Melting point	180-184 ºC**
Density	1.181±0.06 g/cm3 (20 º

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Source	SDS/MSDS Samples
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Peer-Reviewed Papers

Mesenchymal stem cells attenuate liver fibrosis by suppressing Th17 cells - an experimental study.Neda Milosavljevic et al.Transplant international : official journal of the European Society for Organ Transplantation, 31(1), 102-115 (2017-08-15) Human serum enhances the proliferative capacity and immunomodulatory property of MSCs derived from human placenta and umbilical cord.Sermporn Thaweesapphithak et al.Stem cell research & therapy, 10(1), 79-79 (2019-03-09) Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.Ting Wen Chung et al.Asian Pacific journal of cancer prevention : APJCP, 15(18), 7995-8001 (2014-10-09) Fast dendritic cells matured with Poly (I:C) may acquire tolerogenic properties.Bojan Pavlović et al.Cytotherapy, 17(12), 1763-1776 (2015-10-13) Trypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells.Philipp Stahl et al.PloS one, 9(10), e110512-e110512 (2014-10-24) T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells.Imane Azzaoui et al.Blood, 128(8), 1081-1092 (2016-06-25) Dental pulp stem cells suppress the proliferation of lymphocytes via transforming growth factor-β1.Gang Ding et al.Human cell, 28(2), 81-90 (2015-01-22) The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal.Vitor L A Lima et al.PloS one, 7(6), e38349-e38349 (2012-06-16) The Utilization of Freezing Steps in Mesenchymal Stromal Cell (MSC) Manufacturing: Potential Impact on Quality and Cell Functionality Attributes.Sofia Oja et al.Frontiers in immunology, 10, 1627-1627 (2019-08-06) Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection.Quentin Lepiller et al.Journal of innate immunity, 7(5), 530-544 (2015-03-21) Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress.Xiao Zheng et al.Brain, behavior, and immunity, 79, 244-255 (2019-02-23) Indoleamine 2,3-Dioxygenase Is Involved in the Inflammation Response of Corneal Epithelial Cells to Aspergillus fumigatus Infections.Nan Jiang et al.PloS one, 10(9), e0137423-e0137423 (2015-09-12) IFN-γ-tethered hydrogels enhance mesenchymal stem cell-based immunomodulation and promote tissue repair.José R García et al.Biomaterials, 220, 119403-119403 (2019-08-12) Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance.Mariam Mathew George et al.Journal of immunology (Baltimore, Md. : 1950), 197(5), 1864-1876 (2016-07-29) Mutual interaction between human multipotent adult progenitor cells and NK cells.Sandra A Jacobs et al.Cell transplantation, 23(9), 1099-1110 (2013-04-09) HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.Rémi Planès et al.PloS one, 8(9), e74551-e74551 (2013-09-28) Crosstalk between mesenchymal stem cells and T regulatory cells is crucially important for the attenuation of acute liver injury.Marina Gazdic et al.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 24(5), 687-702 (2018-03-04) Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus.Bonnie Reinhart et al.Advances in virology, 2012, 815465-815465 (2012-08-28) Human serum enhances the proliferative capacity and immunomodulatory property of MSCs derived from human placenta and umbilical cord.Sermporn Thaweesapphithak et al.Stem cell research & therapy, 10(1), 79-79 (2019-03-09) Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes.E Vogt et al.Reproductive biomedicine online, 19(3), 352-368 (2009-09-26) Multiresponse optimization of a UPLC method for the simultaneous determination of tryptophan and 15 tryptophan-derived compounds using a Box-Behnken design with a desirability function.Widiastuti Setyaningsih et al.Food chemistry, 225, 1-9 (2017-02-15) Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation.F Liotta et al.British journal of cancer, 112(4), 745-754 (2015-02-04) Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue.Jin-Hee Kim et al.Stem cells international, 2018, 8429042-8429042 (2018-05-16) Sequence requirements of oligonucleotide chiral selectors for the capillary