Melting point	145-147 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

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Peer-Reviewed Papers

Pirfenidone treatment of idiopathic pulmonary fibrosis.Arata Azuma Therapeutic advances in respiratory disease, 6(2), 107-114 (2012-02-16) The evolving pharmacotherapy of pulmonary fibrosis.Harpreet K Lota et al.Expert opinion on pharmacotherapy, 14(1), 79-89 (2012-12-26) Antifibrotic activities of pirfenidone in animal models.C J Schaefer et al.European respiratory review : an official journal of the European Respiratory Society, 20(120), 85-97 (2011-06-03) Pirfenidone inhibits fibrosis in foreign body reaction after glaucoma drainage device implantationJung K I and Park C K Drug design, development and therapy, 10(6), 1477-1477 (2016) Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells.Shingo Kozono et al.Cancer research, 73(7), 2345-2356 (2013-01-26) Into the matrix: targeting fibroblasts in pulmonary fibrosis.Pitchumani Sivakumar et al.Current opinion in pulmonary medicine, 18(5), 462-469 (2012-08-01) Pirfenidone for the treatment of idiopathic pulmonary fibrosis.Sabina A Antoniu Expert opinion on investigational drugs, 15(7), 823-828 (2006-06-22) Pirfenidone: a novel agent for the treatment of idiopathic pulmonary fibrosis.Jason Potts et al.The Annals of pharmacotherapy, 47(3), 361-367 (2013-02-14) Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy.Jacob D Estes et al.The Journal of infectious diseases, 211(5), 744-754 (2014-09-24) Pharmacokinetic evaluation of tissue distribution of pirfenidone and its metabolites for idiopathic pulmonary fibrosis therapy.Kohei Togami et al.Biopharmaceutics & drug disposition, 36(4), 205-215 (2014-12-10) Inhibition of pirfenidone on TGF-beta2 induced proliferation, migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04.Yangfan Yang et al.PloS one, 8(2), e56837-e56837 (2013-02-26) A simple method for the determination of Bosutinib in rat plasma by UPLC-MS/MS.Yihua Xu et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1004, 93-97 (2015-10-12) The Protective Mechanism of Fluorofenidone in Renal Interstitial Inflammation and Fibrosis.Yiting Tang et al.The American journal of the medical sciences, 350(3), 195-203 (2015-06-03) Pirfenidone should be prescribed for patients with idiopathic pulmonary fibrosis.Gisli Jenkins Thorax, 68(7), 603-605 (2013-03-07) This issue of Current Opinion in Pulmonary Medicine contains articles that readers will find informative and challenging.Bouros D Current Opinion in Pulmonary Medicine, 18(5), 416-417 (2012) Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosisLancaster L H, et al. European Respiratory Review, 26(146), 170057-170057 (2017) Current and novel drug therapies for idiopathic pulmonary fibrosis.Huzaifa I Adamali et al.Drug design, development and therapy, 6, 261-272 (2012-10-12) CX3CL1 (fractalkine) and TNF alpha production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signalingSzukiewicz D, et al. Inflammation Research, 63(3), 179-189 (2014) Pirfenidone enhances the efficacy of combined radiation and sunitinib therapy.Seo-Hyun Choi et al.Biochemical and biophysical research communications, 462(2), 138-143 (2015-05-04) Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production.B S Lee et al.The Journal of clinical endocrinology and metabolism, 83(1), 219-223 (1998-01-22) Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.Xiaomei Qi et al.Oncotarget, 5(12), 4269-4282 (2014-06-26) Pirfenidone in idiopathic pulmonary fibrosis.T M Maher Drugs of today (Barcelona, Spain : 1998), 46(7), 473-482 (2010-08-05) A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies.K Huber et al.Histochemistry and cell biology, 142(4), 361-371 (2014-05-16) Into the matrix: targeting fibroblasts in pulmonary fibrosis.Pitchumani Sivakumar et al.Current opinion in pulmonary medicine, 18(5), 462-469 (2012-08-01) Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis.Arata Azuma Expert review of respiratory medicine, 