Boiling point	122 ºC
Flash point	86 ºC
Density	1.038
Refractive index	1.5749

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36/37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
Oakwood	View & Download

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Peer-Reviewed Papers

A comparison of histamine effects on the sympathetic neurotransmission of testicular capsule and rat vas deferens.Edilson Dantas da Silva Júnior et al.Naunyn-Schmiedeberg's archives of pharmacology, 387(8), 719-731 (2014-04-17) Combating against methicillin-resistant Staphylococcus aureus - two fatty acids from Purslane (Portulaca oleracea L.) exhibit synergistic effects with erythromycin.Ben C L Chan et al.The Journal of pharmacy and pharmacology, 67(1), 107-116 (2014-09-13) Origins of 1,6-stereoinduction in torquoselective 6π electrocyclizations.Ashay Patel et al.Journal of the American Chemical Society, 135(12), 4878-4883 (2013-03-02) Catecholamine regulation of stromal precursors and hemopoietic stem cells in cytostatic myelosuppression.A M Dygai et al.Bulletin of experimental biology and medicine, 152(6), 723-727 (2012-07-18) Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates.Andrei Papkou et al.Nature communications, 11(1), 3970-3970 (2020-08-10) Reserpine-induced supersensitivity to the cardiac effects of agonists.K D Meisheri et al.Life sciences, 24(6), 473-480 (1979-02-05) Depressive reactions associated with reserpine.S V Ambrosino New York state journal of medicine, 74(5), 860-864 (1974-05-01) A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.Yuwei Yao et al.eLife, 4 (2015-03-05) Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.Kenji Maeda et al.The Journal of pharmacology and experimental therapeutics, 350(3), 589-604 (2014-06-21) Salt effects in electromembrane extraction.Knut Fredrik Seip et al.Journal of chromatography. A, 1347, 1-7 (2014-05-06) Characterization of tetA-like gene encoding for a major facilitator superfamily efflux pump in Streptococcus thermophilus.Stefania Arioli et al.FEMS microbiology letters, 355(1), 61-70 (2014-04-29) [Reserpine and breast cancer].S Głuszek Wiadomosci lekarskie (Warsaw, Poland : 1960), 37(5), 367-370 (1984-03-01) Antidepressant and anxiolytic-like effects of 4n, a novel 5-HT3 receptor antagonist using behaviour based rodent models.Baldev Kumar et al.Indian journal of experimental biology, 50(9), 625-632 (2012-11-13) Reserpine: a relic from the past or a neglected drug of the present for achieving cost containment in treating hypertension?G J Magarian Journal of general internal medicine, 6(6), 561-572 (1991-11-01) Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.Arnaud Tauffenberger et al.Neurobiology of aging, 34(9), 2175-2182 (2013-04-18) Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging.Sheerin K Shahidi-Latham et al.Analytical chemistry, 84(16), 7158-7165 (2012-07-26) Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free mediumToimela T, et al. Reproductive Toxicology, 70, 116-125 (2017) Gallic acid decreases vacuous chewing movements induced by reserpine in rats.Patrícia Reckziegel et al.Pharmacology, biochemistry, and behavior, 104, 132-137 (2013-01-15) Hydrophilic interaction chromatography versus reversed phase liquid chromatography coupled to mass spectrometry: effect of electrospray ionization source geometry on sensitivity.Aurélie Periat et al.Journal of chromatography. A, 1356, 211-220 (2014-07-16) [Effect of euodiae fructus on hepatic energy metabolism-related mechanisms of reserpine-induced asthenia cold syndrome rats].Li-Ping Huang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(20), 3539-3543 (2014-02-05) Reserpine. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 24, 211-241 (1980-01-01) Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates.Gyan Modi et al.ACS chemical neuroscience, 5(8), 700-717 (2014-06-25) Repetitive injection method: a tool for investigation of injection zone formation and its compression in microfluidic liquid chromatography.Martin Gilar et al.Journal of chromatography. A, 1381, 110-117 (2015-01-22) Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes.Norimasa Jinno et al.Xenobiotica; the fate of foreign compounds in biological systems, 44(8), 677-686 (2014-03-01) Investigations of analyte-specific response saturation and dynamic range limitations in atmospheric pressure ionization mass spectrometry.Clint M Alfaro et al.Analytical chemistry, 86(21), 10639-10645 (2014-10-01) Enantioselective total synthesis of (+)-reserpine.Naomi S Rajapaksa et al.Organic letters, 15(3), 706-709 (2013-01-22) Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity.Biswanath Majumder et al.Nature communications, 6, 6169-6169 (2015-02-28) Association between arterial stiffness and serum L-octanoylcarnitine and lactosylceramide in overweight middle-aged subjects: 3-year