Melting point	213-216 ºC

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Peer-Reviewed Papers

Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors.B Ebert et al.Molecular pharmacology, 52(6), 1150-1156 (1997-12-16) Post-tetanic influences on primary afferent depolarization in the cat spinal cord.B D Gynther et al.Experimental brain research, 74(2), 365-374 (1989-01-01) Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.Norbert Topf et al.Anesthesiology, 98(2), 306-311 (2003-01-29) Brain-stem areas tonically inhibiting dorsal horn neurones: studies with microinjection of the GABA analogue piperidine-4-sulphonic acid.F W Foong et al.Pain, 27(3), 361-371 (1986-12-01) Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.E H Wong et al.Journal of neurochemistry, 44(4), 1162-1167 (1985-04-01) Divalent cations reduce depolarization of primary afferent terminations by GABA.D R Curtis et al.Brain research, 422(1), 192-195 (1987-09-29) Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.Gustav Akk et al.Molecular pharmacology, 74(3), 614-627 (2008-06-12) A NanoLuc Luciferase Reporter Pseudorabies Virus for Live Imaging and Quantification of Viral Infection.Yalin Wang et al.Frontiers in veterinary science, 7, 566446-566446 (2020-11-17) Identifying agonistic and antagonistic mechanisms operative at the GABA receptor.E Galvez-Ruano et al.Journal of neuroscience research, 42(5), 666-673 (1995-12-01) Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.Marc C Gielen et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(17), 5707-5715 (2012-04-28) Muscimol-scopolamine interactions in the rat brain: a study with 2-deoxy-D-[1-14C]glucose.P Helén et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 4(6), 1405-1413 (1984-06-01) Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.S L Hansen et al.British journal of pharmacology, 133(4), 539-549 (2001-06-16) Role of the fastigial nucleus in generalized seizures as demonstrated by GABA agonist microinjections.J W Miller et al.Epilepsia, 34(6), 973-978 (1993-11-01) Propofol increases agonist efficacy at the GABA(A) receptor.S M O'Shea et al.Brain research, 852(2), 344-348 (2000-03-11) GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid.E Falch et al.Journal of neurochemistry, 44(1), 68-75 (1985-01-01) Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones.M S Jensen et al.Neuropharmacology, 23(12A), 1441-1450 (1984-12-01) Analysis of GABAA Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites.Daniel J Shin et al.Molecular pharmacology, 95(1), 70-81 (2018-10-20) On the probable absence of GABA receptors on the terminations of motor axon collaterals in the cat spinal cord.D R Curtis et al.Experimental brain research, 64(1), 114-118 (1986-01-01) Eighteen-year follow-up cohort study on hepatitis B and C virus infections related long-term prognosis among hemodialysis patients in Hiroshima.Ko Ko et al.Journal of medical virology (2020-06-25) The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor.Angelo Keramidas et al.The Journal of physiology, 575(Pt 1), 11-22 (2006-06-10) Piperidine-4-sulphonic acid, a new specific GABA agonist.P Krogsgaard-Larsen et al.Journal of neurochemistry, 34(3), 756-759 (1980-03-01) GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.P Krogsgaard-Larsen et al.Journal of medicinal chemistry, 28(11), 1612-1617 (1985-11-01) Modulation of GABA(A) receptor channel gating by pentobarbital.J H Steinbach et al.The Journal of physiology, 537(Pt 3), 715-733 (2001-12-18) The role of the laterodorsal tegmental nucleus of the rat in experimental seizures.J W Miller et al.Neuroscience, 43(1), 41-49 (1991-01-01) A pharmacological study of group I muscle afferent terminals and synaptic excitation in the intermediate nucleus and Clarke's column of the cat spinal cord.D R Curtis et al.Experimental brain research, 64(1), 105-113 (1986-01-01) Characterization of GABAergic seizure regulation in the midline thalamus.J W Miller et al.Neuropharmacology, 29(7), 649-655 (1990-07-01) Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.B Ebert et al.Molecular pharmacology, 46(5), 957-963 (1994-11-01) Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors.G Maksay et al.European journal of pharmacology, 411(1-2), 55-60 (2001-01-04) Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis.Lorenzo Ricci et al.Biochemical pharmacology, 71(10), 1510-1519 (2006-03-17) Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator.Alison L Althaus et al.Neuropharmacology, 181, 108333-108333 (2020-09-26) The apparent voltage dependence of GABAA receptor activation and modulation is inversely related to channel open probability.Kate K O'Toole et al.Molecular pharmacology, 81(2), 189-197 (2011-11-02) Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit.G Akk et al.The Journal of physiology, 532(Pt 3), 673-684 (2001-04-21)

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