Boiling point	215.7±8.0 ºC (760 Torr
Flash point	79.8±15.9 ºC, 计算值*
Density	1.001±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Synthetic Route

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Peer-Reviewed Papers

Inhibition of CYP2E1 leads to decreased advanced glycated end product formation in high glucose treated ADH and CYP2E1 over-expressing VL-17A cells.Kavitha Swaminathan et al.Biochimica et biophysica acta, 1830(10), 4407-4416 (2013-05-28) Low symmetry pyrazole-based tripodal tetraamine ligands: metal complexes and ligand decomposition reactions.John R Cubanski et al.Dalton transactions (Cambridge, England : 2003), 42(6), 2174-2185 (2012-11-30) Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.Yoko Beniyama et al.Bioorganic & medicinal chemistry letters, 23(6), 1662-1666 (2013-02-12) Self-assembly of metallomacrocycles with dipyrazole ligands and anion sensing of [Pd4Fe2] macrocycle with ferrocene-based dipyrazole ligand.Liao-Yuan Yao et al.Dalton transactions (Cambridge, England : 2003), 42(10), 3447-3454 (2012-12-22) Selective deposition of organic molecules onto DPPC templates--a molecular dynamics study.Michael Hirtz et al.Journal of colloid and interface science, 389(1), 206-212 (2012-10-10) Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives.Ana Cristina Martínez et al.PloS one, 9(9), e106372-e106372 (2014-09-13) From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.Kentaro Futatsugi et al.Bioorganic & medicinal chemistry letters, 23(1), 194-197 (2012-11-28) Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain.Sara Marchesan Oliveira et al.Pharmacology, biochemistry, and behavior, 124, 396-404 (2014-07-19) Synthesis and biological evaluation of 5-aryloxypyrazole derivatives bearing a rhodanine-3-aromatic acid as potential antimicrobial agents.Chang-Ji Zheng et al.Bioorganic & medicinal chemistry letters, 22(23), 7024-7028 (2012-10-27) Air oxygenation chemistry of 4-TBC catalyzed by chloro bridged dinuclear copper(II) complexes of pyrazole based tridentate ligands: synthesis, structure, magnetic and computational studies.Ishita Banerjee et al.Dalton transactions (Cambridge, England : 2003), 42(5), 1879-1892 (2012-11-23) POMA analyses as new efficient bioinformatics' platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues.Mohamed Jawed Ahsan et al.Bioorganic & medicinal chemistry letters, 22(23), 7029-7035 (2012-10-27) An unprecedented octadecanuclear copper(II) pyrazolate-phosphonate nanocage: synthetic, structural, magnetic, and mechanistic study.Javeed Ahmad Sheikh et al.Inorganic chemistry, 52(17), 9717-9719 (2013-08-16) A concise synthesis of pyrazole analogues of combretastatin A1 as potent anti-tubulin agents.Roberta Zaninetti et al.ChemMedChem, 8(4), 633-643 (2013-02-26) Degradation of rizazole in water-sediment systems.Changpeng Zhang et al.Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 48(5), 319-323 (2013-02-26) Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal.Melissa A Riegle et al.Alcohol and alcoholism (Oxford, Oxfordshire), 50(5), 501-508 (2015-04-15) Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes.Armen Petrosyan et al.Scientific reports, 5, 17127-17127 (2015-11-27) Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.Ke-Ming Qiu et al.Bioorganic & medicinal chemistry, 20(22), 6648-6654 (2012-10-16) Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.Heather J Finlay et al.Bioorganic & medicinal chemistry letters, 23(6), 1743-1747 (2013-02-19) Synthesis and insecticidal evaluation of novel N-pyridylpyrazolecarboxamides containing cyano substituent in the ortho-position.Mingzhen Mao et al.Bioorganic & medicinal chemistry letters, 23(1), 42-46 (2012-12-12) New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.Tiphaine Rogez-Florent et al.Bioorganic & medicinal chemistry, 21(6), 1451-1464 (2012-11-22) Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure.Kavitha Swaminathan et al.Life sciences, 92(6-7), 325-336 (2013-01-29) In a nongenomic action, steroid hormone 20-hydroxyecdysone induces phosphorylation of cyclin-dependent kinase 10 to promote gene transcription.Wen Liu et al.Endocrinology, 155(5), 1738-1750 (2014-02-13) Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives.Xiao-Guang Bai et al.Bioorganic & medicinal chemistry letters, 22(22), 6947-6951 (2012-10-06) Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors.Zhuming Sun et al.Journal of medicinal chemistry, 57(24), 10544-10550 (2014-12-05) Silver-pyrazole complexes as hybrid multifunctional materials with metallomesogenic and photoluminescent behaviour.Paloma Ovejero et al.Dalton transactions (Cambridge, England : 2003), 42(6), 2107-2120 (2012-11-29) An efficient microwave-assisted Suzuki reaction using a new pyridine-pyrazole/Pd(II) species as catalyst in aqueous media.Liqun Shen et al.Molecules (Basel, Switzerland), 18(2), 1602-1612 (2013-01-29) Direct access to pyrazolo(benzo)thienoquinolines. Highly effective palladium catalysts for the intramolecular C-H heteroarylation of arenes.Fátima Churruca et al.Chemical communications (Cambridge, England), 49(14), 1413-1415 (2013-01-16) Stable and potent analogues derived from the modification of the dicarbonyl moiety of curcumin.Soumyananda Chakraborti et al.Biochemistry, 52(42), 7449-7460 (2013-09-26) Development of a UHPLC-MS/MS method for the determination of plasma histamine in various mammalian species.Jia Liu et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 35-42 (2014-09-30) Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones.Babasaheb P Bandgar et al.Bioorganic & medicinal chemistry letters, 23(3), 912-916 (2013-01-08) Quantitation of the ligand effect in oxo-transfer reactions of dioxo-Mo(VI) trispyrazolyl borate complexes.Partha Basu et al.Dalton transactions (Cambridge, England : 2003), 42(9), 3071-3081 (2012-12-06) Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.Maria Letizia Barreca et al.Journal of medicinal chemistry, 56(6), 2270-2282 (2013-02-16) Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala.Kristen E Pleil et al.Neuropharmacology, 99, 735-749 (2015-07-19) Pyrazolium- versus imidazolium-based ionic liquids: structure, dynamics and physicochemical properties.Cinzia Chiappe et al.The journal of physical chemistry. B, 117(2), 668-676 (2012-12-21) Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice.Changchun Cai et al.Hepatology (Baltimore, Md.), 60(3), 990-1002 (2014-05-07) Critical period for dopaminergic neuroprotection by hormonal replacement in menopausal rats.Ana I Rodriguez-Perez et al.Neurobiology of aging, 36(2), 1194-1208 (2014-11-30) Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum.Ji Won Park et al.The Biochemical journal, 464(2), 241-249 (2014-09-23) Heterocycles, 37, 2087-2087 (1994) Vinylogous reactivity of enol diazoacetates with donor-acceptor substituted hydrazones. Synthesis of substituted pyrazole derivatives.Xinfang Xu et al.The Journal of organic chemistry, 78(4), 1583-1588 (2013-01-11) Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).James S Scott et al.Journal of medicinal chemistry, 55(22), 10136-10147 (2012-10-24) Pretreatment with turmeric modulates the inhibitory influence of cisplatin and paclitaxel on CYP2E1 and CYP3A1/2 in isolated rat hepatic microsomes.Enas M Ahmed et al.Chemico-biological interactions, 220, 25-32 (2014-06-03) Cholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization.Beatriz Apellániz et al.Journal of virology, 88(22), 13367-13377 (2014-09-12) Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling.E Litwa et al.The Journal of steroid biochemistry and molecular biology, 144 Pt B, 334-347 (2014-08-06) Two new scorpionate oxomolybdenum(VI)-poly(pyrazolyl)borate complexes: synthesis, structure, and catalytic performance in the oxidation of cyclohexane.Na Xing et al.Dalton transactions (Cambridge, England : 2003), 42(2), 359-363 (2012-11-14) Cationic gold(I) heteroleptic complexes bearing a pyrazole-derived N-heterocyclic carbene: syntheses, characterizations, and cytotoxic activities.Haresh Sivaram et al.Dalton transactions (Cambridge, England : 2003), 42(34), 12421-12428 (2013-07-19) Transition Met. Chem. (London), 19, 165-165 (1994) New trends in synthesis of pyrazole nucleosides as new antimetabolites.Galal H Elgemeie et al.Nucleosides, nucleotides & nucleic acids, 24(8), 1227-1247 (2005-11-08)

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