4(3), 301-310 (2010-06-09) Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats.Jun-Feng Chen et al.American journal of physiology. Renal physiology, 304(6), F676-F685 (2012-11-16) A simple U-HPLC-MS/MS method for the determination of liensinine and isoliensinine in rat plasma.Li-Sheng Peng et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 991, 29-33 (2015-04-25) Intraindividual response to treatment with pirfenidone in idiopathic pulmonary fibrosis.Benjamin Loeh et al.American journal of respiratory and critical care medicine, 191(1), 110-113 (2015-01-01) All-cause mortality rate in patients with idiopathic pulmonary fibrosis. Implications for the design and execution of clinical trials.Talmadge E King et al.American journal of respiratory and critical care medicine, 189(7), 825-831 (2014-01-31) [Successful resection of lung cancer with idiopathic pulmonary fibrosis treated by pirfenidone during perioperative period].Shin Shomura et al.Kyobu geka. The Japanese journal of thoracic surgery, 66(10), 890-893 (2013-09-07) A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.Talmadge E King et al.The New England journal of medicine, 370(22), 2083-2092 (2014-05-20) [Patient treated with pirfenidone].Claudia Valenzuela Archivos de bronconeumologia, 48 Suppl 2, 19-20 (2013-05-01) Evaluation of pirfenidone as a new postoperative antiscarring agent in experimental glaucoma surgeryZhong H, et al. Investigative Ophthalmology & Visual Science, 52(6), 3136-3142 (2011) The big clinical trials in idiopathic pulmonary fibrosis.Fabrizio Luppi et al.Current opinion in pulmonary medicine, 18(5), 428-432 (2012-07-05) Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells.Shingo Kozono et al.Cancer research, 73(7), 2345-2356 (2013-01-26) Local delivery of biodegradable pirfenidone nanoparticles ameliorates bleomycin-induced pulmonary fibrosis in mice.Ruchit Trivedi et al.Nanotechnology, 23(50), 505101-505101 (2012-11-29) Early Experience of Pirfenidone in Daily Clinical Practice in Belgium and The Netherlands: a Retrospective Cohort Analysis.Marlies S Wijsenbeek et al.Advances in therapy, 32(7), 691-704 (2015-07-16) Pirfenidone treatment in idiopathic pulmonary fibrosis: too much of a great expectation?Spyros A Papiris et al.The European respiratory journal, 40(3), 794-795 (2012-09-04) Chronic potentiation of cardiac L-type Ca(2+) channels by pirfenidone.Roberto Ramos-Mondragón et al.Cardiovascular research, 96(2), 244-254 (2012-08-01) A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.Yasmina Bauer et al.American journal of respiratory cell and molecular biology, 52(2), 217-231 (2014-07-17) Update in diffuse parenchymal lung disease 2011.Tracy R Luckhardt et al.American journal of respiratory and critical care medicine, 186(1), 24-29 (2012-07-04) Pirfenidone: significant treatment effects in idiopathic pulmonary fibrosis.Ole Hilberg et al.The clinical respiratory journal, 6(3), 131-143 (2012-06-16) Pirfenidone. First, do no harm. Prescrire international, 22(138), 117-119 (2013-07-03) Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection.Peyman Bizargity et al.Transplantation, 94(2), 114-122 (2012-06-30) Pharmacokinetics of pirfenidone after topical administration in rabbit eye.Guoying Sun et al.Molecular vision, 17, 2191-2196 (2011-08-26) Pirfenidone: anti-fibrotic agent with a potential therapeutic role in the management of transplantation patients.Amrita Dosanjh European journal of pharmacology, 536(3), 219-222 (2006-04-04) Pirfenidone: in idiopathic pulmonary fibrosis.Natalie J Carter Drugs, 71(13), 1721-1732 (2011-09-10) Idiopathic pulmonary fibrosis.Owen J Dempsey et al.BMJ (Clinical research ed.), 347, f6579-f6579 (2013-11-10) Adverse events of pirfenidone for the treatment of pulmonary fibrosis: a meta-analysis of randomized controlled trials.Chunguo Jiang et al.PloS one, 7(10), e47024-e47024 (2012-10-12) Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagen type I in rat hepatic stellate cells in vitro.Xian-Hong Xiang et