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N,N-Dimethylbenzeneethanamine | CAS:1126-71-2
N,N-Dimethylbenzeneethanamine
  • Name:N,N-Dimethylbenzeneethanamine
  • CAS:1126-71-2
  • Synonyms:N,N-Dimethylphenylethylamine; N-(2-Phenylethyl)dimethylamine; N-Phenethyldimethylamine; NSC 1849; [(Dimethylamino)ethyl]benzene
  • Molecular Formula:C10H15N
  • Molecular Weight:149.23
  • EINESC:

Description

Properties

Melting point 208 ºC (分解)**
Boiling point 210-215 ºC (760 Torr)***
Flash point 71.4±18.4 ºC, 计算值*
Density 0.918±0.06 g/cm3 (20 º
Refractive index 1.507 (589.3 nm 20 ºC)****

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SDS

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Articles
Peer-Reviewed Papers
Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.Whocely Victor de Castro et al.Journal of agricultural and food chemistry, 56(12), 4840-4845 (2008-05-23) Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect.Hsia-Lien Lin et al.Drug metabolism and disposition: the biological fate of chemicals, 40(5), 998-1006 (2012-02-22) Food-drug interactions: grapefruit juice.Camelia Harapu Diaconu et al.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 115(1), 245-250 (2011-06-21) The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs.Jasminder Sahi et al.Drug metabolism and disposition: the biological fate of chemicals, 30(2), 135-140 (2002-01-17) In vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents.Marie Bräunlich et al.Planta medica, 79(2), 137-141 (2012-12-20) Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4.E C Row et al.Bioorganic & medicinal chemistry, 14(11), 3865-3871 (2006-02-17) Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cellsKim M-S, et al. Cancer Cells, 354(01), 153-163 (2014) Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.Shinsuke Marumoto et al.Bioorganic & medicinal chemistry, 20(2), 784-788 (2012-01-10) Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4.E C Row et al.Organic & biomolecular chemistry, 4(8), 1604-1610 (2006-04-11) [Contents of furanocoumarins in grapefruit juice and health foods].Narue Sakamaki et al.Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 49(4), 326-331 (2008-09-13) Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4.Kyung Myung et al.Applied microbiology and biotechnology, 78(2), 343-349 (2008-01-10) Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice.Y Uesawa et al.Die Pharmazie, 66(7), 525-528 (2011-08-05) Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.Ute M Kent et al.The Journal of pharmacology and experimental therapeutics, 318(3), 992-1005 (2006-06-21) The use of heat treatment to eliminate drug interactions due to grapefruit juice.Yoshihiro Uesawa et al.Biological & pharmaceutical bulletin, 29(11), 2274-2278 (2006-11-02) Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells.Whocely Victor de Castro et al.Journal of pharmaceutical sciences, 96(10), 2808-2817 (2007-06-02) Major furocoumarins in grapefruit juice I: levels and urinary metabolite(s).Anastasia Messer et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(12), 3224-3231 (2011-09-29) Determination of bergamottin in human plasma after grapefruit juice ingestion by an UPLC/MS/MS method.Y Uesawa et al.Die Pharmazie, 63(2), 110-112 (2008-04-03) White and colored grapefruit juice produce similar pharmacokinetic interactions.Y Uesawa et al.Die Pharmazie, 63(8), 598-600 (2008-09-06) Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test.S Olguín-Reyes et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(9), 3094-3099 (2012-06-19) Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.Jennifer S Mammen et al.Pharmacogenetics and genomics, 15(3), 183-188 (2005-04-30) Probable interaction of bergamottin and cyclosporine in a lung transplant recipient.Philip E Johnston et al.Transplantation, 79(6), 746-746 (2005-03-24) Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-?B signalling pathway in human chronic myelogenous leukaemiaKim M-S, et al. Pharmaceutical biology, 54(10), 2050-2060 (2016) Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice.Paul F Cancalon et al.Journal of food science, 76(4), C543-C548 (2012-03-16) Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies.Whocely Victor De Castro et al.Journal of agricultural and food chemistry, 54(1), 249-255 (2006-01-05) Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents.Nallely E Sandoval-Montemayor et al.Molecules (Basel, Switzerland), 17(9), 11173-11184 (2012-09-21) A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6.Cesar Kenaan et al.Nature protocols, 5(10), 1652-1658 (2010-10-05) Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells.Kim SM, Lee JH, Sethi G, et al. Cancer Letters, 354(1), 153-163 (2014) Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.Yong Pil Hwang et al.Molecular nutrition & food research, 54(7), 977-990 (2009-11-28) Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.Ram M Uckoo et al.Journal of food science, 77(9), C921-C926 (2012-09-11)
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