Boiling point	125.5 ºC***
Flash point	95.9±15.2 ºC, 计算值*
Density	1.0248 g/cm3 (25 ºC)**
Refractive index	1.4738 (589.3 nm 25 ºC)****

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Source	SDS/MSDS Samples
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Synthetic Route

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Articles

Peer-Reviewed Papers

Structure-based design of novel pyrimido[4,5-c]pyridazine derivatives as dihydropteroate synthase inhibitors with increased affinity.Ying Zhao et al.ChemMedChem, 7(5), 861-870 (2012-03-15) Characterizing and optimizing (co-)pyrolysis as a function of different feedstocks, atmospheres, blend ratios, and heating rates.Jingyong Liu et al.Bioresource technology, 277, 104-116 (2019-01-20) Multiclass screening in urine by comprehensive two-dimensional liquid chromatography time of flight mass spectrometry for residues of sulphonamides, beta-agonists and steroids.M H Blokland et al.Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 35(9), 1703-1715 (2018-08-15) Hydrolysis of the amide bond in histidine- and methionine-containing dipeptides promoted by pyrazine and pyridazine palladium(II)-aqua dimers: Comparative study with platinum(II) analogues.Marija D Živković et al.Bioorganic chemistry, 72, 190-198 (2017-05-02) Regular Two-Dimensional Arrays of Surface-Mounted Molecular Switches: Switching Monitored by UV-vis and NMR Spectroscopy.Carina Santos Hurtado et al.Journal of the American Chemical Society, 142(20), 9337-9351 (2020-04-25) Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive moleculesHe Z-X, et al. European Journal of Medicinal Chemistry, 112946-112946 (2020) Pyridazinium-based ionic liquids as novel and green corrosion inhibitors of carbon steel in acid medium: electrochemical and molecular dynamics simulation studiesEl-Hajjaji F, et al. Journal of Molecular Liquids, 249(1), 997-1008 (2018) Ultrafast resonance-enhanced multiphoton ionization in the azabenzenes: pyridine, pyridazine, pyrimidine, and pyrazine.Timothy D Scarborough et al.The Journal of chemical physics, 136(5), 054309-054309 (2012-02-11) Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II.Dorina Mantu et al.European journal of medicinal chemistry, 45(11), 5164-5168 (2010-09-04) Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).Mariangela Urbano et al.Bioorganic & medicinal chemistry letters, 22(23), 7135-7141 (2012-10-20) Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivativesPopovici L, et al. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 230-243 (2019) Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors.Hongliang Wang et al.Bioorganic & medicinal chemistry letters, 21(3), 1057-1059 (2011-01-11) 2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus.Abdelselam Ali et al.Bioorganic & medicinal chemistry letters, 21(14), 4160-4163 (2011-06-21) 4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors.Takeshi Hondo et al.Journal of medicinal chemistry, 56(9), 3582-3592 (2013-04-10) Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.Andrew J Zych et al.Bioorganic & medicinal chemistry letters, 22(14), 4896-4899 (2012-06-13) Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.Carlo Ballatore et al.Bioorganic & medicinal chemistry, 20(14), 4451-4461 (2012-06-22) Response of chronic gingivitis to hygiene therapy and experimental gingivitis. Clinical, microbiological and metabonomic changes.Malgorzata Klukowska et al.American journal of dentistry, 28(5), 273-284 (2015-12-31) Synthesis and biological evaluation of new heteroaryl carboxylic acid derivatives as anti-inflammatory-analgesic agents.Khaled Abouzid Mohamed Abouzid et al.Chemical & pharmaceutical bulletin, 61(2), 222-228 (2013-02-02) A new and efficient synthetic route for the anxiolytic agent CL285032.Victor P Ghidu et al.Bioorganic & medicinal chemistry letters, 21(1), 259-261 (2010-11-26) A modular synthesis of teraryl-based α-helix mimetics, part 2: Synthesis of 5-pyridine boronic acid pinacol ester building blocks with amino acid side chains in 3-position.Martin Peters et al.Chemistry (Weinheim an der Bergstrasse, Germany), 19(7), 2450-2456 (2013-01-03) The diazines: Pyridazine, pyrimidine, and pyrazine: reactions and synthesis Heterocyclic Chemistry (2013) A Raman study on preferential interactions in the formamide/pyridine/pyridazine system and complementary thermodynamic information on the formamide/pyridazine mixture.Elaine F da Silva et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 71-74 (2012-12-12) Six membered heterocyclic compounds with two or more heteroatoms Heterocyclic Chemistry (2010) Pyridazine based scorpionate ligand in a copper boratrane compound.Gernot Nuss et al.Inorganic chemistry, 50(24), 12632-12640 (2011-11-19) Structural insight for imidazopyridazines as malarial kinase PfPK7 inhibitors using QSAR techniques.Nitendra K Sahu et al.Medicinal chemistry (Shariqah (United Arab Emirates)), 8(4), 636-648 (2012-04-26) Bromopyridazinedione-mediated protein and peptide bioconjugation.Vijay Chudasama et al.Chemical communications (Cambridge, England), 47(31), 8781-8783 (2011-07-09) Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.Scott S Walker et al.Antimicrobial agents and chemotherapy, 55(11), 5099-5106 (2011-08-17) Isomer Dependence on the Reactivity of Diazenes with Pentaphenylborole.Venkata A K Adiraju et al.Chemistry (Weinheim an der Bergstrasse, Germany), 23(47), 11437-11444 (2017-07-05) N-Phenyl-4-pyrazolo [1, 5-b] pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacyTavares FX, et al. Journal of Medicinal Chemistry, 47(19), 4716-4730 (2004) Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor.Masaomi Terajima et al.European journal of pharmacology, 698(1-3), 455-462 (2012-11-28) Electrochemical, computational, and photophysical characterization of new luminescent dirhenium-pyridazine complexes containing bridging OR or SR anions.Alessio Raimondi et al.Inorganic chemistry, 51(5), 2966-2975 (2012-03-01) Determination of liquid chromatography/flame ionization detection response factors for N-heterocycles, carboxylic acids, halogenated compounds, and others.Christian Becker et al.Analytical and bioanalytical chemistry, 412(1), 171-179 (2019-12-14) Electron stimulated desorption from condensed pyrimidine and pyridazine.L Ellis-Gibbings et al.Physical chemistry chemical physics : PCCP, 19(20), 13038-13048 (2017-05-10) Hydrogen bonding and reactivity of water to azines in their S1 (n,π*) electronic excited states in the gas phase and in solution.Jeffrey R Reimers et al.Physical chemistry chemical physics : PCCP, 14(25), 8791-8802 (2012-04-26) Using Voltammetry to Measure the Relative Hydrogen-Bonding Strengths of Pyridine and Its Derivatives in Acetonitrile.Malcolm E Tessensohn et al.Chemphyschem : a European journal of chemical physics and physical chemistry, 18(16), 2250-2257 (2017-06-14) Shape and core excited resonances in electron collisions with diazines.Zdeněk Mašín et al.The Journal of chemical physics, 137(20), 204312-204312 (2012-12-05) Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.Emily A Peterson et al.Bioorganic & medicinal chemistry letters, 22(15), 4967-4974 (2012-07-07) Pyridazine-derived γ-secretase modulators.Zehong Wan et al.Bioorganic & medicinal chemistry letters, 21(13), 4016-4019 (2011-06-04) Synthesis and antiproliferative effects of 5,6-disubstituted Pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 Analogues.Mohamed Elagawany et al.Anti-cancer agents in medicinal chemistry, 13(7), 1133-1140 (2013-04-12) Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.Robert H Bradbury et al.Bioorganic & medicinal chemistry letters, 21(18), 5442-5445 (2011-07-26) Photocatalytic degradation of N-heterocyclic aromatics-effects of number and position of nitrogen atoms in the ring.Jasmeet Kaur et al.Environmental science and pollution research international, 20(6), 3956-3964 (2013-05-08) Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study.Jörn F Dopheide et al.Clinical research in cardiology : official journal of the German Cardiac Society, 104(9), 751-763 (2015-03-17)

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