al.Molecular medicine reports, 12(1), 309-314 (2015-03-05) Photosafety assessments on pirfenidone: photochemical, photobiological, and pharmacokinetic characterization.Yoshiki Seto et al.Journal of photochemistry and photobiology. B, Biology, 120, 44-51 (2013-02-20) Experience with perioperative pirfenidone for lung cancer surgery in patients with idiopathic pulmonary fibrosis.Takekazu Iwata et al.Surgery today, 45(10), 1263-1270 (2014-11-22) Determination of trifolirhizin in rat plasma by UPLC: Application to a pharmacokinetic study.Kong-hai Ni et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 181-184 (2015-04-17) Pirfenidone in respirable powder form for the treatment of pulmonary fibrosis: a safer alternative to the current oral delivery system?Satomi Onoue et al.Therapeutic delivery, 4(8), 887-889 (2013-08-08) Pirfenidone: an anti-fibrotic therapy for progressive kidney disease.Monique E Cho et al.Expert opinion on investigational drugs, 19(2), 275-283 (2010-01-07) Suppression of TGF-beta pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitroStahnke T, et al. Testing, 12(2), e0172592-e0172592 (2017) Pirfenidone for IPF: pro/con debate; the 'con' viewpoint.Ganesh Raghu et al.Thorax, 68(7), 605-608 (2013-03-07) Interventions to improve symptoms and quality of life of patients with fibrotic interstitial lung disease: a systematic review of the literature.Sabrina Bajwah et al.Thorax, 68(9), 867-879 (2012-12-04) [Idiopathic pulmonary fibrosis: treatment with pirfenidone].Esteban Cano-Jiménez Archivos de bronconeumologia, 48 Suppl 2, 16-18 (2013-05-01) Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.Kohei Togami et al.Biological & pharmaceutical bulletin, 38(2), 270-276 (2015-03-10) [Clinical experience with pirfenidone for the treatment of idiopathic pulmonary fibrosis].F Bonella et al.Deutsche medizinische Wochenschrift (1946), 138(11), 518-523 (2013-02-21) AbbVie considers harms to be commercially confidential information: sign a petition.Peter C Gøtzsche BMJ (Clinical research ed.), 347, f7569-f7569 (2013-12-25) Antifibrotic effect of pirfenidone on human pterygium fibroblasts.Kihwang Lee et al.Current eye research, 39(7), 680-685 (2014-01-10) A new hope for idiopathic pulmonary fibrosis.Gary M Hunninghake The New England journal of medicine, 370(22), 2142-2143 (2014-05-20) Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.Inge M Westra et al.Toxicology and applied pharmacology, 274(2), 328-338 (2013-12-11) [Antifibrotic treatment].D von der Beck et al.Deutsche medizinische Wochenschrift (1946), 139(49), 2523-2525 (2014-11-26) Lung fibrosis: drug screening and disease biomarker identification with a lung slice culture model and subtracted cDNA Library.Tong Guo et al.Alternatives to laboratory animals : ATLA, 42(4), 235-243 (2014-10-08) Pirfenidone in idiopathic pulmonary fibrosis: the CAPACITY program.Luca Richeldi et al.Expert review of respiratory medicine, 5(4), 473-481 (2011-08-24) Pathobiology of Novel Approaches to Treatment AIDS Patient Care and STDs, 26(146), 170057-170057 (2018) Antifibrotic effects of pirfenidone in rat proximal tubular epithelial cells.Koji Takakura et al.Renal failure, 34(10), 1309-1316 (2012-09-26) The role of pirfenidone in the treatment of idiopathic pulmonary fibrosis.Vincent Cottin Respiratory research, 14 Suppl 1, S5-S5 (2013-06-14) [Characteristics and management of idiopathic pulmonary fibrosis: INSIGHTS-IPF registry].J Behr et al.Deutsche medizinische Wochenschrift (1946), 137(49), 2586-2588 (2012-11-29) Evaluation of pirfenidone as a new postoperative antiscarring agent in experimental glaucoma surgery.Hua Zhong et al.Investigative ophthalmology & visual science, 52(6), 3136-3142 (2011-02-19) InterMune and Boehringer blaze trails for idiopathic pulmonary fibrosis drugs.Katie Kingwell Nature reviews. Drug discovery, 13(7), 483-484 (2014-07-02) Pirfenidone.Joseph Lasky IDrugs : the investigational drugs journal, 7(2), 166-172 (2004-04-02)

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