electrophoresis resolution of low-affinity DNA binders.Luma Tohala et al.Electrophoresis, 38(9-10), 1383-1390 (2017-03-04) CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/β-Catenin Pathway in Osteoporosis.Wenbin Wu et al.Molecular therapy : the journal of the American Society of Gene Therapy, 28(6), 1518-1532 (2020-04-19) Cyclic peptide-capped gold nanoparticles as drug delivery systems.Nasrolahi Shirazi A, et al. Molecular Pharmaceutics, 10(2), 500-511 (2012) Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection.Quentin Lepiller et al.Journal of innate immunity, 7(5), 530-544 (2015-03-21) Role of 4-1BB receptor in the control played by CD8(+) T cells on IFN-gamma production by Mycobacterium tuberculosis antigen-specific CD4(+) T Cells.Carla Palma et al.PloS one, 5(6), e11019-e11019 (2010-06-15) Phenotypic, Transcriptional, and Functional Analysis of Liver Mesenchymal Stromal Cells and Their Immunomodulatory Properties.Timucin Taner et al.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 26(4), 549-563 (2020-01-18) Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.Ting Wen Chung et al.Asian Pacific journal of cancer prevention : APJCP, 15(18), 7995-8001 (2014-10-09) Fast dendritic cells matured with Poly (I:C) may acquire tolerogenic properties.Bojan Pavlović et al.Cytotherapy, 17(12), 1763-1776 (2015-10-13) Apoptotic cells induce dendritic cell-mediated suppression via interferon-gamma-induced IDO.Charlotte A Williams et al.Immunology, 124(1), 89-101 (2007-12-11) Substrate Oxidation by Indoleamine 2,3-Dioxygenase: EVIDENCE FOR A COMMON REACTION MECHANISM.Elizabeth S Booth et al.The Journal of biological chemistry, 290(52), 30924-30930 (2015-10-30) Bystander inhibition of humoral immune responses by Epstein-Barr virus LMP1.Chao-Yuan Tsai et al.International immunology, 30(12), 579-590 (2018-08-24) Somatostatin Interneurons Promote Neuronal Synchrony in the Neonatal Hippocampus.Tom Flossmann et al.Cell reports, 26(12), 3173-3182 (2019-03-21) Liver myofibroblasts from hepatitis B related liver failure patients may regulate natural killer cell function via PGE2.Min Zhang et al.Journal of translational medicine, 12, 308-308 (2014-11-05) Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis.Yang Luo et al.EBioMedicine, 43, 620-631 (2019-05-12) Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori.Tiziana Larussa et al.Journal of immunology research, 2018, 3739593-3739593 (2018-11-08) Association of breast carcinoma growth with a non-canonical axis of IFNγ/IDO1/TSP1.Bruno Lopes-Bastos et al.Oncotarget, 8(49), 85024-85039 (2017-11-22) Immunosuppressive Mediators Impair Proinflammatory Innate Lymphoid Cell Function in Human Malignant Melanoma.Giuseppe Ercolano et al.Cancer immunology research, 8(4), 556-564 (2020-02-06) Macrophage regulation of B cell proliferation.Naomi Goldman et al.Cellular immunology, 314, 54-62 (2017-02-28) CD44+CD24-/low sphere-forming cells of EBV-associated gastric carcinomas show immunosuppressive effects and induce Tregs partially through production of PGE2.Dayang Hui et al.Experimental cell research, 390(2), 111968-111968 (2020-03-22) Development of a L?Tryptophan?Based Ligand for Regioselective Copper Catalyzed N2?Arylation of 1, 2, 3?Triazoles.Lopes A B, et al. ChemistrySelect, 2(22), 6544-6548 (2017) Human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis via regulation of B lymphocyte maturation.Tae-Hoon Shin et al.Oncotarget, 8(1), 512-522 (2016-11-27) The Mechanisms of Human Renal Epithelial Cell Modulation of Autologous Dendritic Cell Phenotype and Function.Sandeep Sampangi et al.PloS one, 10(7), e0134688-e0134688 (2015-08-01) The mechanism of formation of N-formylkynurenine by heme dioxygenases.Jaswir Basran et al.Journal of the American Chemical Society, 133(40), 16251-16257 (2011-09-07) Investigation on the combined effect of cocaine and ethanol administration through a liquid chromatography-mass spectrometry metabolomics approach.Elena Sánchez-López et al.Journal of pharmaceutical and biomedical analysis, 140, 313-321 (2017-04-07) Carboxyamidotriazole combined