimodal contrast agent.Elke Debroye et al.Dalton transactions (Cambridge, England : 2003), 41(35), 10549-10556 (2012-07-26) Analytical performance of a lab-made concomitant metal analyzer to generate volatile species of Ag, Au, Cd, Cu, Ni, Sn and Zn using 8-hydroxyquinoline as a reaction media.Julia Villanueva-Alonso et al.Talanta, 100, 45-50 (2012-11-13) [Synthesis and antimicrobial ivestigation of 8-quinolinols glucosaminides].T A Chupakhina et al.Bioorganicheskaia khimiia, 38(4), 482-488 (2012-11-30) Synthesis, structure, and spectral and electrochemical properties of chromium(III) tris-(8-hydroxyquinolinate).Ana R Freitas et al.Dalton transactions (Cambridge, England : 2003), 44(25), 11491-11503 (2015-06-02) Synthesis and characterization of tris-(8-hydroxyquinoline) aluminumLi H, et al Materials Science and Engineering, B, 100(1), 40-46 (2003) Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats.Bhimashankar Mitkari et al.Experimental neurology, 239, 158-162 (2012-10-13) Cooperative assembly of Zn cross-linked artificial tripeptides with pendant hydroxyquinoline ligands.Meng Zhang et al.Inorganic chemistry, 51(21), 11315-11323 (2012-10-09) Rational design of indoleamine 2,3-dioxygenase inhibitors.Ute F Röhrig et al.Journal of medicinal chemistry, 53(3), 1172-1189 (2010-01-09) An asymmetric synthesis of 1,2,4-trioxane anticancer agents via desymmetrization of peroxyquinols through a Brønsted acid catalysis cascade.David M Rubush et al.Journal of the American Chemical Society, 134(33), 13554-13557 (2012-08-09) An analytical quality by design (aQbD) approach for a L-asparaginase activity method.Han Yao et al.Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18) Antioxidant properties of 4-quinolones and structurally related flavones.Jane Greeff et al.Bioorganic & medicinal chemistry, 20(2), 809-818 (2011-12-27) Antioxidation and DNA-binding properties of binuclear lanthanide(III) complexes with a Schiff base ligand derived from 8-hydroxyquinoline-7-carboxaldehyde and benzoylhydrazine.Yongchun Liu et al.Chemistry & biodiversity, 9(8), 1533-1544 (2012-08-18) Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.Erik Serrao et al.Journal of medicinal chemistry, 56(6), 2311-2322 (2013-03-01) Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis.Qi-Pin Qin et al.European journal of medicinal chemistry, 92, 302-313 (2015-01-13) Determination of descriptors for polycyclic aromatic hydrocarbons and related compounds by chromatographic methods and liquid-liquid partition in totally organic biphasic systems.Thiloka C Ariyasena et al.Journal of chromatography. A, 1361, 240-254 (2014-08-30) PEG modification on (111)In-labeled phosphatidyl serine liposomes for imaging of atherosclerotic plaques.Mikako Ogawa et al.Nuclear medicine and biology, 42(3), 299-304 (2014-12-24) Synthesis, characterization and antibacterial activity of mixed ligand dioxouranium complexes of 8-hydroxyquinoline and some amino acids.Sunil S Patil et al.Acta poloniae pharmaceutica, 69(4), 679-686 (2012-08-11) Bioactive pyridine-N-oxide disulfides from Allium stipitatum.Gemma O'Donnell et al.Journal of natural products, 72(3), 360-365 (2008-12-20) Photoluminescence of Alq3 - and Tb-activated aluminium-tris(8-hydroxyquinoline) complex for blue chip-excited OLEDs.P W Yawalkar et al.Luminescence : the journal of biological and chemical luminescence, 28(1), 63-68 (2012-06-27) Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT.P Stephen Patrick et al.Stem cell research & therapy, 11(1), 256-256 (2020-06-27) NMR, DFT and luminescence studies of the complexation of Al(III) with 8-hydroxyquinoline-5-sulfonate.M Luísa Ramos et al.Dalton transactions (Cambridge, England : 2003), 41(40), 12478-12489 (2012-09-08) Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.María Isabel Fernández-Bachiller et al.Journal of medicinal chemistry, 53(13), 4927-4937 (2010-06-16) CoFe2O4 nano-particles functionalized with 8-hydroxyquinoline for dispersive solid-phase micro-extraction and direct fluorometric monitoring of aluminum in human serum and water samples.Hossein Abdolmohammad-Zadeh et al.Analytica chimica acta, 881, 54-64 (2015-06-05) Preconcentration of trace elements in sea water by complexation with 8-hydroxyquinoline and adsorption on C18 bonded silica gel. Watanabe H, et al. Analytical Chemistry, 53(4), 738-739 (1981) [Allergies to 8-hydroxyquinoline derivatives].D Hutzler et al.Dermatosen in Beruf und Umwelt. Occupation and environment, 36(3), 86-90 (1988-05-01) Determination of cadmium(II), cobalt(II), nickel(II), lead(II), zinc(II), and copper(II) in water samples using dual-cloud point extraction and inductively coupled plasma emission spectrometry.Lingling Zhao et al.Journal of hazardous materials, 239-240, 206-212 (2012-09-22) Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analysed by flow cytometry.Jitka Novakova et al.Journal of medical microbiology, 63(Pt 12), 1663-1669 (2014-10-10) Structural and photophysical studies on gallium(III) 8-hydroxyquinoline-5-sulfonates. Does excited state decay involve ligand photolabilisation?M Luísa Ramos et al.Dalton transactions (Cambridge, England : 2003), 42(10), 3682-3694 (2013-01-10) Genotoxic effects of 8-hydroxylquinoline in loach (Misgurnus anguillicaudatus) assessed by the micronucleus test, comet assay and RAPD analysis.Ping Nan et al.Environmental toxicology and pharmacology, 35(3), 434-443 (2013-03-12) New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation.Nicolas Audic et al.Organic & biomolecular chemistry, 11(5), 773-780 (2012-12-18) New trick for an old ligand! The sensing of Zn(II) using a lanthanide based ternary Yb(III)-cyclen-8-hydroxyquinoline system as a dual emissive probe for displacement assay.Steve Comby et al.Inorganic chemistry, 51(19), 10158-10168 (2012-09-15) Separation of Metal Complexes with Counter Ions by Tube Radial Distribution Chromatography Using a Ternary Solvent Containing 8-quinolinol.Yuji Kawai et al.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(11), 1177-1182 (2015-11-13) Identifying chelators for metalloprotein inhibitors using a fragment-based approach.Jennifer A Jacobsen et al.Journal of medicinal chemistry, 54(2), 591-602 (2010-12-30) Synthesis and characterization of 8-hydroxyquinoline complexes of tin(IV) and their application in organic light emitting diode.Yousef Fazaeli et al.Journal of fluorescence, 22(5), 1263-1270 (2012-06-15) Experimental and DFT studies of (E)-2-[2-(2,6-dichlorophenyl)ethenyl]-8-hydroxyquinoline: electronic and vibrational properties.Wenqi Sun et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 106, 275-283 (2013-02-19) Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2).Emme C K Lin et al.Bioorganic & medicinal chemistry letters, 22(2), 868-871 (2012-01-06) A Simple RNA Preparation Procedure from Yeast for Northern Blot Using Hot Phenol. Wei Y. Bio-protocol, 2(12) (2012)

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