Melting point	89-91 ºC

Symbol(GHS)	Xi
Hazard Codes	R36/37/38
SDS/MSDS	S26;S37/39

Source	SDS/MSDS Samples
Alfa-Aesar	View & Download
Sigma-Aldrich	View & Download
TCI	View & Download

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Peer-Reviewed Papers

S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.M J Millan et al.The Journal of pharmacology and experimental therapeutics, 282(1), 132-147 (1997-07-01) 5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm.M J Millan et al.The Journal of pharmacology and experimental therapeutics, 269(1), 121-131 (1994-04-01) Agonist and inverse agonist efficacy at human recombinant serotonin 5-HT1A receptors as a function of receptor:G-protein stoichiometry.A Newman-Tancredi et al.Neuropharmacology, 36(4-5), 451-459 (1997-04-01) Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism.Jasmin M Dao et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(7), 1319-1331 (2011-03-18) 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis.Sietse F de Boer et al.European journal of pharmacology, 526(1-3), 125-139 (2005-11-29) 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis.Sietse F de Boer et al.European journal of pharmacology, 526(1-3), 125-139 (2005-11-29) Differences in the effects of 5-HT(1A) receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice.Alexa H Veenema et al.Psychopharmacology, 178(2-3), 151-160 (2004-09-28) The control of feather pecking by serotonin.Yvonne M van Hierden et al.Behavioral neuroscience, 118(3), 575-583 (2004-06-04) Serotonergic serotonin (1A) mixed agonists/antagonists elicit large-magnitude phase shifts in hamster circadian wheel-running rhythms.R L Gannon Neuroscience, 119(2), 567-576 (2003-05-29) Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats.Judith R Homberg et al.Psychopharmacology, 200(3), 367-380 (2008-06-27) Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.M J Millan et al.The Journal of pharmacology and experimental therapeutics, 268(1), 337-352 (1994-01-01) Population pharmacokinetic-pharmacodynamic modelling of S 15535, a 5-HT(1A) receptor agonist, using a behavioural model in rats.P Vis et al.European journal of pharmacology, 414(2-3), 233-243 (2001-03-10) Parallel evaluation of 5-HT1A receptor localization and functionality: autoradiographic studies with [35S]-GTP gamma S and the novel, selective radioligand, [3H]-S 15535.A Newman-Tancredi et al.Annals of the New York Academy of Sciences, 861, 263-264 (1999-02-03) Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.A Newman-Tancredi et al.Naunyn-Schmiedeberg's archives of pharmacology, 357(3), 205-217 (1998-04-29) Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535.F Lejeune et al.Synapse (New York, N.Y.), 30(2), 172-180 (1998-09-02) Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model.L Cervo et al.Neuropharmacology, 39(6), 1037-1043 (2000-03-23) Somatodendritic 5-HT(1A) autoreceptors mediate the anti-aggressive actions of 5-HT(1A) receptor agonists in rats: an ethopharmacological study with S-15535, alnespirone, and WAY-100635.S F de Boer et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 23(1), 20-33 (2000-06-28) Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.Jean-Louis Peglion et al.Journal of medicinal chemistry, 45(1), 165-176 (2002-01-05) S 15535, a benzodioxopiperazine acting as presynaptic agonist and postsynaptic 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine.M Carli et al.British journal of pharmacology, 128(6), 1207-1214 (1999-12-01) S 15535 and WAY 100,635 antagonise 5-HT-stimulated [35S]GTP gamma S binding at cloned human 5-HT1A receptors.A Newman-Tancredi et al.European journal of pharmacology, 307(1), 107-111 (1996-06-20) S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties.M J Millan et al.The Journal of pharmacology and experimental therapeutics, 282(1), 148-161 (1997-07-01) Serotonin1A autoreceptor activation by S 15535 enhances circadian activity rhythms in hamsters: evaluation of potential interactions with serotonin2A and serotonin2C receptors.R L Gannon et al.Neuroscience, 137(1), 287-299 (2005-11-18)

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