with IDO1-Kyn-AhR pathway inhibitors profoundly enhances cancer immunotherapy.Jing Shi et al.Journal for immunotherapy of cancer, 7(1), 246-246 (2019-09-13) A combination of nanosystems for the delivery of cancer chemoimmunotherapeutic combinations: 1-Methyltryptophan nanocrystals and paclitaxel nanoparticles.P Calleja et al.Pharmacological research, 126, 77-83 (2017-09-13) Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes.Maria Teresa Pallotta et al.Journal of cellular and molecular medicine, 18(10), 2082-2091 (2014-09-13) Human renal tubular epithelial cells suppress alloreactive T cell proliferation.M W H J Demmers et al.Clinical and experimental immunology, 179(3), 509-519 (2014-10-15) Human adipose-derived mesenchymal stem cells alleviate obliterative bronchiolitis in a murine model via IDO.Guoping Zheng et al.Respiratory research, 18(1), 119-119 (2017-06-18) Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO).Juliana Croitoru-Lamoury et al.PloS one, 6(2), e14698-e14698 (2011-03-02) Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin.Itzel Y Rojas et al.International journal of obesity (2005), 44(4), 948-963 (2020-01-09) The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells.Christiane A Opitz et al.PloS one, 6(5), e19823-e19823 (2011-06-01) Mechanisms utilized by feline adipose-derived mesenchymal stem cells to inhibit T lymphocyte proliferation.Nopmanee Taechangam et al.Stem cell research & therapy, 10(1), 188-188 (2019-06-27) Total synthesis of (?)-ardeemin.He B, et al. The Journal of Organic Chemistry, 74(1), 298-304 (2008) Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells.Sergej Tomić et al.International journal of nanomedicine, 13, 6941-6960 (2018-11-23) Human diploid MRC-5 cells exhibit several critical properties of human umbilical cord-derived mesenchymal stem cells.Kehua Zhang et al.Vaccine, 32(50), 6820-6827 (2014-08-03) Novel Cβ-Cγ bond cleavages of tryptophan-containing peptide radical cations.Tao Song et al.Journal of the American Society for Mass Spectrometry, 23(2), 264-273 (2011-12-03) Involvement of indoleamine 2,3-dioxygenase in impairing tumor-infiltrating CD8 T-cell functions in esophageal squamous cell carcinoma.Ge Zhang et al.Clinical & developmental immunology, 2011, 384726-384726 (2011-10-21) Streptococcal Pyrogenic Exotoxin A-Stimulated Monocytes Mediate Regulatory T-Cell Accumulation through PD-L1 and Kynurenine.Katharina Giesbrecht et al.International journal of molecular sciences, 20(16) (2019-08-16) Reovirus activates a caspase-independent cell death pathway.Angela K Berger et al.mBio, 4(3), e00178-e00113 (2013-05-16) IDO1 Maintains Pluripotency of Primed Human Embryonic Stem Cells by Promoting Glycolysis.Xin Liu et al.Stem cells (Dayton, Ohio), 37(9), 1158-1165 (2019-05-31) Regulatory Rebound in IL-12-Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells.Qingsheng Li et al.Journal of immunology (Baltimore, Md. : 1950), 195(3), 1293-1300 (2015-06-19) Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population.Enikő Szabó et al.Stem cells and development, 24(18), 2171-2180 (2015-07-15) Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy.Kapil Chaudhary et al.Journal of immunology (Baltimore, Md. : 1950), 194(12), 5713-5724 (2015-05-17) Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation.Jeroen F J Bogie et al.Journal of neuroinflammation, 8, 85-85 (2011-07-26) BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model.Biao Wang et al.Cell death & disease, 9(10), 1024-1024 (2018-10-05) Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs.Christine M Field et al.Current biology : CB, 29(12), 1999-2008 (2019-06-11) Inhibition of indoleamine 2,3-dioxygenase attenuates endotoxin-mediated tolerance in granulosa cells through kynurenine pathway.Sunita Dahiya et al.Journal of cellular biochemistry (2019-04-16) IDO1 and TGF-β Mediate Protective Effects of IFN-α in Antigen-Induced Arthritis.Jaya Prakash Chalise et al.Journal of immunology (Baltimore, Md. : 1950), 197(8), 3142-3151 (2016-09-21)

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