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Synthetic Route

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Peer-Reviewed Papers

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.Mohane Selvaraj Coumar et al.Bioorganic & medicinal chemistry letters, 17(5), 1274-1279 (2006-12-30) Biosynthesis of 2-amino-2,3-dimethylbutyramide by nitrile hydratase from a newly isolated cyanide-resistant strain of Rhodococcus qingshengii.Zhi-Jian Lin et al.Biotechnology letters, 33(9), 1809-1813 (2011-04-26) Regulation of cAMP accumulation and activity by distinct phosphodiesterase subtypes in INS-1 cells and human pancreatic β-cells.Evan P S Pratt et al.PloS one, 14(8), e0215188-e0215188 (2019-08-24) Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys.Hongjian Zhang et al.Drug metabolism and disposition: the biological fate of chemicals, 35(5), 795-805 (2007-02-17) Cross-Platform Comparison of Therapeutic Delivery from Multilamellar Lipid-Coated Polymer Nanoparticles.Sharon Golan-Paz et al.Macromolecular bioscience, 19(4), e1800362-e1800362 (2018-12-28) Synthesis of uniform protein-polymer conjugates.Bhalchandra S Lele et al.Biomacromolecules, 6(6), 3380-3387 (2005-11-15) Butyramide and monobutyrin: growth inhibitory and differentiating agents.M A Lea et al.Anticancer research, 13(1), 145-149 (1993-01-01) R-stereoselective amidase from Rhodococcus erythropolis No. 7 acting on 4-chloro-3-hydroxybutyramide.Ha-Ju Park et al.Journal of microbiology and biotechnology, 18(3), 552-559 (2008-04-05) Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.Mamiko Kobayashi et al.Biochemical and biophysical research communications, 486(2), 499-505 (2017-03-23) A microreactor for the study of biotransformations by a cross-linked gamma-lactamase enzyme.Anne Marie Hickey et al.Biotechnology journal, 4(4), 510-516 (2009-03-18) Steric hindrance regulation of the Pseudomonas aeruginosa amidase operon.R A Norman et al.The Journal of biological chemistry, 275(39), 30660-30667 (2000-07-13) Effect of butyrate analogues on proliferation and differentiation in human neuroblastoma cell lines.P Rocchi et al.Anticancer research, 18(2A), 1099-1103 (1998-06-06) 4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.Gabor Butora et al.Bioorganic & medicinal chemistry letters, 16(18), 4715-4722 (2006-07-28) Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.Sina Oppermann et al.The Journal of pharmacology and experimental therapeutics, 350(2), 273-289 (2014-05-23) On the use of T61 for euthanasia of domestic and laboratory animals; an ethical evaluation.L J Hellebrekers et al.Laboratory animals, 24(3), 200-204 (1990-07-01) Synthesis of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine analogues. n-Butyramide, 3-chloropropionamide, 3-aminopropionamide, and isovaleramide analogues.J J Kaylor et al.Carbohydrate research, 331(4), 439-444 (2001-06-12) Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, amiC.B P O'Hara et al.Protein engineering, 13(2), 129-132 (2000-03-10) Bench scale production of butyramide using free and immobilized cells of Bacillus sp. APB-6.Rajendra Singh et al.Bioprocess and biosystems engineering, 41(8), 1225-1232 (2018-05-12) Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet.Giuseppina Mattace Raso et al.PloS one, 8(7), e68626-e68626 (2013-07-19) Its preferential interactions with biopolymers account for diverse observed effects of trehalose.Jiang Hong et al.Biophysical journal, 109(1), 144-153 (2015-07-15) 4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.Maja D Vitorović-Todorović et al.Bioorganic & medicinal chemistry, 18(3), 1181-1193 (2010-01-12) NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo.Jiahua Jiang et al.PloS one, 7(3), e34283-e34283 (2012-04-06) PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.Will McDonough et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 12533-12548 (2020-08-02) (R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides.Natalia N Dioubankova et al.Organic letters, 4(26), 4607-4610 (2002-12-20) An experiment in enzyme evolution. Studies with Pseudomonas aeruginosa amidase.P H Clarke et al.Bioscience reports, 8(2), 103-120 (1988-04-01) Bioconversion of butyronitrile to butyramide using whole cells of Rhodococcus rhodochrous PA-34.J Raj et al.Applied microbiology and biotechnology, 74(3), 535-539 (2007-01-12) Discordant effects of butyrate analogues on erythroleukemia cell proliferation, differentiation and histone deacetylase.M A Lea et al.Anticancer research, 15(3), 879-883 (1995-05-01)

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