Melting point	155-159 ºC
Boiling point	289 ºC (40 mmHg)

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S36

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

Synthetic Route

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Articles

Peer-Reviewed Papers

Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear model.Mattis Bertlich et al.Life sciences, 187, 17-21 (2017-08-19) Prognostic Factors in Sudden Sensorineural Hearing Loss.Gamze Atay et al.Balkan medical journal, 33(1), 87-93 (2016-03-12) Involvement of histamine receptors in SAPK/JNK phosphorylation.Radhika D Dandekar et al.International immunopharmacology, 13(2), 190-196 (2012-04-11) Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.Giacomo Russo et al.International journal of pharmaceutics, 560, 294-305 (2019-02-17) Duplicate internal auditory canals with facial and vestibulocochlear nerve dysfunction.T Y Kew et al.The Journal of laryngology and otology, 126(1), 66-71 (2011-08-27) Menière-like syndrome in Camurati-Engelmann disease.Lea Pollak The Israel Medical Association journal : IMAJ, 15(7), 390-391 (2013-08-16) Vestibular rehabilitation with virtual reality in Ménière's disease.Adriana Pontin Garcia et al.Brazilian journal of otorhinolaryngology, 79(3), 366-374 (2013-06-08) Betahistine in the treatment of tinnitus in patients with vestibular disorders.Maurício Malavasi Ganança et al.Brazilian journal of otorhinolaryngology, 77(4), 499-503 (2011-08-24) Betahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches.Brahim Tighilet et al.Frontiers in neurology, 9, 431-431 (2018-06-27) Benign paroxysmal positional vertigo (BPPV): influence of pharmacotherapy and rehabilitation therapy on patients' recovery rate and life quality.Sinisa Maslovara et al.NeuroRehabilitation, 31(4), 435-441 (2012-12-13) [Betahistine in the treatment of vestibular and coordination disturbances in multiple sclerosis].N F Popova et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 111(2 Pt 2), 77-81 (2011-09-16) Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo.Fritz Ihler et al.PloS one, 7(6), e39086-e39086 (2012-06-30) The effects of betahistine in addition to epley maneuver in posterior canal benign paroxysmal positional vertigo.Enis Alpin Guneri et al.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 146(1), 104-108 (2011-08-20) [Treatment of vestibular vertigo and Ménière syndrome in outpatient clinics].E V Kostenko et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(12), 36-40 (2013-02-08) Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model.Chao Deng et al.Journal of psychopharmacology (Oxford, England), 26(9), 1271-1279 (2012-06-15) Topical application of betahistine improves eustachian tube function in an animal model.Burkhard Franz et al.Acta oto-laryngologica, 131(11), 1155-1159 (2011-09-13) [Prospects for the use of histaminergic preparations for the purpose of noise otoprotection].E I Matsnev et al.Vestnik otorinolaringologii, (3)(3), 59-64 (2011-07-02) Transdermal delivery of betahistine hydrochloride using microemulsions: physical characterization, biophysical assessment, confocal imaging and permeation studies.Rania M Hathout et al.Colloids and surfaces. B, Biointerfaces, 110, 254-260 (2013-06-05) Meniere's disease: an evidence based approach to assessment and management.I Syed et al.International journal of clinical practice, 66(2), 166-170 (2012-01-20) Effects of haloperidol inhalation on MK-801- and memantine-induced locomotion in mice.Hiroshi Ueno et al.The Libyan journal of medicine, 15(1), 1808361-1808361 (2020-08-19) Using Chemoinformatics, Bioinformatics, and Bioassay to Predict and Explain the Antibacterial Activity of Nonantibiotic Food and Drug Administration Drugs.Nour Aldin Kahlous et al.Assay and drug development technologies, 15(3), 89-105 (2017-03-28) Effect of transtympanic low-pressure therapy in patients with unilateral Menière's disease unresponsive to betahistine: a randomised, placebo-controlled, double-blinded, clinical trial.R Gürkov et al.The Journal of laryngology and otology, 126(4), 356-362 (2012-03-01) Bayesian model selection techniques as decision support for shaping a statistical analysis plan of a clinical trial: an example from a vertigo phase III study with longitudinal count data as primary endpoint.Christine Adrion et al.BMC medical research methodology, 12, 137-137 (2012-09-12) [Clinical effectiveness and safety of sanchi tong shu capsule in the treatment of aural vertigo: a multi-center randomized controlled clinical trial].Juan Meng et al.Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 26(7), 295-299 (2012-06-29) Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study.Arne-Wulf Scholtz et al.Clinical drug investigation, 32(6), 387-399 (2012-04-18) Histamine and antipsychotic drug-induced weight gain.Gavin P Reynolds Journal of psychopharmacology (Oxford, England), 26(12), 1608-1609 (2012-11-30) Development of novel sustained release matrix pellets of betahistine dihydrochloride: effect of lipophilic surfactants and co-surfactants.Rehab Nabil Shamma et al.Pharmaceutical development and technology, 17(5), 583-593 (2011-07-21) Betahistine or Cinnarizine for treatment of Meniere's disease.Jasminka Djelilovic-Vranic et al.Medical archives (Sarajevo, Bosnia and Herzegovina), 66(6), 396-398 (2013-02-16) [Efficacy of vestibo in the treatment of vertebrobasilar insufficiency].E I Chukanova et al.Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(4), 53-56 (2012-07-20) [Vertigo: patient management tactics].I S Vasyl'chuk et al.Likars'ka sprava, (7)(7), 84-87 (2013-01-29) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.G Desmadryl et al.British journal of pharmacology, 167(4), 905-916 (2012-05-26) Histamine H1 Receptor Contributes to Vestibular Compensation.Zhang-Peng Chen et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(3), 420-433 (2018-11-11) Reducing antipsychotic-induced weight gain in schizophrenia: a double-blind placebo-controlled study of reboxetine-betahistine combination.Michael Poyurovsky et al.Psychopharmacology, 226(3), 615-622 (2012-12-15)

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