Melting point	246-247 ºC**
Density	1.321±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Name	CAS

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Articles

Peer-Reviewed Papers

[Antiherpetic effect of RNA-tilorone molecular complex in cell culture].O I Skrots'ka et al.Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 69(3), 62-68 (2007-08-09) [Effects of diphenyl derivatives on electrophoretic mobility of murine T lymphocytes].O V Dolga et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(3), 31-38 (2013-08-21) [Antiviral effectiveness of the combined use of amixine and virasole in experimental hemorrhagic fever with renal syndrome in sucking albino mice].S Ia Loginova et al.Voprosy virusologii, 50(6), 30-32 (2006-01-18) Simultaneous quantification of tiloronoxim and tilorone in human urine by liquid chromatography-tandem mass spectrometry.Xianhua Zhang et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 875(2), 349-357 (2008-10-10) Pharmacokinetics of a synthetic interferon inducer amixin in mice.Vladimir G Zinkovsky et al.Pharmacological reports : PR, 59(6), 739-751 (2008-01-16) [Interferonogenic activity of amixin analogs and diphenyl derivatives].D S Shaĭ et al.Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 69(5), 59-64 (2008-01-26) Pharmacokinetics of amixin after repeated peroral administration to mice.N Ya Golovenko et al.Bulletin of experimental biology and medicine, 140(6), 708-710 (2006-07-20) Development of sustained-release matrix tablets of BKP-01-041 (tilorone derivative) containing Hypromellose.Liangmei Chen et al.Die Pharmazie, 68(10), 796-799 (2013-11-28) SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.Michael R Schrimpf et al.Bioorganic & medicinal chemistry letters, 22(4), 1633-1638 (2012-01-28) The effects of coadministration of tilorone dihydrochloride and culture supernatants from Lactobacillus reuteri on the mouse hepatoma cell line.Mahsa Alem et al.Journal of cancer research and therapeutics, 15(1), 176-184 (2019-03-19) [Effects of amixine on electrophoretic mobility of murine T lymphocytes].O V Dolha et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 57(2), 14-18 (2011-08-19) Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo.Outi Leppäranta et al.American journal of respiratory cell and molecular biology, 48(4), 448-455 (2012-12-22) Discovery of inhibitors of Bacillus anthracis primase DnaG.Tapan Biswas et al.Biochemistry, 52(39), 6905-6910 (2013-09-06) Performance of tiloronoxim and tilorone determination in human blood by HPLC-MS/MS: method validation, uncertainty assessment and its application to a pharmacokinetic study.Xianhua Zhang et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 492-496 (2010-01-02) New synthetic routes to tilorone dihydrochloride and some of its analogues.H M Burke et al.Journal of medicinal chemistry, 21(10), 1084-1086 (1978-10-01) DNA-drug interaction measurements using surface plasmon resonance.G Bischoff et al.Journal of biomolecular structure & dynamics, 16(2), 187-203 (1998-12-02) Elevation of efficacy of cancer vaccine combined with interferon and inducer of endogeneous interferon synthesis amixin.G P Potebnya et al.Experimental oncology, 30(4), 319-323 (2008-12-30) [Allergenic and immunotropic properties of yeast RNA-tilorone hydrochloride molecular complex].I V Tkachenko et al.Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (2)(2), 70-74 (2006-06-09) [Effect of amyxine, loramyxine and their composites with yeast RNA on spontaneous and induced mutagenesis in Salmonella typhymurium].L N Butsenko et al.Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 72(4), 44-49 (2010-09-04) Dose-dependent IFN-stimulating and immunomodulating properties of 6H-indolo[2,3-B] quinoxaline derivatives.G V Antonovych et al.Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 74(4), 79-86 (2012-10-24) [Experimental and clinicolaboratory evaluation of complex therapy efficacy in arboviral infections].M G Romantsov et al.Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 57(7-8), 12-22 (2013-01-29) [Perspectives of prevention and treatment of herpes symplex with regular recurrence].V A Isakov et al.Terapevticheskii arkhiv, 83(11), 44-47 (2012-02-09) Effect of tilorone and its analogues on the change of mitochondrial potential of rat hepatocytes.N M Zholobak et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 58(2), 39-43 (2012-08-10) Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.Rajiv R Ratan et al.Annals of the New York Academy of Sciences, 1147, 383-394 (2008-12-17) [Open population comparative randomized clinical trial of lavomax efficacy and safety in combined treatment of non-gonococcal urethritis].N V Kungurov et al.Urologiia (Moscow, Russia : 1999), (5)(5), 46-52 (2011-01-25) Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.Tehila Mayer-Sonnenfeld et al.Cellular and molecular neurobiology, 28(7), 1005-1015 (2008-03-20) alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.C A Briggs et al.British journal of pharmacology, 153(5), 1054-1061 (2007-12-25) [The antiviral activity of diphenyl derivatives in different model systems].O S Bogorad-Kobel's'ka et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 58(1), 36-42 (2012-05-17) DNA binding of tilorone: 1H NMR and calorimetric studies of the intercalation.Tomoki Nishimura et al.Biochemistry, 46(27), 8156-8163 (2007-06-19) [Lavomax in outpatient treatment of urogenital chlamidiasis in males].I G Leont'ev Urologiia (Moscow, Russia : 1999), (5)(5), 58-58 (2008-02-08)

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