follow-up study.Minjoo Kim et al.PloS one, 10(3), e0119519-e0119519 (2015-03-18) Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.Cheng-Xue Ji et al.European journal of pharmacology, 691(1-3), 46-51 (2012-07-14) Modulations of brain amines and dopaminergic behavior by a novel, reversible and selective MAO-B inhibitor.Nibha Mishra et al.Brain research, 1470, 45-51 (2012-07-07) [Milestones of cardiovascular therapy. IV. Reserpine].P Jerie Casopis lekaru ceskych, 146(7), 573-577 (2007-08-29) Blood pressure lowering efficacy of reserpine for primary hypertension.Sandy D Shamon et al.The Cochrane database of systematic reviews, (4)(4), CD007655-CD007655 (2009-10-13) How reserpine and chlorpromazine act: the impact of key discoveries on the history of psychopharmacology.G Curzon Trends in pharmacological sciences, 11(2), 61-63 (1990-02-01) Wide injection zone compression in gradient reversed-phase liquid chromatography.Martin Gilar et al.Journal of chromatography. A, 1390, 86-94 (2015-03-10) Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines.Anna B Wennerström et al.PloS one, 9(8), e103873-e103873 (2014-08-26) Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.Patrizia Spigaglia et al.Antimicrobial agents and chemotherapy, 53(6), 2463-2468 (2009-04-15) Reserpine: a tragic victim of myths, marketing, and fashionable prescribing.H S Fraser Clinical pharmacology and therapeutics, 60(4), 368-373 (1996-10-01) The biological fate of reserpine.R E Stitzel Pharmacological reviews, 28(3), 179-208 (1976-09-01) Light Regulation of Chlorophyll and Glycoalkaloid Biosynthesis During Tuber Greening of Potato S. tuberosum.Haruko Okamoto et al.Frontiers in plant science, 11, 753-753 (2020-08-08) Effects of antipsychotic treatment on cognition in healthy subjects.Tanja Veselinovic et al.Journal of psychopharmacology (Oxford, England), 27(4), 374-385 (2012-11-03) The reserpine receptor.A Giachetti et al.Life sciences, 23(2), 89-92 (1978-07-10) A novel stable isotope labelling assisted workflow for improved untargeted LC-HRMS based metabolomics research.Christoph Bueschl et al.Metabolomics : Official journal of the Metabolomic Society, 10(4), 754-769 (2014-07-25) [Use of reserpine in myocardial contraction studies].J Spadaro Arquivos brasileiros de cardiologia, 28(5), 569-575 (1975-10-01) Electrical Stimulation at the ST36 Acupoint Protects against Sepsis Lethality and Reduces Serum TNF Levels through Vagus Nerve- and Catecholamine-Dependent Mechanisms.Albino Villegas-Bastida et al.Evidence-based complementary and alternative medicine : eCAM, 2014, 451674-451674 (2014-07-25) Mechanisms of the anti-inflammatory and antifibrotic activity of a sympatholytic agent during toxic pulmonary fibrosis.E G Skurikhin et al.Bulletin of experimental biology and medicine, 153(5), 638-643 (2012-11-01) Detection of OXA-48-type carbapenemase-producing Enterobacteriaceae in diagnostic laboratories can be enhanced by addition of bicarbonates to cultivation media or reaction buffers.Vendula Studentova et al.Folia microbiologica, 60(2), 119-129 (2014-09-30) Altered plasma lysophosphatidylcholines and amides in non-obese and non-diabetic subjects with borderline-to-moderate hypertriglyceridemia: a case-control study.Sae Young Lee et al.PloS one, 10(4), e0123306-e0123306 (2015-04-10) [Influence of morphine and reserpine on the experimental effect of electrostimulation of biologically active points].V V Iasnetsov et al.Farmakologiia i toksikologiia, 43(2), 161-164 (1980-03-01) Reserpine. IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 10, 217-229 (1976-01-01) Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity.Patricia Muñoz et al.Biochimica et biophysica acta, 1822(7), 1125-1136 (2012-04-10) [Reproduction of passive avoidance reactions after neurotensin microinjection into nucleus accumbens of rat brain against the background of reserpine action].N P Shugalev et al.Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 62(3), 357-363 (2012-08-16) Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.M Marti et al.British journal of pharmacology, 168(4), 863-879 (2012-09-22) Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.Ki Sung Kang et al.Brain research, 1497, 1-14 (2012-12-05) [Reserpine-diuretic combinations in therapy of arterial hypertension. Current considerations].M Siepmann et al.Medizinische Klinik (Munich, Germany : 1983), 93(12), 733-737 (1999-02-20) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.Naoya Hirata et al.Nature communications, 5, 4806-4806 (2014-09-26) 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.Yan Ding et al.American journal of physiology. Renal physiology, 305(5), F753-F763 (2013-07-05) Performance and geometry optimization of the ceramic-based rectilinear ion traps.Liang Wang et al.Rapid communications in mass spectrometry : RCM, 26(17), 2068-2074 (2012-08-01) Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.Toru Taguchi et al.Pain, 156(3), 415-427 (2015-01-20) Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization.Mark Johnson et al.Journal of medicinal chemistry, 55(12), 5826-5840 (2012-05-31) The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.Dubravka Švob Štrac et al.Croatian medical journal, 53(3), 214-223 (2012-06-05) Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex.M Julia García-Fuster et al.Neuropharmacology, 89, 204-214 (2014-10-07) The chlorpromazine enigma.Alan A Baumeister Journal of the history of the neurosciences, 22(1), 14-29 (2013-01-18) Surface-activated chemical ionization-electrospray ionization source improves biomarker discovery with mass spectrometry.Ilaria Sogno et al.Rapid communications in mass spectrometry : RCM, 26(10), 1213-1218 (2012-04-14) GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine.David B Horton et al.Journal of neurochemistry, 127(2), 177-186 (2013-07-24) Ofloxacin resistance in Mycobacterium tuberculosis is associated with efflux pump activity independent of resistance pattern and genotype.Zhaogang Sun et al.Microbial drug resistance (Larchmont, N.Y.), 20(6), 525-532 (2014-06-19) (-) Epigallocatechin-3-gallate attenuates reserpine-induced orofacial dyskinesia and oxidative stress in rat striatum.Mao-Hsien Wang et al.Pharmacology, biochemistry, and behavior, 131, 71-76 (2015-02-11) The effects of reserpine on hypothalamo-pituitary adrenocortical function.S V Vellucci General pharmacology, 9(5), 275-285 (1978-01-01) Endogenous dopamine is involved in the herbicide paraquat-induced dopaminergic cell death.Yasuhiko Izumi et al.Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 466-478 (2014-04-20) Pharmacological interference with 123I-metaiodobenzylguanidine: a limitation to developing cardiac innervation imaging in clinical practice?A Stefanelli et al.European review for medical and pharmacological sciences, 17(10), 1326-1333 (2013-06-07) Deep brain stimulation of the substantia nigra pars reticulata improves forelimb akinesia in the hemiparkinsonian rat.Alexander C Sutton et al.Journal of neurophysiology, 109(2), 363-374 (2012-10-19) Striatal monoamines and reserpine and chlorpromazine rigidity.I Jurna Pharmacology & therapeutics. Part B: General & systematic pharmacology, 2(1), 113-128 (1976-01-01) What All Should Know about Plant Drugs Essentials of Biochemistry for Medical Students, 35-61 (2015) The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry.Donna M Omiatek et al.Scientific reports, 3, 1447-1447 (2013-03-15) The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.Kari A Johnson et al.Neuropharmacology, 66, 187-195 (2012-05-02) Heart and circulatory system drugs and diuretics Drugs During Pregnancy and Lactation, 193-236 (2007) Depressions following reserpine: a reevaluation.F K Goodwin et al.Seminars in psychiatry, 3(4), 435-448 (1971-11-01) Alteration of dopamine uptake into rat striatal vesicles and synaptosomes caused by an in vitro exposure to atrazine and some of its metabolites.Muhammad M Hossain et al.Toxicology, 248(1), 52-58 (2008-04-22) Forward genetic analysis to identify determinants of dopamine signaling in Caenorhabditis elegans using swimming-induced paralysis.J Andrew Hardaway et al.G3 (Bethesda, Md.), 2(8), 961-975 (2012-08-22) A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans.Julia Zwirchmayr et al.Scientific reports, 10(1), 12323-12323 (2020-07-25) Reserpine: a challenge for total synthesis of natural products.Fen-Er Chen et al.Chemical reviews, 105(12), 4671-4706 (2005-12-15) [Effect of sijunzi decoction on salivary amylase secretion disorder and VIP-cAMP signaling pathway in splenasthenic rats].Yu-Long Chen et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(1), 83-87 (2012-06-28) Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling.Ilenia Segatto et al.Oncotarget, 5(15), 6267-6279 (2014-07-16) Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500.Chih-Jung Yao et al.Integrative cancer therapies, 13(6), 541-554 (2014-11-02) Reserpine and the medical marketplace.F A Lederle et al.Archives of internal medicine, 153(6), 705-706 (1993-03-22) Using mass spectrometry to detect, differentiate, and semiquantitate closely related peptide hormones in complex milieu: measurement of IGF-II and vesiculin.Kate L Lee et al.Endocrinology, 156(3), 1194-1199 (2014-12-30) Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation.Tip W Loo et al.Biochemical pharmacology, 92(4), 558-566 (2014-12-03) Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates.Guilian Li et al.PloS one, 10(2), e0119013-e0119013 (2015-02-20) A torquoselective 6π electrocyclization approach to reserpine alkaloids.Gregg A Barcan et al.Organic letters, 14(21), 5388-5391 (2012-10-09)

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